Disinfecting composition used for disinfecting medical equipment with metal parts
(57) Abstract:The invention relates to the field of sanitation and applies disinfectants. Disinfecting composition used for disinfecting medical equipment with metal parts, contains a low-molecular percolate, stabilizer percolate and corrosion inhibitor components take in certain proportions, and percolate is not in equilibrium, and the composition is obtained by mixing two solutions, one of which includes a low-molecular percolate, and the other is a corrosion inhibitor and stabilizer peroxide and/or stabilizer percolate. The proposed two-module composition made in the form of two modules, one module contains a first aqueous solution comprising a lower aliphatic percolate, and the other module comprises a second aqueous solution containing a corrosion inhibitor and stabilizer of hydrogen peroxide and/or stabilizer percolate. Composition eliminates corrosion of metal equipment. 2 C. and 15 C.p. f-crystals. The invention relates to compositions, methods of making such compositions, two systems for the preparation of such composition is astory lower aliphatic perkiset, and their use as a disinfectant compositions.Lower aliphatic percolate are effective antibacterial agents with broad spectrum of action, the particular advantages of which are that they remain after using only residues corresponding lower aliphatic acids, and are therefore particularly suitable in cases where required disinfectants, not polluting the environment. While here are the lower aliphatic percolate, for example, those who belong to the aliphatic carboxylic acids containing from 2 to 9 carbon atoms, peracetic acid is given special attention, since it is already an important industrial percolate used for disinfectant purposes. Although the following description refers to peracetic acid, it is clear that it can be replaced and other percolate, provided that the industrial conditions will allow it.Industry produces aqueous solutions of peracetic acid containing up to 45% by weight peracetic acid. Such solutions can be obtained by reacting in aqueous medium of a concentrated peroxide in another strong mineral acid. The acid catalyst may be present in amounts of from 0.1% to 0.5% by weight from the reaction mixture.Aqueous solutions of peracetic acid present in the equilibrium mixture of reactants and reaction products, and at a relatively accelerated the reaction conditions, for example, when using one or more catalysts in large quantities, increased reaction temperature and the reaction mixture was concentrated, the equilibrium can be essentially achieved within a relatively short time. When using a strong acid catalyst in an amount of from 2 to 5% of the reaction mixture, the temperature from 30 to 50oC and an acid concentration higher than 20% by weight of the reaction mixture, it is possible to reach equilibrium within a few hours. For some uses, or when you need long-term storage, it may be undesirable to percolation product was attended by the remains of a catalyst, especially in the diluted products intended for use in everyday life. In many cases it is necessary to dilute solutions of peracetic acid, for example, less than 5% by weight, and often less than 2%, for example from 0.1 to 2% by weight. The concentration of peracetic acid above 0.5% by weight, for example from 0.5 the dilute solutions of peracetic acid can be obtained directly by reacting acetic acid and hydrogen peroxide diluted in a suitable reaction medium, but balance can be achieved over a very long period of time, particularly at extremely high dilutions. At concentrations of percolate below 1% by weight, the balance can be achieved in the course of a month or more, if the response speed of an acid catalyst, or in the course of a week or more, if the reaction speed by using an acid catalyst. This leads to very severe conditions of use of plant and equipment on an industrial scale.If the concentrated equilibrium solution of peracetic acid diluted with water, the equilibrium point of the system gradually evolves as dilution in favor regeneration of the initial reagents. The ageing time required to reach a new equilibrium point, after dilution, is the value of the same order, which is necessary for the immediate receipt of dilute solution from the appropriate reagents. This diluted solution can be used directly, although it is not in equilibrium and, therefore, when storing its composition can change. Such nonequilibrium diluted solutions also have the structure prescribed by the equilibrium point when per">The authors in the paper (Proc. 42-nd Ann. Mtg. Chem. Spec. Man. Ass. Dec, 1955) found that sustainable dilute solutions of peracetic acid can be obtained by using percolate stabilizers in combination with the corresponding regulation of the relative concentrations of the components of the