For the treatment and prevention of fungal diseases of the skin based on grizeofulvina
(57) Abstract:The tool is intended for treatment and prophylaxis of fungal diseases of the skin. The tool contains, wt%: fungistatic antibiotic griseofulvin 1-4, salicylic acid 0.5 to 2.0, menthol 0,5-5,0, camphor 0.1 to 5.0, water-emulsion ointment base, including oil component 10-30, solvent, 10-25, combined-Trilon B 0.05 to 0.15, the emulsifier is a mixture of polyoxyethyleneglycol ethers of higher fatty alcohols, 1,5-5,0 with glycerin esters of fatty acids 2-6 and higher fatty alcohols fraction from C12to C243-8 and water - the rest. Ointment based grizeofulvina eliminates symptomatic manifestations of fungal skin - itching, irritation, and pain. 6 C.p. f-crystals, 1 table. The invention relates to medicine, namely to the pharmaceutical industry and relates to means for the treatment and prevention of fungal diseases comprising as an antifungal agent griseofulvin, anti-inflammatory agents and antiseptics - salicylic acid.Morbidity statistics shows a steady increase in the frequency of mycotic, in particular dermatological, lesions of the person. In most cases, is but the long and cured. The problem of prevention of ringworm and reduce side effects in the treatment remains one of the topical issues in dermatology.Antibiotic griseofulvin produced by the domestic industry, is one of the main treatments for patients with dermatomycosis. Griseofulvin has a moderate fungistatic activity, lack of resistance to it pathogenic fungal flora. Most common in dermatological practice of oral grizeofulvina tablets and suspensions. However, the actual problem is the creation of local legform.It is known for the treatment of ringworm , representing the ointment of the following composition, wt.%:
Griseofulvin - 9,0 - 10,0
Streptocide - 9,0 - 10,0
Boric acid - 2,0 - 3,0
Dimexide - 9,5 - 10,0
Remezov - Rest
Closest to the proposed invention is a liniment grizeofulvina of 2.5% . The liniment is applied in dermatological practice, is an effective means share therapy trihofitii, microscopy and plicarum smooth skin of onychomycosis.The drawbacks include the presence in the composition of the dosage form dioxin and high gigroskopichny, resulting irritating dehydrating action Essentials - itching, dry skin, dermatitis, redness, etc., in Addition, in some cases, the function of Dimexidum as conductor grizeofulvina is a negative factor, because there is the possibility of resorption grizeofulvina and its circulation in the blood. This limits the field of use of the drug and its dose in the local application, eliminates the possibility of treating large group of patients.The objective of this invention is to provide an effective dosage forms grizeofulvina for topical application for the treatment and prevention of ringworm with no irritant effect, suitable for prolonged use, a positive effect on the skin, eliminating symptomatic symptoms - itching, irritation, and pain.The task is implemented the proposed drug in the form of a cream containing fungistatic antibiotic griseofulvin, antiseptic - salicylic acid, painkillers and anti-aircraft components - menthol and camphor and auxiliary substances-water emulsion base.Experimental designs offer certain studies have shown, the ratios of the main and auxiliary components of the proposed tools have a direct impact on therapeutic effect.The obtained data allowed to determine the quantitative content and ratio of components, which is achieved ego highest bioavailability in the absence of resorption grizeofulvina in the blood; in addition, mild sedative effect on damaged skin, reducing pain and itching allow to speak about achieving optimal therapeutic effect when a certain ratio of the main and auxiliary components of the proposed tools.The proposed remedy meets the requirements for soft dosage forms and cosmetic creams: high bioavailability, thermal and colloidal stability, good absorbency, ease of use.The invention is illustrated in the examples (table).Griseofulvin suspended in vaseline or vegetable oil; salicylic acid, menthol and camphor dissolved in propylene glycol or polyethylene glycol; prepare the alloy surface-active substances with butter, mix all the components and emuleret. Th the cream convenient and pleasant consistency, having high contact bioavailability.The means obtained in example 6, is an unstable liquid emulsion.The means obtained in example 7, is a heterogeneous bystrorasshiryayuscheysya emulsion, unfit for consumption.The means obtained in example 8, is a heterogeneous unstable emulsion.The means obtained in example 9, is a hard unstable emulsion.Thus, the proposed tool is based on grizeofulvina in the form of a cream to treat ringworm has several advantages:
