Concentrate for the treatment of psoroptes farm animals
(57) Abstract:The invention relates to veterinary medicine, namely to means of combating psoroptes farm animals. Concentrate for the treatment of psoroptes farm animals includes current structurae substance thiophene series and the filler (solvent and emulsifier). As serosoderjaschei component concentrate contains di-, trialkylamines and/or functional derivatives of thiophene series in the amount of 40-50 wt.%, the rest is filler. In addition, as the filler is used a mixture of solvent nefras and surface-active substances (surfactants) in the ratio of 1.0 to 1.2: 1. Another modification of the concentrate further comprises an active additive - camphor oil in the amount of 0.5-1.5 wt.%. The invention allows to expand the Arsenal of remedies against psoroptes-based compounds, thiophene series with a low toxicity, and to reduce the consumption of the active substance due to the introduction of supplements. The proposed concentrate spend handling infected animals and their habitats. 2 C.p. f-crystals, 2 tab. The invention relates to veterinary medicine, namely to means of combating psoroptes selskapet drugs related to different classes of chemical compounds: organo-phosphorus compounds (neocidol, diazinon), pyrethroids (MT, butox), avermectins (ivomec) and others (see N.T. Kadyrov, A. D. Taneev "Chemical drugs used in parasitic diseases of farm animals" - Tselinograd - 1985, S. 48-49; REV N 7, 1989, I. Malinowska "Modern methods of dealing with the major ectoparasites of farm animals").However, some of these drugs are highly toxic to animals (neocidol, diazinon), other, although less toxic, but rather expensive (MT, butox), others will dress up with high cost, have on the organism of animals immunosuppressive effects. All of the above compounds are synthesized multistage.The closest in content to the claimed concentrate is the product of meifen", where the active substance is used methylthiophene (O. H. Iskhakov, A. S. Salikova, C. S. Sucevic, A. N. The Sinyavin, N. P. Biryukov, A. I. Boldyrev. Rational use of drugs in veterinary medicine. M: Rosselchozizdat, 1984). The tool also contains a filler (solvent and emulsifier), but does not contain active additives, allowing the achievement of The present invention consists in the expansion of the means of combating psoroptes-based compounds, thiophene series, with low toxicity, and the decreased consumption of the active substance due to the introduction of supplements. The proposed concentrate spend handling infected animals and their habitats.This object is achieved in that the concentrate for the treatment of psoroptes farm animals, including current structurae substance thiophene series and the filler (solvent and emulsifier), as serosoderjaschei component taken di-, trialkylamines and/or functional derivatives of thiophene series of 40 - 50 wt.%, the rest is filler.In addition, as the filler is used a mixture of solvent nefras and surface-active substances (surfactants) in the ratio of 1.0 to 1.2 : 1.Another modification of the concentrate further comprises an active additive - camphor oil in the amount of 0.5 - 1.5 wt.%.Camphor oil, known as anti-inflammatory, analgesic and antiseptic [Brains I. E. Pharmacology. -M.: Kolos, - 1974. -S. 112-117] , is used as supplements, possessing in addition to these properties of the synergy effects that reduce the concentration of the active substance.Solvent - nefras AP 120/200 (TU 38101809-80).The resulting composition based on a mixture of thiophene compounds of the number of active additive, emulsifier and solvent allows you to get a new therapeutic agent, namely a composition having a high acaricidal action, superior in its medical effect of meifen", low-toxic and available in original synthesis of thiophene compounds. The latter is obtained from the corresponding furan derivatives under the action of hydrogen sulfide in acidic media [Kharchenko Century BC, Gubina T. I. Voronin, S. P., Markusen I. A. About the reaction of furan compounds with hydrogen sulfide and its implications / Chemistry of heterocycle. connect. - 1985. - N 11. - S. 1453-1456].The inventive concentrate is prepared by mechanical mixing of the components.Example 1.Composition 1 prepared by mixing 40 g of thiophene compound, 0.5 g of camphor oil, 29,75 g nefras and 29,75 g neonols. Formulation compositions shown in table. 1.The active ingredient in the concentrate should be no more than 50%, as higher contents is impossible to achieve good solubility in water, which is necessary for p is mFor testing acaricidal activity, and also for the treatment of animals from mulgirigala concentrate prepare working emulsion by diluting it with water.Working emulsion concentrate is prepared immediately before use. The calculation of the number mulgirigala concentrate for preparation of the working of the emulsion is carried out according to the formula X = AB/C [Veterinary medicines. Ed. by A. Tretyakov D.-M.: Agropromizdat. - 1988. - N-29] where:
