The way to prepare for childbirth and method for making medicinal electrophoresis on a region of the body of the uterus

 

(57) Abstract:

The invention relates to medicine, obstetrics, physiotherapy. Method of childbirth preparation is as follows. Inject 1 ml of a 5% solution of vitamin E and 10 ml of 20% aqueous solution of choline chloride. The introduction is carried out simultaneously by electrophoresis on a body area of the uterus. The way medicinal electrophoresis in the region of the uterus is carried out by applying electrode on the upper part of the anterior abdominal wall. On the lateral surface of the thigh impose oppositely charged electrodes in relation to the first. The electrodes impose two on each hip, against each other. The solution of the medicinal product applied to the surface of the thighs between the electrodes. Strip all moisten electrodes with water. Expanding the range of use. Reducing the negative impact on the body of matter and the fetus. 2 S. p. f-crystals, 1 Il.

The invention relates to medicine, in particular: electrotherapy, and can be used in obstetrics to prepare for childbirth pregnant women risk group for development opportunities disorders of contractile activity of the uterus and suffering intrauterine fetus.

In rezultatele way to treat weakness of labor activity on the background of fatigue mothers (USSR, A. with. N 1806740, 07.04.93 year, A 61 K 31/00), according to which intravenously administered selective beta-blocker cardnum at a dose of 40...50 mg 200 ml of 5% glucose solution with subsequent radarsystem oxytocin 2-2,5 ED 200 ml of 5% glucose solution.

Closest to the proposed method of childbirth preparation is a method of agostinelli, including separate introduction of spasmolytic and vitamins, namely intravenous drip of oxytocin, the sequential introduction of cocarboxylase 1,0, 5% solution of lipoic acid 4.0 and 20% solution of Pantothenate calcium 2,0 40% wage glucose solution and 15 ml for each drug intramuscularly and 1% solution of Riboflavin - mononucleotide and 1.0. (USSR and.with. N 2007166, A 61 K 31/00 A 61 B 17/42, 27.01.94).

The disadvantage of known methods of childbirth preparation is that for stimulation of labor, use of oxytocin, which is a potent drug and provides rapid development and rapid delivery that may impact negatively not only on the mother but also the child. In addition, the method of administration of oxytocin intravenous drip is a complex invasive method requires a large accurate the camping duration of intravenous drugs (up to 4 hours or more) often occur in pregnant unpleasant sensations: nausea, the dizziness.

With the introduction of oxytocin in the body of the woman is the inhibition of the production of endogenous oxytocin, the impact of which on the smooth musculature of the uterus falls caused by exogenous oxytocin labor activity without his continuous administration is weakening, which requires the continuation of the infusion until the end of delivery. Negative changes in the body condition of pregnant in turn can have a negative impact on the state of the intrauterine fetus.

Oxytocin, as well as other exogenous input uterotonic means, causing the powerful muscles of the uterus, in varying degrees, affects the utero-placental circulation and promotes the redistribution of blood between mother and fetus in the direction of increasing red blood cell mass of the fruit, which naturally accompanied by a more massive hemolytic process and the development of jaundice in the newborn.

The basis of the detected known methods of preparation of pregnant women for childbirth is to use invasively methods of administering drugs that may contribute to the infection of the body, which reduces the security of the method and mo the ordinary preparation for childbirth have restrictions on use, due to contraindications to the use of oxytocin. In this regard, the known methods do not apply when there is a breach of the condition, the more pronounced the suffering intrauterine fetus, and in the presence of insufficient maturity of the cervix, i.e., in the absence of full readiness of the pregnant woman's body for childbirth.

Thus, the known methods of preparation for childbirth if their implementation does not allow to achieve the technical result consists in expanding the range of application due to the narrowing of the list of contraindications for use, and in reducing the possibility of a negative impact on the mother and fetus by reducing the likelihood of rapid development and rapid delivery, by eliminating the need for invasive administration of medicinal substances by preventing the negative impact of the method on the utero-placental circulation and redistribution of blood between mother and fetus, through the elimination of the appearance of a pregnant adverse reaction to a method of administering drugs, as well as in simplifying the way.

In the result of a patent search on the invention "Method of implementation is to childbirth, the following has been discovered.

A known method for making medicinal electrophoresis, in accordance with which the surface subject to exposure of body parts of the patient impose two oppositely charged electrode, while laying under one of them moisten with water, and under the other the solution was injected medicinal substance, and the solution of a medicinal substance is applied to the pad electrode of the same name with the subject electrophoretic introduction of the ion. (Great medical encyclopedia, M.: Soviet encyclopedia, 1986, T. 28, S. 117).

