Iron-containing composition for preventing anemia, the method of production of iron containing composition and method for the treatment of anemia

 

(57) Abstract:

Iron-containing composition can be used to prevent and treat anemia in animals - suckers. The tool contains bioavailable iron and amino acid ingredient. The combination of components in a certain ratio ensures the preservation of physiologically normal composition of the blood of the animal. The spray-drying method of production makes it possible to obtain a composition in the form of Svobodnoye powder. The composition comprises an inner core covered with a continuous layer with an amino acid ingredient. Iron from the proposed structure is well absorbed, which prevents the death of animals. 3 S. p. 54 C.p. f-crystals, 4 Il., table 2.

As will be discussed in detail below, an important feature of the present invention is that it can be effectively used for covering the load-bearing particles, which consist of a material which is soluble or swellable in water, including as a typical example of food voloknistihm ingredients. Opening that led to the present invention, were made in connection with a thorough study of the coating process is performed by using a model consisting of intensely red pokryvaemostju end products.

Research focused coverage in connection with spray drying. Be plated white powder consisted of pectin fiber, razbuhavshie upon contact with water so quickly that their scattering in the covering agent was impossible. Covering agent consisted of a red-colored solution of protein droplets which are known to be very quick-drying.

Studies have shown that even when a small amount of coating composition in comparison with the powder can be attained full covering, i.e., not recorded no visible white particles in the final red product prepared according to the invention.

I think that covers the structure by means of its high speed when moving from the spray device shifts a large portion of the molecules of air in the annular region around the device. Therefore, if conditions are not met according to the invention, it creates a vacuum that sucks the drying air. During the collision of drops of coating composition and molecules drying air has been a gradual slowdown in the last while filling the vacuum. The energy exchange between the hot drying air and drops in this phase all the tro decreases the ability of the droplets to spread over the surface of the particles, partly occurs when a thin layer covering agent spreads over all particles.

The method according to the invention solves this problem. Powder (powder), scattered in the air, is introduced into the inner part of the above vacuum, so that the collision of particles and droplets have a place in the annular region so close to the spray device, that the drying air enters or penetrates only a very small amount. Thus the scattering is included in the sputtering process, in which the covering agent is distributed from the spray device in the form of a film, which by collisions with gas (air) molecules and particles is broken into drops.

Gas, such as air, is used to disperse the powder, should be managed taking into account both the quantity and temperature. The number should be small enough so that the above-mentioned vacuum region was not filled. If this happens, the final product will appear white particles. The temperature should be so low that the covering properties of the drops were not significantly disturbed.

In the method according to the invention, however, the introduction of scattering manifests itself only in such a way that particles and droplets form to enter the TB thread occupied by the particles, is formed in the form of clear-cut cylinder, whereas the trajectory of the droplets formed in the shape of a cone in the case of a spray nozzle in the form of a disk in case of spraying the centrifuge. The curve of the transition between the cylinder and the cone/disc similarly well-defined. If the spray is too strong, the region of this transition begins to become blurry, and in the model system can be found white particles in the rest of the red product that shows incomplete coverage.

When the operations of coating, covering where the agent goes from a liquid to a solid state by cooling spray, uses the same principles with regard to management ratio of powder and air, and the ratio between the dispersed powder and covering agent, as when coating by spray drying. On the other hand, the temperature of the air used for dispersion of the powder, should be high enough to cover the agent began to harden in the field of collisions.

Of course full coverage requires a significant amount of covering agent to cover the entire surface of the particles. Otherwise, a minor flaw covering agent obtained purely sticky product.

The method according to the invention thus also confirmed that it is an effective way to produce sticky products, consisting of partially powder covered synthesised material and partially liquid source materials.

Flow smooth flow of particles in the area of impacts can be made by other methods, depending on whether the floor through unit with spray wheel or nozzle.

Most simply this filing is to spray the plants with a spray wheels, because the preferred embodiment of the feeder consists of a casing around a conical or cylindrical nozzle placed at a suitable distance from him, so that the flow of particles in the air are able to pass into the space between them. In a preferred embodiment, the particles wauwautosa tangentially at the top and therefore move downwards along spiral trajectories to the annular outlet opening directly over the annular area of the collisions. In a preferred embodiment, the tangential inlet is positioned so that the stream of particles at the output rotates in the direction opposite the direction of rotation is the area of impacts, as well as the maximum relative velocity between particles and drops at the moment of collision.