A number of working emulsion (l) required for cooking;
B - the concentration that must be obtained in the working emulsions;
C - number (%) of active ingredient in the emulsion concentrate.A study prepared by the working of the emulsion was carried out on isolated ticks of the genus Psoroptes.Example 2.Fresh scrapings took 10 ticks and put them on filter paper on a watch glass. Inflicted working emulsion with 1% of active substance - 2.5 dimethylthiophene, kept for 1 minute and then placed filter paper with ticks in a Petri dish and kept in a thermostat at T = 28oC and 80% humidity. About acaricidal action used substances were tried for the death of 100% of all ticks within a water.Example 3.The experiment was carried out analogously to example 2, was used a composition containing 2% of active substance 2,5-dimethylthiophene. Within an hour, killed 100% of the ticks.Example 4.The experiment was carried out analogously to example 2, was used a composition containing 3.5% of the active substance 2,5-dimethylthiophene. The result is similar to example 4.For the other studied thiophene compounds were established following the optimal concentration causing death 100% of all ticks within 1...24 hours (table 2).Using concentrations of thiophene compounds listed below in table caused the death of ticks from 50 to 70%. When the concentration of the active substance of the above table, the loss of 100% of the ticks came in a few seconds.Example 5.Determination of therapeutic efficacy of the studied drugs was performed on 5 rabbits, patients psoroptes with varying degrees of invasion. For the treatment of psoroptes in rabbits experienced workers emulsion with a content of from 0.5% to 3% of the active substance 2,5-dimethylthiophene. After preparation of working emulsions were collected in disposable syringes and put 1-2 ml on the inner surface of the ears, odnovremenno the destruction of the pathogen within 15 days.In rabbits treated with 0,5%; 1%; 1.5% and 2% of the working emulsion, on the seventh day in the scrapings were found living mites, and rabbit treated with 3% emulsion were found fragments of dead mites, lesions were pink and were free of crusts. After research was conducted reprocess working emulsions of the same concentrations. The second study was conducted in 8 days. In rabbits treated with 0,5%; 1%; 1.5% and 2% of emulsions, in scrapings found living mites, and rabbit treated with 3% emulsion was clinically healthy, the surface of the auricles smooth and pink, a rare delicate hair.Example 6.Determination of acute toxicity of the compounds selected based on the results of tests on laboratory animals, with strong acaricidal action and recommended for implementation in veterinary practice.2.5-Dimethylthiophene were administered per os in different quantities. Watched the animals for 10 days. The results of the experiments were considered at death. Sredneseriynoe dose was determined by Dahmane and LeBlanc. The value of LD50for mice, determined by this method was 1650 mg/kg for rabbits 2250 mg/kg, which peeiod observations General condition and behavior of animals any abnormalities were noted.The value of LD50for mice to connect 5-methyl(thienyl-2)- butane-3-ol is 1300 mg/kg 1. Concentrate for the treatment of psoroptes farm animals, including current structurae substance thiophene series and the filler (solvent and emulsifier), characterized in that as serosoderjaschei component taken di-, trialkylamines and/or functional derivatives of thiophene series of 40 - 50 wt.%, the rest is filler.2. Concentrate on p. 1, characterized in that the filler is used a mixture of solvent nefras and surface-active substances (surfactants) in the ratio of 1.0 to 1.2 : 1.3. Concentrate on PP.1 and 2, characterized in that it additionally contains active additive - camphor oil in the amount of 0.5 - 1.5 wt.%.
FIELD: pharmaceutical industry and cosmetics.
SUBSTANCE: composition contains, wt %: biologically active component isolated from medicinal leech or its parts 0.01-6.0, menthol 0.15-0.25, aqueous-alcoholic extract of horse-chestnut fruitage 8-10, camphor 0.15-0.30, ethoxydiglycol 3-5, polyethyleneglycol 1500, 0.8-1.2, emulgin B2, 0.8-1,2, Carbomer 0.6-0.8, triethanolamine 0.6-0.8, methylparben 0.25-0.35, Bronopol 0.04-0.06, butyloxyanisol 0.06-0.08, and water to 100%. Composition is made in the form of gel and provides antithrombic and analeptic effects on skin and hypodermic tissues, enhances antiinflammatory action, favors deep penetration of active components through skin, strengthens venous vessel walls, improves microcirculation of blood, and accelerated restoration of vascular wall tone.
