The treatment for burns

 

(57) Abstract:

The invention relates to medicine, in particular to pharmacology, concerns the creation of funds for the treatment of burns 1, II, IIIa and IIIB degree. The treatment for burns contains olive oil, beeswax and organic lead salt at the ratio of ingredients, wt. %: wax 14,0-30,0; organic lead salt 0,05-0,11; olive oil else. The treatment for burns is a radical treatment for at defeat 2/3 % of the body surface. 1 C. p. F.-ly.

The invention relates to medicine, in particular to pharmacology, and can be used as a treatment for burns I, II, IIIA and IIIB degree.

Known healing ointment (U.S. Patent N 4883664, A 61 K 35/78, 31/19, 1993).

Ointment suitable for topical treatment of various burns caused by boiling water or steam and contains about 2. including olive oil, about 1. including beeswax, about 4. including anhydrous lanolin and trace amount of pine tar.

It is also known remedy for treating burns, infections, wounds, ulcers, skin lesions, which comprises as active ingredients the calculated amount of silver or of mineral or organic salts and antibiotics, such as apologizin, t SU 1805952 A 61 K 9/06, 1993 ), which is an ointment that as fat product contains vegetable oil, as a bee product - wax, and as an antiseptic, rivanol. The developed tool has a high penetration in the tissue and used for the successful treatment of trophic ulcers and burns II and III. This recovery occurred within 12 to 15 days.

The objective of the invention is to increase the pharmacological activity of drugs for local treatment of burns.

The task was achieved through the creation of an ointment containing vegetable oil, such as olive wax, and as the active ingredient of the drug lead, in the following ratio of ingredients, wt.%:

Wax - 14,0 - 30,0

Preparation of lead - 0,05 - 0,11

Vegetable oil - Rest

As a drug lead the product contains organic salts, in particular the acetate of lead.

For preparation of ointment uses olive oil VFS 42-1776-87, wax GOST 21179-90 and acetate of lead (the register. ID 67/554/204).

Lead acetate is a crystalline solid with a weak acetic smell. The drug is soluble in 2.5 g of cold and 0.5 g of boiling water (N. D. Mash solutions as binders in inflammatory diseases of the skin and mucous membranes.

The ointment is prepared as follows: vegetable oil is brought to a boil in a steam bath, after which it add the wax to dissolve, then enter the acetate of lead with continuous stirring. After adding lead acetate to the melt tank with cool ointment on system flow cooling with simultaneous flow mixing until you obtain the consistency of the ointment and complete cooling. Keep ointment need in a glass container in a cool place. Shelf life - 2 years.

Application of ointments: before use, means the wound should be treated with antiseptic solution, such as reunala, then apply a thin layer of ointment on undyed cotton cloth and apply with capture 2-3 cm nearby healthy tissues and bandaging. Burns a large square bandage change carried out every 4 hours, with a small area once a day.

therapeutic properties of the tools are manifested in healing and bactericidal action.

The possible mechanism of action of the product is that the drug lead, in particular the acetate of lead, having astringent properties, prevents the development proliferative-exudative phase, which speeds up the Gah.

Beeswax has antibacterial properties, preventing infection of burn surface.

Olive oil promotes epithelialization.

Example 1. Patient C. for 1.5 years. Got the burn I tbsp. boiling water, area of 95%. Used the opening of bubbles and specific treatment. Immediately after applying the ointment significant reduction in pain. The ointment was applied 6 times a day. Once the operation has been performed how agressively to debride in the neck and groin (ointment in these places was not used). Complete recovery after 2 weeks without the formation of post-burn contractures and scars.

Example 2. Patient N. 42. Received burns to the face and hands IIIB tbsp. melted tar 15%. Conducted traditional treatment in the hospital.

After applying ointment 2 times a day, on the background of specific treatment, complete healing of 1.5 weeks, without the formation of keloid scars. Surgical intervention was not performed.

Example 3. The patient And. 2 years. Got chemical burns on the face of caustic soda. Damage to the lips, oral mucosa, cheek. The treatment of outpatients with exceptional use of ointments. Immediately after applying the ointment significant reduction in pain. Full wisdo the th flame II senior Use only the ointment, treatment on an outpatient basis. Blistering occurred. Full recovery 1.5 weeks.

Example 5. Patient R. 32 years. Electromag right half of the body. Inpatient treatment with the use of conventional therapy. As external funds were used ointment 3 times a day. Pain was not. How agressively to debride was not made. Full recovery after 3 weeks without scarring.

Just treated 51 people.

Of them: burn Art. I - 10, burn Art. II - 16 burn IIIA - 14, burn IIIB - 5, a chemical burn 4 electromag - 2.

Ineffective treatment.

The treatment time of 1.5-3 weeks.

The following are specific examples of the preparation of the ointment for the treatment of burns.

Example 6. Olive oil, taken in an amount 799,3 g, brought to boiling on the steam bath, then it is added to 200.0 g of beeswax until dissolved. Then in the resulting homogeneous mixture is injected under continuous stirring, 0.7 g of lead acetate. Further, the container of ointment cooled, Packed and sent to storage for further use.

Example 7. Analogously to example 5 is prepared max, the ointment is a radical treatment for burns even if the affected 2/3% of the body surface. Burns third degree, if the ointment slice apply to damaged areas, bubbles with serenitybase content does not appear. Promotes ointment and also rapid rejection of the scab and the development of granulation tissue. Post-burn scar when its use becomes less dense. Keloid scars are not visible.

If you did not apply surgical treatment, there is no scar formation after burn contractures.

1. Means for treatment of burns, containing wax and vegetable oil, characterized in that it additionally contains an organic salt of lead in the following ratio of ingredients, wt.%:

Wax - 14,0-30,0

Organic lead salt - 0,05-0,11

Vegetable oil - Rest

2. Means under item 1, characterized in that as the organic salts of lead it contains lead acetate.

 

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22
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