As mentioned above, an advantage of this invention is that it avoids the evaporation of coating material to the collision of the coated particles with a covering material.

Compared with the known technology of coating particles of the inventive method for the production of coated product includes a number of important advantages. These advantages include the following:

a) can be used commercially available spray-drying installation;

b) the present invention provides a continuous process, which compared with the traditional methods of coating gives lower costs of production;

C) the method according to the present invention has the advantage that, on the one hand, the flow of carrier gas with particles scattered therein a bearing material, and, on the other hand, the flow of the drying gas is directed parallel to each other and adjusted in order to form a distinct region of the interaction constant form and to prevail in the area above and adjacent to the one where the collision of liquid droplets with particles. Compared with the known object to the right and drops of the coating composition by adjusting the flow of air, which is efficient and flexible adjustment, giving a much more efficient and controlled process and the overall flexibility compared to conventional spray-drying units;

g) the present invention makes possible the coating of the particles, which are soluble in water and are non-permanent form.

A special embodiment of the method according to the invention can be characterized as a method of coating particles of the powder (powder) liquid agent in the spray-drying or spray-cooling installation comprising:

d) uniform dispersion of the particles in the air stream with a controlled ratio of powder (powder) and air;

e) the introduction of diffused into the air powder (powder) into contact with the covering agent in the inner part of the annular vacuum area formed by the motion of droplets covering agent from the spray device, and the drying or cooling air cannot penetrate into this area;

g) controlling the amount of dispersion of the powder in the air supplied per unit of time, so that at any time it was less than the number required to fill the annular vacuum region;

C) controlling the ratio of the fixation characteristics of the stream, formed by the particles of the powder immediately before and after the collision with drops covering agent; and

and management of ambient temperature air flow, drying or cooling to stop the initial transition of the liquid covering agent in solid form before will collide with the particles of the powder.

Fig. 3 shows the spray coating installation having a casing 36 of the conical spray and spray ring 37. The casing 38 is placed at a distance from the atomizing wheel, which guarantees the appropriate speed of the air and particles in the space between the nozzle body and the casing. Numerals 39 and 40 designate the annular region of the collisions.

In installations with sopelem spray, which typically have multiple nozzles, means for supplying to the individual nozzle is in a preferred embodiment of the tube with double walls, where the nozzle and its feeding tube placed in the centre, and where the particles wauwautosa at an angle into the space between the walls with the end opposite the nozzle.

Fig. 2 shows the spray coating installation with sopelem spray. The nozzle 7 with a perforated disk 35 sprays covering gardeley space 31, the inlet flow to the annular region 34 of collisions.

In the case of multiple nozzles this, however, means that regulated the flow of the particles should be divided into several partial streams to each nozzle. In the preferred embodiment, this is done by applying the General flow of regulated substances into the center of the centrifugal fan, which has as many outputs as there are nozzles. By producing outputs exactly the same form it is guaranteed that the partial streams of particles to individual nozzles will be exactly the same.

Fig. 4. a, b shows a centrifugal fan with 6 outputs to separate the flow of powder to 6 partial flows. Numeral 43 denotes a casing, and numeral 42 is one of the 6 identical outputs, which are arranged symmetrical with respect to rotation. Numeral 45 denotes a fan wheel, a 46 - Central entrance for the flow of powder and 47 input for transporting air.

Fig. 1 schematically illustrates a conventional spray-drying or spray-cooling installation. This type of spray-drying or spray-cooling installation can be used when performing the method according to the invention. Liteline-cooling chamber 9, where the carrier material is covered with a covering composition. Spray-drying or spray-cooling setup, shown in Fig. 1, equipped with nozzles for spraying liquid coating composition. However, it can be used by spray-drying or spray-cooling installation with a spray wheel for spraying a liquid coating composition. Spray-drying or spray-cooling installation in Fig. 1 may be provided with several nozzles, such as 1-24, but to simplify the description of the spray-drying or spray-cooling installation in Fig. 1 with only one nozzle.