1. The scope of the proposed tools is expanding due to the absence in the composition of Dimexidum, providing local irritant action and is the conductor of griseofulvin in the blood.2. Proposed product is suitable for long-term use, has a beneficial effect on the skin, has pretiosum and analgesic effect, can be used for preventive purposes.The technology for the proposed tool is simple; all auxiliary substances and materials pharmacologically indifferent available, the resolution is myshlennostj
1. USSR author's certificate 1685447, class A 61 K 9/06, publ. 23.10.91. bull. N 39.2. VFS 42-1404-84. Liniment grizeofulvina of 2.5%. the prototype. 1. For the treatment and prevention of ringworm, including fungistatic antibiotic griseofulvin, salicylic acid ointment base, characterized in that it additionally contains menthol and camphor, as well as ointment bases contains aqueous emulsion base comprising an oil component, a solvent, as complexone - Trilon B (salt is the disodium Ethylenediamine - N, N, N - tetraoxane acid) as an emulsifier is a mixture of surface-active substances polyoxyethyleneglycol ethers of higher fatty alcohols (product OS-20, grade a) with glycerin esters of fatty acids and higher fatty alcohols fractions from C12to C24and water in the following ratio, wt.%:
Griseofulvin - 1,0 - 4,0
Salicylic acid is 0.5 to 2.0
Menthol - 0,5 - 5,0
Camphor - 0,1 - 5,0
The oil component is 10 - 30
Solvent - 10 - 25
The combined-Trilon B (salt is the disodium Ethylenediamine - N, N, N - tetraoxane acid) 0.05 to 0.15
Polyoxyethyleneglycol esters of higher fatty alcohols (s from C12to C24- 3,0 - 8,0
Water - the Rest
2. Means under item 1, characterized in that the oil component contains liquid paraffin.3. Means under item 1, characterized in that the oil component contains vegetable oil.4. Means under item 1, characterized in that the solvent contains a polyethylene glycol-400.5. Means under item 1, characterized in that the solvent contains 1,2-propylene glycol.6. Means under item 1, characterized in that as glycerol esters of fatty acids contains distilled monoglycerides (MHD).7. Means under item 1, characterized in that as glycerol esters of fatty acids contains emulsifier "Solid-2" (T-2).
FIELD: agriculture, animal husbandry, organic chemistry.
SUBSTANCE: antiseptic ointment comprises cationic surface-active substance, lower glycols, polyethylene glycols, water and ethylene glycol monophenolic ester and higher polyethylene glycols taken in the definite ratio of components. As cationic surface-active substance ointment comprises N-alkyl-N-alkoxycarbonylmethylhexahydroazipinium chloride or alkyldimethylbenzylammonium chloride, or cetylpyridinium bromide, or cetylpyridinium chloride, or 1,2-ethylenebis-(N-methylcarbdecyloxymethyl)ammonium dichloride, or ethylhexadecyldimethylammonium chloride, or chlorhexidine; as lower glycol ointment comprises 1,2-propylene glycol or polyethylene glycol-300, or polyethylene glycol-400; as higher polyethylene glycol ointment comprises polyethylene glycol-1500 or polyethylene glycol-3000, or polyethylene glycol-4000, or polyethylene glycol-6000. Ointment elicits the high antibacterial activity, broad spectrum of bactericidal effect and low irritating effect with respect to udder skin. Invention can be used for sanitary-hygienic treatment of udder of lactating cows for prophylaxis and rapid healing external damages of udder and nipples (arising cracks), prophylaxis of mastitis, enhancing milk purity by microbiological indices.
EFFECT: valuable antiseptic properties of ointment.
2 cl, 1 tbl, 22 ex
SUBSTANCE: the present innovation deals with curative ointments of antiphlogistic and wound-healing action and could be applied for treating hemorrhoid, burns, bruises, fractures, wounds, chronic bronchitis, polyarthritis, periarthritis, radiculitis, trophic ulcer and psoriasis. Three variants of ointments have been suggested. They contain oily extract of plant components and, also, honey, mumiye, propolis and bear oil. This innovation enables to widen the assortment of ointments of antiphlogistic and wound-healing and the range of curative action upon a body.
EFFECT: higher efficiency of application.
3 cl, 11 ex
SUBSTANCE: invention provides topical blood circulation improving remedy containing simultaneously nitroglycerine and aminophylline. Remedy can be provided in the form of emulsion, gel, or ointment, which are administered 1-2 times a day.
EFFECT: strengthened blood circulation activation effect, which is prolonged to 24 hours.
5 cl, 9 ex
FIELD: pharmaceutical industry.
SUBSTANCE: invention relates to developing medicaments in the form of ointment based on vegetable components and designed, in particular, to treat psoriasis as well as fungus diseases and can also be used in cosmetology. Psoriasis treatment cream includes water extracts of bur-marigold (Bidens tvipartita), white birch leaves (Betula alba L), greater celandine (Chelidonium majus), calendula (Calendula officanalis L), cudweed (Gnphalium uliginosum L), medical vaseline, lanolin, camphor, linseed oil, and medical solid oil at specified proportions of components.
