The device of the fluid injector, the method of administration of liquid medicines

 

(57) Abstract:

The injector is designed for injection of drugs. The injector includes a camera for taking pre-Packed cartridges injection drugs stock for the application of force and drive the liquid medication out of ammo through the injection needle and the source of driving force, the vehicle speed control, direction and protaginist the introduction and withdrawal of the needle, the injection or aspiration of fluid. 2 C. and 17 C.p. f-crystals, 8 ill.

The present invention relates to injection devices-aspiration, injection devices and cartridge tubes intended for use with any one or more devices in the medical and research purposes, and more specifically to devices designed for injection of drugs and other liquids in people and other subjects, using hollow needles.

The invention also concerns methods of introduction of liquid medication through injection corresponding to the invention the device.

Corresponding to the invention the element is injection-aspiration and some of the elements of the cartridge tubes manufactured the logical drive can be adapted for use with a large number corresponding to the invention of ammo.

Under normal medical procedure, injection of drugs or suction blood or fluid using a syringe with a hollow needle injection-aspiration-type needle for subcutaneous injection. Needle disgusting to many patients, particularly those who need to regularly take injections of a drug or to take blood samples. These include elderly patients and people who must take daily insulin injections or other medications. Similarly, pediatric patients are especially afraid of needles. Open or visible needle undesirable because they cause many of the subjects of fear and anxiety.

Another problem in the medical field is the likelihood of the spread of infectious diseases caused by used needles and syringes and liquids of them with whom you come into contact doctors, nurses or other medical personnel. The tips of the needles are often left open after aspiration of fluid or blood from a subject or after injection of the drug in the subject, and medical personnel sometimes accidentally punctured such ends. This problem is particularly acute in such situations, when the syringe and needle is dirty especially adalat special importance after the injection, because the finger, hand or other body part of the person doing the injection, usually located in close physical proximity to the needle during its removal from the tissues of the subject, at the time of replacement of needle or closing the needle or during removal of the needle from the syringe to resolve the issue.

There is also a risk of such exposures to personnel, the type of caring people, not related to medical staff when the used needle and syringe put aside or thrown away with more open tip of the needle. This danger is not eliminated even when the used needle and syringe is placed in the vessel for removal. For example, everyday medical practice to use a device that cuts off the open tip of the needle, so it can't be reused. However, this technique still remain fragments of needles and parts of the syringe, which may be contaminated with infectious agents and with which people may be exposed and become infected. Thus, there is nothing unusual in the fact that the discarded fragments of needles protrude through the plastic bags for trash or other vessels and present a serious risk of receiving a stab wound, Chelonia needle is removed from the syringe and put in airtight vessels, open the syringe should also be put in sealed vessels to reduce the risk of infectious contact with staff. Hygienic removal of used needles and used syringes is expensive and requires a long time to process and entails a substantial risk of exposure to vectors of infectious diseases.

As is known in the art, many needles provide a removable cap that can be removed before injection and re-install after injection to prevent unwanted injections the needle. Action replace the needle cap exposes the user the additional risk of the injection, because the end with the hole of the conventional cap of the needle has a small surface area around the hole, which can protect the user from the needle.

A related problem is the danger of opening of the needle to the influence of the atmosphere before it can be used when performing the injection or extraction of fluid from the body. There is not only danger of injury staff users open with the tip of a needle, but also the danger that open the needle becomes contaminated transportable by air or aerosol m is acute in hospitals and other areas of drug treatment, where strains of antibiotic-resistant microorganisms endemicheski pollute the air and all exposed surfaces. Is the indispensable contact with non-sterile air under normal proper use of the syringe with an open needle, because with this technique the needle is traditionally open air or surfaces for some discrete amount of time during use. In addition, in situations of use in emergencies, such as combat, natural disasters or industrial accidents, unused needle can remain open to such pollution untrained, weary or inexperienced personnel.

Another common problem with the conventional injection syringe is associated with incorrectly entered by injection. The difference is the speed at which the needle should move during introduction into the tissue of the subject, and exceptions to them, and the speed at which the plunger of the syringe should operate to painless way to inject or aspirate the fluid material. Various medical personnel using conventional syringes, applies a different methodology. The method is changed in accordance with the position of the subject, i.e. the part analytische staff. This problem is particularly acute in relation to the untrained or inexperienced personnel. Too slow introduction of the needle causes unnecessary pain. These problems largely arise from the difficulty to actuate the syringe and needle in a way that appropriately alters the rate of introduction and withdrawal of the needle and the speed of injection and aspiration of fluids.

The next challenge in this area is the problem of dosing control. For people who inject themselves, either because they require regular doses of pharmaceutical drugs, either because of a lack of medical personnel, is critical to ensure the correct dosage. In such situations, often people who have diabetes, especially those who suffer from the associated state of blindness. Similarly, other blind people need the product, which ensures that the type of drug and its dose fit their specific needs. Similarly, the soldiers in the field, travelers who need regularly injected drugs and people who find themselves in emergency situations when it is necessary to savinjske, chenie in the use of conventional syringes. Such problems are compounded also by the darkness provided to poor lighting on the battlefield, interruption of electricity supply, and other crisis and emergency situations.

In the medical field injection is known that with intramuscular injection of a drug or other substance you are trying to suck blood or other physiological fluid after injection needle in the alleged appropriate place. This aspiration test carried out to assess the site of injection /that is, essentially as implied in engineering, volume directly near the open end of the needle and in fluid communication with him/ against the presence of blood, lymph, cerebrospinal fluid, or similar liquids. This assessment is made to ensure that pharmaceutical substances or other fluids wrong way unintentionally will not be introduced, for example, into a blood vessel, lymphatic vessel, or cerebrospinal fluid. Inappropriate introduction of a drug or other substance in a blood vessel, lymphatic vessel, cerebrospinal cavity can result in any number of negative actions, including mikologicheskijj substances in inappropriate places often leads to a weakening or loss expected from substances of special functional characteristics or activity. Thus, of paramount importance is ensuring that the needle used for the introduction of a drug or other substance was administered in the appropriate place for injection.