Covering the composition in liquid form is introduced into the spray-drying or spray-cooling chamber 9 through the spray nozzle 7 high pressure (located in the upper part, mostly 6-8 m, more preferably 7 m above the bottom of the spray-drying or spray-cooling chamber 9), the spray liquid covering the composition into droplets. The spray nozzle 7 high pressure liquid is supplied covering composition under pressure through the feed tube 5. The pressure generated by the pump 4 high pressure fed supply notele-cooling chamber 9 has the shape of a hollow pyramid with a hole 2 in the bottom, this opening 2 preferably with a diameter of 2.2 m, and almost all top opening 8, preferably having an inner diameter of about 1.2 m Pump 4 high pressure produces a pressure within the boundaries of 50-400 psi, preferably generates a pressure of 2-3 ATM. Feeding tube 5 is a high pressure tube, preferably with an inner diameter of about 8 mm

Particles of a carrier material of the inner core to which are attached the droplets of the liquid coating composition, are served by a stream of carrier gas, preferably air, spray-drying or spray-cooling chamber 9 from input 19 connected to the tube 10 transport of particles. The particles of the carrier material is distributed from the metering device 13 into the tube 10 transport of particles and are carried by the flow of carrier gas inlet 19. The carrier gas flow provided by the fan 12 from the atmosphere through the air inlet filter 11.

After coating of the particles in the spray-drying or spray-cooling chamber 9 portable air coated particles are introduced into contact with the drying or cooling gas, preferably air, for up to at least partial re the fan 15, taking air from the atmosphere through the air inlet filter 16. The lattice provides a lower pressure drop in the drying or cooling the air and gives a more laminar flow of the drying or cooling air in the spray-drying or spray-cooling chamber 9. Depending on the specific process performed by using spray-drying or spray-cooling installation, the feed tube 14 may be supplied with hot air device type gas burner, or vozduhoohladitelnye device 17, respectively.

The direction and flow rate of carrier gas is regulated by the regulator 18, preferably a frequency Converter that regulates the flow through the fan 12. This adjustment prevents contact between, on the one hand, the drying gas and, on the other hand, drops, so that the liquid covers the composition before drying, forms a continuous liquid covering layer on the particles.

Usually the supply of the drying gas or cooling gas may be regulated by regulators, not shown in the drawings.

Particles of at least partially hardened coating in the spray-drying or spray the contact on the movable belt conveyor 21 from a breathable material. The speed of the tape 21 is preferably adjustable. The agglomerates 20 is transported by the tape 21 in at least one drying chamber 22, performing the further second drying agglomerates 20 and preferably in the cooling chamber 23 for cooling the agglomerates 20 before they leave the tape 21. The resulting agglomerates 20 are transported to a point 25 where the tape is returned, the agglomerates fall into the hopper 26 to perform further operations. The tape may have a length of 10-12 m and preferably a width of 1.6 m and 2.0 m, for example 1.8 m

Under the movable filter belt 21 in position under the spray-drying or spray-cooling chamber 9, the chambers 22 and 23 provided with the exhaust chamber 24 connected to the adjustable suction fans. The exhaust chamber 24 pulls the drying or cooling air through the layer of product and breathable material. Breathable material is preferably made from polyester or polypropylene, and is a type of fabric that has a small loop on the front side and the big loop on the wrong side, to protect the material from creasing.

The spray nozzle 7 to the high pressure used in the spray-drying or spray-the Orme hollow cone.

Movable tape 21, a drying chamber 22, the cooling chamber 23, the exhaust chamber 24 and the fan 12 and 15 preferably may be parts from installation F5000 N1RO Filtermat.

Fig. 2 illustrates the area around the spray nozzle 7 high-pressure spray-drying or spray-cooling installation, as described in Fig. 1. In this zone, on the one hand, the flow 31 of the carrier gas with dispersed therein particles of a carrier material (supplied from the tube 10 transport of particles) and, on the other hand, the flow of the drying or cooling gas 32 (supplied from the feed tube 14) is directed parallel to each other and are regulated so that they formed a distinct zone of contact of the permanent shape in 33 above and adjacent to the region 34, in which we have the collision of drops of liquid particles. Drops are distributed from the distribution nozzle 7 high pressure with the disc 35 with a Central hole from which the drops are distributed in the form of a mist in the form of a hollow cone.

