Drops petrosian n 1a n 2a - n 7a variants) for treatment of allergic and diatopically diseases of the eyes and nose

 

(57) Abstract:

The invention relates to the field of medicine. Drops for treatment of allergic and diatopically diseases of the eyes and nose contain kromolin sodium or nedocromil sodium, or cromoglicate acid, dexamethasone-21-phosphate sodium salt, gramicidin, neomycin sulfate, sterile buffer solution, if necessary, ephedrine hydrochloride. Other options are drops containing instead dexamethasone diphenhydramine and ephedrine hydrochloride. Proposed drops have more effective while reducing side effects. 3 S. and 4 C.p. f-crystals.

The invention relates to medicine, in particular to the treatment of allergic and diatopically diseases of the eyes and nose.

Known traditional separate application of antihistamines, sympathomimetics, corticosteroids for treatment of allergic and diatopically diseases of the eyes and nose [1] . To ensure also used simple and complex composition of the droplets. This eye drops "Octadecanethiol containing a dexamethasone-21-phosphate of 0.1% [2]. Also known composition drops "Deksona" for the eyes and Sofradex" for the eyes, nose and ears [3]. Successfully apply the nose drops, sostojashie karstenii funds is the lack of profilaktirujut immunological mechanism of action, warning emergence and development of allergic and diatopically diseases of the eyes and nose, low efficiency in the treatment of these diseases.

The most similar content offered drops are drops for the eyes and/or nose, containing any drug interoperably group of substances that differ from each other equivalent signs and have shared significant technical equivalent sign inflamatornog immunological mechanism of inhibition of degranulation mastocytes (fat cells) and the allocation of these inflammatory mediators. These include drops "Bromohexyl" containing cromoglicic acid 2% [5], spray for intranasal use "Tiled" containing nedocromil sodium, eye drops and nose "Lamusa" containing kromolin sodium (disodium cromoglycate) 2% [6]. The proposed solution will improve all three similar, any of which may be selected for the prototype. As a prototype of the claimed invention are considered the most widely used in Russia drops for eyes and nose "Iteral", consisting of the following components:

Kromolin sodium - 2 wt.%/volume

The benzalkonium chloride is 0.01 wt.%/volume

(as preservative, what he does not possess anti-allergic, anti-inflammatory and antibacterial action, not pain acute manifestations of allergic and diatopically diseases of the eyes and nose, in particular, complicated by infection, but only to some extent warns them. The effect of the application drops "Iteral" minor, develops slowly, reaching a maximum within 2-4 weeks of starting treatment, this increases the incidence of idiosyncrasy to the drug.

The aim of the present invention is to eliminate the above drawbacks and increase the efficiency of the drops in the treatment of allergic and diatopically diseases of the eyes and nose, in particular, complicated by infection, by adding drops of new properties, allowing multi-dimensional impact on the disease, arising from anti-allergic, anti-inflammatory, local anesthetic, desensitization, vasoconstrictors, antihistamines, anti-inflammatory, reduces capillary permeability and antibacterial action in combination with immunological mechanism for the prevention of disease, and increase effectiveness by obtaining direct and synergistic photoxicity and side effects, receive new properties, allowing to arrest the acute manifestations of the disease.