People, do yourself the injections themselves at home in case of emergency or in battle, it is virtually impossible to perform the correct procedure. Similarly, if staff are not trained to perform medical procedures injections due to crisis or emergency situations, the much more likely it can enter the substance or by the application of an incorrect dose, or during introduction of the needle tip in the wrong place /for example, with the introduction of substances directly into the blood stream and not intramuscularly/.

Example, when a pharmaceutical substance is necessary to bring in the right place, is the designation of certain chemotherapeutic drugs for the treatment of malignant tumors. It is important to chemotherapeutic drugs was introduced exactly in the target tissue". The effects of some of these drugs on the skin or in the tissue or the bloodstream can cause serious side effects. Thus, it is desirable to have the tool before the charity and love, or other body fluids will not be inappropriately aspirated from the possible site of injection into the device before the introduction of the device of the drug.

Thus, it would also be desirable to have a device that automatically prevents the injection of pharmaceuticals in undesirable or inappropriate injection. However, in other cases, it may be desirable or necessary to import the drug, for example, in the bloodstream; in these cases it is necessary to make a determination for the purpose of guaranteeing that the injection device before using it for the introduction of drug absorbed physiological fluid type blood.

In those cases, when there is no need to perform the test aspiration, it is still desirable to maintain the sterility of the injection needle and the medicine before injection and automatically enter the required dose of the liquid. In cases where motorized injectors are very sensitive to damage to the battery or electrical system, the desired automatic injector is driven mechanically.

Driven by mechanical automatic injectors also desirable when long-term storage may prevent or reduce the effectiveness of motors the social cost of manufacturing mechanical injectors simple design is an important advantage compared to more complex designs and compared with structures requiring the use of electrical components and electrical circuits.

A summary of the nature and purposes of the invention.

The purpose of this invention is the provision of the closing of the injection needle at all stages of use, thereby reducing the fear of the patient.

Similarly, the present invention is to maintain the sterility of the injection needle at all stages of use by providing a means through which the needle before contact with the patient's skin to penetrate through it, never exposed to any potentially contaminating surfaces of aerosols or airborne particles or microbes.

Another purpose of this invention is the provision of injection tubes, eliminating the risk of getting infections or damage due to accidental contact with exposed needles.

Another objective of the present invention is to provide hygienically used injection tube with a needle after use in injection completely removed in hermetically sealed tube to reduce the risk of disease transmission caused by exposure to contaminated needle or contaminated the key used injection tubes, which can be safely disposed of without the need of special equipment or container, and which can be safely and hygienically to throw outside the hospital, in serious or emergency circumstances.

The aim of the present invention is to provide an ampoule or cartridge designed to release the liquid drug, which can be filled through the use of conventional pharmaceutical packaging mechanism, avoiding, thus, the significant costs that would be required for the development and production of unusual ways and mechanisms of the package.

The next objective of the present invention is to reduce the danger of incorrect injection by providing a means for accurate, automatic and programmable control of the speed of insertion of the needle, the speed of pulling out the needle, the speed of injection of the medicinal product and the speed of the aspiration fluid.

The aim of the present invention is also reducing the danger that the wrong dose of a liquid drug to be introduced by injection.

The next objective of the present invention Avraam will introduce myself.

The aim of the present invention is to provide a means for the automatic evaluation of the injection site to determine, in an appropriate or desired place put the tip of the needle and into the required whether the target tissue".

The next objective of the present invention is the provision of means designed to automatically scan cartridge injection/aspiration during operation to determine from actual or potential site of injection of aspirated blood or other body fluids in the cartridge.

The aim of the present invention is the provision of means designed to automatically prevent the injection of drugs or other liquids in an undesirable or inappropriate tissue or place.

In addition, the present invention is the provision of means for introducing a medicinal product in a pre-selected the target tissue, and avoid the impact of drug in the tissue, which may produce undesirable defeat such exposures.

Another objective of the present invention is the provision of means intended for the introduction or Samovodene the pile-men.

The next objective of the invention is the provision of a mechanically driven injector, which does not require electrical energy and electrical circuits and which can be stored for a long period of time.

Similar to the aim of the invention is the provision of a mechanically driven injector, which is not suitable for re-use and which is suitable for sterilization by radiation, electron rays and gases.

In accordance with the purposes of the invention provides a tube for injection of fluid. The injection tube is a cartridge with two ends, having a first end and a second end, the cartridge has a cylindrical hole defined by a wall running between the first end and the second end, where the hole is suitable for storing a charge of liquid, which should be replaced. Inside the holes of the first piston and the second piston, the moving image is located relative to the cylindrical wall of the hole, and the first piston includes a tool designed for reverse clutch, with the plunger. The cartridge is provided with a sharp end cap, which is rigidly attached to the second hollow injection needle, having an outer end and an inner end, where the inner end rigidly attached to the second piston and passes through it, and the outer end is held in the direction of the end cap, not speaking of it, and a tool designed for non-reversible blocking together of the first piston and the second piston when the first piston and the second piston is located at a predetermined distance from each other. Prefer sharp end cover was made of self-sealing material, although the implementation in practice of the invention it is optional.

The flask can also provide human-readable indicator to indicate the type of medicinal product information for the patient, amount of drug, which belongs to the introduction and different speeds of introducing and retracting the needle and injection and /or/ aspiration fluid.

In accordance with another aspect of the invention provide a programmable automatic injection aspiration, having a housing, a chamber located within the housing, designed to reverse the decision of the cartridge tubes operate the plunger, a sliding image located in the housing. Provided takesplace means of regulators, designed to control the speed, direction and length of movement of the plunger. Thus secured control over the said tool driving, but also provided a programmable processor that is designed to guide and control unit, a sensor for determining the speed, direction and extent of movement of the plunger, the indicator used to reading speed, direction and extent of movement of the plunger and for indicating the amount of liquid remaining and is expelled from the tube with the liquid, and a sensor for determining the existence of an in vitro aspirated physiological fluids. Similarly provided with means designed to automatically prevent the injection of unwanted fabric-target" detection of aspirated fluids, and blocking means designed to prevent unintended release of the drug from the cartridge tubes located in the device injection aspiration.