The disadvantage of this method implementation medicinal electrophoresis is that it is not possible to simultaneously separate introduction different from other drugs. In addition, in the known method of medicinal electrophoresis is introduced into the body from 1 to 10% of the drug substance, i.e., 90...99% solution of a medicinal substance remains on the strip.

Thus, there is a method of electrophoresis in its implementation does not allow to achieve the technical result consists in the possibility of separate introduction different from other drugs, and what to offer is a way of making medicinal electrophoresis on a body area of the uterus, described in method prevention of recurrent miscarriage due to estrogenic receptor deficiency of the endometrium (the USSR and.with. N 1297872, 23.03.87, A 61 N 1/20). In accordance with the way the woman laid on the couch on his back, the anode is placed in nadannoj region, and the cathode is placed on the sacrum, i.e., the projection area of the fundus of the uterus. The gasket under the anode, size x cm, moisten the drug, and okladka under the cathode, the size of h cm, moistened with tap water.

The disadvantage of this method medicinal electrophoresis is the impossibility of simultaneous separate introduction different from each other medicinal substances, and unproductive waste of drugs.

In addition, with this arrangement of the electrodes (the anode in nadannoj region, and the cathode - rump) medicinal substance accumulates mainly in a small area on the front wall of the uterus, which causes mainly local effects of drugs introduced by electrophoresis, and reduces the impact on the body's humoral way that reduces the effectiveness of the method.

The lack izvestno acceptable only for the treatment of non-pregnant women. This is because the electrodes are located far from each other, and the density of the electric field with this arrangement of the electrodes in non-pregnant women is significantly less than a pregnant woman, because the latter in the path of the electric field is the fruit. Therefore, the normal current density (0,03 - 0,08 mA/cm2) that do not have a negative effect on a living organism, for performing electrophoresis is not enough. In addition, in this case, the electric field is closed through the body of the fetus, which is undesirable because it can have a negative impact on the fetus as in the present time, and in its further life after birth.

Thus, the known method for making medicinal electrophoresis on a body area of the uterus in its implementation does not allow to achieve the technical result consists in increasing the efficiency of the method of medicinal electrophoresis due to the possibility of simultaneous separate introduction different from other drugs, as well as by improving the efficiency of use of injected drugs, expanding the range of application and to reduce the possible negative wlien the task of creating an appropriate way, which in its implementation ensures the achievement of the technical result consists in expanding the range of application due to the narrowing of the list of contraindications for use, and in reducing the possibility of a negative impact on the mother and fetus by reducing the likelihood of rapid development, rapid delivery, by eliminating the need for invasive administration of drugs by preventing the negative impact of the method on metoclopramidee the circulation and redistribution of blood between mother and fetus, and by eliminating the occurrence of a pregnant adverse reaction to a method of administering drugs, as well as to simplify the method and to increase its effectiveness.

The essence of the invention lies in the fact that the way to prepare for childbirth by separate administration of drugs, injected with 1.0 ml of a 5% solution of vitamin E and 10.0 ml of 20% aqueous solution of choline chloride, with the introduction of medicines carried out simultaneously by medicinal electrophoresis on a body area of the uterus.

The technical result by carrying out the invention "Method of childbirth preparation" is achieved following the ESA and provides in the process of metabolism protect cells from the adverse reactions with oxygen or other compounds, capable of causing disease in cellular structures by potentiation reactions of lipid peroxidation. It is known that pregnant women risk group after the occurrence of obstetric complications significantly activated processes of free radical and lipid peroxidation, and inhibition of autookislenia seriously affected, including in the form of lower levels of the natural antioxidant vitamin E in the body (Century. Century. Abramenko, E. C. Kostousov, L. A. Scherbina, Antioxidants and antihypoxants in obstetrics. - S.-Petersburg, - Logos - 1995. - 120 C.). Additional amounts of vitamin E, administered exogenously, suppress the activation and accumulation of products of lipid peroxidation, protect biomembranes cells from the damaging effects of lipid peroxides and free radicals, increase the resistance of erythrocytes in relation to hemolytic agents and prevents changes in the cells, characteristic of the aging process. The purpose of vitamin E patients increases the level of activity of their immune system and prevents the formation of carcinogenic nitrosoamines. Apart from the above, vitamin E has other polyfunctional properties: it protects against oxidation of selenium in the composition of nekogami and hem-comprising proteins, as evidenced by the disturbance of heme synthesis in E-avitaminosis; actively participates in the intracellular processes of oxidation and oxidative phosphorylation; required as a dietary factor contributing to the absorption of polyunsaturated fatty acids in the intestine. In addition, vitamin E activates the regenerative processes in the body by increasing the pool of restorative substrates, improves the permeability of the blood capillaries and microcirculation. These mechanisms contribute to the normalization condition of the body and restoration of physiological parameters during heavy exercise. Introduction vitamin E increases the tolerance of humans and animals to the action of extreme stimuli that causes the regulating action of vitamin E on the processes of microcirculation and transcapillary exchange, on the metabolism of blood corpuscles and regional trophism.

