Candles that have anti-inflammatory and wound-healing effect

 

(57) Abstract:

The invention relates to medicine, namely to pharmaceutical production, and for the creation of new dosage forms. The essence of the invention lies in the fact that candles contain sea buckthorn oil and the basis in the form of cocoa butter. With a minimum number of the active substance is a high clinical result. Candles do not cause side effects. table 1.

The invention relates to medicine, namely to pharmaceutical production, and for the creation of new dosage forms containing sea buckthorn oil, which can be used for the treatment of gastrointestinal and proctologic diseases.

Known application of sea buckthorn oil as anti-inflammatory agents [1].

Known anti-inflammatory agent, including sea buckthorn oil and the basis [2]. As the base used confectionery fat solid based on plasticized hydrogenated fat or mixture of triglycerides of natural food acids WITH13- C18with mono - and diglycerides of the same acid and emulsifier - monoglycerides of stearic acid. This tool is closest to the proposed is for a certain group of persons is unacceptable.

Object of the invention is the creation of new anti-inflammatory drugs, which can significantly extend the possibility of its use for patients suffering from diseases of the large intestine (chronic colitis, ulcerative colitis), chronic hemorrhoids, anal fissures, with the aim of improving the process of repair of the mucosa of the rectum and anal canal with erosive catarrhal proctitis and after operations on the rectum, when anitah, postradiation lesions of the mucous membrane of the anus, Inositol, shinkaryov, proctitis and simplify the technology of its production is due to the exclusion of confectionery fat solid, used as the basis.

The solution of this problem is achieved by the fact that the proposed anti-inflammatory agent in the form of suppositories containing sea buckthorn oil, and cocoa butter as the basis of the following ratio of components 1 candle weight of 1.7 g of 5%: sea buckthorn oil (FS 42-17730-95) 0.1 g; the basis for suppositories: cocoa butter the rest. Received suppositories should have the following physicochemical characteristics:

The full deformation is Not more than 15 min

The melting point is Not higher than the 35oWITH

Kisloid) - Not less than 0.16 mg

While experimentally it was found that good results on the compatibility of sea buckthorn oil based and therapeutic effect was achieved using as the basis of cocoa butter. This combination results in a therapeutic effect associated with rapid improvement in painful hemorrhoid symptoms (pain, burning, itching, feeling of tension), and stimulation of regenerative processes in the damaged mucosa of the anal canal.

Anal suppositories with sea-buckthorn oil and cocoa butter as the basis is a highly effective therapeutic tool to be used in patients with pathology of the anorectal region. Their advantage is that local effects on tissue and therefore reducing the need for enteral and parenteral administration of necessary medications that are not desirable in polipragmazie and high allergization of the population.

The content of sea buckthorn oils offer anti-inflammatory agent 0.1 g on a candle weighing 1.70 g of 5%. This dose of sea buckthorn oils are chosen experimentally in combination with the base - cocoa butter.

Example 1. Part 1 candle weight of 1.62 g: sea buckthorn oil 0.1 g;howl - cocoa butter in the amount of 152 g 28 - 31oTo obtain a homogeneous mass. The resulting homogeneous mass is fed to the machine for the manufacture of suppositories. The mass is poured into a cell from a film of polyvinyl chloride (type EP-73).

Received suppositories have the following physicochemical characteristics:

The full deformation and 5.36

Melting point - 30,8

Acid number - of 2.26

The content of carotenoids (in terms of beta-carotene) - 0,2931

Example 2. Part 1 spark a mass of 1.78 g: sea buckthorn oil 0.1 g; the basis for suppositories 1,68, the Technology of production of suppositories similar to example 1. Received suppositories have the following characteristics:

The full strain - 6,21

Melting point - 32,1

Acid number - 2,35

The content of carotenoids (in terms of beta-carotene) - 0,2513

Example 3. Part 1 candle weight 1.70 g: sea buckthorn oil 0.1 g; the basis for suppositories 1,60, the Technology of production of suppositories similar to examples 1 and 2. The weight poured candles should be 1.7 to 5% ,

The color and smell of the suppository storage for 27 months do not change. The analysis results characterizing the quality of suppositories during storage at the rate the quality of suppositories, not change during storage in the refrigerator.

Below are examples of the clinical study experienced parties suppositories with sea-buckthorn oil.