In accordance with the invention, the cartridge tube containing a charge of liquid medicinal product, can be inserted into ostream injection. And finally, the cartridge tube with a fully drawn by the needle can be removed and discarded, while the device is injection-aspiration can be repeatedly reused with different cartridge tubes.

In accordance with other objectives of the invention provided with a mechanically actuated cartridge tube for injection of fluid. Mechanically driven cartridge tube is a cartridge having a first end and a second end, the cartridge has a cylindrical hole that extends from the second end of the cartridge to form a cylindrical chamber stay site of the needle body, designed to reverse the decision node of the needle body, and the sharp end cap, where the end cap seals the second end of the cartridge and has located therein the guide needle.

Inside the cartridge is a vial having an aperture, and the aperture has a first cylindrical section, the second cylindrical section adjacent to the first section and it already and the third cylindrical section adjacent the second section and wider than him, and vials suitable for storage of a charge of liquid intended to displace it. Mnopoly tightly and sealing manner attach peelable tube ampoule.

The site of the needle housing has a cylindrical bore of the Chuck, and the site includes a casing, a hollow injection needle rigidly attached to the housing and having an inner end and an outer end. The inner end of the needle passes through the needle case node towards the peelable tube sealed, and the outer end of the hollow injection needle passes towards the sharp end cap of the cartridge, not speaking of it. The node further includes an actuator that is designed to lock the cartridge tube and to promote the ampoule to the sharp end cap, as well as to advance the piston within the ampoule to the stopper of the vial with the purpose of the injection fluid.

Located inside the cartridge node needle housing provided with means for locking designed for non-reversible blocking of the needle housing of the node relative to the ampoule when the node of the needle body and the vial are at a predetermined distance from each other. Corresponding to the invention of the mechanical drive element includes a drive housing having a first end and a second end where the first end is adapted for making the cartridge tube, and a second end adapted to bring into action the OK has the end surface of the piston, designed for contact with the piston of the ampoule, the transmission surface is designed to transmit the force of the move from the housing stock, and the trigger end, designed to be able to limit engagement of the second end of the housing. In the second trigger end of the actuator is also provided with a latch designed to able to limit engagement of the piston rod, means for releasing the latch, designed for attachment of the piston rod from the second end, and a push mechanism, located between the transmitting surface and the second end of the housing, designed to drive the piston rod towards the sharp end cap activates when the tool is released the latch.

In accordance with still the same purposes of the invention, located in the mechanical drive mechanism is a spring made of a single material or more from the group including metals, glass, mixtures and plastics. Alternatively, a push mechanism can serve as a compressed gas, such as air, nitrogen, carbon dioxide and the like, released by image contained in the vessel.

Brief description of drawings

Now the invention will be described with Ref and aspiration, illustrating the relative placement of the cartridge tubes and other items;

Fig. 2 represents a view in longitudinal section of the cartridge tubes made in accordance with the first embodiment of the invention.

Fig. 3 - illustrates a second variant implementation of the cartridge tube, which is able to slide ampoule operates similar to the first piston shown in Fig. 2 options, and provided with other means for retracting the needle and the vial can be produced using conventional pharmaceutical packaging mechanism.

Fig. 4 - illustrates another variant implementation of the cartridge tube, shown in Fig. 3, but only for use for injection.

Fig. 5 is a view in longitudinal section of the device of the cartridge tubes intended for use with mechanically driven actuator, illustrating the relative location of the vial, cartridge, site, needle case, and other items.

Fig. 6 is a view in longitudinal section powered by a spring actuator cartridge tube prior to inserting the cartridge tube and illustrates the relative positioning of the housing when the tion.

Fig. 7 is an enlarged view shown in Fig. 6 node activating cap with a view to more clearly illustrate details of the invention.

Fig. 8 is a view in longitudinal section of the cartridge tubes intended for use with mechanically driven actuator, which is coupled with this drive, and illustrates the relative location of the main elements of the tube and the actuator upon activation of the actuator, the completion of the injection and closing the open injection needle pin drive protection.

Detailed description of preferred embodiments of the invention.

It is shown in Fig. 1 the device is injection-aspiration includes a housing 201 for the location of different elements having the chamber 219, designed to receive the reverse way of the cartridge tubes of the type described below and shown in Fig. 2 and 3, the motor 203 DC, lead screw 205, linear bearing 207, designed to hold the drive nut and drive nut 213 surrounding the lead screw and svodimy safety switch 209 of the injector, the indicator light-emitting diodes 211, the plunger 215 attached to the chassis screw 205, the cartridge tube 217, located in what about the current 225, switch on-off switch 227, the solenoid 229 lock the position of the cartridge and sealed with the rod 231 of the solenoid, the sensor 233 aspirated fluid and the sensor 235 of speed, position and direction of the plunger.

Corresponding to the invention the device is injection-aspiration works together with the cartridge tubes, as described below. All the elements of the device actuates a source of DC voltage 225 after turning on the switch 227. Engine 203 DC drives the lead screw 205, which is connected to chassis nut 213, and pull the plunger 215, which is reversible attached to the traction end 216 of the cartridge tube by means of keyways provided on the end of the thrust plunger 215. For smooth operation of the lead screw 205 and thrust 215 plunger provided with a linear bearing 207. As a fixing means designed to connect the lead screw 205 with a thrust plunger 215, provided the nut of the lead screw 213. The electronic control unit 221 is a programmable electronic processor connected by wires not shown motor 203 DC to control the speed, direction and length of movement of hygenia traction end 216 of the cartridge tube. As the traction end 216 of the cartridge tubes you can use any type made to create a hard, but reversible fixing to pull plunger 215. Similarly, as will be described below, the rod 215 of the plunger can be adapted to actuate the other of the cartridge tubes, for example tubes, designed for use with a spear thrust, type of traction, known in the field of dental cartridges. The electronic control unit 221 programmed by programmable random-access memory /EPROM/ and programmable matrix logic, which, depending on the use of the device, can be replaced with the purpose of adapting the device to the age or sex of the patient, the parameters of the injection site (for example, intramuscular, subcutaneous or intravenous, in terms of speed and pulled the needle in terms of speed of injection of the charge of the medicinal product. The electronic control unit also includes an electronic time relays that control General synchronization and special speeds during the injection process. Set programmerelated commands is stored in a replaceable and removable crystal memory /not shown/ e is itallow memory can be modified programmable way different device features injection-aspiration. The mechanism 229 lock the position of the cartridge and capsules is the solenoid, which can be actuated to block the cartridge tubes in a specific location using a stud 231 solenoid lock the position of the cartridge and capsules so that you can suck the blood or other fluids. Although the locking mechanism it describes the solenoid and the rod of the solenoid, it can be clearly demonstrated that it is possible to use many other tools to accomplish goals a device designed to block any type of cartridge tubes in a specific location in the device injection-aspiration.