1. The pump supply

2. Hole

3. Container

4. Feeding the high-pressure pump

5. Feeding tube

6. Grill

7. The spray nozzle high pressure

8. Chastic

11. The inlet air filter

12. Fan

13. Dosing device for carrying material

14. Feeding tube

15. Fan

16. The inlet air filter

17. Vozduhonagrevatele or air cooled device

18. Controller

19. Input for transporting gas

20. Sticky coated particles

21. Movable tape

22. Secondary drying or cooling Luggage

23. Cooling Luggage

24. Exhaust Luggage

25. The point of issuance of the product

26. Bunker

...

31. Transporting gas

32. The drying or cooling gas

33. The scope of collisions

34. The scope of collisions

35. Drive

36. The nozzle body

37. Spray the wheel

38. Cover

39. The scope of collisions

40. The scope of collisions

...

42. Output

43. The fan casing

45. The fan wheel

46. Entrance powder

47. The input carrier gas

As noted above, the present invention relates to a method for the treatment of anemia individuals suffering from anemia, including receiving individual compositions defined in the invention.

The composition is made in the quantities and within the time that d, thodic and to prevent anemia in Sankovich piglets. Suitable mode of supply of iron to piglets is receiving the proposed composition for a period of two weeks after birth in total a maximum of 35 g per pig. The composition, for example, scattered on the floor of the pen for pigs, from which it is voluntarily ingested by pigs. One of the common modes of composition is the division of the total dose at six or seven daily doses taken every second day during the submission period.

It is clear, however, that the method specified in the invention is not limited to use in pigs. Other animals, especially animals on the predominant diet of milk or milk replacer can with food to take iron, which they don't have to save physiologically acceptable hemoglobin level. The feeding of the proposed iron containing composition may be a suitable way of ensuring an adequate supply of iron such animals. The composition can be fed to these animals, by incorporating a suitable quantity of milk or milk replacer or may be offered animals as a food additive. Further, the method can IP the s illustrated by the following examples:

Example 1

Preparation of iron-containing composition

Was prepared liquid mixture containing the ingredients (see tab.A).

Hydrolyzed hemoglobin is prepared as described in Olsen, Zeitschrift fur Lebeusmitted Technologie und Verfahrenstechnik, 1983, T. 34, N 5, on the basis of frozen blood cells, separated from pig blood collected in sterile conditions at the slaughterhouse by processing in the centrifuge and subsequent freezing. Frozen blood cells getting warm by using the circulation in the heat exchanger for receiving the thawed suspension of blood cells having a temperature of about 55oC, which consistently leads to hydrolysis in the following order:

AlcalaseTMfood is added directly into the thawed red blood cells in a vessel equipped with heating and mixing devices, and NaOH is added to the mixture using a metering pump controlled by a pH meter to achieve and maintain the pH within the boundaries of 8.0 to 8.5. The temperature in the reaction mixture to about 55oC, and the reaction time is about 4 hours, until it reaches the degree of hydrolysis (DH) 18-20.

Ferrous fumarate obtained from freshly prepared party, prepared in accordance with the method described in US patent N 3.478.073. Snachala volume of 6 m3. 2 x 500 kg of ferrous sulfate (FeSO4, 7H2O) dissolved in 2 x 1200 kg of boiled water in a vessel with a volume of 2 m3and then run through a centrifugal pump through the filtration tank in the vessel containing the NaOH solution, to obtain a ferrous hydroxide and sodium sulfate. 450 kg of fumaric acid is slowly added to the vessel with a volume of 6 m3with stirring using a centrifugal pump to obtain a suspension of precipitated ferrous fumarata. This precipitate ferrous fumarata is passed through a filter to remove particles larger than 50 μm, and then the operation of transfusion, which removes a large part of the sodium sulphate solution.