Choline plays an important role in holinoliticheskoy regulating functions of the uterus and in the maintenance of physiological parameters of homeostasis of the whole organism. Choline is a biologically active substance, necessary for the synthesis of phospholipids - lecithins and sphingomyelins, which is mandatory camponeschi predecessors mediator of neural excitation of acetylcholine. Choline is involved in the biogenesis of amino acids (methionine, glycine, serine), protein metabolism (with the lack of choline disturbed protein formula blood), in the processes of hematopoiesis. Important functions of choline are the body's supply of labile methyl groups, cleavage which occurs during its oxidation to betaine, as well as participation in biologically significant reactions peremetilirovaniya. The lack in the body, choline is manifested in the development of fatty infiltration of the liver, degenerative changes in the kidneys, myocardium, blood vessels and other organs in the occurrence of anemia, gipoproteinemii. The decrease in the intensity of synthesis of lecithins and signoriello with deficiency of choline leads to reduced use of triglycerides and cholesterol in the formation of lipoproteins. This leads to the accumulation of triglycerides and, to a lesser extent, cholesterol in the liver, reduced oxidation of fatty acids and the development of fatty infiltration of the body.

Study of the effect Kalinovo failure in pregnancy showed that pregnant women with Kalinovo failure observed the development of anemia and disorders of protein metabolism, and after childbirth - hypogalactia. In the literature there are indications that drug and childbirth, largely depend on unbalanced diets, which takes place among different groups of pregnant women (Fundamentals of clinical nutrition pregnant. Edited by E. P. Sambir, L. B. Gutman, A. A. Zakrevsky - 2nd ed. Kyiv. Health, 1989, - 144). Choline in the body comes from food (it is found in meat, fish, poultry, soy beans, peas, liver, egg yolk), and therefore in violation of the principles of a balanced diet, which is very widespread among pregnant women due to various reasons, there is a more or less pronounced Kalinova failure.

The metabolic disorder caused by deficiency of choline, allow to consider it as a B vitamin, specifically the vitamin B4.

In medicine as an analogue of choline used drug, "choline chloride", which refers to the complex of B vitamins as vitamin-like product in this group. Choline chloride is the biosynthetic precursor of acetylcholine, i.e., the substance from which the body produces acetylcholine is one of the main mediators of neural excitation, which explains its weak atsetilholinopodobnym action, and large doses of choline can wizualna chloride on the smooth musculature of the uterus is explained by the following. First, it contributes to the formation of the woman's body acetylcholine. Furthermore, it is known that gipotalyamo-hypophyseal system of the woman's body produces the hormone oxytocin that stimulates contraction of the uterus muscles. Oxytocin is a peptide hormone (oktapeptid), consists of pentapeptidnogo and the side chain of three amino acid residues, of which two groups of cysteine in position 1 and 6 are linked by a disulfide bridge):

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The biological activity of oxytocin depends on its tertiary structure (conformation) in solution. The removal of the terminal group NH2increases the biological activity of oxytocin. The essence of the biological effect of choline chloride is explained as follows: choline chloride, having a chemical formula

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and as a stable source of methyl groups required for what is happening in the body's biochemical processes, facilitates the removal of the terminal group NH2in the oxytocin and this increases its biological activity. In the result of the combined action of acetylcholine, resulting in the body under the action of the injected choline chloride, and endogenous oxytocin organism that has improved his Biologicheskie is Tracii directly acting on the smooth muscle cells of the uterus substances (acetylcholine and oxytocin) does not occur, and the higher their level is carried out indirectly through physiological mechanisms, stimulation is of a soft nature, approaching natural stimulates a woman's body to use its own reserves. As a result of its application virtually eliminates the possibility of quick and swift delivery, which positively affects the health of the mother and the fetus.