Similarly, although in the example described here, a programmable and/or replacing the memory crystals, it can be clearly demonstrated that for the purposes of the invention it is possible to use many other software defined functions.

It is also clear that although the controls are different speeds of operation of various relevant for the invention of the elements described here, the motor voltage DC power supply with electronic elements, you can also use other tools, type of compressed gas with cepediana electrical circuits.

You also need to understand there are many different tools designed for reliable connection of the cartridge tube with a thrust plunger 215 and easily detach from it. As an example and not as limitations described is shown in Fig. 3 rod 47 of the plunger device injection-aspiration, having peaked which may be scabrose head 49 of the thrust plunger, similar pointed tagum known in the field of ammo dental injection, which is given to such a sufficient distance in the piston 45 during operation corresponding to the invention of a device that is reliable enough connection for actuation of the piston 45 in both directions. Disconnecting serrated head 49 of the piston 45 is performed by the discharge of the thrust plunger 47 and the head 49 of the thrust of the plunger at a sufficient distance in the running nut 213, which has a corresponding inner diameter to perform the separation.

Corresponding to the invention the part of the cartridge tube includes a hollow needle injection aspiration, attached to the piston so that its outer pointed end, for hygienic reasons, the original is mentioned inside the end cap. Ensure the in movement of the injection needle and the injection fluid in the subject, and then withdrawal of the injection needle by the first piston from the subject through reinforced end cap at a sufficient distance that the tip of the needle was not open to the air before, during and after work the relevant invention device. The present invention provides a tool for pulling the needle tip and free cartridge immediately after injection and before the injector device will take you from physical contact with the subject. This reduces the risk of unintentional exposure to the tip of the used needle on users and nonusers, because the tip of the needle should never be open.

Corresponding to the invention of the automatic portion of the injector includes a chamber for accommodating a test tube, a piston working plunger, designed to actuate the tubes, and a power source that is designed to actuate the plunger. The injector also includes a control device for changing the speed of insertion and withdrawal of the needle and the speed of injection of the liquid. The invention can be used for aspiration of blood or other liquids.

Variants of the cartridge tubes

The advantage of the emission can be explained in the following detailed description of one variant of the device of the injection aspiration and three variants of the cartridge tube in conjunction with the accompanying drawings, which will be given as examples and not limitations.

In Fig. 3 shows that the cartridge tube includes a cylindrical housing 1 with two ends, is constructed from a rigid material and having a hole 53 for the rod of the solenoid lock cartridge and capsules, holes 42 for sensors aspirated liquid chamber 15 for a stay of the ampoule and the camera 11 for making cylindrical node of the needle body. The Chuck body 1 is equipped with a peelable sealing end cap 3 of elastic material, a plastic guide 5 needle rigidly mounted in the end cover 3 formed therein a guiding hole 7 for the needle and the guide 9 installation in the desired position of the injection device. The camera 11 making the needle site is further provided with curved lugs 13 configured to allow entry of body 16 needle node in the camera 11 of the adoption of the housing of the needle site and logoff. The housing 16 of the needle hub and the ampoule 31 first feature inside the chamber 15 stay capsules. Glass ampoule 31 located inside the cartridge, equipped with a camera of the three sections, in which you store the battery 51 of the liquid. The first section 33 of the ampoule 31 sobule of elastic material. The stop 40 of the piston chamber ampoule forms a transition between the first section 33 of the ampoule and the second section 35 of the ampoule and forms a stop for the piston 45 while the invention. The outer part of the transition between the first section 33 of the ampoule and the second section 35 of the ampoule forms a shoulder 41 of the capsule. The vial 31 is further provided with flanged edges 43 of the gear, which is formed by tapering the transition region between the second section 35 of the camera and the third section 37 of the camera.

The vial 31 is further provided with a piston 45 of elastic material designed for reversible engagement of the pointed head 49 of the thrust plunger having a plunger rod 47 device injection-aspiration. This vial can reverse way to concatenate with the device injection-aspiration using a different tool other than piston-like plunger 45, as shown, for example, using the T-shaped rod and keyways or any other means providing reliable reversing clutch device of a cartridge with injection device aspiration.

The housing 16 of the needle site is provided with a base 18 of the body of the needle hub, the walls 17 of the needle body, the flanges 19 of the body of the needle hub and the edges 21 of the housing, the yoke of the hollow injection needle 23, which passes through and has an internal tip 25, located towards the peelable lid 39 of the ampoule, and the outer tip 27, which passes through the hole 7 of the guide 5 needles, but does not penetrate through the sealing end cap 3.

Wall 17 of the housing needle site have sufficient length so that when the cartridge as described below, the third section 37 of the ampoule is captured by engagement of flange edges 21 of the needle housing site for flanged ledge 43 gearing ampoule 31, before the inner end 25 of the needle in contact with the sharp end of the tube 39 ampoule, and the ampoule 31 will move a sufficient distance to peelable sealing end cap 3 of the cartridge, the housing 16 of the needle site is completely inside the chamber 11 making body of the needle site.

Although as an effective means for marking corresponding to the invention of the cartridge tubes and elements of the injector-aspirator shows the barcode, you can use any other tool or other means for marking the invention in order to enable machine reading and for reading man. For example, both elements of the invention m is Provimi characters.