The resulting ferrous fumarate in the form of a dough containing from 30 to 35 wt. % salt is transferred to a vessel with a volume of 2 m3and goes into further filtering, followed by a return of the obtained test vessel with a volume of 6 m3. About 2 m3boiled water is added with stirring using a centrifugal pump. The mixing process is repeated twice, 511 kg thus purified test glandular fumarata with the composition of the dry matter of about 27 wt.%, used on.

During subsequent operation of the resulting coating liquid iron-containing composition is delivered in a spray-drying process of covering the surface of the particles of the dry powder mixture of the following ingredients is prepared by mixing in the device NautaTM.

BiopectTM3) - 82,0 kg

The mixture of vitamins - 9,0 kg

3) BiopectTMis powdered pectin containing product, consisting of the following ingredients:

20 wt.% dry potato fiber, 54 weight percent of dry Apple pomace, 5 wt.% citrus pulp, 10 weight percent of Irish moss, 10 weight percent of Psyllium seeds and 1 weight percent of betaine hydrochloride. The particles of the product are with the long-drying unit with the use of spray-drying equipment type FiltermatTMF500 with the speed of evaporation of 500 pounds per hour. This spray-drying equipment includes spray-drying chamber and the spray device in the form of spray nozzle type DelavanTMworking at a pressure of 150 bar and giving dispersion in the form of an open hollow cone.

Equipment FiltermatTMF500 consists of the following components:

a) spray-drying tower with a square bottom 2x2 m, distance from the spray nozzle to the conveyor belt 7 m,

b) a feed tube for particles of a carrier material having a diameter of 12 cm, the tube is provided in the center of the inner tube with a diameter of 8 mm, which ends in a nozzle,

the Filtermat belt width of 1.8 m and a total length of 11 m, the part of the tape, the host is covered with powder, has a length of 5 m Tape Filtermat contains a breathable filter material is made from a double layer of polymeric material, woven so that the air-permeable pores of the top layer have a smaller diameter than the pores of the lower layer,

g) check the camera above the ribbon next to the spray tower,

d) secondary drying chamber next to check Luggage and

e) a cooling chamber at the output end of the tape.

oC.

Operation covering consisted of feeding the above-mentioned liquid emulsion containing a salt of iron, as a coating composition in a spray nozzle of the spray-drying equipment and spraying the liquid coating composition into a stream of droplets, the flow of carrier gas containing the carrier material particles of the above powder mixture of pectin containing, dispersed therein, a spray-drying chamber separately from the covering composition, flow of drying gas into the chamber at a temperature that provides a curing liquid coating composition.

In the process, the equipment was regulated so that the droplets of the stream of liquid droplets of the coating composition could collide with particles of a carrier material, dispersed in transporting gas, the direction and flow rate of carrier gas was adjusted so that the contact between, on the one hand, the drying gas and, on the other hand, drops was prevented, so that the liquid covers the composition prior to drying has formed a continuous liquid layer on the particles of the carrier material. Then put thus continuous covering layer on the particles partially you Stacy was additionally dried in retarding chamber and the drying chamber on the filter substrate by using air, having an input temperature of about 75oC and the output is about 60oC. the Dried coated particles were then cooled at ordinary temperature.

In the result of the above process covering was obtained iron-containing composition in the form of Svobodnoye powder, containing lumps of primary particles having an average size of about 50 microns, these lumps primary particles are in the form of a continuous coating layer consisting of dry matter containing the above layer of iron emulsion surrounding the inner core of the pectin containing composition. The final composition had an iron content of about 9.6 wt.%, and pectin containing composition is about 18 wt.%. The weight ratio between the amount of dry matter covering layer and the composition of the inner core was about 4:1.

Example 2

Effect of iron-containing composition the composition of the blood and the mortality rate of piglets

Annual tests, covering 950 litters of piglets, was conducted under the supervision of the State Committee for pig production. Half of the litters were offered the product described in example 1, 60 g per litter on Mondays, Wednesdays and Fridays during the first two weeks of life. This dose is appropriate is) were given 200 mg of iron by injection of commercial iron-containing drug on the third day of life.

Subjects piglets swallowed the whole composition. At the end of the second and third weeks, respectively, were collected the blood samples of all pigs and these samples were analyzed for hemoglobin concentration (g/l) and hematocrit (percentage of red blood cells).

