A wound healing agent "empircal"

 

(57) Abstract:

We offer healing wounds "Empircal" is a gel at neutral collagen-based, effective in the treatment of severe radiation injuries of the skin, burns, wounds, trophic ulcers of different etiology, bedsores. Neutral collagen does not irritate the skin and the wound surface, hydrophilic, easily absorbed, with subsequent resorption and effects on wound process. The tool contains, wt%: the emoxipin 1-5, parmidin 2-5, dimethylsulfoxide 10-20, nipagin of 0.05-0.1 and neutral collagen on borax-phosphate buffer with pH 7.0 - 7.5 to 100. The tool can optionally contain 1 wt.% lidocaine or trimekainom. 1 C.p. f-crystals.

The invention relates to medicine, namely the production of medicines for external use.

Known ointments containing in its composition derivatives of collagen and fatty acids [1]. However, to get a reasonable consistency of these ointments should contain thickeners and other auxiliary substances, which reduces their therapeutic effectiveness and creates difficulties in the manufacture.

Also known ointment [2], containing analiziruyuschei substance and as a hydrophilic agestructure at low temperature. The disadvantage of ointments, in addition to the difficulties associated with obtaining powder is that the powder is aging during storage and loses its solubility, which affects the quality of the ointment. The use of this ointment is very narrow and limited local anesthesia in dentistry.

Acetic acid collagen [3] found use as ointment bases due to strong irritant action of the acid on the skin.

Closest to the proposed healing tool are based ointment neutral collagen mass or dry collagen (pharmaceutical) drugs (streptocid, amination) [4]. The disadvantage of these ointments was poor solubility of neutral collagen or dry collagen in water, which required an additional injection of citric acid and, therefore, increase its irritating effect on the skin. In addition, these drugs do not stimulate the processes of wound healing.

The present invention relates ointment collagen at neutral basis, containing in its composition emoxipin, parmidin, dimethylsulfoxide - substances with antioxidant, anti-inflammatory and stimulates the regeneration activity. The proposed komogorov, wounds, trophic ulcers of different etiology, bedsores. Neutral collagen does not irritate the skin wound surface, hydrophilic and easily absorbed with subsequent resorption and effects on wound process.

Declare a wound healing agent "empircal" on the basis of neutral collagen, characterized in that as a medicinal substance use emoxipin, parmidin, dimethylsulfoxide and collagen-based, soluble in borax-phosphate buffer at pH 7.0-7.5 and the following ratios, wt.%:

The emoxipin - 1,0 - 5,0

Parmidin - 2,0 - 5,0

Dimethyl sulfoxide - 10,0 - 20,0

Nipagin - 0,05 - 0,10

Neutral collagen 2% in 0.05 M borax-phosphate buffer with pH 7.0 - 7.5 to 100

Active principle ointment emoxipin and parmidin. The emoxipin refers to the antioxidant nutrient type, is a structural analogue of vitamin B. Parmidin has anti-inflammatory and antioxidant effects, has antiexudative and expressed anti-sclerotic effect. It is experimentally shown that in the presence of collagen appears the synergistic action of emoxipin and parmidina on the regeneration of damaged tissue.

In the composition of ointments included dimethyl sulfoxide that potholed has a wide range of effects on the wound healing process anti-inflammatory, dehydrating, bacteriostatic. It enhances the overall therapeutic effect of ointments and by accelerating the penetration of drugs into the lesion.

A wound healing agent "empircal" is intended for the treatment of severe radiation injuries of the skin, deep burn wounds, trophic ulcers of various etiologies, sores, lesions of the mucous.

To prevent microbial contamination in the composition is injected 0,05 - 0,100 wt.% nipagina. Additionally, to minimize potential pain in the composition include up to 1 century including anesthetic is lidocaine or trimekainom.

A wound healing agent is prepared as follows. First, prepare a 2% neutral collagen based on borax-phosphate buffer with pH 7 and 7.5. Then in a viscous system with constant stirring enter pre-dissolved in water and dimethylsulfoxide the emoxipin and parmidin with mipagina. The obtained viscous gel-like composition Packed in lacquered tubes or jars.

Specific examples of the preparation "anarkali".

Example 1. 1. 5 g emoxipin dissolved in 35 ml of water. 2. 10 g parmidina and 0.05 g nipagina dissolved in 50 g of dimethyl sulfoxide. 3. In a mixer with resultsfile stirred until a homogeneous viscous system. 4. In a thoroughly mixed neutral collagen based small portions add a solution of emoxipin (1) and the solution parmidina with mipagina (2). 5. The gel after thorough mixing Packed in tubes or jars.

Example 2. 1. 5 g emoxipin and 1 g of lidocaine or trimekainom dissolved in 34 ml of water 2. Further on PP.2-5 example 1.

Example 3. 1. 25 g of emoxipin dissolved in 50 ml of water. 2. 25 g parmidina and 0.10 g nipagina dissolved in 100 g of dimethylsulfoxide 3. In the mixer with the mixer pour 135 g 0.15 M borax phosphate buffer pH 7.0 - 7.5 and 165 g of 6% by weight of collagen. The mixture was thoroughly stirred. 4. Gel Packed in lacquered tubes or jars.

Literature

1. Patent Romania N 88838, A 61 K 31/13, 1983.

2. USSR author's certificate N 833241, 1981.

3. Hilkin A. M. and others: Collagen and its application in medicine. Medicine, 1976.

4. Panina, Etc., Studies on the use of collagen in technology ointments. Abstract. Kida.dis. - 1981.

1. A wound healing agent on the basis of neutral collagen, characterized in that it further comprises the emoxipin, parmidin, dimethylsulfoxide, nipagin and 0.05 M borax-phosphate buffer solution with pH 7.0 and 7.5 while the ratio of components, wt.%:

Epackage 2% in 0.05 M borax - phosphate buffer solution with pH 7.0 - 7.5 to To 100.0.

2. Means under item 1, characterized in that it further contains 1 wt.% lidocaine and trimekainom.

 

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