(57) Abstract:The invention relates to the field of medicine and applies ointment bases. The invention lies in the fact that the ointment base contains fat ( oil) mink, citral ( tigera), glycerin, ethyl alcohol, nipagin, nipazol, wax emulsion, water and optionally contains an odorant content components within acceptable limits. The invention provides for the elimination of allergic reactions. 1 C.p. f-crystals. The invention relates to medicine, namely to pharmaceutical drugs.Known emulsion ointment base containing as a paraffin hydrocarbon liquid paraffin and low molecular weight polyethylene, emulsifier ester limit fatty acids with 16 to 18 carbon atoms and water (AV. St. 1627181, A 61 K 9/06).It is known that for the manufacture of ointments used as a base of lanolin base (AB. St. 405549, A 61 K 906) containing liquid paraffin, vaseline medical and water lanolin.A well-known basis for medical ointments, which includes emulsion containing petrolatum or liquid paraffin in the mixture c paraffin, ceresin and wax, food emulsifier, such as T-1 or T-2, or you for medical ointments is the ability when it is used in ointments irritating emulsifier T2 and vaseline the ability to cause baselinearray skin.The objective of this invention is the elimination of the phenomenon of irritation, inflammation and peeling of the skin.The problem is solved in that ointment base contains ethyl alcohol, nipagin and nipazol, citral, tigera, glycerin, water and oil oil(oil) mink in the form of finely dispersed water emulsion, and as an emulsifier wax emulsion in the following ratio, wt%:
Fat (oil) mink - 3 - 10
Citral(tigera) - 0,03 - 3,0
Glycerol - 3 - 10
Ethyl - 2 - 6
Nipagin - 0,2 - 0,5
Nipazol - 0,05 - 0,2
The wax emulsion - 3 - 10
Odorant - 0,2
Water - the Rest
Prepare the ointment basis as follows:
Example 1. In thermostated at 50oC chemical beaker 250 ml, containing 88,72 ml of purified water, temperature 50oC, pour in when the stirrer speed of 150...200 rpm alloy 3G emulsion of wax and 3 g fat (oil) mink heated to 70...75oC. Emuleret 15 - 20 minutes, cooled to 42 - 45oC and pour in when the stirrer a solution containing 0.03 g of citral (zagarola), 3 g glycerol 2 g ethyl alcohol, 0.2 g Nipah analogously to example 1.In temperature-controlled chemical beaker containing 59,3 ml of water and 10 g of glycerin temperature of 50 - 55oC, pour in when the stirrer speed (150 - 200 rpm alloy 10 g of emulsion of wax and 10 g fat (oil) mink heated to 70 to 75oC. Emuleret 15-20 minutes, cooled to 42 - 45oC and pour in when the stirrer a solution of 3 g of citral (zagarola), 2G odorants, 0.5 g nipagina, 0.2 g nipazola in 6 g of ethyl alcohol. Emuleret 15 minutes. Cool to room temperature.The obtained ointment base is highly stable, has good quality, characterized by complete harmlessness (no allergic effect, as well as giving the basis bactericidal, anti-inflammatory and moisturizing action). Biological value and quality of ointment bases do not depend on the storage conditions. The composition of the ointment bases is a composition of white color.The change in the optimal ratio of components in the direction of their increase or decrease results in the following:
the introduction of a fat (oil) mink and glycerine below the lower limit does not provide nourishing, softening effect, and when the excess is attached to the base of excessive oiliness and stickiness;
dobavliaet the stability of the emulsion;
citral (tigera) introduced below the lower limit, do not show beneficial effects on the skin and above the specified limit are excessive unilateral action, as a medicinal substance;
nipagin and nipazol (preservatives) is added to the formulation in amounts, use below which does not provide microbiological stability, and the excess is impractical due to signs of toxic properties.Conducted external treatment ointment base in combination with the main pathogenetic methods General treatment of 36 patients with skin diseases including 10 patients with ichthyosis, 8 - psoriasis of the skin of the trunk, limbs and scalp, 6 - neurodermatitis, 4 - contact allergic dermatitis, 2 patients with follicular diskeratoz Daria and 6 patients with senile dryness.All treated patients had a positive clinical effect of application of ointment bases: decreased in lesions erythema, infiltration, desquamation, with excoriation and microcracks were observed rapid epithelialization; decreased subjective disorder (itching, feeling of tightening of the skin). All patients after application of ointment bases, there was an increase ELAST the areas of skin lesions, and averaged 10 days.The basis of the ointment does not have General toxic, irritant and allergic action and can be recommended as a new ointment basis for the preparation of ointments for medicine and for the treatment of patients with skin diseases. 1. Ointment base containing wax, oil, water, emulsifier, characterized in that it contains ethyl alcohol, nipagin and nipazol, citral (tigera), glycerin and oil oil (oil) mink in the form of finely dispersed water emulsion, as an emulsifier wax emulsion in the following ratio, wt.%:
Fat (oil) mink - 3,0-10,0
Citral (tigera) - 0,03-3,0
Glycerin - 3,0-10,0
Ethyl alcohol - 2,0-6,0
Nipagin - 0,2-0,5
Nipazol - 0,05-0,2
The wax emulsion - 3,0-10,0
Water - the Rest
2. Based on p. 1, characterized in that it further comprises a perfume in an amount of not more than 2.0 wt.%.
FIELD: agriculture, animal husbandry, organic chemistry.
SUBSTANCE: antiseptic ointment comprises cationic surface-active substance, lower glycols, polyethylene glycols, water and ethylene glycol monophenolic ester and higher polyethylene glycols taken in the definite ratio of components. As cationic surface-active substance ointment comprises N-alkyl-N-alkoxycarbonylmethylhexahydroazipinium chloride or alkyldimethylbenzylammonium chloride, or cetylpyridinium bromide, or cetylpyridinium chloride, or 1,2-ethylenebis-(N-methylcarbdecyloxymethyl)ammonium dichloride, or ethylhexadecyldimethylammonium chloride, or chlorhexidine; as lower glycol ointment comprises 1,2-propylene glycol or polyethylene glycol-300, or polyethylene glycol-400; as higher polyethylene glycol ointment comprises polyethylene glycol-1500 or polyethylene glycol-3000, or polyethylene glycol-4000, or polyethylene glycol-6000. Ointment elicits the high antibacterial activity, broad spectrum of bactericidal effect and low irritating effect with respect to udder skin. Invention can be used for sanitary-hygienic treatment of udder of lactating cows for prophylaxis and rapid healing external damages of udder and nipples (arising cracks), prophylaxis of mastitis, enhancing milk purity by microbiological indices.
EFFECT: valuable antiseptic properties of ointment.
2 cl, 1 tbl, 22 ex
SUBSTANCE: the present innovation deals with curative ointments of antiphlogistic and wound-healing action and could be applied for treating hemorrhoid, burns, bruises, fractures, wounds, chronic bronchitis, polyarthritis, periarthritis, radiculitis, trophic ulcer and psoriasis. Three variants of ointments have been suggested. They contain oily extract of plant components and, also, honey, mumiye, propolis and bear oil. This innovation enables to widen the assortment of ointments of antiphlogistic and wound-healing and the range of curative action upon a body.
EFFECT: higher efficiency of application.
3 cl, 11 ex
SUBSTANCE: invention provides topical blood circulation improving remedy containing simultaneously nitroglycerine and aminophylline. Remedy can be provided in the form of emulsion, gel, or ointment, which are administered 1-2 times a day.
EFFECT: strengthened blood circulation activation effect, which is prolonged to 24 hours.
5 cl, 9 ex
FIELD: pharmaceutical industry.
SUBSTANCE: invention relates to developing medicaments in the form of ointment based on vegetable components and designed, in particular, to treat psoriasis as well as fungus diseases and can also be used in cosmetology. Psoriasis treatment cream includes water extracts of bur-marigold (Bidens tvipartita), white birch leaves (Betula alba L), greater celandine (Chelidonium majus), calendula (Calendula officanalis L), cudweed (Gnphalium uliginosum L), medical vaseline, lanolin, camphor, linseed oil, and medical solid oil at specified proportions of components.
EFFECT: increased treatment efficiency, avoided use of chemical additives, and prolonged shelf time.
FIELD: pharmaceutical industry.
SUBSTANCE: invention provides antiinflammatory and wound-healing ointment based on natural components, which invention, along with vegetable oils, may further contain ursine fat, ursine bile, propolis, lanoline, honey, and mummified guano. Variously formulated ointments can be used for treating hemorrhoids, burns, antritis, post-stroke condition, gunshot and stab-punctured wounds, trophic ulcer, postoperative fistula, oophoritis, diabetic microangiopathy of lower extremities, as well as papillomas, birthmarks, seborrhea, and psoriasis.