The test results are summarized in table 1.

Subjects litters had an average scale of diarrhea 9.2% during the first week of life, while the control litters were 10.3 percent respectively. The mortality rate in subjects piglets during the period from the third day of life to take away from the nipple was a 3.9, while the corresponding figure in the control piglets - 4,7 (p<0,09).
Effect of iron-containing composition the composition of the blood and the mortality rate of piglets

The tests were carried out for three months on a pig farm at the agricultural College of Lancashire. The goal was to record characteristics of pigs at two different modes of supply of iron: the injection of 1 ml of iron dextran on the second day of the life of the pig (the control group) in comparison with oral feeding about 60 g of the composition described in Example 1, applied as described in Example 2, the spreading of the composition on the floor Pametnik compartments (epithesis the following data: (1) characteristics of blood measured at 10 or 21 days, including the concentration of hemoglobin, the iron concentration in serum and the hematocrit value, and (2) mortality rates.

The results of the analysis of blood samples (average of all animals) are summarized in table 2.

On the tenth day mortality rate in the control group was 6.2% in comparison with 2.7% in the test group. On day 21 the corresponding figures for the period from 10 to 21 days were 2,9 1,4 against. For the period from 0 to 21 days mortality rate in the control group was 9.0, and tested to 4.0. This difference is statically significant (p<0,05).

1. Iron-containing composition for preventing anemia, containing a combination of two - or trivalent iron, characterized in that it further includes containing the amino acid ingredient in the following ratio, wt.%:

containing the amino acid ingredient is 1 - 99

connection of two - or trivalent iron - Rest

these two connection which allows a free flowing powder of the particles, containing a continuous covering layer with amino acid ingredient and the inner core.

2. The composition according to p. 1, characterized in that the particles have an average size of not more than 1 mm

3. The composition according to p. 1, characterized in that the iron is presented in the form of organic iron compounds.

4. The composition according to p. 3, characterized in that the organic compound selected from iron fumarata, acetate, glutamate, succinate, format, lactate, dextran, propionate, iron salts and fatty acids, iron salts and amino acids, and mixtures thereof.

5. The composition according to p. 4, characterized in that the organic compound of iron is ferrous fumarate.

6. The composition according to p. 3, characterized in that the iron content is within 3 to 10 wt.% from the composition.

7. The composition according to p. 3, characterized in that the organic compound of iron is in the form of particles with an average size of not more than 50 μm.

8. The composition according to p. 7, characterized in that the particles of organic iron compounds have an average size of not more than 30 μm, mostly not more than 10 μm.

9. The composition according to p. 1, characterized in that the amino acid ingredient selected from a protein, peptide, AMI the tsya hydrolyzed protein.

11. The composition according to p. 10, wherein the protein hydrolysate has a degree of hydrolysis of not less than 5%.

12. The composition according to p. 11, wherein the protein hydrolysate has a degree of hydrolysis of not less than 10%.

13. The composition according to p. 12, characterized in that the hydrolyzed protein derived from hemoglobin.

14. The composition according to p. 1, characterized in that the amino acid content of ingredient is in the range of 5 to 30 wt.% from the composition.

15. The composition according to p. 1, wherein the covering layer further comprises a substance containing fatty acid in the amount of 1 to 50 wt. % of the composition.

16. The composition according to p. 15, characterized in that the amount of substance containing the fatty acid is in the range of 5 to 20 wt.% from the composition.

17. The composition according to p. 1, wherein the covering layer contains emulsifying the mixture of amino acid ingredient and substances containing fatty acid.

18. The composition according to p. 1, characterized in that it further contains at least one ingredient selected from the food volocesanomaderno ingredient, flavoring agent, a vitamin, a mineral, bacterial culture, enzyme, alkaline substances and the food voloknistihm ingredient.

20. The composition according to p. 19, characterized in that at least 50% dietary fiber food volocesanomaderno ingredient is dissolved in the water.

21. The composition according to p. 19, characterized in that the content of dietary volocesanomaderno ingredient is 1 to 50 wt.% from the composition.

