Biologically active additive in cosmetic products

 

(57) Abstract:

The invention relates to the field of medicine and for the creation of preventive and curative cosmetics for skin care, prevention and elimination of inflammation, acne, pustular rash, containing biologically active additives. As a dietary Supplement use progestogen, namely 3,17-dihydroxy-6-methylpregna-4,6-diene or 3,17-decyloxybenzoate with antiandrogenna activity, in particular the well-known drug acetamidophenol, in combination with extrogen, in particular ethinyl estradiol, to regulate the estrogen-androgen balance of the skin and soft antibiotic action, in particular chloramphenicol, and spirtovanie and/or oil extracts of medicinal plants, namely, calendula, horsetail and succession, in an effective amount. The additive is included in the proposed treatment-and-prophylactic gel containing gelling, tween-80, glycerin, salicylic acid and citric, urea, ammonia water, paraform, brontril, perfume, water, oil calendula extract, spirtovanie extracts of medicinal herbs and the antibiotic chloramphenicol. The proposed gel has kompleksy body systems. 2 C. p., 1 C.p. f-crystals.

The invention relates to medicine, namely concerns the creation of health care resources, which can be used in medicine and cosmetology to care for the skin, prevention and elimination of inflammation, acne and pustular rash.

Pyoderma or pustular skin diseases - a group of skin diseases, the main symptom is the appearance of pimples, rashes and other manifestations of inflammatory processes. The emergence of pyodermia, usually occurs at puberty age (the so-called acne) and is caused by the violation of the protective properties of the skin and, as a consequence, the development of infections pyogenic microorganisms.

It is known that the main cause of violations of protective balance of the skin is increased hormonal activity of the sex glands, which shift the androgen-estrogenove balance in the skin in the direction of androgens, having a stimulating effect on the sebaceous glands. Increased fat secretion is accompanied by obstruction of the small seminal ducts of the sebaceous glands, blockage of skin pores. On the background of the homeostasis of the skin develop local microbial infection, as a rule, streptococcal and stafilo). The emergence of pyodermia associated with hormonal imbalance can also be identified at a later age in women after the menopause, when the secretion of androgens may decrease unevenly and temporarily dominated by androgens (Tepperman J., Tepperman H. Physiology of metabolism and endocrine system, M., Mir, 1989, page 199).

In the treatment of pyodermia, usually pay attention to two factors: the elimination of the pathogen microbial infection and increasing the resistance of the organism.

It is known that in order to eliminate and prevent the development of microbial infection used drugs acting on gram-positive microflora, namely antibiotics (sulfonamides, nitrofuranovye drugs levamisole and others), preparations of medicinal plants having both antimicrobial and firming the body action (charpillet, novoimanin, sangviritrin and others). To increase the resistance of the organism appoint vitamins, iron supplements and phosphorus, etc. (Sokolov, S. I., zamotaev I. P. Handbook of medicinal plants", 1988, M, Medicine, S. 370-374; Mashkovsky M. D. "Drug", 1993, T. 11, S. 4-56, 245-345). As a regulator of the metabolism of the skin, apply sodium salt gram of the local balance of the skin, but also reduces the intensity of synthesis and accumulation of cholesterol, cause qualitative and quantitative changes in the content of steroid hormones (ed. St. USSR N 507322, A 61 K 7/00, 1976).

The disadvantages of the above methods are: a) lack of efficacy of medicinal and cosmetic products aimed at addressing the secondary manifestations of the disease, not eliminating its main cause, namely a hormonal imbalance in the body and b) the possibility of relapse in the long-term use of antibiotics.

The closest in technical essence and the achieved result is a cream for the face with dietary supplements of medicinal herbs extracts that provide anti-inflammatory effect and regulate the balance of the skin. The cream contains emulphor, butilstearat, perfume oil, stearinovokisly zinc, magnesium sulfate, methyl ester of para-oksibenzoynoy acid, propyl ester of para-oksibenzoynoy acid, hops extract, chamomile extract, flavoring, water (ed. St. N1165396, A 61 K 7/00, 1985).

The objective of the invention is the creation of effective therapeutic and cosmetic preparations for skin care of the face, treatment of acne, the region is an antimicrobial effect.

This objective is achieved in that the composition of cosmetic products to care for skin as biologically active compounds, namely progestogen with antiandrogenna activity, is entered into effective amount of 3,17-dihydroxy-6-methylpregna-4,6-Dien-20-one or its 3,17-decyloxybenzoate, including known drug ACETAMIDOPHENOL (Mashkovsky, M. D. "Drug",1993,T. 1, C. 694), General formula 1

< / BR>
where R and RI=H, or allgraph CORIIcontaining C1 to C5 carbon atoms, and R may be equal to RIor it may differ.

