Method for the treatment of endometritis in cows

 

(57) Abstract:

The method is intended for the treatment of endometritis in cows. The early treatment of endometritis was diagnosed in cows 6-12 day after calving, performed by intrauterine rehabilitation of 0.2-0.3% aqueous solution of desagana at a dose of 50-200 ml simultaneously with the introduction of intramuscular prostaglandin f2-alpha in a dose of 2-3 ml per head, and endometritis identified by 15-25 day after calving by intrauterine rehabilitation of 0.3-0.5% aqueous solution of desagana in the same dose (50-200 ml) along with intramuscular injection of 2-3 ml of 2% aqueous solution sinestrola. Treatment with an interval of 72 h not more than three times. The solution desagana cows injected uterine catheter connected with a syringe Janet. The invention is applicable when the content of cows at livestock farms, complexes and farms. The method allows to reduce treatment time and improve the fertility of cows. table 1.

The invention relates to veterinary medicine, in particular, to methods of treatment of endometritis in cows using medicinal product prepared from peracetic acid-desoxin, in combination with the organic active substances.

Known methods of treatment and the injection, or StabiliTrak at a dose of 20-30 mg per one injection. He and other drugs intramuscularly daily for 3-5 days. The use of these drugs leads to significant changes in the genitals: opens the cervix, quickly recovering her motor function; the uterus is exempt from exudate; increases secretion of uterine glands and restored sexual cyclicity (A. P. of Studentsi. Veterinary obstetrics and gynecology. - M.: Kolos, 1970, S. 364). However, the use of these drugs does not provide complete suppression of putrefactive microflora in the genitals cows. For this purpose you need intrauterine reorganization. Term treatment of cows in a known way longer: the effectiveness of their treatment does not exceed 65-70%. Currently, these drugs are very expensive.

There is a method of treatment of inflammatory processes in the uterus of cows and increase their fertility through the use of prostaglandin f2-alpha produced in two forms: natural prostaglandin f2alpha (lutalyse and hansaplast) and synthetic analogues (estrofan, remian and others). So, the treatment of andamerica in cows with estrofem carried out by intramuscular injection of 2 ml of the drug after poker and washing, as a rule, simultaneously with the introduction. 11-the day the drug is administered repeatedly, on a 14-day cows are inseminated, and on the 15th day of re-insemination (passport:estrofan (Oestrophan) injection for veterinary use. Led by spoof. United pharmaceutical plants. Prague, Czechoslovakia).

Treatment of endometritis by estrofem effectively if cows functioning of the yellow body. In the absence of a functioning luteum efficiency of astropan minimal or absent. In highly productive cows sick after calving endometritis luteum in the ovary, usually absent. In this regard, prostaglandina cows cured hidden and mild forms of endometritis.

The known method etiopathogenetic therapy of acute postpartum catarrhal-purulent endometritis in cows of black-motley breed at the age of 3-10 years with productivity 3000 kg milk per year by intrauterine injection of etiotropic drugs: indexer, Eridon, detoxify, lodgical, furazolidone, in the recommended quantities every 48 h to recover. The best performance obtained from cows, which were introduced detoxifer and lodgical. The improvement noted in their average after 13-15 days, then the, receiving sticks with furazolidone by 20.0 - of 12.4%. Insemination of cows these groups came through 70 and 73 days after calving or 18.1 - 14.8 days less than in the other groups.

When using novocaine (vnutriaortalina 100 ml, 1% solution) combined with sinestrola (intramuscularly, 1.5 ml, 2% solution) and methoxyfuran recovery marked by 9,3 day, fertilization 4 months 100% cows, A. Cheremisinov, Y. G. Tkachenko, L. A. Manakova. Complex therapy of cows suffering from endometritis. Abstracts Vsesojuzn. the scientific. technology. conference "the Use of hormonal drugs in animal husbandry" 1-2 September 1991 , and the settlement of dubrovitsy, Moscow region. - Dobrovici: agricultural Sciences, VIGÉE, 1991, pp. 101-102).

This method allows to obtain the relatively high results in the treatment of endometritis in cows. However, they achieved in the treatment of cows with productivity 3000 kg milk per year. You know, highly productive cows the body's resistance is much lower. In addition, the achievement of positive results contributed to the early detection of endometritis: you know, chronic endometritis cured harder, regardless of the selection of medicines.

Known way, Zack is taglandin f2-alpha, in particular estrofan, in combination with the units. The method provides pregnancy from the first insemination, 70.4% of cows, but it is associated with the use of a relatively expensive drug foreign production - units.