EFFECT: expanded therapeutical possibilities.
2 cl, 2 tbl
FIELD: pharmaceutical industry.
SUBSTANCE: invention relates to creating drugs for treatment and prevention of inflammatory lesions of support-motor apparatus (myosites, arthrites, tendovaginites, etc.). Therapeutical composition according to invention contains, wt %: essential oil of silver fir 1.0-2.0, camphor 4.0-5.0, oil extract of red capsicum 0.06-0.08, biologically active component isolated from medicinal leech or its parts 0.01-6.5, Ibuprofen 60.0-65.0, ethoxydiglycol 3.0-5.0, Emulgin B2 0.4-0.6, Carbomer 0.5-0.8, triethanolamine 0.6-0.8, methylparben 0.2-0.3, propylparben 0.02-0.03, butyloxyanisol 0.08-0.1, Bronopol 0.04-0.05, and water the rest. Composition activates metabolic processes in skin and subcutaneous fat layer, normalizes blood supply, eliminates stagnant phenomena, accelerates getting active therapeutical substances into membranes of biological cells, which results in rapid achievement of stable therapeutical effect in what concerns elimination of inflammatory process in joints and muscles.
EFFECT: increased therapeutical efficiency.
FIELD: pharmaceutical industry, in particular anesthetic and vasodilating ointment.
SUBSTANCE: claimed ointment is prepared on the base of fine dispersed formulation contains apitoxin extract melittin, camphor, lavender, rosemary and eucalyptus oils and revitalin in specific component ratio. Ointment of present invention is useful in treatment of reumathysm, muscle and joint diseases, myodynia, radiculitis, ischias, neurodynia, polyneuritis, etc.
EFFECT: ointment with reduced apiotoxin toxicity, decreased side effects and improved therapeutic effect.
FIELD: pharmaceutical industry, in particular analgesic, vasodilatation, anti-inflammation ointment for topical application.
SUBSTANCE: claimed ointment is prepared in form of fine dispersed formulation containing bee venom extract melittin, lavender oil, camphor, arnica tincture, rosemary oil, eucalyptus oil, revitalin, carbopol, 30 % solution of sodium hydroxide, hydrophilic anionic ointment, soy lecithin, glycerol, conserving solution, ethanol, distilled water.
EFFECT: reduced toxicity of bee venom, decreased side effects and improved therapeutic effect.
2 tbl, 3 ex
SUBSTANCE: method involves administering immune correction therapy, vitamin C and group B vitamins, local treatment with antivirus ointments, antiseptics and analgesic remedies, as well as phytotherapy with helium-neon laser treatment. Fentaline, Thianeptine, Bioparox, oral rinsing with 0.1% aqueous Levamisol solution prepared immediately before being applied. Gltoxime is administered at the tenth day beginning from the exacerbation onset. 20% Levocarnitine solution and oral rinsing with 10% aqueous ASD-2F solution prepared immediately before being applied. Ajurvedic preparation Chavanprash is additionally prescribed for 108 days and then daily from full moon to full moon 1 year long. Tooth pastes like Cloves and Sweet Basil are to be alternatively applied during the whole treatment period.
EFFECT: enhanced effectiveness of treatment; prevented relapses; normalized mental and emotional state of patients.
3 cl, 1 dwg, 2 tbl
FIELD: medicine, chemical-pharmaceutical industry, pharmacy.