In addition, the cosmetic may further comprise: a natural or synthetic estrogen, as is used, for example, ethinylestradiol, esters of estradiol, diethylstilbestrol, etc. (Mashkovsky, M. D. "Drug", 1993, T. 1, S. 681-688); anti-inflammatory antibiotic mild, as is used, for example, chloramphenicol, lincomycin, etc., (Mashkovsky, M. D. "Drug", 1993, T. 11, page 245-345); anti-inflammatory oil and/or spirtovanie extracts of medicinal herbs, such as calendula, horsetail, series, etc.

As an example Rechnoy, oil calendula extract, urea, ammonia water, paraform, brontril and additionally tween-80, and as biologically active substances, the antibiotic chloramphenicol, hormones acetaminophenol and levonorgestrel, spirtovanie the herbal extracts in the following ratio, wt.%:

Name of the component Mass fraction (%)

1. Gelling, zacapa - 0,5-3

2. Glycerin - 3-5

3. Tween-80 - 1-3

4. Salicylic acid - 0,01-0,2

5. Citric acid food - 0,01-0,05

6. Chloramphenicol - 0,1-0,8

7. Extracts spirtovanie - 1-3

horsetail - 1-3

a series of 0.5-2

calendula - 1-2

8. Urea, a grade - 0,1-0,5

9. Atsetomepregenol - 0,01-0,07

10. Levonorgestrel - 0,0003 -0,0007

11. Ammonia water, conc. (pH 7) - 0.5 to 1.5

12. Oil calendula extract - 1-3

13. Paraform - 0,03-0,07

14. Brontril - 0,03-0,07

15. Agidol-1 - 0,1-0,3

16. Odorant - 0,1-0,7

17. Water - the rest.

In this gel the idea of multifunctionality actions of its components and the distribution of their effects in time. The design of the gel contains the following biologically active functional components:

1) a balanced complex of hormones, introduced with the purpose of correction of the androgen-estrogen bashennogo hormone (modified progestogen) and estrogenove hormone;

2) anti-inflammatory antibiotic mild chloramphenicol,

3) anti-inflammatory spirtovanie extracts of horsetail, succession and calendula oil and calendula extract;

4) constructive basic ingredients: gelling, a solubilizer, an antioxidant, a pH Adjuster gel, stabilizer, flavoring.

Spirtovanie and oil extracts of plants have short-term disinfectant, analgesic and anti-inflammatory action. Medium-term anti-inflammatory effect has antibiotic. More long-term effect has a range of hormones, eliminating one of the major causes of teenage acne and acne - hormonal imbalance associated with the lack or the prevalence of certain hormones in the skin.

All components in the gel, is permitted for use in medicine and cosmetics, and everyone has the pharmacological article or technical terms.

For the first time with us to correct the androgen-oestrogen balance responsible for the emergence of pathological acne and pustular rash on the skin, in the medical-cosmetic product is a complex of hormones, including antiandrogenna hormone belonging to the class nirvanam increased concentration of hormones. At the same time in the specified dosage of hormones have an effect only in the area of application of the gel without disrupting the operation of other hormone-dependent systems of the body.

The novelty of the gel lies in the combined use of both spirtosoderjasimi and fat-soluble substances. This saved one of the most important properties of the gels is instantly absorbed into the skin while maintaining the high efficiency of action of its components.

Example 1 of the invention:

N Name of component Mass fraction (%)

1. Gelling, zacapa - 1,00

2. Glycerin - 5,00

3. Tween-80 - 1,00

4. Salicylic acid - 0,10

5. Citric acid food - 0,05

6. Chloramphenicol - 0,50

7. Extracts spirtovanie

horsetail - 2,00

a series of 1.00

calendula - 1,50

8. Urea, a grade - 0,30

9. Atsetomepregenol - 0,05

10. Levonorgestrel - 0,0005

11. Ammonia water, conc. (pH 7) - 1,00

12. Oil calendula extract - 2,00

13. Paraform - 0,05

14. Brontril - 0,05

15. Agidol-1 - 0,20

16. Odorant - 0,10

17. Water - the rest.

We offer cosmetic gel is a gel with a light color with pleasant smells aetsa combined therapeutic and cosmetic means includes:

a) hydrophobic and hydrophilic fillers, traditionally used in cosmetics for the manufacture of creams and lipsticks,

b) anti-inflammatory, biologically active substances: the antibiotic chloramphenicol, spirtovanie extracts of calendula, horsetail and succession; b) a balanced complex of hormones, consisting of: antiandrogenna hormone (modified progestogen and oestrogen hormone.

The gel, called by the applicant "Youth", tested at the Russian state University for the Department of skin and venereal diseases, pediatric faculty, Moscow.

Example 2.