22. The composition according to p. 21, characterized in that the content of dietary volocesanomaderno ingredient is 5 - 30 wt.% from the composition.

23. The composition according to p. 1, characterized in that the iron contains in the covering layer.

24. The composition according to p. 1 or 23, wherein the inner core comprises a mixture of food volocesanomaderno ingredient and organic compounds of iron.

25. The composition according to p. 1, characterized in that the mass ratio of the covering layer and the inner core is in the range from 10 : 90 to 99 : 1.

26. The composition according to p. 25, characterized in that the mass ratio is in the range from 20 : 80 to 60 : 40.

27. The composition according to p. 26, characterized in that the mass ratio of about 1 : 1.

28. The composition according to p. 1, characterized in that it is Svobodnoye powder containing particles with an average size in the range of 10 to 500 μm.

29. The composition according to p. 1, hotelchaumette particles have an average size in the range of 20 1000 microns.

31. The composition according to p. 30, characterized in that the agglomerates of the particles have an average size in the range of 30 - to 750 microns.

32. Method of production of iron containing composition in the form of Svobodnoye powder containing particles of the material carrier of the inner core coated with a continuous layer of a coating composition containing amino acid ingredient, including the preparation of the components, characterized in that it comprises preparing a liquid coating composition containing the amino acid ingredient in quantities of 1 to 99 wt.% from iron containing composition, obtaining a carrier material particles, the average particle size is in the range from 1 to 100 microns, adding in covering the composition and/or material media inner core of iron compounds in an amount to provide the iron content in the range from 0.1 to 25 wt.% from iron containing composition; applying the coating composition in liquid form to the spray device, the spray-drying unit containing the spray-drying chamber, and spraying the liquid coating composition into a stream of droplets; the flow of carrier gas containing dispersed therein particles of a carrier material, the spray is which hardens liquid covering composition, when this drops from a stream of liquid droplets of the coating composition collide with particles of a carrier material, dispersed in transporting gas, the direction and flow rate of carrier gas regulate to prevent contact between one side of the drying gas and the other side drops so that the liquid covers the composition before drying has formed a continuous liquid layer on the particles of the carrier material; at least partially drying caused by particles continuous covering layer by drying in contact with the drying air and removing the coated particles of the spray-drying chamber.

33. The method according to p. 32, characterized in that on the one hand the flow of carrier gas with dispersed therein particles of a carrier material and, on the other hand, the flow of the drying gas is directed parallel to each other and adjusted so that they formed a distinct area of cooperation is quite constant form in the area above and adjacent to the area where the collision of liquid droplets with particles.

34. The method according to PP. 32 and 33, characterized in that the spray-drying chamber is only a partial hardening of aerovane loose agglomerates in mutual contact, picking up moderately sticky particles on a substrate made from breathable material in the form of loose agglomerates and further drying of the particles on the substrate to completely dry coating layer on the agglomerated particles.

35. The method according to p. 32, characterized in that the iron used in the form of organic iron compounds.

36. The method according to p. 35, characterized in that the organic compound selected from iron fumarata, acetate, glutamate, succinate, format, lactate, dextran, propionate, iron salts of fatty acids, salts of iron, amino acids and mixtures thereof.

37. The method according to p. 32, characterized in that the iron used in the form of particles of organic compounds of iron with an average size of not more than 50 μm.

38. The method according to p. 37, characterized in that the particles of organic iron compounds have an average size of not more than 30 μm, preferably not more than 10 μm.

39. The method according to p. 32, wherein the amino acid ingredient selected from a protein, peptide, amino acids and mixtures thereof.

40. The method according to p. 39, wherein the amino acid ingredient is a protein hydrolysate.

41. The method according to p. 40, wherein the protein hydrolysate has a degree of Hydra is oglobin.

43. The method according to p. 32, characterized in that the amino acid content of the ingredient is in the range of 5 to 30 wt.% from the composition.

44. The method according to p. 32, wherein the covering layer further comprises a substance containing fatty acid in the amount of 1 to 50 wt.% from the composition.

45. The method according to p. 44, characterized in that the amount of substance containing the fatty acid is in the range of 5 to 20 wt.% from the composition.