Since the introduction of vitamin E and choline chloride improves the condition of the cardiovascular system, liver, kidneys, endocrine organs pregnant, respectively, and normalized utero-placental circulation, which also positively affects the state of the intrauterine fetus. Due to the fact that both medication (vitamin E and choline chloride) refer to vitamin drugs, they have on the body beneficial effect and virtually no contraindications for use, extends the range of application of the method. In addition, the soft mode to stimulate contraction of smooth muscles of the uterus allows the use of the proposed method of childbirth preparation, even in cases when there are initial or moderate forms of suffering intrauterine fetal or missing a full range of application of the method. Soft action of medicinal substances is provided in this way also and their introduction into the body through a medical electrophoresis. This is because the medicinal substance introduced by electrophoresis, can act on the body by reflex, by humoral and, in addition, to provide local action.

The electric current used for electrophoresis, causes the body a variety of physical-chemical, metabolic and tissue reaction, against which the effect of introduced by electrophoresis drugs gain a number of features and advantages in comparison with conventional invasive methods of administration of drugs, namely, for the proposed method: a more gradual flow in the body, a longer action of the medicinal product and slow down due to the formation in the skin depot ion having pharmacological activity; less likelihood of side reactions; the administration of a medicinal product in the most pharmacologically active form in the form of ions; the painless administration of drugs; non-invasive; no deformation danego simultaneous drug in his appointment intramuscularly or subcutaneously. All this increases the efficiency of the proposed method of childbirth preparation and reduces the possibility of its negative impact on the mother and child.

Besides, due to the fact that the electrophoresis is carried out on the area of the body of the uterus, there is the possibility of forming a directional input medicines, namely the optimization of the functional state of the uterus, which also increases the efficiency of the method. Simultaneous separate introduction of vitamin E and choline chloride may improve the use of medicines, which also increases the efficiency of the method and at the same time reduces the potential for adverse impacts of the proposed method on the body of the mother and fetal intrauterine because stimulation of contraction of smooth muscles of the uterus occurs on the background of simultaneous restorative actions introduced medicines.

Using the proposed method for administering drugs electrophoresis simplifies the way, and a limited list of contraindications to the use of electrophoresis (objective contraindications to the use of electrotherapy and relevant lekarstvennogo for childbirth.

The amount of injected drugs in the proposed method provides for obtaining the desired effect: the occurrence of spontaneous labour with simultaneous provision on the body of the mother and fetal intrauterine restorative action that increases the effectiveness of the method and reduces the possibility of its negative effects on the body of the mother and child.

Thus, the proposed method of childbirth preparation in its implementation ensures the achievement of the technical result consists in increasing the efficiency of the method, reducing the possibility of a negative impact on the mother and fetal intrauterine, in expanding the range of applications and simplify the method.

The invention "Method for making medicinal electrophoresis on a body area of a uterus" used in the proposed method of childbirth preparation, solves the problem of creating an appropriate way of medicinal electrophoresis, in the exercise of which is the technical result consists in increasing the efficiency of the method of medicinal electrophoresis due to the possibility of simultaneous separate introduction different from d is edst, the extension of the scope of application of the method, and to reduce the possible negative impact on the mother and the fetus.

The essence of the invention lies in the fact that in the method of implementation medicinal electrophoresis on a body area of the uterus, according to which one electrode is placed on the area of the bottom of the body of the uterus, the electrode placed on the upper part of the anterior abdominal wall women, and on the side surfaces of the thighs impose electrodes oppositely charged with respect to the electrode placed on the bottom of the body of the uterus, two on each hip, against each other, the solution medicines put on located between the electrodes of the front surface of the thighs, and strip all moisten electrodes with water.

