Concentrate for the treatment of psoroptes farm animals

 

(57) Abstract:

The invention relates to veterinary medicine, namely to means of combating psoroptes farm animals. Concentrate for the treatment of psoroptes farm animals includes current structurae substance thiophene series and the filler (solvent and emulsifier). As serosoderjaschei component concentrate contains di-, trialkylamines and/or functional derivatives of thiophene series in the amount of 40-50 wt.%, the rest is filler. In addition, as the filler is used a mixture of solvent nefras and surface-active substances (surfactants) in the ratio of 1.0 to 1.2: 1. Another modification of the concentrate further comprises an active additive - camphor oil in the amount of 0.5-1.5 wt.%. The invention allows to expand the Arsenal of remedies against psoroptes-based compounds, thiophene series with a low toxicity, and to reduce the consumption of the active substance due to the introduction of supplements. The proposed concentrate spend handling infected animals and their habitats. 2 C.p. f-crystals, 2 tab.

The invention relates to veterinary medicine, namely to means of combating psoroptes selskapet drugs related to different classes of chemical compounds: organo-phosphorus compounds (neocidol, diazinon), pyrethroids (MT, butox), avermectins (ivomec) and others (see N.T. Kadyrov, A. D. Taneev "Chemical drugs used in parasitic diseases of farm animals" - Tselinograd - 1985, S. 48-49; REV N 7, 1989, I. Malinowska "Modern methods of dealing with the major ectoparasites of farm animals").

However, some of these drugs are highly toxic to animals (neocidol, diazinon), other, although less toxic, but rather expensive (MT, butox), others will dress up with high cost, have on the organism of animals immunosuppressive effects. All of the above compounds are synthesized multistage.

The closest in content to the claimed concentrate is the product of meifen", where the active substance is used methylthiophene (O. H. Iskhakov, A. S. Salikova, C. S. Sucevic, A. N. The Sinyavin, N. P. Biryukov, A. I. Boldyrev. Rational use of drugs in veterinary medicine. M: Rosselchozizdat, 1984). The tool also contains a filler (solvent and emulsifier), but does not contain active additives, allowing the achievement of The present invention consists in the expansion of the means of combating psoroptes-based compounds, thiophene series, with low toxicity, and the decreased consumption of the active substance due to the introduction of supplements. The proposed concentrate spend handling infected animals and their habitats.

This object is achieved in that the concentrate for the treatment of psoroptes farm animals, including current structurae substance thiophene series and the filler (solvent and emulsifier), as serosoderjaschei component taken di-, trialkylamines and/or functional derivatives of thiophene series of 40 - 50 wt.%, the rest is filler.

In addition, as the filler is used a mixture of solvent nefras and surface-active substances (surfactants) in the ratio of 1.0 to 1.2 : 1.

Another modification of the concentrate further comprises an active additive - camphor oil in the amount of 0.5 - 1.5 wt.%.

Camphor oil, known as anti-inflammatory, analgesic and antiseptic [Brains I. E. Pharmacology. -M.: Kolos, - 1974. -S. 112-117] , is used as supplements, possessing in addition to these properties of the synergy effects that reduce the concentration of the active substance.

Solvent - nefras AP 120/200 (TU 38101809-80).

The resulting composition based on a mixture of thiophene compounds of the number of active additive, emulsifier and solvent allows you to get a new therapeutic agent, namely a composition having a high acaricidal action, superior in its medical effect of meifen", low-toxic and available in original synthesis of thiophene compounds. The latter is obtained from the corresponding furan derivatives under the action of hydrogen sulfide in acidic media [Kharchenko Century BC, Gubina T. I. Voronin, S. P., Markusen I. A. About the reaction of furan compounds with hydrogen sulfide and its implications / Chemistry of heterocycle. connect. - 1985. - N 11. - S. 1453-1456].

The inventive concentrate is prepared by mechanical mixing of the components.

Example 1.

Composition 1 prepared by mixing 40 g of thiophene compound, 0.5 g of camphor oil, 29,75 g nefras and 29,75 g neonols. Formulation compositions shown in table. 1.

