A drug for prevention and treatment of radiation injuries

 

(57) Abstract:

Developed drug for the treatment and prevention of radiation injuries. The drug is polydisulfide Gallic acid. The drug is more effective than used in practice tsistamin. table 2.

The invention relates to biology and medicine and relates to means against radiation damage.

Know the use case of radiation lesion of the n-aminopropiophenone and its derivatives [1], thiols [2], tiofosfornoy acid derivatives [3], derivatives of thiazolidine [4], diazinon [5], metal complexes of acylhydrazones [6] , -tocopherol [7]. Wide use for the prevention and treatment of radiation injuries received tsistamin [8].

The problem to which the invention is directed, is the extension of the range, with preventive and therapeutic agents against radiation damage. The problem is solved by the use as a drug for prevention and treatment of radiation injuries of polydisulfide Gallic acid, formula , where n = 12 to 16.

Polydisulfide Gallic acid obtained by condensation of Gallic acid with odnoklasniki grey.

Primea and with vigorous stirring, 13.5 g (8.1 oz) odnoklasniki sulfur within 15 20 minutes, then heated the reaction mass at 110 - 120oC to complete the termination of allocation of hydrogen chloride. At the end of the reaction the precipitate of polydisulfide Gallic acid is filtered off, washed with o-, m-, p-xylene and then with water until a negative reaction to chlorine ion. The synthesis time is 30 hours, exit 92 - 95%, T square = 260 - 262oC with decomposition. The reaction scheme:

,

Polydisulfide Gallic acid - substance light yellow color. The elemental composition, wt.%:

Found: C 38,60; H 1,33; S 24,59.

Calculated: C 36,21; H 1,72; S 27,59.

Molecular weight (cryoscopy in diphenyl) found - 3600.

The infrared absorption spectrum of cm-1: 480-S-S-, 870-C-H - pentamidine benzene, 1230-S-C-OH, 1480-benzene ring, 1630-COOH, 3300-OH polymer.

Evaluation of preventive and therapeutic actions of the drug were carried out on outbred adult rats of both sexes weighing 160 to 200 g Total single renthenolohiya conducted on the apparatus RUM-17 under the following conditions: voltage of 200 kV, current - 11.5 mA, filters - 0.5 mm Cu + 1 mm Al, dose - 0,35 Gr/min, skin-focal length 60 see Drug was administered intraperitoneally once per 30 minutes before irradiation. For therapeutic purposes, the drug wodent survival of animals and life expectancy.

The results of the effectiveness of polydisulfide Gallic acid are presented in table. 1 and 2.

Polydisulfide Gallic acid is more effective in much smaller amounts than a widely used radioprotector tsistamin.

Sources of information used in the compilation of the description:

1. Oldfield D, Donil 9, Pizak V "Radiation Res" 1965, 26, N1, p 12 - 26

2. Vladimirov Century, and other Radiobiology, 1974, 14, N 3, S. 415 - 418.

3. Mukhin, E. A., Pariahs B. I., Hykawy Century. And. Physiology hypertensive funds, Kishinev, 1974. S. 38 - 62

4. Fernandez V, Robbe Y, Chapat V "V. Med Chem 1983, 26, N 9, p 1317 - 1319

5. Romantsev E. F., Blohina C. D., Zhulanova H. I. Biochemical basis of the effect of radioprotectors. M: Atomizdat, 1980, 168, C.

6. FloerecheinG, Floerechein P "Beit V Radiol" 1986, 59, N 702, p 597 - 602

7. Tsvetkova T. C., zocor E. C. Radiobiology, 1989, T. 28, vol. 6, S. 780 - 782

8. Kuna P. Chemical radiocasete. M.: Medicine, S. 127 - 129, 1989.

A drug for prevention and treatment of radiation injuries, characterized in that it is polydisulfide Gallic acid of General formula

< / BR>
where n = 12 to 16.

 

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