diluted percolating solution, in other words, if prepared diluted solution is not fully in equilibrium, when the balance control for the components of the mixture can be achieved sustainability.The solutions in question can be obtained by diluting a commercial, for example, a fully-equilibrium peracetic acid, which is obtained by the use of minor amounts of a mineral acid catalyst.In U.S. patent N 4297298 describes the obtaining of aqueous lower aliphatic percolate by making the first stage of the method of the concentrated solution percolate from the corresponding carboxylic acid or anhydride and concentrated hydrogen peroxide in the presence of minor amounts of a strongly acidic catalyst and dilution of the solution with a solution containing at least one reagent from the first stud is the filtration of the diluted reagent or reagents are chosen so that "so that immediately after dilution system were no longer in a state of equilibrium, and tended to further education aliphatic percolate with a very slow speed. In the method, described in detail in U.S. patent N 4297298 receive a non-equilibrium composition, which contains an extremely high concentration of hydrogen peroxide, for example from 28% to 46%. This concentration in contact with the user will cause skin discoloration and pain.In U.S. patent N 4743447 described to obtain solutions containing hydrogen peroxide is used to disinfect contact lenses, and the solution contains 0.005 to 0.1% by weight of peracetic acid, from 1 to 8% hydrogen peroxide and acetic acid in a quantity sufficient to achieve an equilibrium state of the system. Such a solution can be obtained by direct interaction, using highly diluted reaction mixture with a long establishing equilibrium, or stable industrial weak solution of peracetic acid, which is added to the other components of the composition. The patent States that it does not avoid individual initial stage of obtaining a stable weak solution of peracetic acid, from which, in criada strong oxidising agent, the corrosion inhibitor of copper and brass, buffer additive, at least one anti-corrosion additive, warning corrosion at least aluminum, carbon steel and stainless steel, and a wetting agent. Corrosion inhibitors presented specifically for brass and aluminum, containing triazole and molybdates, which are known to have adverse toxicity and which are therefore undesirable for use in medical equipment.The aim of the present invention to provide a disinfecting compositions based on diluted solution percolate, which can be used for medical equipment containing metal parts subjected to disinfection.In accordance with the present invention offers a method of obtaining a water disinfectant composition, characterized in that it comprises mixing a first aqueous solution containing a lower aliphatic percolate, with a second aqueous solution containing a corrosion inhibitor and stabilizer of hydrogen peroxide and/or stabilizer percolate.According to another aspect of the present invention provides a disinfectant composition obtained SRAM aqueous solution, contains corrosion inhibitor and stabilizer of hydrogen peroxide and/or stabilizer percolate. It is clear that persikota composition of the present invention is not in equilibrium and contains a relatively high concentration of the stabilizer(s) than the concentration that a person skilled in the art would expect to find in a composition that is in equilibrium and contains the same concentration of percolate.According to another aspect of the present invention provides a two-module system for obtaining a disinfectant composition, characterized in that one module contains a first aqueous solution containing a lower aliphatic percolate, and the other module contains a second aqueous solution containing a corrosion inhibitor and stabilizer of hydrogen peroxide and/or stabilizer percolate.The first aqueous solution preferably contains a lower aliphatic percolate, such as peracetic, in the amount of from 2 to 10%, more preferably from 3 to 7% by weight of the solution. The first aqueous solution may optionally contain a stabilizer(s) for hydrogen peroxide and/or percolate in the equilibrium solution, with each stabilizer is present in predpochtitelnei, receiving the preferred concentration of the combined stabilizer from 3000 to 6000 ppm. A suitable stabilizer percolate is dipicolinic acid, and a suitable peroxide stabilizers include phosphonic acids and their salts, for example the products sold F. Monsanto under the brand name "Dequest", for example hydroxyethylidenediphosphonic, diethylenetriaminepentaacetate and such stabilizers, which are presented in the European patent application 0426949, in particular cyclohexane-1,2-diaminetetraacetate acid and its salts (CD TSR). It is clear that the first solution is usually an equilibrium mixture of reactants and reaction products, as generally