The study involved 50 patients (27 women and 23 men) aged from 15 to 31 years with a diagnosis of acne vulgaris (12 women diagnosed with premenstrual acne). The duration of the disease in 27 patients (54%) of 3 years, in 15 (30%) - 5 years, 8 patients (18%) - 1 year. Common skin was observed in 29 patients, and limited - 21.

The gel was applied in a thin layer on affected areas 2 times a day (morning and evening) after cleansing within 7-10 days, and when premenstrually - 3-4 times a day for 3-5 days.

Each patient was under observation is the dynamics of the severity of the pathological process (starting point 4 = day 10), as well as numerically in terms of the intensity of the inflammatory phenomena.

The survey revealed that in 15 (30%) there was a positive effect from the first days of drug treatment, "Youth", and it significantly decreased inflammation (before visit 2). To visit 3 - flattening pustular elements and desiccation or in their crust was noted in 22 patients (44%) and to visit 4 in 11 (22%). There were no changes in 2 patients (4%).

As a result of treatment in 12 patients (7 men and 5 women) with a diagnosis of acne vulgaris" and 2 women with premenstrual acne, there was complete clinical cure the pathological process. In 19 patients (12 men and 7 women) with vulgar eels and 6 women with premenstrual acne - significant improvement (most pathological elements being sihanya in peel and flattening). 5 patients (3 men and 2 women) with vulgar eels and 4 women with premenstrual acne - improvement process of the skin (some items were completely resolved, however, were still pockets of acute inflammatory nature). Side effects of the drug "Youth" in the appearance of dryness and feeling of tightening of the skin was observed only in 3 bol is tion did not interrupt.

Thus, 78% of patients had a good or very good effect, and 18% is insignificant.

The presence of chloramphenicol in the gel is optional, but enhances therapeutic effect. This is confirmed by the data of the comparative analysis presented in example 3.

Example 3.

Analysis of the effectiveness of the proposed means were carried out by comparing the test results of gel "Youth" and gel of the same composition not containing biologically active additive, namely a combination of progestogen and estrogen.

In the control trials involving 10 patients with common skin process (8 women and 2 men) aged from 15 to 30 years with a diagnosis of acne vulgaris (2 women diagnosed with premenstrual acne).

The gel was applied in a thin layer on affected areas 2 times a day (morning and evening) after cleansing within 7-10 days, and in pre - 3-4 times a day for 3-5 days.

Each patient was under observation for 14 days.

About the effectiveness of the control drug in subjects patients were judged by the dynamics of the severity of the pathological process (the starting point of the visit 1 = day 0, visit 2 = day 4 cured the s.

In the result, it was revealed that the whole group of patients there was a positive effect only on the third day of treatment the control drug. To visit 4 - simplification of pustular elements and desiccation or in their crusts were observed in 2 people (20%). There were no changes in 3 patients (30%). Further positive dynamics in time is not revealed.

Thus, the comparative analysis of the effectiveness of the proposed framework with the control drug was shown that the effect is ensured by the presence in the preparation of biologically active additives, namely the combination of progestogen and estrogen.

Thus, the proposed gel represents a new therapeutic and preventive cosmetic product having a high anti-inflammatory and antimicrobial activities and not having irritating to the skin.

The tests showed that the gel "Youth" is a highly effective way to care for skin, treatment of acne and has a pronounced anti-inflammatory action.

Contraindications to the use of the gel is not detected.

1. Biologically active additive to treatment-and-prophylactic means for skin care, prevention is connected with the fact, she is a progestogen General formula I

< / BR>
where R and R1=H or allgraph COR11containing C1 to C5 carbon atoms, and R1can be equal to R or to differ from him.

2. Additive under item 1, characterized in that it further comprises a natural or synthetic estrogen in an effective amount.

3. Therapeutic gel for skin care, prevention and elimination of inflammation, acne and pustular rash, containing the gel, perfume and water, characterized in that it further contains glycerin, salicylic acid, tween-80, citric acid, oil calendula extract, spirtovanie extracts of horsetail, succession, calendula, urea, aqueous ammonia, paraform, brontril, Agidol-I, progestogen atsetomepregenol estrogen ethinyl estradiol and the antibiotic chloramphenicol, and as a gel - zacapa in the following ratio, wt.%:

Gelling, zacapa - 0,5 - 3

Glycerol - 3 - 5

Tween-80 - 1 - 3

Salicylic acid - 0,01 - 0,2

Citric acid food - 0,01 - 0,05

Chloramphenicol - 0,1 - 0,8

Extracts spirtovanie:

horsetail - 1 - 3

a series of 0.5 - 2

calendula - 1 - 2

Urea, m is - 1.5 to

Oil calendula extract - 1 - 3

Paraform - 0,03 - 0,07

Brontril - 0,03 - 0,07

Agidol-I - 0,1 - 0,3

Odorant - 0,1 - 0,7

Water - Ostalnoe

 

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