The technical result is achieved in the following way. Since the implementation of medicinal electrophoresis an electrical circuit is as follows: power supply positively charged electrode surface (or part) of the body that are affected negatively charged electrode, the power source, the proposed location of the oppositely charged electrodes on the body of beremend is formirovanie electric field, directed along the anterior and lateral surfaces of the abdomen, and therefore along the front and side surfaces of the body wall of the uterus. This action prevents the closure of the electric field through the foetus, and is not required to exceed the current density during electrophoresis above is valid because the electric current between the electrodes passes through the skin surface and its upper layers, unlike the prototype, where the electrical circuit through the foetus. This has a positive effect on the mother's body, and intrauterine fetal, and also extends the range of application of the method, because you can use it for non-pregnant and pregnant women. Due to the fact that the same electrodes are oppositely charged with respect to the electrode placed on the region of the fundus of the uterus, placed on the lateral surface of the thigh, two on each hip, against each other, on the side surfaces of the legs is formed of the same name the charged sites of the electric field. Due to the fact that strip all moisten electrodes with water, ensures reliable electrical contact of the electrodes with the patient's skin. Since the solution of the medicinal product on the lateral surface of the thigh, and subject to electrolytic introduction of ions medicines are charged the same name with these electrodes (the basis for the execution of any medicinal electrophoresis), ions medicines are charged in the same electric field which acts on the ions on the left and right sides. This allows you to concentrate ions injected drugs and to limit the dissipation in the tissues of the anterior surface of the thighs. In addition, using the same pair of electrodes allows for the usual medicinal electrophoresis current density to increase to twice the charge of the electric field of the same name on the sign with the input ions medicines. In the ions injected drugs during the procedure electrophoresis under the action of the repelling forces of the same name of a charged electric field actively move towards the oppositely charged electrode placed on the bottom of the body of the uterus that prevents their accumulation, mainly in the tissues of the impact area and favors saturation ions medicines tissues of the abdomen, which are in close lo the ions injected drugs, compared with conventional electrophoresis, increases the effects of galvanic effects on the physical and chemical processes occurring in the tissues, in particular promotes better blood circulation and lymph circulation. This allows you to abandon the traditional application of the solution was injected drugs for the laying of the respective electrode and the solution applied to a medicinal product directly on the front of the thighs between the electrodes, which increases the efficiency of the use of medicines, as well as the effectiveness of the method. Due to the fact that the electrodes are oppositely charged with respect to the electrode placed on the bottom of the body of the uterus, impose on both hips, allows simultaneous separate introduction different from other drugs, which increases the effect of medicinal electrophoresis, and hence increases the efficiency of the proposed method medicinal electrophoresis.

Thus, the present invention "Method for making medicinal electrophoresis on a body area of a uterus" used in the proposed "Method of childbirth preparation, made possible negative effects on the mother and the fetus and in the extension of the application range.

The drawing shows the placement of electrodes on the body of the patient in accordance with the method of implementation medicinal electrophoresis on a body area of the uterus.

Method of childbirth preparation is as follows. The patient through the medical electrophoresis on a region of the body of the uterus is administered separately and simultaneously with 1.0 ml of a 5% solution of vitamin E and 10.0 ml of 20% aqueous solution of choline chloride. The number of sessions electrophoresis varies from 2 to 10. Exposure to cease with the onset of spontaneous labour. The duration of the first treatment no more than 10 minutes. The duration of the subsequent procedures increased to 15 minutes. If after 10 sessions of spontaneous contractions do not appear - the impact of drug electrophoresis overturned.

Medicinal electrophoresis in the present method of childbirth preparation was performed by means of the proposed method of implementation medicinal electrophoresis on a body area of the uterus.

Method for making medicinal electrophoresis on a body area of the uterus performed as follows. One electrode 1 is placed on the area of the bottom of the body of the uterus, namely, on the upper part of the anterior abdominal wall women (see drawing). The electrodes 2,211and 3.31respectively. Strip all moisten electrodes with water.

In the examples of the process of preparation for childbirth and the manner of exercise of medicinal electrophoresis on a region of the body of the uterus to the region of the bottom of the body of the uterus puts negatively charged electrode 1 (cathode), and on the lateral surface of the right and left hips were applied positively charged electrodes 2,21and 3.31(anodes), respectively. This is due to the fact that ions of vitamin E and choline chloride have a positive charge, therefore, when the electrophoresis should be entered with the anode.

For the preparation of medicinal products working solutions applied to the front surface of the thighs between the electrodes 2 and 21and between the electrodes 3 and 31as a solvent used Dimexidum (dimethyl sulfoxide) is one of the most effective solvents recommended in the literature (Great medical encyclopedia. - M.: Soviet encyclopedia, 1986. , 28, - S. 118; Cintra P. J., Momemtarily I. D., Mikeladze D. G., Eliashvili C. M., Kherodinashvili W. W. Prospects for creation and gynecology. - 1986. - N 12. - S. 47-50.). When 1.0 ml of a 5% solution of vitamin E was mixed with 1.0 ml of a 50% aqueous solution of Dimexidum, and 10.0 ml of a 20% aqueous solution of choline chloride was mixed with 5.0 ml of a 50% aqueous solution of Dimexidum.