described in the paragraph linking pages 1 and 2, and that the above amount of percolate essentially indicates the number of percolate in solution. The preferred method of receipt of dilute solutions of lower aliphatic parkinlot suitable in the present invention, is disclosed in the PCT application for a patent, having N WO 91/13058.The second aqueous solution preferably contains from 0.1 to 5%, more preferably from 0.1 to 1% by weight solution of the corrosion inhibitor. Preferably, the corrosion inhibitor is a phosphate of an alkali metal, most Pregolya (K2HPO4).The second aqueous solution preferably contains from 0.1 to 2%, often from 0.1 to 1%, more preferably from 0.2 to 0.7% or 0.7 to 1% by weight solution of the stabilizer of hydrogen peroxide and/or stabilizer percolate, for example 0.5 or 1% stabilizer. Preferably use a stabilizer of hydrogen peroxide. The preferred peroxide stabilizers are phosphonic acids and their salts, such as those described above as suitable for the first aqueous solution.A suitable stabilizer percolate is dipicolinic acid. Mixing the first and second solution immediately yields a disinfectant composition comprising after mixing at least 0.05% and usually not more than 1% by weight of percolate. In many embodiments, the mixture of the two solutions obtained immediately after mixing, contains from 0.1 to 0.25%, or from 0.25 to 0.5% by weight of percolate. It is also desirable that the mixture contain from 0.1 to 5% corrosion inhibitor and from 0.1 to 1% of peroxide stabilizer and/or stabilizer percolate. Such mixtures can be appropriately obtained by selecting the volumetric relationship of the first solution to the second solution, which is typically at each solution.One or both of the aqueous solution may contain other components, suitable disinfectant compositions, for example corrosion inhibitor triazole and/or wetting agent, although the presence of such components is not essential to obtain the advantages of the invention (in fact, such components can be somewhat harmful). One or both of the solution may contain an indicator that undergoes a color change, in order to indicate that the two solutions are mixed together.It was recognized that the compositions provided by the method of the present invention, are not in equilibrium and that in the natural course of events percolates component compositions are given to equilibrium. For example, the composition described above, will vary within a relatively short period of time from mixing of the first and second solutions together, and as time progresses, the concentration of percolate in solution will decrease as it will be closer to equilibrium. You can expect the usual equilibrium will be reached in two days, if we assume that percolate and/or peroxide does not decompose in this period of time.Compositions of the present invention is of compositions used for disinfecting medical equipment, with metal parts, for example, aluminum, brass, copper and especially steel, are subject to disinfection. For example, the composition is particularly suitable for disinfecting endoscopes. The present invention has, in addition, advantages over known compositions Steris. Selected components of the composition of the invention cooperate to protect metal parts, in particular of steel from the local in particular pitting corrosion; this is achieved by protecting the same, if not better, than the case when there molybdate, triazole and/or wetting agent. This is the most surprising in the light of the description of the composition Steris (S. 4, lines 7-9).The present invention has the advantage consists in obtaining a diluted composition containing a relatively high concentration of percolate. Moreover, the method of the present invention achieve a longer shelf life separate aqueous solutions compared to those that can be achieved if the composition is to use ready to use. The invention is illustrated by the following examples.Example 1.Preparation of compositions in accordance with the present invention
the Yeosu. The other contained 10 l of an aqueous solution containing 0.6% by weight of the secondary acid potassium phosphate and 0.5% by weight CD TSR. The contents of the two modules were mixed together to form a composition of the present invention.Example 2.Preparation of compositions in accordance with the present invention
A solution containing 5 wt.% peracetic acid, 20 wt.% hydrogen peroxide, 8 wt.% acetic acid, diluted in 14 times with a solution containing 1 wt. % CD TSR and 0.8% recycled acid potassium phosphate, to form a solution containing 3500 ppm (3500 mg/l peracetic acid.Example 3 and comparative example A.Corrosion testing of the compositions of the disinfectant
