Ointment base


(57) Abstract:

The invention relates to the field of medicine and applies ointment bases. The invention lies in the fact that the ointment base contains fat ( oil) mink, citral ( tigera), glycerin, ethyl alcohol, nipagin, nipazol, wax emulsion, water and optionally contains an odorant content components within acceptable limits. The invention provides for the elimination of allergic reactions. 1 C.p. f-crystals.

The invention relates to medicine, namely to pharmaceutical drugs.

Known emulsion ointment base containing as a paraffin hydrocarbon liquid paraffin and low molecular weight polyethylene, emulsifier ester limit fatty acids with 16 to 18 carbon atoms and water (AV. St. 1627181, A 61 K 9/06).

It is known that for the manufacture of ointments used as a base of lanolin base (AB. St. 405549, A 61 K 906) containing liquid paraffin, vaseline medical and water lanolin.

A well-known basis for medical ointments, which includes emulsion containing petrolatum or liquid paraffin in the mixture c paraffin, ceresin and wax, food emulsifier, such as T-1 or T-2, or you for medical ointments is the ability when it is used in ointments irritating emulsifier T2 and vaseline the ability to cause baselinearray skin.

The objective of this invention is the elimination of the phenomenon of irritation, inflammation and peeling of the skin.

The problem is solved in that ointment base contains ethyl alcohol, nipagin and nipazol, citral, tigera, glycerin, water and oil oil(oil) mink in the form of finely dispersed water emulsion, and as an emulsifier wax emulsion in the following ratio, wt%:

Fat (oil) mink - 3 - 10

Citral(tigera) - 0,03 - 3,0

Glycerol - 3 - 10

Ethyl - 2 - 6

Nipagin - 0,2 - 0,5

Nipazol - 0,05 - 0,2

The wax emulsion - 3 - 10

Odorant - 0,2

Water - the Rest

Prepare the ointment basis as follows:

Example 1. In thermostated at 50oC chemical beaker 250 ml, containing 88,72 ml of purified water, temperature 50oC, pour in when the stirrer speed of 150...200 rpm alloy 3G emulsion of wax and 3 g fat (oil) mink heated to 70...75oC. Emuleret 15 - 20 minutes, cooled to 42 - 45oC and pour in when the stirrer a solution containing 0.03 g of citral (zagarola), 3 g glycerol 2 g ethyl alcohol, 0.2 g Nipah analogously to example 1.

In temperature-controlled chemical beaker containing 59,3 ml of water and 10 g of glycerin temperature of 50 - 55oC, pour in when the stirrer speed (150 - 200 rpm alloy 10 g of emulsion of wax and 10 g fat (oil) mink heated to 70 to 75oC. Emuleret 15-20 minutes, cooled to 42 - 45oC and pour in when the stirrer a solution of 3 g of citral (zagarola), 2G odorants, 0.5 g nipagina, 0.2 g nipazola in 6 g of ethyl alcohol. Emuleret 15 minutes. Cool to room temperature.

The obtained ointment base is highly stable, has good quality, characterized by complete harmlessness (no allergic effect, as well as giving the basis bactericidal, anti-inflammatory and moisturizing action). Biological value and quality of ointment bases do not depend on the storage conditions. The composition of the ointment bases is a composition of white color.

The change in the optimal ratio of components in the direction of their increase or decrease results in the following:

the introduction of a fat (oil) mink and glycerine below the lower limit does not provide nourishing, softening effect, and when the excess is attached to the base of excessive oiliness and stickiness;

dobavliaet the stability of the emulsion;

citral (tigera) introduced below the lower limit, do not show beneficial effects on the skin and above the specified limit are excessive unilateral action, as a medicinal substance;

nipagin and nipazol (preservatives) is added to the formulation in amounts, use below which does not provide microbiological stability, and the excess is impractical due to signs of toxic properties.

Conducted external treatment ointment base in combination with the main pathogenetic methods General treatment of 36 patients with skin diseases including 10 patients with ichthyosis, 8 - psoriasis of the skin of the trunk, limbs and scalp, 6 - neurodermatitis, 4 - contact allergic dermatitis, 2 patients with follicular diskeratoz Daria and 6 patients with senile dryness.

All treated patients had a positive clinical effect of application of ointment bases: decreased in lesions erythema, infiltration, desquamation, with excoriation and microcracks were observed rapid epithelialization; decreased subjective disorder (itching, feeling of tightening of the skin). All patients after application of ointment bases, there was an increase ELAST the areas of skin lesions, and averaged 10 days.

The basis of the ointment does not have General toxic, irritant and allergic action and can be recommended as a new ointment basis for the preparation of ointments for medicine and for the treatment of patients with skin diseases.

1. Ointment base containing wax, oil, water, emulsifier, characterized in that it contains ethyl alcohol, nipagin and nipazol, citral (tigera), glycerin and oil oil (oil) mink in the form of finely dispersed water emulsion, as an emulsifier wax emulsion in the following ratio, wt.%:

Fat (oil) mink - 3,0-10,0

Citral (tigera) - 0,03-3,0

Glycerin - 3,0-10,0

Ethyl alcohol - 2,0-6,0

Nipagin - 0,2-0,5

Nipazol - 0,05-0,2

The wax emulsion - 3,0-10,0

Water - the Rest

2. Based on p. 1, characterized in that it further comprises a perfume in an amount of not more than 2.0 wt.%.


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