The above option corresponding to the invention of the cartridge tube ampoule type functions as described below.

The piston 45 moves toward the sealing end cap 3 by the application of force to pull plunger 47, and this force is communicated through the head 49 of the thrust plunger piston 45, applying, therefore, the hydraulic pressure through the battery 51 of the liquid and moving the vial needle 31 to the node 16. Continued pressure on the head 47 of the thrust plunger is communicated through the flanges 19 of the needle housing wall 17 of the needle housing and the base 16 of the needle body, the needle 23, promoting thus the needle 23 through the opening 7 of the guide needle, causing piercing of the outer end 27 of the needle sharp end cover 3. The continuing effort towards the sharp end cap 3 of the cartridge piston 45 continues to push the needle 23 outward until the needle housing 16 will stop sealing end cap 3, having, thus, the housing 16 of the needle site inside the chamber 11 of the adoption of the needle hub, which has a larger diameter than the diameter of the chamber 15 stay capsules. The location of the needle site 16 inside the chamber making the needle site allows the flanges 19 and the walls of the needle 17 of the node 16 raleene force in the same direction causes the promotion peelable tube 39 ampoule ampoule 31 to the inner end 25 of the needle, piercing, thus, the tube 39 ampoules and causing the contact plugs 39 ampoule with the base 18 of the housing needle site. At this point, the operation corresponding to the invention of the device, the solenoid 29 of the lock location cartridges and ampoules /shown in Fig. 1 but not shown in Fig. 3/ is excited, causing the passage of the core 31 of the solenoid lock location cartridges and capsules are also shown in Fig. 1 but not shown in Fig. 3/ through hole 53 of the solenoid lock the location of the cartridge capsules, hard blocking, thus, the ampoule 31 and the needle site 17 relative to the guide 5 needles. Then the direction of application of force to the head 49 of the thrust of the plunger can be changed to reverse, causing a slight abstraction of the piston 45 from the end cover 3, thus causing the suction in the liquid 51 in the ampoule 31 body fluids /liquids/ if the tip 27 of the needle located now possible site of injection in the tissue, it is reported with such fluid. Then, the sensor 233 aspirated fluid and the light source, type photodiode or photocell 232 corresponding to the invention the element is injection-aspiration /shown in Fig. 1 but not shown in Fig. 3/ scans liquid in the ampoule 31 through the CTE is eskay liquid /fluid/. If the fluid is not detected and is considered to be desirable or appropriate, when nothing is absorbed in the injected drug from the injection site, or if the liquid /liquid/ that can be detected, showing that the possible site of injection, which is the tip 27 of the needle, are not unwanted or improper, the injection cycle continues and the place where is located the tip 27 of the needle, is used as the injection site. The ongoing effort in the same direction to the end cap 3 on the piston 45 causes the popping charge fluid 51 through a needle 23 in the subject.

When the operation corresponding to the invention an automatic injection device aspiration of the above type, the speed of advancement of the head 49 of the thrust of the piston is changed to control the speed of insertion of the needle 23 and the speed of injection of the charge of fluid 51. In addition, when the operation corresponding to the invention of the device, the usual time this sequence of introducing the hollow injection needle 23 is of the order of 100 milliseconds. After injection of the charge of liquid 51, the operational sequence proceeds to the stage of abstraction and grip needle through the reversing force golovy vacuum, created by the abstraction of the piston 45 causes the abstraction ampoule 31 from the needle 23 a sufficient distance so that the inner tip 25 of the needle no longer penetrates through peelable tube 39 ampoules. Abstraction ampoule 31 from the tip 25 of the needle contributes to the bias force caused by contact between the curved flanges 19 of the body of the needle hub and curved shoulder 41 of the capsule. Thus, the flanges 21 of the needle housing of the node are then concatenated with flanges siteplease ledges 43 on the vial 31. Then the rod 231 solenoid lock /shown in Fig. 1 but not shown in Fig. 3/ play, allowing you to continue to keep connected node ampoules and needles. Thus, irreversible connected node ampoule and needle play, when the piston 45 is given continuing effort in the direction from the peelable sealing end cap 3, removing thus the needle 23 from the site of injection at a sufficient distance so that the outer end 27 of the needle was completely trapped inside the chamber 11 making the needle site. Thus, no portion of the needle 23 do not need to open any environment, but the tissues of the subject or the inner part of the cartridge tube. The usual duration of a sequence of abstraction and sight of the device, if the sensor is aspirated fluid 233 detects undesirable or inappropriate physiological fluid /for example, blood or absence of physiological fluid /for example, lack of blood, if it is assumed injection/, the sequence of injections can be automatically stopped, thus preventing the injection of drugs or other liquids in an undesirable or unsatisfactory injection.

Considering Fig. 4, note that there is illustrated corresponding to the present invention a variant of the cartridge tubes intended for injections, and one does not need to aspirate. The cartridge 401 is equipped with is able to slip the vial 431 having a piston 445 for receiving the head serrated thrust of the plunger, known in the field of dental injection cartridges, and having a second section 435 of the ampoule, which is less than the third section 437 of the ampoule, and the area between them forms a surface engagement for saralaya flanges 419 node 418 needle housing. The housing 418 needle Assembly is provided with walls 417 of the housing needle site of sufficient length so that when the flanges capture the third section 437 capsules 431, the tip 425 needles already pierced n the 423 is executed, not allowing you to withdraw the tip 425 needle from the sharp end caps 439.

Additional advantages and features relevant to the present invention the variant non-ampoule type can also be described in the following detailed description of the second variant of the element cartridge tubes in conjunction with the accompanying drawings, which should be considered as an example and not by limitation.