Double samples of low-carbon steel and 316 stainless steel were immersed for 72 hours at room temperature (15-25oC) in a solution of disinfectant. In example 3, the solution of the disinfectant prepared in accordance with the method of example 2 after dilution 25 times to obtain a solution containing 2000 ppm peracetic acid. In the comparative example And the solution of the disinfectant prepared in accordance with the example shown in the first table, page 6, line 1 of the samples as to the naked eye, and under an optical microscope after testing showed that both metals were present in the compositions in accordance with the application "Steris", there was considerable local corrosion and pitting, and metals that were present in the solution of the disinfectant in accordance with the present invention, there was very little local corrosion.A significant decrease in local corrosion achieved by using the claimed compositions, in comparison with compositions which are disclosed of S. 4 rows 7-9 applications "Steris", is particularly advantageous, because the results were achieved without the use of toxic molybdate and triazole. 1. Disinfecting composition used for disinfecting medical equipment with metal parts containing the low-molecular percolate, stabilizer percolate and corrosion inhibitor, characterized in that the composition contains the following quantitative ratios, weight. %:
Low percolate - 0,05 - 0,5
The corrosion inhibitor is 0.1 to 5.0
The stabilizer percolate - 0,1 - 1,0
percolate is not in equilibrium, and the composition is obtained by mixing two solutions, Odie is or stabilizer percolate.2. The composition according to p. 1, characterized in that it comprises from 0.1% to 0.25%, or from 0.25 to 0.5% by weight of percolate and that percolate is not in equilibrium.3. The composition according to p. 1, where the corrosion inhibitor used a phosphate of an alkali metal.4. The composition according to p. 3, where the phosphate of an alkali metal is a secondary acid orthophosphate potassium.5. The composition according to p. 1, where as a stabilizer of hydrogen peroxide or percolate use of phosphonic acids or their salts.6. Composition according to any one of paragraphs.1 to 5, characterized in that it comprises from 0.25 to 0.5 wt.% peracetic acid, from 0.1 to 5 wt.% secondary acid orthophosphate potassium and 0.1 to 1 wt.% cyclohexane-1,2-diaminetetraacetate acid or a salt thereof.7. A disinfectant composition, made in the form of two modules, wherein one module contains a first aqueous solution comprising a lower aliphatic percolate, and the other module comprises a second aqueous solution containing a corrosion inhibitor and stabilizer of hydrogen peroxide and/or stabilizer percolate.8. The composition according to p. 7, wherein the first aqueous solution contains (C2- C9) azizia under item 8, wherein the first aqueous solution contains peracetic acid.10. The composition according to PP.7 to 9, characterized in that the second aqueous solution contains from 0.1 to 5%, preferably from 0.1 to 1% by weight solution of the corrosion inhibitor under item 3 or 4.11. Composition according to any one of paragraphs.1 to 10, characterized in that the second aqueous solution contains from 0.1 to 2% by weight solution of the stabilizer of hydrogen peroxide and/or stabilizer percolate.12. The composition according to p. 11, wherein the second aqueous solution contains from 0.2 to 0.7% or 0.7 to 1% by weight solution of the stabilizer of hydrogen peroxide and/or stabilizer percolate.13. Composition under item 1, or from two modules according to any one of p. 11 or 12, characterized in that only use the stabilizer of hydrogen peroxide.14. The composition according to p. 1, or two modules on p. 13, characterized in that the stabilizer (s) used phosphonic acids or their salts.15. Composition under item 1, or from two modules under item 14, characterized in that the stabilizer is used as cyclohexane-1,2-diaminetetraacetate acid or a salt thereof.16. Composition under item 1, or from two modules according to any one of the preceding paragraphs, t from 1:10 to 1:50, preferably from 1:5 to 1:30.17. Composition under item 1, or from two modules according to any one of paragraphs.1 to 17, characterized in that one or both of an aqueous solution containing an indicator that changes color when mixing solutions.
FIELD: veterinary sanitation.
SUBSTANCE: in the suggested disinfectant one should dissolve electrochemically activated neutral anolyte, containing 0.6 mg/ml active chlorine, with running water at 1:5 ratio and the composition of diluted electrochemically activated neutral anolyte should be supplemented with 1-1.5 mg acetic acid per 1 ml preparation. The innovation enables to decrease the concentration of active chlorine and energy expenses at keeping initial high bactericidal activity of electrochemically activated neutral anolyte and, also, apply it in aerosol form for air sanitation in poultry-breeding housings when poultry is present.
EFFECT: higher efficiency of disinfection.