These goals are achieved by the fact that the drops for the treatment of allergic and diatopically diseases of the eyes and nose, containing kromolin sodium, a drug that has the technical equivalent sign interoperably group of substances, namely immunological mechanism of inhibition of degranulation mastocytes and allocation of these mediators of inflammation, providing profilaktirujut impact on the disease, also include in various embodiments, the dexamethasone-21-phosphate sodium salt, has anti-inflammatory, desensitizing and anti-allergic effects, diphenhydramine (diphenhydramine hydrochloride), providing an antihistamine, a local anesthetic, anti-inflammatory and reduces capillary permeability effect, ephedrine hydrochloride, calling vasoconstrictor and decongestant effects, gramicidin and neomycin sulfate providing antibacterial action. A consequence of direct synergies and article concludes that the influence of the ingredients of the composition and impart new properties drops substantially increase the efficiency of the drops, the possibility of multi-faceted environmenta the NGO new therapeutic properties, allows you to arrest the acute manifestations of the disease, has antibacterial action, reduces swelling and inflammation of the mucous membranes, which dramatically reduces the amount of discharge from eyes and nose, make contact inflamatornog ingredient with mucous, which increases the efficiency of its action. In turn interoperable profilaktirujut effect on the mucous increases the efficiency of the accompanying ingredients. This interaction leads to a rapid regression of the disease, can significantly reduce, in comparison with traditionally used used dosages of the components of the compositions. The use of lower dosages of the drugs, while maintaining a more pronounced action drops, explains the significant reduction of toxic and side effects. The presence of some of the compositions Dimedrol and/or dexamethasone-21-phosphate can prevent the occurrence of idiosyncrasy to intopathname component compositions. This is accomplished in seven cases drops. In the proposed composition N 1A ingredients used in the following ratio, wt.%/volume:

Kromolin sodium or nedocromil sodium, or cromoglicate acid - 0.5 - 4

Dexamethasone-21-the first solution As you want,

the basis of action which lies interoperably immunological mechanism in combination with desensitizing, anti-inflammatory and anti-allergic action of dexamethasone-21-phosphate and antibacterial effect of gramicidin and neomycin. Drops are more effective new therapeutic properties, antibacterial effect, direct and synergistic article concludes that the effects of lower toxicity and side effects, the ability to arrest the acute manifestations of the disease, to reduce the swelling and inflammation of the mucous membranes, the amount of discharge from eyes and nose, to prevent the development of idiosyncrasy to kromolin sodium.

In the song drops N 2A ingredients used in the composition in weight. %/volume:

Kromolin sodium or nedocromil sodium, or cromoglicate acid - 0.5 - 4

Dexamethasone-21-phosphate sodium salt - 0,05 - 0,1

Ephedrine hydrochloride - 1-5

Gramicidin - 0,005 - 0,01

Neomycin sulfate - 0,2 - 0,5

Sterile buffer solution - as you want,

the basis of action which lies interoperably immunological mechanism in combination with desensitizing, anti-inflammatory and antiallergic effect on the and antibacterial effect of gramicidin and neomycin. Drops are more effective than the prototype and drops N 1, new therapeutic properties, antibacterial effect, direct and synergistic article concludes that the effects of lower toxicity and side effects, the ability to arrest the acute manifestations of the disease, to reduce the swelling and inflammation of the mucous membranes, the amount of discharge from eyes and nose, to prevent the development of idiosyncrasy to kromolin sodium.

In the song drops N 3A ingredients used in the composition in weight. %/volume:

Kromolin sodium or nedocromil sodium, or cromoglicate acid - 0.5 - 4

Diphenhydramine - 0,1 - 0,5

Gramicidin - 0,005 - 0,01

Neomycin sulfate - 0,2 - 0,5

Sterile buffer solution - as you want,

the basis of action which lies interoperably immunological mechanism in combination with an antihistamine, a local anesthetic, anti-inflammatory and reduces the permeability of the capillary action of demerol and antibacterial action of gramicidin and neomycin. Drops are more effective new therapeutic properties, antibacterial effect, direct and synergistic article concludes that the effects of lower toxicity and side effects inost mucous, the amount of discharge from eyes and nose, to prevent the development of idiosyncrasy to kromolin sodium.