The active ingredient in the concentrate should be no more than 50%, as higher contents is impossible to achieve good solubility in water, which is necessary for p is m

For testing acaricidal activity, and also for the treatment of animals from mulgirigala concentrate prepare working emulsion by diluting it with water.

Working emulsion concentrate is prepared immediately before use. The calculation of the number mulgirigala concentrate for preparation of the working of the emulsion is carried out according to the formula X = AB/C [Veterinary medicines. Ed. by A. Tretyakov D.-M.: Agropromizdat. - 1988. - N-29] where:

A number of working emulsion (l) required for cooking;

B - the concentration that must be obtained in the working emulsions;

C - number (%) of active ingredient in the emulsion concentrate.

A study prepared by the working of the emulsion was carried out on isolated ticks of the genus Psoroptes.

Example 2.

Fresh scrapings took 10 ticks and put them on filter paper on a watch glass. Inflicted working emulsion with 1% of active substance - 2.5 dimethylthiophene, kept for 1 minute and then placed filter paper with ticks in a Petri dish and kept in a thermostat at T = 28oC and 80% humidity. About acaricidal action used substances were tried for the death of 100% of all ticks within a water.

Example 3.

The experiment was carried out analogously to example 2, was used a composition containing 2% of active substance 2,5-dimethylthiophene. Within an hour, killed 100% of the ticks.

Example 4.

The experiment was carried out analogously to example 2, was used a composition containing 3.5% of the active substance 2,5-dimethylthiophene. The result is similar to example 4.

For the other studied thiophene compounds were established following the optimal concentration causing death 100% of all ticks within 1...24 hours (table 2).

Using concentrations of thiophene compounds listed below in table caused the death of ticks from 50 to 70%. When the concentration of the active substance of the above table, the loss of 100% of the ticks came in a few seconds.

Example 5.

Determination of therapeutic efficacy of the studied drugs was performed on 5 rabbits, patients psoroptes with varying degrees of invasion. For the treatment of psoroptes in rabbits experienced workers emulsion with a content of from 0.5% to 3% of the active substance 2,5-dimethylthiophene. After preparation of working emulsions were collected in disposable syringes and put 1-2 ml on the inner surface of the ears, odnovremenno the destruction of the pathogen within 15 days.

In rabbits treated with 0,5%; 1%; 1.5% and 2% of the working emulsion, on the seventh day in the scrapings were found living mites, and rabbit treated with 3% emulsion were found fragments of dead mites, lesions were pink and were free of crusts. After research was conducted reprocess working emulsions of the same concentrations. The second study was conducted in 8 days. In rabbits treated with 0,5%; 1%; 1.5% and 2% of emulsions, in scrapings found living mites, and rabbit treated with 3% emulsion was clinically healthy, the surface of the auricles smooth and pink, a rare delicate hair.

Example 6.

Determination of acute toxicity of the compounds selected based on the results of tests on laboratory animals, with strong acaricidal action and recommended for implementation in veterinary practice.

2.5-Dimethylthiophene were administered per os in different quantities. Watched the animals for 10 days. The results of the experiments were considered at death. Sredneseriynoe dose was determined by Dahmane and LeBlanc. The value of LD50for mice, determined by this method was 1650 mg/kg for rabbits 2250 mg/kg, which peeiod observations General condition and behavior of animals any abnormalities were noted.

The value of LD50for mice to connect 5-methyl(thienyl-2)- butane-3-ol is 1300 mg/kg

1. Concentrate for the treatment of psoroptes farm animals, including current structurae substance thiophene series and the filler (solvent and emulsifier), characterized in that as serosoderjaschei component taken di-, trialkylamines and/or functional derivatives of thiophene series of 40 - 50 wt.%, the rest is filler.

2. Concentrate on p. 1, characterized in that the filler is used a mixture of solvent nefras and surface-active substances (surfactants) in the ratio of 1.0 to 1.2 : 1.

3. Concentrate on PP.1 and 2, characterized in that it additionally contains active additive - camphor oil in the amount of 0.5 - 1.5 wt.%.

 

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