It is shown in Fig. 2 tube cartridge type contains a cylindrical glass tube 101 with two ends, provided with a peelable sealing end cap 103 of elastic material; solid plastic guide 105 needle rigidly clamped in sharp end cap, and the first piston 117, sliding image installed inside the holes 118 of the cartridge. The first piston 117 is equipped with a rod 119 gearing thrust with the end 120 of the rod. The cartridge also contains a second piston 115, which is also a moving image is located inside the hole 118 of the cartridge. The inner end 111 of the hollow inyectoras needle 107 passing through the piston 115 rigidly attached washer 119 mounting needle. Hollow injectory needle 107 is also the outer end 109 which passes through the cylindrical hole 104 Krysko 103. The cylindrical hole 104 has a sufficient diameter to allow expulsion of air from the chamber 125 during operation of the device. The second piston 115 is also fixed notch clutch 121 stainless steel, which goes in the direction of the first piston 117. Charge 123 liquid drug is located between the piston 117 and the piston 115.

Corresponding to the invention of the cartridge tube operates as described below.

The space in the hole 118 between the piston 117 and the piston 115 is filled with a charge of liquid drug 123, intended for introduction into the subject. The piston 117 moves through rigidly connected piston rod 119 of the piston towards the piston 115, moving the piston 117 in the direction of the piston 115, applying, therefore, the hydraulic pressure through the charge 123 fluid to the piston 115 which moves the piston 115 in the longitudinal direction of the hole 118 of the cartridge. This, in turn, leads hollow injection needle 107, which is directed needle guide 104 through the sharp end cap 103. Continued pressure on the head 120 of the piston rod, reported through the piston rod 119 of the piston causes the piston 115 to the needle direction is atrona with an ampoule /not shown in Fig. 2, but is available in Fig. 1/ introducing the rod 231 solenoid /not shown in Fig. 2, shown in Fig. 1/, thus blocking the cylinder 101 relative to the end cover 103.

After that, the direction of the force applied to the head 120 of the plunger rod of the piston can be reversed to cause a slight abstraction of the piston 117 from the end caps 103, thus causing the absorption of body fluids /liquids/ charge 123 fluid, if the tip 109 of the needle, now located in a possible injection into tissue, is associated with such fluid. Then, the sensor 233 aspirated fluid and the light source /photodiode or photocell 232/ /shown in Fig. 1 but not shown in Fig. 2/ in accordance with the invention element injection-aspiration /not shown in Fig. 1, shown in Fig. 2/ scans fluid in the bore between the piston 117 and the piston 118 to detect the presence of physiological fluids /liquids/. If the fluid is not detected, and is required as a desirable or appropriate, to avoid sucking in a possible injection site, which is the tip 109 of the needle, or if the liquid /liquid/ that can be detected suggests that the processes in place as the actual site of injection or injection of charge drug.

Continued application of force to the piston 117 through the rod 119 of the piston then causes the popping charge 123 of the liquid drug through a hollow injection needle 107 and the subject. Continued application of force to pull 119 of the piston results in movement of the piston 117, so that he was within a predetermined distance from the piston 115 sufficiently on the notch 121 order irreversible blocking of the needle 107 and piston 117 relative to the piston 115, when the last part of the charge 123 liquid drug is pushed out from the hole. Rod 231 solenoid lock /not shown in Fig. 2, shown in Fig. 1/ now displayed, allowing you to take the bullet. When the direction of the force applied to the thrust 119 of the piston is changed to the opposite, the piston 117 moves away from the end cover 103 in the bore of the Chuck, pulling the piston 115, which is locked relative to the piston 117 through the locking notch 121 stainless steel, needle control 104, giving, thus, the needle 107, which is rigidly attached to the anchoring plate 113 to the piston 115. Continued application of force in this direction leads attached to the piston 119 removes the end 109 of the needle 107 through sharp end to the on. Thus, after the completion of all injection needle 107 is completely inside the hole 118 of the cartridge.

During the term of this option, if the sensor 233 aspirated fluid detects undesirable or inappropriate logical physiological fluid /for example, blood or absence of physiological fluid /for example, lack of blood, if it is assumed intravenous injection, the sequence of injection is automatically stopped, thereby preventing the injection of medication or other fluids to unwanted or improper injection.

Although one preferred method of use of the cartridge tubes of the above type are presented with an automatically actuated unit injection aspiration as described above, it is possible to show that under some circumstances it is preferable to use such ammunition tubes with mechanical or manual actuation of the injection device. For example, in cases when not in the presence of a battery or power source, or their use is undesirable because of problems of storage, or where there is neveda mechanical injector. In addition, it is desirable to have the injector in which all the elements can be stored for a long period of time and which is suitable for sterilization by gamma or other radiation, electron rays and gases such as ethylene oxide. Fig. 5 to 8 illustrate the preferred option corresponding to the invention of the mechanical drive and cartridge.

In Fig. 5 illustrates a variant corresponding to the present invention the cartridge tubes intended for injection when you don't need to aspirate. Chuck 2401 is equipped with is able to slip the vial 2431 having a piston 2445 intended to displace liquid from the liquid chamber 2438 and having a second section 2435 of the ampoule, the outer diameter of which is less than that of the third section 2437 of the ampoule, and the area between them forms siteplease surface 2436 designed to engage the flanges 2419 node 2418 needle housing. Case 2418 needle Assembly is provided with walls 2417 housing the needle site of sufficient length so that when the flanges 2419 will capture the third section 2437 capsules 2431, the tip 2425 needle is punctured peelable sample 2439 capsules. Wall 2417 housing the needle site are of sufficient diameter to enlarge 2417 could not occur in the assumptions can slide capsules 2431.

In Fig. 6 and 7 illustrate a variant of the corresponding present invention actuator cartridge tubes intended for injection. Case 2001 drive cartridge tube equipped with a camera 2005 adoption of the cartridge tube that is designed to accept the cartridge tube shown in Fig. 5 type and equipped with recesses 2004 lockout cartridge tubes intended for engagement and fitting the cartridge tube. Case 2001 drive cartridge tube is also equipped with a focus 2003 on-site installation of the cartridge tubes designed to hold the cartridge tube in a predetermined location. Case 2001 drive cartridge tube equipped with a camera 2006 stay on the piston rod, in which the moving image has the 2007 stock piston.

