The way to obtain quaternary ammonium compounds

 

(57) Abstract:

The invention relates to methods of producing Quaternary ammonium compounds. The method consists in the fact that tertiary amines condensed with benzyl chloride and after condensation of the mass of the reactants editorial mixture is treated with alkali, and then benzyl chloride. The method allows to reduce the toxicity of the target product.

The invention relates to the production of Quaternary ammonium compounds (QAC), which is widely used as detergents and disinfectants.

A method of obtaining the HOUR according to the scheme:

RN(CH3)2+ ClCH2C6H5---> [R(CH3)2NCH2C6H5]+Cl-,

where

R is a mixture of alkyl residues of the C12-C14. (Surfactants: synthesis, technology, application and development trend. Sat. scientific papers, Niitekhim, M, 1988, S. 88) [1].

Thus the condensation product contains 1-2% impurities of unreacted amines (both high molecular weight and low molecular weight). The presence of these impurities, mostly leads to increased toxicity of the product. Depending on manufacturing firms toxicomanie) [2] . Report of the Crimean medical Institute "Development and scientific substantiation of the maximum permissible concentrations of alkyldimethylbenzylammonium C12-C14" 1987, , Simferopol, C. I. Zyablov.

The present invention is to reduce the toxicity of the HOUR, since these substances are used for domestic purposes.

The task is solved in that the Quaternary ammonium bases obtained by condensation of tertiary amines with benzyl chloride, and after condensation of the main mass of the reagents, the reaction mixture is treated with alkali, and then benzyl chloride. In the first stage are reaction to almost complete conversion of benzyl chloride, and then the reaction mixture was added a solution of alkali to pH 11. After that the reaction mixture serves this amount of benzyl chloride, which is equivalent to the released amines by the reaction in the aquatic environment:

[R2NH HCl] + NaOH ---> R2NH + NaCl + H2O.

It was found that under this treatment the alkali content of amines (both high molecular weight and low molecular weight) per HOUR almost was not determined.

Example 1. In a flask with stirrer load 122 g of a mixture of tertiary amines (CH3)2C12H25and (Snareware at 60oC and holding time of 2 h the reaction mixture was added 2 g of 40% alkali, which gave a pH of 11.

Then, under stirring at 70oC for 1 min add 2.5 g of benzyl chloride and the reaction mixture is kept for 2 hours After cooling the reaction mixture was not detected the presence of amines (< 0,01%). Study of the toxicity of the product showed that LD50= 950 mg/kg of the Sample obtained by known techniques [1], gave LD50250 mg/kg

Example 2. The experience carried out as in example 1, in contrast to which in the flask is charged with industrial faction amines C12C14obtained from a mixture of fatty alcohols with hydrochloridebuy them in the presence of zinc chloride with gaseous hydrogen chloride. The number of amines, amine, benzyl chloride, water as in example 1. After cooling the reaction mixture almost amines were not detected.

Example 3. To obtain a detergent disinfectant composition is prepared samples of the Quaternary ammonium compound according to example 2 of the faction amines C12C14and it is prepared from 9% aqueous solution and the test on the washing and bactericidal ability. It is established that under standard conditions the cleaning ability of WA were tested on the Golden state "W" strain 209 and Escherichia coli strain 1306. It is shown that at the concentration of 0.1% active substance lasts for 5 minutes Similar imported drugs showed the same duration.

The way to obtain Quaternary ammonium compounds by condensation of tertiary amines with benzyl chloride, characterized in that after the condensation of the main mass of the reagents, the reaction mixture is treated with alkali, and then benzyl chloride.

 

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14 cl, 4 sch, 2 dwg, 1 tbl

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5 cl, 5 tbl, 1 ex

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EFFECT: increased quality of target product and excluded presence of sodium chloride in aqueous solution of dimethyldiallylammonium chloride.

4 cl

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