SUBSTANCE: invention relates to creature of agents used in prophylaxis and treatment of diseases and pathological states associated with the locomotor system. Agent represents the complex preparation including the composition № 1 and № 2. The composition № 1 on hydrophobic base comprises the following active substances: phytocomponents of peppermint, common wormwood, mountain arnica, grape seeds, matricary, pine cones, pot-marigold, bur-marigold, sea-buckthorn oil, red pepper oil, red palm oil, mixture of essential oils of peppermint, lavender and clove in the ratio 1:1:1, bee venom, menthol, synthetic camphor and the following accessory substances: form-forming thickening agent - bee wax; preserving agent - propylparaben; emolents - cetiol CC, DC 345 and vaseline oil; antioxidant - kovi-ox. The composition № 2 on hydrophilic base comprises the following active substances: aqueous extracts of lilac flowers, mountain arnica, walnut peel; propocyanides of grape berries, propolis alcoholic extract, Kova-B-trox, and accessory substances: gel-forming agent - natrosol 250; moistening agents - propylene glycol and urea; chelating agent - disodium-EDTU; emolent - PLN phospholipids; preserving agents - methylparaben and caton CG; pH regulating component - triethanolamine and deionized water. Proposed agent possesses the expressed and prolonged curative effect that allows its using both for prophylaxis and treatment of different diseases and damages of structures in locomotor system and for improving skin state and adjacent tissues. Agent shows high therapeutic activity, namely its rapid and deep penetration into tissues, heating and relaxing effect, improving circulation in tissues and enlargement of blood vessels. Agent shows analgesic, anti-inflammatory, anti-edematous effect, accelerates reparative processes and improves tissue trophism. Agent shows the complex directivity on all mechanisms in base of diseases and pathological states of the locomotor system and their clinical symptoms and possesses the broad spectrum of pharmacological effect and both recovers the damaged functions of organ and shows the systemic effect on all body.
EFFECT: valuable medicinal properties of agent.
SUBSTANCE: method involves carrying out histological study of smear imprint, bioptate or operation preparation. Histological picture corresponding to the first stage of wound process, conservative therapy course is to be complemented with peroral introduction of Pinaverium bromide at a dose of 50 mg thrice a day 10 days long and local transanal instillations 2 ml 0.1% glycerol trinitrate solution twice a day 6 weeks long. Conservative therapy course at the second stage of wound process is to be complemented with Mebeverine hydrochloride at a peroral dose of 200 mg thrice a day 2 weeks long and intramuscular introduction of Dalargin at a dose of 1 mg twice a day 2 weeks long. Conservative therapy course at the third stage of wound process is to be complemented with Mebeverine hydrochloride at a peroral dose of 200 mg twice a day 2 weeks long and intramuscular introduction of Dalargin at a dose of 2 mg twice a day 2 weeks long and local transanal instillations with 2 ml 0.1% glycerol trinitrate solution twice a day 4 weeks long. Conservative therapy course at the second and the third stage of wound process is also to be complemented with peroral introduction of nonsteroid anti-inflammatory means.
EFFECT: enhanced effectiveness of treatment when applied as rational drug the in postoperative period; accelerated rehabilitation; reduced frequency of disease recurrence.
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention concerns pharmaceutical industry and medicine, namely to creation of an agent for treatment and prevention of benign hyperplasia of prostate (BPH), prostatitis, impotency, sterility and a cancer of prostate and a method of its application. The agent and method of application of an agent on the basis of camphor (dextrogyrate [D-] either levogyratory (L-) or racemic [DL-camphor] in the form of fat-oil-dimexide emulsion (Emulsio Camphorae Axungio Oleo - Dimexidosa), oil-water emulsion (Emulsio Camphorae Oleo-Aguosa) and in the form of candles where quantity of camphor totals 0.1-15.0 are offered. The presented agents are applied rectal. The oil-fat-dimexide emulsion can be applied for prevention of cancer of prostate, or a candle, 1 time a day by courses up to 20 days annually. Camphor preparations raise fastness of tissue colloids, show opposing action in relation to capillary poisons, activate erection centre of sacrum of parasympathetic nervous system, posses M - and N - cholinolytic action, tone up the centre of the ejaculation, located in sympathetic part of the central nervous system, normalise tonus of capillaries and venules, stimulate vasculomotor centres of a spinal cord, strengthen synthesis of high-energy phosphates and brake splitting of ATF-ACID in the conditions of hypoxia, possess analgesic, bactericidal and fibrinolitic action. Application of treatment methods and prevention of BPH, prostatitis, impotency, sterility and cancer of prostate with use of camphor preparations; dilates assortment of preparations and methods of treatment applied to ill with BPH, prostatitis, sterility, impotency; allows to spend preventive treatment of these diseases within many decades.
EFFECT: expansion of assortment of preparations and methods of treatment and prevention, applied to patients with BPH, prostatitis, sterility, an impotency.
15 cl, 10 ex