In the song drops N 4A ingredients used in the composition in weight. %/volume:

Kromolin sodium or nedocromil sodium, or cromoglicate acid - 0.5 - 4

Diphenhydramine - 0,1 - 0,5

Dexamethasone-21-phosphate sodium salt - 0,05 - 0,1

Gramicidin - 0,005 - 0,01

Neomycin sulfate - 0,2 - 0,5

Sterile buffer solution - as you want,

the basis of action which lies interoperably immunological mechanism in combination with an antihistamine, a local anesthetic, anti-inflammatory and reduces capillary permeability effect Dimedrol, as well as desensitizing, anti-inflammatory and anti-allergic action of dexamethasone-21-phosphate in combination with antibacterial action of gramicidin and neomycin. Drops are more effective than the prototype and drops N-1A and N 3A, new therapeutic properties, antibacterial effect, direct and synergistic article concludes that the effects of lower toxicity and side effects, the ability to arrest the acute manifestations of the disease, reduce swelling, inflammation, pain and sensitivity of the mucous membranes, the composition of droplets N 5A ingredients used in the composition, weight. %/volume:

Kromolin sodium or nedocromil sodium, or cromoglicate acid - 0.5 - 4

Diphenhydramine - 0,1 - 0,5

Ephedrine hydrochloride - 1 - 5

Gramicidin - 0,005 - 0,01

Neomycin sulfate - 0,2 - 0,5

Sterile buffer solution - as you want,

the basis of action which lies interoperably immunological mechanism in combination with an antihistamine, a local anesthetic, anti-inflammatory and reduces capillary permeability effect Dimedrol, as well as with vasoconstrictors, anti-edematous action of ephedrine hydrochloride in combination with the antibacterial action of gramicidin and neomycin. Drops are more effective than the prototype and drops N 3A, new therapeutic properties, antibacterial effect, direct and synergistic article concludes that the effects of lower toxicity and side effects, the ability to arrest the acute manifestations of the disease, reduce swelling, inflammation, pain and sensitivity of the mucous membranes, the amount of discharge from eyes and nose, to prevent the development of idiosyncrasy to kromolin sodium.

In the song drops N 6A ingredients used in the composition in weight. %/volume:

Kromolin sodium or nedocromil sodium is>/BR>Ephedrine hydrochloride - 1 - 5

Gramicidin - 0,005 - 0,01

Neomycin sulfate - 0,2 - 0,5

Sterile buffer solution - as you want,

the basis of action which lies interoperably immunological mechanism in combination with an antihistamine, a local anesthetic, anti-inflammatory and reduces capillary permeability effect Dimedrol, as well as desensitizing, anti-inflammatory and anti-allergic action of dexamethasone-21-phosphate, with vasoconstrictor and anti-inflammatory effect of ephedrine hydrochloride, as well as with the antibacterial action of gramicidin and neomycin. Drops are more effective than the prototype and drops N 1A - N 5A and N 7A, new therapeutic properties, antibacterial effect, direct and synergistic article concludes that the effects of lower toxicity and side effects, the ability to arrest the acute manifestations of the disease, reduce swelling, inflammation, pain and sensitivity of the mucous membranes, the amount of discharge from eyes and nose, to prevent the development of idiosyncrasy to kromolin sodium.

In the song drops N 7A ingredients used in the composition in weight. %/volume:

Kromolin sodium or nedocromil sodium, or at - 0,2 - 0,5

Sterile buffer solution - as you want,

the basis of action which lies interoperably immunological mechanism in combination with vasoconstrictor and anti-inflammatory effect of ephedrine hydrochloride and antibacterial effect of gramicidin and neomycin. Drops are more effective than the prototype, new therapeutic properties, antibacterial effect, direct and synergistic article concludes that the effects of lower toxicity and side effects, the ability to arrest the acute manifestations of the disease, reduce swelling, inflammation of the mucous membranes, the amount of discharge from eyes and nose,

The analysis claimed the compositions reveals that the author of the improved three similar: kromolin sodium, nedocromil sodium and cromoglicate acid, each of which can be the prototype.

Compositions differ from the prototype with additional ingredients, namely dexamethasone-21-phosphate, Dimedrol, ephedrine hydrochloride, gramicidin and neomycin. Thus the claimed invention meets the criterion of "Novelty."

Analysis of the known preparations and compositions of the drops used to treat allergic and n is co, their use separately or in known compositions do not provide such properties that they exhibit in the present decision and the absence of any of them in essential features is not possible to obtain a positive effect. The inventive solution is characterized by a new set of essential features, and meets the criterion of "Substantial differences".