46. The method according to p. 32, wherein the covering layer contains emulsified mixture of amino acid ingredient and substances containing fatty acid.

47. The method according to p. 32, characterized in that the coated inner core contains food voloknistihm ingredient.

48. The method according to p. 47, characterized in that at least 50% of dietary fiber food volocesanomaderno ingredient soluble in water.

49. The method according to p. 47, characterized in that the content of dietary volocesanomaderno ingredient in the material of the inner core is in the range from 1 to 50 wt.% from the composition.

50. The method according to p. 49, characterized in that the content of dietary volocesanomaderno ingredient is in the range of 5 to 20 wt.% from the composition.

52. The method according to p. 32, characterized in that the mass ratio between the covering layer and the inner core is in the range from 10 : 90 to 99 : 1.

53. The method according to p. 52, characterized in that the mass ratio is in the range from 20 : 80 to 60 : 40.

54. A method for the treatment of anemia, including iron administration individuals suffering from anemia, characterized in that it includes the purpose specified individuals of a composition defined in any of paragraphs.1 - 31, in the amount and within the time, which result in the concentration of hemoglobin in the blood specimens of at least 90 g/l

55. The method according to p. 54, in which the individual is macunkoy Piglet.

56. The method according to p. 55, characterized in that the composition is made within two weeks a total of not more than 35,

57. The method according to p. 54, characterized in that the consumption of the composition is carried out voluntarily.

Priority points:

20.01.92 - PP.1 - 31 54 - 57;

17.12.92. - PP.32 - 53.

 

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The invention relates to medicine, namely to addiction

Antianemic agent // 2108102
The invention relates to the production of therapeutic and preventive drugs for diseases associated with hematopoiesis, can be used in food industry, medicine and veterinary

The invention relates to medicine, namely to Pediatrics, and can be used for the treatment of iron deficiency anemia in children

The invention relates to medicine, in particular to pharmacology and therapy, and can be used for the treatment of iron deficiency anemia of various etiology

The invention relates to complex compounds of iron, used in medicine, namely to search for new treatments for cancer

The invention relates to the field of metal powders and can be used in chemical industry, medicine
The invention relates to pharmaceutical industry and can be used to obtain iron-containing drugs
The invention relates to medicine and can find application in the treatment of infiltrative tuberculosis of the lungs

The invention relates to biologically active agents with antiproliferative and cytotoxic activity and can be used in pharmaceutical, chemical industries and medicine

The invention relates to new chemical compounds, specifically to derived TRANS-sodium dichloro(bromo)-bis{ gamma-1,2,5-trimethyl-4-(3,4-dimethyl-3,4 - dihydroxy-1-pentenyl)-4-piperidin this, N}Pt (II), General formula

< / BR>
where

X is Cl or Br;

- the remainder of the ligand-gamma 1,2,5-trimethyl-4-(3,4-dimethyl-3,4-dihydroxy-1-pentenyl)-4-piperidone,

showing antihelminthic activity

The invention relates to animal breeding and fur farming and can be used for the prevention and treatment of iron deficiency anemia and enhance the growth of fur-bearing animals, farm and domestic animals, as well as to maintain the microelemental composition of the feed

The invention relates to medicine, specifically to drug anti-TB drugs

Antianemic agent // 2079307
The invention relates to medicine and veterinary medicine, namely to the treatment and prevention of iron deficiency in humans and animals

The invention relates to new biologically active compounds, namely the derived thiazole General formula

< / BR>
with antitumor activity, and can be used in the chemical-pharmaceutical industry

The invention relates to medicine and can be used to suppress HIV, which causes AIDS in humans

The invention relates to new biologically active chemical compounds, as well as the coordination compound CIS-chloro-N1 (21-tetrahydrofuryl)-5-floralarrangements (II) exhibiting antitumor activity

The invention relates to organic chemistry, specifically to a new chemical compound - complex PtCl2with 1,3-bis(isopotential)-6-methyluracil formula

showing immunotropic activity

The invention relates to the field of medicine and for the creation of preventive and curative cosmetics for skin care, prevention and elimination of inflammation, acne, pustular rash, containing biologically active additives
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