Drug against shock

 

(57) Abstract:

Developed the drug against shock polydisulfide Gallic acid. The drug is more effective than used in practice contrical. table 1.

The invention relates to biology and medicine and relates to a medicinal product that protects from shock.

Known use as antishock drugs plasmaatomic solutions, promedol, droperidola, dopamine, and Talamone. But when the shock is observed when the drugs are administered in large enough doses and do not provide a high survival rate.

Closest to the invention on the effectiveness of actions is used as antishock drug kontrikala.

The problem to which the invention is directed, is the extension of the range of funds with antishock effect and higher efficiency compared to the prototype.

The problem is solved by the use as an anti-shock tool polydisulfide Gallic acid of the formula I

,

where n = 12 to 16.

Polydisulfide Gallic acid obtained by condensation of Gallic acid with odnomerno dried o-, m-, p-xylene and with vigorous stirring, 13.5 g (8.1 oz) odnoklasniki sulfur within 15 - 20 min, then heated the reaction mass at 110 - 120oC to complete the termination of allocation of hydrogen chloride. At the end of the reaction the precipitate of polysulfide Gallic acid is filtered off, washed with o-, m-, p-xylene and then with water until a negative reaction to chlorine ion. The synthesis time is 30 hours; exit 92 - 95%. TPL= 260 - 262oC with decomposition. A reaction scheme II:

< / BR>
Polydisulfide Gallic acid - substance light yellow color.

Found, wt.%: C 38,60; H 1,33; S 24,59.

Calculated, wt.%: C 36,21; H 1,72; S 27,59.

Mol. mass (cryoscopy in diphenyl) found 3600.

Infrared absorption spectrum ( cm-1): 480-S-S-,

870-C-H - pentamidine benzene;

1230-S-C-OH;

1480-benzene ring;

1630-COOH;

3300-OH polymer.

Antishock effect of polydisulfide Gallic acid tested in the laboratory, experiments are performed on 40 rats "Wistar" weighing 200 - 250 g To simulate the shock applied by the imposition of a tight tourniquet on the hind limbs of rats for a period of 6 hours drug injected intraperitoneally immediately before the removal of the tourniquet.

Characteristics of drugs in the antishock efficiency are presented in table illustrating the status of the rats at various times after removal of the tourniquet.

It is established that the proposed tool increases their life expectancy by 20 - 30% compared with the action antishock drug-kontrikala, i.e. it has a more pronounced antishock effect compared to the prototype.

Polydisulfide Gallic acid by antishock action exceeds contrical and has an antioxidant effect (inhibits the oxidation of lipids) that can be used in conditions of experimental clinic for the correction of various pathological conditions involving shock body conditions of the animals, and with the permission of the pharmacological Committee in humans, particularly during ischemia associated with shock.

Drug against shock, characterized in that the submission

 

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