The 2007 stock piston exempt well established through the support surface 2019 flange of the piston rod in the body housing 2001 through flanges 2017 releasing piston rod attached to the shoulders 2015 release of the piston rod. The 2007 stock piston equipped with a spring 2013 piston rod, which is located around the shoulders 2015 release the piston rod in a compressed condition and rests on the shoulder of 2009 to the spring of the piston rod and the second tubes.

Case 2001 drive cartridge tube equipped with a cap activation 2021, with the surface of the 2035 design of flange, which freely rest on the flanges 2017 release of the piston rod. Cap 2021 activation equipped with rim 2023 mounting cap activation, which surrounds the ring 2018 gearing cap activation and is further provided with a groove 2025 cap activation, which allows longitudinal movement of the cap 2021 activation relative to the housing 2001 drive cartridge tubes. Cap 2021 activation is also equipped with a hole 2027 for safety locking pin cap activation, intended for adoption through the needle cap 2031 safety pin.

Thus, we can clearly see that the shoulders of the 2015 release of the piston rod and flanges 2017 piston rod is kept mounted on the flange support 2019 piston rod by lengthening the cavity 2029 safety locking pin piston rod cap 2031 safety locking pins and needles. The safety cap of the stopper pin and needle equipped with a hole 2033 needle cap, which you can use to Zack the IG. 5. /see Fig. 8/.

Corresponding to the invention is mechanically driven cartridge tube, as shown in Fig. 5 and 8, works as described below.

The space in the chamber 2438 liquid in the ampoule is filled with charge 2440 liquid medicinal product intended for injection into the subject of the end cap 2403. Continued pressure on the piston 2445 further causes the tension flange 2419 housing the needle hub and the piercing tube 2439 ampoule inner end 2425 needle.

Continued pressure on the piston 2445 through lengthening of the stem 2013 piston connected by a rod 2007 of the piston, causing the injection of charge 2440 fluid through a hollow injection needle 2423 until the piston 2445 will relate to the internal focus 2432 capsules. Then mechanically actuated cartridge tube away from the target area of the subject, and then the cap 2031 safety locking pins and needles is located over the open part of the elongated needles 2423 to prevent unwanted or inadvertent needle sticks. Thus, no portion of the needle 2423 never need to open any environment, in addition to tissue of the subject or the inner part prana, the body of the needle hub, the cap activation, needle guide, end cover, lid safety locking pin and needle and piston rod is known in the field of medical equipment resistant to irradiation of polypropylene. However, we can clearly prove that the area of medical and dental packages and hypodermic syringes are standard many other materials, such as plastics, including plastic, glass filler, the compositions of graphite fibers, rubber, known in the art of synthetic and non-synthetic materials and blends of nylon and graphite filaments. The preferred material for the injection needle and the flange bearing piston pin is stainless steel. However, there are other acceptable replacement materials such as glass, ceramics and mixed with graphite fibers.

The preferred material for the piston rod is a mixture of nylon and graphite fibers, although the implementation in practice of the present invention is acceptable various other materials having sufficient elasticity, rigidity and tensile strength.

Preferred materials for the piston of the ampoule, the end caps of Patras the new rubber with a glass filler and various plastics, if they have the required characteristics of the possibility of seal prokalivaemosti and manufacture with precise tolerances. The preferred material for peelable tube ampoule is a rubber disk or diaphragm, rigidly attached to the ampoule and sealing it with aluminum cover, standard in medical and dental technology.

The preferred material is glass ampoules United States Pharmacopeia with silicon processing, although well known in those peak many plastic and composite materials.

Suitable materials for the spring piston rod also include carbon steel, stainless steel, nylon, glass-filled, various glass or any other material capable of shifting and moving force in accordance with the invention.

Prefer that all of the elements of the invention had the opportunity to be sterilized through the use of gamma rays, electron rays or ethylene oxide. Such materials include plastics American Bureau of standards, polycarbonates and mixtures of graphite filaments.

The size of the needle site, you must rely on alausa to expand the flanges of the needle housing site when a specific amount of force passed from spring to the piston rod. Of course, you can also show that the characteristics of the springs, such as the length of the uncompressed material and the stiffness can be changed to accommodate the spring piston rod for use with specific types of ampoules and buildings needle sites.

With little change in the present invention can be adapted to be actuated by forces different from the release of the compressed spring. For example, corresponding to the invention, the device can be powered by the release of compressed gas released by image contained in a vessel that replaces the shoulders 2015 piston rod and spring 2013, as shown in Fig. 6 and 7. The release of the gas in this case causes the piston 2445 to end cap 2403 body 2401 cartridge tubes located in the receiving chamber 2005, leading thus corresponding to the invention of the device in the manner described above relative to the cartridge, which is driven by the spring.

Naturally, it is also clear that for a small change of the corresponding present invention device, it can give such a configuration, to permit the discharge of the needle after the injection of the trigger rod end 2007 of the piston can be made brittle by the effect of the release latch. For example, the flanges 2017 rod can be made from brittle plastic or composition which, when the pressing cap 2031 activation breaks off from the shoulders 2015 release, to release the energy of spring 2013. Thus, the device can be done such that it cannot be reused, so as to prevent unsanitary or unwanted use. Examples of materials from which to produce fragile items include compositions with glass filler compositions with metal filler, the composition with graphite fibers, fiberglass, glass, nylon, compositions of nylon and graphite fibres and wood.

For example, providing a notch or other means for non-reversing clutch piston of the ampoule with the piston rod and providing a means by which the drive unit can uncouple from the cartridge tube in a way to take the rod of the piston of the ampoule, it is possible to implement the abstraction of the injection needle to its placement inside the cartridge.

You can also clearly show that the corresponding present invention the injector and the injector-suction device suitable for use with cartridges of the type described in the related application pikh the present invention devices for use with some of the two-component cartridges, as described in the application N 07/740.843 may require minor changes to the camera that is designed to accept the cartridge. However, these changes do not go beyond the scope of claims of the present invention, and specialists in this field of technology they can easily perform. These cartridges fit for storing two components, at least one of which is liquid, with the purpose of education immediately before injection of liquid capable of injected drug, and require the application of force to the piston to actuate.