To perform the proposed method of childbirth preparation and therapeutic electrophoresis on a body area of a uterus of the patient laid on the couch in the supine position (with the disadvantage for women in this position she could partially rotated, approaching the position lying on its side). On the upper part of the anterior abdominal wall incorporating a cathode 1, and on the lateral surface of the left and right hips were applied to the anodes 2; 21and 3; 31respectively. The size of the cathode plate was h cm, and the size of the strip under the cathode - 20h15 see the size of the anode - h cm, and the dimensions of the pads under them - 12x10 see All strip moistened with water. On the surface 4 of the right thigh between the electrodes 2 and 21square 6x8 cm glass spatula inflicted prepared solution of vitamin E in Dimexidum, but on the surface 5 of the left femur between the electrodes 3 and 31square 7-8 x 15 cm - solution of choline chloride in Dimexidum. The amperage was set in the range of 0.8-1 mA, it does not allow occurrence of even small feelings is about 15 minutes The number of sessions ranged from 2 to 10 depending on the beginning of the onset of spontaneous labour. After the onset of spontaneous labor procedure electrophoresis was canceled.

The use of the proposed method of childbirth preparation and the manner of exercise of medicinal electrophoresis on a body area of the uterus for childbirth preparation 70 pregnant risk for the occurrence of obstetric complications in childbirth in the mother and fetus, i.e., had burdened obstetric history (suffered in the past abortions, spontaneous abortions, the weakness of the labour forces and uterine bleeding in childbirth), extragenital diseases (obesity, hypertension 1 tbsp., chronic cholecystitis), obstetric pathology (dropsy pregnant, nephropathy pregnant 1 tbsp., intrauterine hypoxia of the fetus), in terms 38-39 weeks of pregnancy in the presence of the unwillingness of the pregnant woman's body for childbirth (had the presence of immature or ripening of the cervix) provided in 86% of cases, the development of spontaneous contractions, which ended in spontaneous births. In childbirth, no cases of development of the weakness of the labour forces and uterine bleeding. Only 1 child born in the state of mild eficacia, the other children were born in Adoos: pregnancy 38 weeks, perforada in 32 years, burdened obstetric history, chronic cholecystitis. In the past suffered 2 megabit. When entering the cervix in women assessed as being "immature". Pregnant appointed preparation for childbirth in the form of electrophoresis of vitamin E and choline chloride using Dimexidum 1 session daily. Procedures pregnant was well tolerated, no adverse events were observed. After conducting 8 sessions the woman appeared spontaneous contractions, and she alone, odoratissimus. The duration of delivery 10 hour 20 minutes Blood loss of 250.0 ml Newborn weight 3350,0 g and a height of 50 cm was estimated at Apgar score of 8 in 5 min - 9 points. The mother of the child was discharged on the 5th day in a satisfactory condition.

Example 2. Pregnant P., 28 years. Diagnosis: pregnancy 38-39 weeks, burdened obstetric history, obesity 11th century, dystonia on hypertonic type, nephropathy pregnant 1 tbsp. women 3 years ago in childbirth about developed weakness of the labour forces used a drip of oxytocin; blood loss reached 600,0 ml, blood transfusion was performed. Child weight 3900,0, was born with a score of 5 points on the Apgar scale, after 5 minutes - 6 points. Upon admission to the hospital the neck Madalina chloride with Dimexidum. After 5 sessions, passed without complications, the woman developed a generic activity. After 8 h 10 min women odoratissimus child weight 4200,0, with rating on a scale of Apgar score of 8 in 5 min - 9 points. Blood loss of 300.0 ml of a Woman with a child was discharged on the 6th day in a satisfactory condition.

1. The way to prepare for childbirth by separate administration of drugs, characterized in that the injected 1.0 ml of a 5% solution of vitamin E and 10.0 ml of 20% aqueous solution of choline chloride, with the introduction of medicines carried out simultaneously by medicinal electrophoresis on a body area of the uterus.

2. Method for making medicinal electrophoresis on a body area of the uterus, according to which one electrode is placed on the area of the bottom of the body of the uterus characterized in that the electrode placed on the upper part of the anterior abdominal wall women, and on the side surfaces of the thighs impose electrodes oppositely charged with respect to the electrode placed on the bottom of the body of the uterus, two on each hip, against each other, the solution medicines put on the front of the thighs, located between these electrodes and pads under all e

 

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