Direct and synergistic article concludes that effects, when using lower than srednestatisticheskiy, dosages of ingredients, the higher the efficiency of the drops, and treatment efficacy, reduce toxicity and side effects from the use of drops, improving contact kromolin sodium with mucous due to a sharp reduce swelling and inflammation of the mucous membranes, as well as reducing the number of discharge from eyes and nose, properties, allowing to arrest the acute manifestations of the disease, including forms, complicated by infection, gives grounds to conclude that under the proposed solutions to the conditions of inventive step.

Advantages of the proposed compositions for the treatment of allergic and diatopically diseases of the eyes and nose, in comparison with analogues, are significant the Finance lower than srednestatisticheskiy, the dosages of the ingredients, the possibility of long-term use, use drops during acute bacterial infection of diseases of the eye and nose. The variety of compositions allows the main requirement for the treatment of allergic and diatopically diseases of the eyes and nose, namely the alternation of species drops every 5-7 days because of the possible development of the idiosyncrasies of the individual ingredients, as well as to prevent the development of side effects, such as tahifilaksii phenomenon or reduce the vasoconstrictive effect of sympathomimetics on 5-7 day of their application, and also facilitates the choice of drops including contraindications. Drops are used for a new purpose, not only as profilaktirujut funds, but also for relief of acute manifestations of the disease. The use of drops does not require prior use of other drugs that restore the patency of the nasal passages. The choice of quantitative and qualitative ratio of components is based on the basis of sex, age, presence of contraindications. As an example, are most often used by the author of the compounds in the following proportions of ingredients in Grammaton-21-phosphate sodium salt - 0,05

Gramicidin - 0,005

Neomycin sulfate 0.5 to

Sterile buffer solution to 100.0 MLB

N 2A Kromolin sodium or nedocromil sodium, or cromoglicate acid - 1,0

Dexamethasone-21-phosphate sodium salt - 0,05

Ephedrine hydrochloride - 1,0

Gramicidin - 0,005

Neomycin sulfate 0.5 to

Sterile buffer solution to 100.0 ml,

N 3A Kromolin sodium or nedocromil sodium, or cromoglicate acid - 1,0

Diphenhydramine - 0,3

Gramicidin - 0,005

Neomycin sulfate 0.5 to

Sterile buffer solution to 100.0 ml,

N 4A Kromolin sodium or nedocromil sodium, or cromoglicate acid - 1,0

Diphenhydramine - 0,2

Dexamethasone-21-phosphate sodium salt - 0,05

Gramicidin - 0,005

Neomycin sulfate 0.5 to

Sterile buffer solution to 100.0 ml,

N 5A Kromolin sodium or nedocromil sodium, or cromoglicate acid - 1,0

Diphenhydramine - 0,2

Ephedrine hydrochloride - 1,0

Gramicidin - 0,005

Neomycin sulfate 0.5 to

Sterile buffer solution to 100.0 ml,

N 6A Kromolin sodium or nedocromil sodium, or cromoglicate acid - 1,0

Diphenhydramine - 0,2

Dexamethasone-21-phosphate sodium salt - 0,05

Ephedrine hydrochloride - 1,0

Grami or nedocromil sodium, or cromoglicate acid - 1,0

Ephedrine hydrochloride - 1,0

Gramicidin - 0,005

Neomycin sulfate 0.5 to

Sterile buffer solution to 100.0 ml,

Proposed drops were used by the author for 6 years, often as the only tool in the treatment of allergic and diatopically diseases of the eyes and nose, in particular, complicated by bacterial infection. The majority of patients noted improvement in health, 21% of patients remission for up to 6 months. The use of drops showed high efficiency for urgent conditions in patients with allergic and autopicking diseases of the eyes and nose, allergic angioedema in the eyes and nose.

All of these songs drops apply 1-2 drops for digging into both halves of the nose and(or) in both eyes 4-5 times a day at equal intervals of time is 4-5 hours. It is recommended that the alternation of the form of drops 7-10 days.