A clinical study was conducted:

- in the Central clinical hospital of medical centre of the President Administration of the Russian Federation in the offices of proctology, gastroenterology aimed at improving the process of repair of the mucosa of the rectum and anal canal when erosive catarrhal proctitis and after operations on the rectum. Candles were administered for 10-14 days treatment;

at the local polyclinic N 1 med. center. When this candle is prescribed by doctors to continue a course of treatment in the postoperative period, anal fissures, hemorrhoids, after radiotherapy to improve reparative processes. Treatment 10-12 days 1-2 suppository per day;

- in clinic N 2 honey.center for the treatment of mixed hemorrhoids, chronic anal fissures, Inositol, spaceritem, proctitis. Candles were introduced into the rectum in dosage: sea buckthorn 0,1 + cocoa butter 1,7 within 7-10 days, 1 St. 2 times a day.

A clinical study was conducted in the United hospital with polyclinic and branch office, clinic and consultative-diagnostic tool for izlagaemykh candles high therapeutic effect is achieved with a minimum number of the active substance in combination with the natural basis - cocoa butter.

Candles do not cause side effects, easy to use and have a good therapeutic effect.

Thus, suppositories with sea-buckthorn oil can be recommended as an anti-inflammatory, wound-healing anal tool.

Candles that have anti-inflammatory, wound-healing effect, containing sea buckthorn oil and a base, characterized in that is used as a base of cocoa butter in the following ratio of components 1 candle weight of 1.7 g of 5%, g:

Sea buckthorn oil - 0,1

Cocoa butter - Ostalnoe

 

Same patents:

The invention relates to medicine, namely to pharmaceutical production and for the creation of new dosage forms

The invention relates to medicine, namely to the pharmaceutical industry and relates to the creation of new dosage forms
Candles // 2119330
The invention relates to pharmaceutical industry and relates to candles containing human leukocyte interferon (CLI)

The invention relates to medicine, in particular to drugs, and can be used in the manufacture of suppositories for the treatment of purulent-inflammatory diseases in gynecology (Trichomonas colpitis, gonorrhea, purulent infection)

The invention relates to medicine and relates, in particular, pharmacology, namely rectally local anesthetic candles

The invention relates to medicine, in particular to drugs, and can be used in the manufacture of candles broad-spectrum
The invention relates to medicine, more accurately to drug forms, namely the method of preparation of homeopathic soft medicinal forms

The invention relates to medicine, namely to facilities for the treatment of chronic inflammatory diseases of the prostate

The invention relates to medicine, namely to pharmaceutical production and for the creation of new dosage forms
The invention relates to medicine, namely to the creation of drugs of natural origin
The invention relates to medicine, specifically to pharmacology
The invention relates to medicine, namely to create a phytotherapeutic of medicated action for persons with diseases of the prostate
The invention relates to medicine, namely to create a phytotherapeutic of medicated action for diseases in the bladder and kidneys
The invention relates to medicine, namely to create a phytotherapeutic means of preventive and curative actions in the field of diseases of the cardiovascular system

The invention relates to medicine, namely to create hypolipidemic and hepatoprotective tools that can be used in cardiology and gastroenterology

The invention relates to medicine, namely to the pharmacy, with the aim of creating funds on the basis of plant materials for the treatment of chronic hepatitis infectious etiology
Antitoxic tool // 2122407
Food // 2122332

FIELD: medicine, cardiology, phytotherapy, pharmacy.

SUBSTANCE: invention relates to the field in development of an agent of vegetable origin used for improvement of the functional state and prophylaxis of organic alterations in cardiovascular system, in particular, atherosclerosis. The biologically active supplement used for prophylaxis of cardiovascular diseases, in particular, atherosclerosis comprises clover dry extract, haw-thorn flowers powder, ascorbic and nicotinic acids, and accessory substances taken in the definite ratio. The biologically active supplement is made in the form of tablet or capsule. No adverse responses observed in intake of the supplement. The blood cholesterol level was reduced to the normal value in 68% of patients and reducing morbidity with acute respiratory-viral infections has been noticed. In patients with ischemic heart disease with cholesterolemia the improvement of the state is noted on the background of conventional therapy: the moderate reducing the arterial pressure value in its elevation, improved in the state of health, enhanced working capacity, reduced retrosternal pains, ear noise, vertigo, headache.

EFFECT: valuable medicinal properties of supplement.

1 ex

Up!