As for the disclosed here elastic materials, such materials are standard materials used in medical and dental packages and hypodermic syringes, type of rubber, plastics, and other known in the art of synthetic and non-synthetic materials intended to perform similar and related tasks. In addition, all disclosed here options of the cartridge tubes fit so that they could produce equipment designed for the manufacture of standard medical and dental vials and packages.

Disclosed is a liquid. However, a typical such tubes contain, when fully charged from 0.5 to 10 milliliters of liquid.

The needles have a length and caliber and are made from materials that are standard in the field of syringes and needles for subcutaneous injections.

1. The unit injector fluid driven mechanically, containing (A) a tubular cartridge having a first end and a second end, and the said cartridge has an internal hole that extended from the mentioned second end of said cartridge to form a camera stay site of the needle body for decision with the possibility of reverse site of the needle body and the sharp end cap, where does it end cover seals mentioned second end of said cartridge; B) a vial located within the said openings of the cartridge, having a first section and a second section, and said ampoule is suitable for storing a charge of liquid, subject to removal from it; C) a piston, a sliding manner inside the aforementioned first section mentioned ampoule; G) peelable tube vials, rigidly attached to the said second portion mentioned ampoule and sealing it, amptron, and referred to the site of the needle body includes a housing, a hollow injection needle rigidly attached to said housing and having an inner end and an outer end, and mentioned inner needle passes through the site of the needle body in the direction of the said peelable tube ampoule, and the outer end of the hollow injection needle passes towards the sharp end cap mentioned cartridge, not leaving it, (E) a drive capable of coupled with said tubular cartridge, designed to promote the capsules towards the mentioned site of the needle body and the sharp end cap and to promote the above-mentioned piston inside the ampoule in the direction of the said tube vials for injection of the above-mentioned charge of liquid through a hollow injection needle.

2. The device under item 1, characterized in that the said site of the needle housing is fitted with a locking tool for nonreversible locking enclosure needle of the node relative to the ampoule, when referred to the site of the needle housing and said ampoule is located at a predetermined distance from each other.

3. The device according to p. 1, wherein the first end is adapted for approval of the above mentioned tubular cartridge, as mentioned second end is adapted to actuate the actuator, (II) a piston rod, a sliding image located in the said casing, and the said rod has an end surface of the piston that is designed to interact with the said piston of the ampoule, the surface of the transfer, meant for promoting strength from the case mentioned rod, and activating the end, designed to be able to break free of the engagement referred to the second end of the drive body, III) a latch on said second activating end intended for able to be free of engagement mentioned piston rod, IV) means to release the latch for activating the second end, designed to release the above-mentioned piston rod from the second end, (V) the mechanism of message traffic located between the surface of the transfer of the second end of the said casing, designed to drive the above-mentioned piston rod towards the sharp end cap when activated mentioned means to release the latch.

4. The device according to p. 3, characterized in that the said mechanism traffic message is spring.

5. The device according to p. 4, atakol, compositions and plastics.

6. The device according to p. 3, characterized in that the said mechanism traffic message is able to release the compressed gas contained in the vessel.

7. The device under item 1, characterized in that it further contains a human-readable indicator.

8. The device under item 1, characterized in that it further contains a locking means designed to prevent the inadvertent emptying of the mentioned devices.

9. The device under item 8, characterized in that the said locking means includes a removable pin having a protrusion that is designed to prevent the activation of the means of releasing the latch.

10. The device according to p. 9, characterized in that the said locking means further comprises a recess corresponding in size, designed for closing and gripping said portion of the needle projecting out of the mentioned sharp end caps after the injection.

11. The device under item 1, characterized in that it further contains a human-readable display, which is intended for coupling the cartridge tubes and vials with the said actuator and to display information to the patient.

13. The device according to p. 12, characterized in that the fragile stem includes one material or more from the group comprising structures with glass filler compositions with metal filler, the composition with graphite fibers, fiberglass, glass, nylon, a blend of nylon with graphite fibres and wood.

14. The device under item 1, characterized in that the said outer end of the said injection needle is located inside the sharp end caps mentioned cartridge at a sufficient distance to provide impermeable to microbes seal, not speaking.

15. The device under item 1, characterized in that the said inner end of the injection needle is located inside sharp screen at a sufficient distance to provide impermeable to microbes seal, not speaking.

16. The device according to p. 15, characterized in that the said sharp end cover of the cartridge is equipped with one or more of the group consisting of antiseptics, antibiotics, antiviral and antimicrobial agents.

17. The device according to p. 15, otlichayushiesya means, antibiotics, antiviral and antibacterial agents.

18. Route of administration of liquid medicines, characterized in that A) provide a cartridge having a first end and a second end, and the said cartridge contains I)a cylindrical hole that extends mentioned near the second end of said cartridge with a possibility of formation of a cylindrical camera stay site of the needle body for decision node of the needle body; (II) the sharp end cap, where does it end cover seals the second end of the said cartridge; (III) a vial located within the said openings of the cartridge, having a first section and a second section, and said ampoule is suitable for storing a charge of liquid, subject to removal from it; (IV) a piston within the first mentioned section mentioned ampoule and the moving image located in the ampoule; V) peelable tube vials, rigidly attached to the said second portion mentioned ampoule and sealing; (VI) the site of the needle housing located in said cylindrical hole of said cartridge, and referred to the site of the needle body includes a housing, a hollow injection needles, the inner end of the said needle passes through the said site of the needle body in the direction of the said peelable tube ampoule, as mentioned outer end of the said hollow injection needle goes in the direction of the said sharp end cap mentioned cartridge, not speaking of it, (VII) the actuator for engagement mentioned cartridge tubes and to promote the capsules towards the sharp end cap and to promote the above-mentioned piston inside the ampoule in the direction of the said tube is sealed with the purpose of the injection fluid, B) have referred to the end cap of the cartridge at the injection site, In) activate the above-mentioned actuator, G) support the above mentioned contact with the said injection before the injection of said fluid, D) assign the said device from the injection site.

19. The method according to p. 18, characterized in that the further exercise E) closing after the injection part of the needle projecting out of the mentioned sharp end caps mentioned by means of blocking the drive.

 

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