The use of drops Petrosian N 1A is contraindicated in fungal diseases of the eye and nose, intolerance to any ingredient. With long-term use drops some patients may experience increased intraocular pressure. Care is needed in ensenaste to any ingredient, requires caution in children under 5 years and pregnant women.

The use of drops Petrosian N 5A and N 7A relatively contraindicated in hypertension, atherosclerosis, intolerance to any ingredient. Used with caution in chronic diseases of the myocardium, ray and in the elderly. Caution should be exercised when prescribing for children up to 5 years and pregnant women.

The use of drops Petrosian N 2A N 4A N 6A is contraindicated in fungal diseases of the eye and nose. With long-term use drops some patients may experience increased intraocular pressure. Contraindicated appointment with hypertension, atherosclerosis, intolerance to any ingredient. Used with caution in chronic diseases of the myocardium, hyperthyroidism, the elderly, children under 5 and pregnant.

Sources of information

1. C. I. Picky, N. In. Adrianova, A. C. Artamonova. Allergic diseases. - M.: Medicine, 1991, page 194, page 205).

2. M. D. Mashkovsky. Medicinal product. - Vilnius, 1994.

3. N. B. Nikolaev, B. R. Alperovitch, C. N. Sazanov, E. C. Shih. On The Main Page. Drugs of foreign firms in Rocha. -Kiev, 1985.

5. C. E. Romanovsky. New drugs in pharmacies Russia. Rostov-on-don, Phoenix, 1996, page 321.

6. C. S. Gasilin, A. I. Martynov, Y. B. Belousov, A. Baryshnikova and other essential medicines, M., Medical center under the government of the Russian Federation, 1994, page 113.

7. Instruction on the use of eye drops "Iteral", 1994, a prototype.

1. Drops for treatment of allergic and diatopically diseases of the eyes and nose containing sterile buffer solution, characterized in that they additionally contain kromolin sodium or nedocromil sodium, or cromoglicate acid, dexamethasone-21-phosphate sodium salt, gramicidin and neomycin sulfate in the following ratio, wt.%/volume:

Kromolin sodium or nedocromil sodium or cromoglicate acid - 0.5 - 4

Dexamethasone-21-phosphate sodium salt - 0,05 - 0,1

Gramicidin - 0,005 - 0,01

Neomycin sulfate - 0,2 - 0,5

Sterile buffer solution - as required

2. Drops under item 1, characterized in that it further contain ephedrine hydrochloride in the amount of 1 - 5 wt.%/volume.

3. Drops for treatment of allergic and diatopically diseases of the eyes and nose, soderjasimi sodium, or cromoglicic acid, diphenhydramine, gramicidin and neomycin sulfate in the following ratio, wt.%/volume:

Kromolin sodium or nedocromil sodium, or cromoglicate acid - 0.5 - 4

Diphenhydramine - 0,1 - 0,5

Gramicidin - 0,005 - 0,01

Neomycin sulfate - 0,2 - 0,5

Sterelny buffer solution - as required

4. Drops on p. 3, characterized in that it further contains dexamethasone-21-phosphate sodium salt in a quantity of 0.05 - 0.1 wt.%/volume.

5. Drops on p. 3, characterized in that it further contain ephedrine hydrochloride in the amount of 1 - 5 wt.%/volume.

6. Drops on p. 3, characterized in that it further contains dexamethasone-21-phosphate sodium salt in a quantity of 0.05 - 0.1 wt.%/volume and ephedrine hydrochloride in the amount of 1 - 5 wt.%/volume.

7. Drops for treatment of allergic and diatopically diseases of the eyes and nose containing sterile buffer solution, characterized in that they additionally contain kromolin sodium or nedocromil sodium, or cromoglicate acid, ephedrine hydrochloride, gramicidin and neomycin sulfate in the following ratio, wt.%/volume:

Kromolin sodium or nedocromil sodium or cromoglicate acid - th buffer solution - How many trebuetsya

 

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