The closest in technical essence is a method of treating endothermic in cows, including the introduction in their body chemotherapeutic drugs in combination with hormonal drug. (see Handbook of veterinary medicine, Compiler, A. Kononov, L., "Kolos", 1978, S. 161) prototype.

When creating the present invention, the task was to develop a method of treatment of endometritis in cows, based on the use of readily available, cheap and highly effective preparation for inhibiting the activity of pathogenic bacteria and fungi in the uterus of cows in the complex mechanism of drugs.

The technical result of the invention is achieved by a method for treatment of endometritis in cows, including the introduction into the body of the cow chemotherapeutic drug in combination with a prostaglandin, an ability which is that as a chemotherapeutic drug use 0.2 to 0.5% podniesinski form of endometritis and the number of putrefactive exudate in the uterus with an interval of 72 h not more than three times in combination with prostaglandin f2-alpha or sinestrola, and early treatment of endometritis identified at 6-12 day after calving, performed by intrauterine rehabilitation of 0.2 - 0.3% aqueous solution of desagana along with intramuscular injection of prostaglandin f2-alpha in a dose of 2-3 ml per head, and endometritis identified on 15 - 25 days after calving, by intrauterine rehabilitation of 0.3 - 0.5% aqueous solution of desagana simultaneously with intramuscular injection of 2-3 ml of 2% sinistral.

Proposed for the treatment of endothermic cows noantibiotics drug desexo (industrial purpose) - peracetic acid (peracetic, Gidropress acetyl) - a colorless liquid with a pungent odor. Formula desagana CH3COOH; molecular weight - 76,05; ; density (d) = 1,226145; melting point - 0,1; boiling point is 105oC; it is soluble in water and common organic solutions (C. A. Rabinovich, Z. Ya havin. Brief chemical reference guide-HP, Chemistry, 1991, S. 190).

The solution desagana inhibits the activity of pathogenic microorganisms, as well as in the period from 6 to 12 bottom after calving in the ovary have a functioning luteum, the introduction of prostaglandin f2-alpha cause lysis of the yellow body is 25 days after calving, when the ovaries no functioning yellow body, simultaneously with the reorganization intramuscularly cow is injected 2-3 ml of 2% sinestrola. In contrast to exogenous prostaglandin f2alpha, sinistral not only enhances the motility of the uterus, but also ensures the activity of the reproductive system, growth of small folliculo, dilates blood vessels fruit of the apparatus and increases the blood flow to them.

The invention is illustrated by the following example. In 1993 - 1994, in the experimental farm "Sapova" Moscow region on cows black-and-white hostingservices breed with an annual milk yield of 6700 kg milk were testing a new method for the treatment of endometritis in comparison with the known (the prototype). The group of cows, including 67 goals, with early endometritis identified at 6-12 day of calving, were intrauterine reorganization 50-200 ml of 0.2-0.3% aqueous solution of desagana simultaneously with the introduction of intramuscular prostaglandin f2-alpha in a dose of 2-3 ml per head. The second group of cows - 49 goals, patients with endometritis identified by 15-25 day after calving, while intrauterine readjustment 50-200 ml of 0.3-0.5% aqueous solution of desagana were injected with 2-3 ml of 2% aqueous solution sinestrola. Treatment in both groups of cows held United with a syringe Janet. The results of treatment are presented in the table.

When treating a new way animals were healthy gynecological 6-12 days earlier, and the impregnation rate was 16.1 and 17.1% higher than treatment in a known manner. The invention is applicable when the content of cows at livestock farms, complexes and farms.

Method for the treatment of endometritis in cows, including the introduction in their body chemotherapeutic drugs in combination with hormonal drug, characterized in that as a chemotherapeutic drug use 0.2 to 0.5% aqueous solution of desagana dose of 50 to 200 ml, and as a hormonal drug - prostaglandin f2-alpha or sinestrol, and the introduction is carried out 1 to 3 times with an interval of 72 h, and the early treatment of endometritis identified at 6 - 12 day after calving, performed by intrauterine rehabilitation of 0.2 - 0.3% aqueous solution of desagana along with intramuscular injection of prostaglandin f2-alpha at a dose of 2 to 3 ml per head, and endometritis identified on 15 - 25 days after calving, by intrauterine rehabilitation of 0.3 - 0.5% aqueous solution of desoxyn, along with intramuscular injection of 2 to 3 ml of 2% aqueous solution Sinestro

 

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< / BR>
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