Drug wound healing, burns and anti-inflammatory action

 

(57) Abstract:

The invention relates to medicine, namely to facilities for the treatment of purulent infected and burn wounds. The proposed product contains, wt%: resin neutral fir 9 - 11, emulsifier T-2 9 - 11 and purified water - the rest. The resulting preparation is superior sea buckthorn oil and liniment of syntomycin in therapeutic activity. table 1.

The invention relates to health, in particular drugs for the treatment of purulent infected and burn wounds, and can be used in chemical and pharmaceutical industry and clinical medicine.

Known for the treatment of infected and purulent post-traumatic and burn wounds such drugs as sea buckthorn oil, balsamic liniment of A. C. Vishnevskaya, pninat sodium on balsam fir and liniment of syntomycin 1%, ointment, levsin, levomicol, dioxidea ointment, ointment butadienovoy 10% and other (Mashkovsky M. D. Medicines. M.: Medicine, 1993, 1 and 2 h, S. 734, 690). These known drugs come in clinics insufficient for effective treatment of patients quantities and, most importantly, have a significant ograniczenia ability to select resistant and chemotherapy strains of microbes, that is generally a serious problem of modern medicine.

The main reason preventing the use of drugs anti-inflammatory drugs, is to use them as ingredients toxic (synthetic) antibiotics and chemical antiseptics. The deficit caused by the recession and the closure of environmentally harmful production of antibiotics.

Sea buckthorn oil is a natural ecological pure drug, but it applies to the 2nd stage of treatment of burn wounds, at the stage of epithelialization, to clean the wound. In addition, the effectiveness of this drug is not high enough (prototype).

Liniment balsamic discontinued due to low efficiency.

The purpose of the invention is improving the efficiency of the treatment of infected, chronic and burn wounds and reduction of terms of treatment of wounds.

This objective is achieved in that the drug wound healing, burns and anti-inflammatory action as the main active substance containing resin neutral fir (TU 13-0281172-46-87) derived from natural plant materials - fir resin, emulsifier "Solid and, wt.%:

Resin neutral fir - 9 - 11

Emulsifier T-2 - 9 - 11

Purified water - the Rest.

To obtain a drug emulsion resin fir 10%, proceed as follows.

Charged to the reactor purified water, heat and load emulsifier T-2, pre-melted and thoroughly filtered, and stirred at 60-70oC to education stability of the emulsion. Next, load the resin neutral fir, pre-melted. After thorough mixing of the finished medicinal product analyze and pour into glass jars or aluminum tubes.

Example. Charged to the reactor 82 wt.h. purified water, heat and load 9 wt. including emulsifier T-2, pre-melted and thoroughly filtered, and stirred at a temperature of 60-70oC before the formation of stable emulsions. Next download 9 wt.h. resin neutral fir, pre-melted. After thorough mixing of the finished drug analyze. Emulsion resin fir (drug) is a smooth, creamy mass of white with a weak smell of pine. Podlinnost the precipitate, which indicates the presence of a carbonyl group). Acid number of the product 2 mg KOH per 1 g of the product. The total content of diterpenoid alcohols in the product is equal to 1.8%. The results of the analysis of the above example are shown in table (example 1). Other examples are given in the table.

Performed comprehensive preclinical trials emulsion resin fir showed the following.

Wound-healing properties of the emulsion resin fir studied in comparison with sea buckthorn oil, liniment of syntomycin 1% liniment balsamic on Vishnevskaya; infected wounds in comparison with the ointment the vegetable "levomekol; floridachickie properties in comparison with ointment buttonboy 10%.

The regenerative ability of the emulsion resin fir and Comparators were evaluated in experiments on the healing of aseptic and infected Staphylococcusaureus wounds on white rats.

Emulsion resin fir shortens the healing of aseptic wounds 43.6% in comparison with untreated animals.

In the treatment of infected wounds under the influence of the emulsion resin fir within 2-3 days is the elimination of perifocal edema and infiltration of the tissues around the wound, in these terms, the wound is cleaned from necrotizes the s for 3-5 days.

Emulsion resin fir, in comparison with untreated animals, reduces the healing time of burn wounds for 65.4 and 53,6%, respectively, surpassing the sea buckthorn oil and liniment syntomycin.

The drug has a moderate anti-edema effect.

Evaluation of the antimicrobial properties of the emulsion resin fir showed that the highest sensitivity to the drug manifests Salmonella BresLauu Listeria monocytog.

Emulsion resin fir low-toxic and has no mutagenic effect.

Drug emulsion resin fir environmentally friendly and harmless. This is because it is, first, based on environmentally friendly natural product obtained by environmentally friendly technology of complex processing of fir oleoresin (ed. St. N 1545592 from 22.10.89. The method of obtaining natural neutral resin) and, secondly, does not contain traditional chemical components antibiotics, antiseptics, etc.

In accordance with the decision of the state pharmacological Committee of the Ministry of health of the Russian Federation (Protocol No. 15 from 13.10.94) conducted with positive results in clinical trials emulsion fir resin 10% in the following clinical settings: vnch, Institute x is liteta at SSMU (, Tomsk). The results of clinical radiation allow to conclude that the drug emulsion fir resin 10%, is an effective tool for local treatment of patients with burns, has sufficient anti-inflammatory and regenerative effect, well tolerated victims, does not cause toxic and allergic reactions and can be recommended for use in the treatment of patients with burns.

Drug wound healing, burns and anti-inflammatory action on the basis of a product of natural origin, characterized in that the active substance contains a resin neutral fir, purified water and emulsifier T-2 in the following ratio, wt.%:

Resin neutral fir - 9 - 11

Emulsifier T-2 - 9 - 11

Purified water - Ostalnoe

 

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