EFFECT: increased treatment efficiency, avoided use of chemical additives, and prolonged shelf time.
FIELD: pharmaceutical industry.
SUBSTANCE: invention provides antiinflammatory and wound-healing ointment based on natural components, which invention, along with vegetable oils, may further contain ursine fat, ursine bile, propolis, lanoline, honey, and mummified guano. Variously formulated ointments can be used for treating hemorrhoids, burns, antritis, post-stroke condition, gunshot and stab-punctured wounds, trophic ulcer, postoperative fistula, oophoritis, diabetic microangiopathy of lower extremities, as well as papillomas, birthmarks, seborrhea, and psoriasis.
EFFECT: expanded therapeutical possibilities.
6 cl, 17 ex
FIELD: pharmaceutical industry.
SUBSTANCE: invention provides novel nontoxic and highly bioavailable acyzol-based agent characterized by high activity in treatment of skin diseases, in restoration of structural skin processes, suppression of nevus pigmentosis, and flattening of folds.
EFFECT: increased assortment of skin-healing drugs.
7 cl, 4 ex
FIELD: organic synthesis.
SUBSTANCE: invention provides a method for preparing water/glycerol complex of (2,3-dihydroxypropyl) ortho-titanate hydrochloride (chloride) having symbolic name "Ephtiderm", which is depicted by following empirical formula: Method consists in that glycerol is mixed with butyl ortho-titanate at molar ratio 12:1, whereupon butanol is distilled off in vacuum, residue is treated with water and aqueous hydrochloric acid to form reaction mass with pH 2.2-3.0, which is heated in vacuum. Method is characterized by that glycerol is mixed with low-grade butyl ortho-titanate and chloroform, reaction mass during the synthesis is maintained at temperature up to 100°C in vacuum 40-200 mm Hg, while chloroform is added at 40-50°C in amount corresponding to 1 L chloroform per 2 L low-grade butyl ortho-titanate.
EFFECT: reduced expenses due to use of low-grade butyl ortho-titanate and simplified technology.
1 tbl, 3 ex
SUBSTANCE: the present innovation deals with medicinal preparation as an ointment for treating skin burns. The suggested preparation contains bee wax, propolis and vegetable oil. Thus, application of initially intact propolis and bee wax in combination with fatty foundation as vegetable oil enables to cheapen and simplify the technique to prepare the preparation, and optimally matched consistence provides prolonged safety of the preparation and accelerates healing of skin burns.
EFFECT: higher efficiency of therapy.
1 cl, 2 ex
FIELD: medicine, gynecology, pharmacology, pharmaceutical industry.
SUBSTANCE: invention proposes a preparation that comprises bacterial mass of live microorganisms as an active component, protecting medium and fat base. The preparation comprises lactobacilli as bacterial mass and one or some eubiotic microorganisms taken among the following group: bifidobacteria, streptococci and lactococci taken in the amount per a single dose. Also, the preparation comprises additionally an acceptable sorbent and a biologically active supplement. Also, invention relates to a method for preparing this preparation that involves preparing firstly lactobacilli bacterial mass and one or some genus of eubiotic microorganisms taken among the following group: bifidobacteria, streptococci and lactococci. Then the prepared bacterial mass of microorganisms is immobilized on sorbent used in medicine in its ratio to bacterial mass of microorganisms = (9-1):(1-9) followed by addition of the protecting medium and biologically active supplement to formed mass in the necessary amount. Also, invention describes a method for prophylaxis and treatment of bacterial vaginitis that involves intravaginal administration of the preparation described above in the amount 1-3 doses, 1-3 times per 24 h. The treatment course is prescribed individually. Invention provides expanding assortment of agents used for treatment of bacterial vaginitis. Invention can be used in obstetric-gynecological practice.
EFFECT: improved method for vaginitis treatment, valuable medicinal properties of preparation.
13 cl, 4 tbl, 1 ex
SUBSTANCE: the suggested composition has got viscosity being below of about 15000 cP and pH being approximately 3.0-9.0 for treating human skin diseases. He suggested composition consists of (a) therapeutically efficient quantity of, at least, one compound being useful in treating the above-mentioned disease; (b) pharmaceutically acceptable, partially bound polymer of polyacrylic acid being compatible with the compound; (c) not obligatory, a solvent being mixed with water, (d) not obligatory, a conserving agent, (e) not obligatory, a component of butyric phase and acceptable surface-active substance, and (f) water. The suggested composition is useful to treat inflammatory skin disease, acne or acne erythematosa. The composition of low viscosity has got its advantage in the fact that it is applied more accurately when in contact with a container that doses the composition in the form of drops.
EFFECT: higher efficiency of application.
23 cl, 15 ex, 19 tbl