EFFECT: expanded therapeutical possibilities.
6 cl, 17 ex
FIELD: pharmaceutical industry.
SUBSTANCE: invention provides novel nontoxic and highly bioavailable acyzol-based agent characterized by high activity in treatment of skin diseases, in restoration of structural skin processes, suppression of nevus pigmentosis, and flattening of folds.
EFFECT: increased assortment of skin-healing drugs.
7 cl, 4 ex
FIELD: organic synthesis.
SUBSTANCE: invention provides a method for preparing water/glycerol complex of (2,3-dihydroxypropyl) ortho-titanate hydrochloride (chloride) having symbolic name "Ephtiderm", which is depicted by following empirical formula: Method consists in that glycerol is mixed with butyl ortho-titanate at molar ratio 12:1, whereupon butanol is distilled off in vacuum, residue is treated with water and aqueous hydrochloric acid to form reaction mass with pH 2.2-3.0, which is heated in vacuum. Method is characterized by that glycerol is mixed with low-grade butyl ortho-titanate and chloroform, reaction mass during the synthesis is maintained at temperature up to 100°C in vacuum 40-200 mm Hg, while chloroform is added at 40-50°C in amount corresponding to 1 L chloroform per 2 L low-grade butyl ortho-titanate.
EFFECT: reduced expenses due to use of low-grade butyl ortho-titanate and simplified technology.
1 tbl, 3 ex
SUBSTANCE: the present innovation deals with medicinal preparation as an ointment for treating skin burns. The suggested preparation contains bee wax, propolis and vegetable oil. Thus, application of initially intact propolis and bee wax in combination with fatty foundation as vegetable oil enables to cheapen and simplify the technique to prepare the preparation, and optimally matched consistence provides prolonged safety of the preparation and accelerates healing of skin burns.
EFFECT: higher efficiency of therapy.
1 cl, 2 ex
FIELD: medicine, gynecology, pharmacology, pharmaceutical industry.
SUBSTANCE: invention proposes a preparation that comprises bacterial mass of live microorganisms as an active component, protecting medium and fat base. The preparation comprises lactobacilli as bacterial mass and one or some eubiotic microorganisms taken among the following group: bifidobacteria, streptococci and lactococci taken in the amount per a single dose. Also, the preparation comprises additionally an acceptable sorbent and a biologically active supplement. Also, invention relates to a method for preparing this preparation that involves preparing firstly lactobacilli bacterial mass and one or some genus of eubiotic microorganisms taken among the following group: bifidobacteria, streptococci and lactococci. Then the prepared bacterial mass of microorganisms is immobilized on sorbent used in medicine in its ratio to bacterial mass of microorganisms = (9-1):(1-9) followed by addition of the protecting medium and biologically active supplement to formed mass in the necessary amount. Also, invention describes a method for prophylaxis and treatment of bacterial vaginitis that involves intravaginal administration of the preparation described above in the amount 1-3 doses, 1-3 times per 24 h. The treatment course is prescribed individually. Invention provides expanding assortment of agents used for treatment of bacterial vaginitis. Invention can be used in obstetric-gynecological practice.
EFFECT: improved method for vaginitis treatment, valuable medicinal properties of preparation.
13 cl, 4 tbl, 1 ex
SUBSTANCE: the suggested composition has got viscosity being below of about 15000 cP and pH being approximately 3.0-9.0 for treating human skin diseases. He suggested composition consists of (a) therapeutically efficient quantity of, at least, one compound being useful in treating the above-mentioned disease; (b) pharmaceutically acceptable, partially bound polymer of polyacrylic acid being compatible with the compound; (c) not obligatory, a solvent being mixed with water, (d) not obligatory, a conserving agent, (e) not obligatory, a component of butyric phase and acceptable surface-active substance, and (f) water. The suggested composition is useful to treat inflammatory skin disease, acne or acne erythematosa. The composition of low viscosity has got its advantage in the fact that it is applied more accurately when in contact with a container that doses the composition in the form of drops.
EFFECT: higher efficiency of application.
23 cl, 15 ex, 19 tbl