Remedy for pain

 

(57) Abstract:

The invention relates to medicine and can be used both in the inpatient and outpatient settings to reduce or eliminate pain. The invention consists in the use of medicines on the basis of the dichloride of mercury in a blocked state of sulfhydryl groups of proteins, with 3 - 4 % sugar content as analgesic. The use of the invention enables the reduction or elimination of pain. Used drugs stimulate many functions of the body, improve metabolism in cells and tissues, improve the General condition. 3 table.

The invention relates to medicine and can be used both in the inpatient and outpatient settings to reduce or eliminate pain.

As you know, currently analgesic action identified the substances belonging to different pharmacological groups.

In particular, based on their chemical nature, the nature and mechanism of pharmacological activity, analgesics are divided into two main groups: narcotic and non-narcotic analgesics /1, S. 178-217/.

For a group Nanay mental and physical dependence.

An example of a non-narcotic means, used as an anesthetic drug, can serve as Aalisin. The drug is used in postoperative, posttraumatic, rheumatic pain, oncological diseases, etc. /1, 208 S./.

The product is a mixture of D-lysine atsetilsalitsilata and glycine. Drinking a mixture containing aalisin, sugar, lemon, food essence and dye. Before use, the mixture is dissolved in the heat of boiling water and taken internally.

Analgesic effect of the drug is due to the impact of the centres of pain sensitivity and the ability to reduce algogennoe action of bradykinin.

In applying the drug may receive noise in the ears, the weakening of hearing, angioedema, skin and allergic reactions.

Of particular value to represent almost clinical drugs exhibiting analgesic activity along with others, the main therapeutic effects, for example, antitussive, antipyretic, anti-inflammatory, which provides a dual therapeutic effect in appropriate situations.

Pain is one of the most private manifestations of cancer-related disease is in the search for new analgesic non-narcotic means of action.

This was the aim of the invention.

Set achieved by applying the previously known means possessing immunostimulatory and antitumor activity for a new purpose.

The invention consists in the application of the compositions on the basis of the dichloride of mercury in reversible blokirovka state of sulfhydryl groups of proteins, with 3-4% sugar content as painkillers.

Preparations on the basis of mercuric chloride known as immunomodulators and means possessing antitumor activity /2/.

Drugs used orally or topically in the form of ointments, applications, lotions, compresses, or douches, depending on the dosage form.

Technology of production of known drugs provides exemption sulfhydryl groups of protein-SH, semi-dry or semi-sweet natural wines, dairy whey or honey, included drugs that reversibly blocked ions of mercury Hg2+due to avoiding the toxicity of the compounds.

Sugar contained in the amount of 3-4% in wine, dairy whey or honey, contribute to maintaining the acidic environment, neoease treatment with these drugs for patients with various diseases has been reduced or in many cases, the disappearance of pain, what initially was associated with improved flow of the underlying disease, and in cancer patients with tumor regression.

However, it was noted that local application of drugs, for example, in cancer patients, reduces sensitivity to pain directly in the zone of localization process.

Reducing pain when taking Viturid inside was observed when the actual regression of the tumors had not come.

The specified observation was the basis for further experimental and clinical studies of the pharmacological properties of drugs based on mercuric chloride, in particular, studies on the experimental model of analgesic action.

From the history of the study of mercury compounds it is known that they are the strongest neurotoxins spending in high concentrations to the structural damage of the nervous tissue. However, the local system and the Central action of low doses of mercury compounds in low concentrations has not been sufficiently studied, and the study of the analgesic properties of drugs on the basis of mercuric chloride and represent a new direction of research. Especially valuable is the availability of these drugs at once is you, other functional formations. These qualities should be fully manifest itself in the treatment of many systemic somatic and infectious diseases.

In the experiment we studied the local analgesic effect of the drug Vita Balm and systemic analgesic effect of the drug Viturid B, on the model of change threshold thermal pain sensitivity in rats exposed to these drugs.

Drugs Balm Vita and Viturid B is a solution of chloride of divalent mercury (corrosive sublimate) in semi-dry white wine. The concentration of mercuric chloride in the Balm Vita 0.33% Viturid B is 0.33%.

For exploring the local analgesic action Balm Vita inflicted white outbred rats by immersing hvostano 2/3 the length of the tube with the drug. Within 4 days it was made 4 applications daily exposure of the drug for 4 hours, the Drug was investigated in dilutions of 1:1 (native), 1:10, 1:30 and 1:90. Systemic analgesic action of Viturid B was studied on rats received the drug orally for 10 days at 4.2V and 0.42 mg/kg of body weight. Control group animals were exposed to water and wine on the basis of which izgotovlyeniya) of the drug conducted a study of threshold heat pain sensitivity. The testing was carried out with the help of the device TAIL FLICK, model DS 20 (firm Ugo Basile, Italy). The device allows you to create a focused thermal beam with a constant temperature, variable voltage applied to the incandescent lamp. Automatic timing stops when the indexed tail with photocell in response to pain. The control indicator is the maximum time during which the rat can withstand the heat of the beam.

Testing the pain threshold for each animal were performed three times in different parts of the tail with subsequent determination of average time for individual groups.

In the second part of the experiment, immediately after the definition of indicators of pain sensitivity, rats respective groups at 2 h were appolicious native Vita Balm, wine and water. The purpose of this experiment was to determine indicators of pain sensitivity immediately after applying the drug and the elucidation of the mechanism of its action.

The results of the experiment showed that 24 h after the last exposure to different concentrations of Balsam Vita reveals his dots is marked in dilutions of 1:10 (p < 0.05)and 1:1 (p < 0,01). Thus a dilution of 1:10 is the maximum effective, significantly raising the threshold of pain sensitivity in rats the local application. Some of the increase in pain threshold causes the wine, which is associated with known analgesic effect of alcohol, but the rate in this group of rats not statically significant in comparison with the control group, which causes the water.

After 0.5 h after the second 2-hour exposure of the drug to the skin of the tail decreased pain threshold to values of the control group (table. 2).

The total reduction in the threshold of pain sensitivity observed in this case in all groups, describes the process of training the animals on the classical principle of avoiding aversive stimulus (more heat). However, only in the group exposed to repeated drug effect, a reduction in the threshold significantly in relation to the daily threshold significantly in relation to the daily threshold at the same concentration (table. 2). Therefore, in the unavoidable process of training animals sandwiches irritation effect of the drug. In this case, the mechanism of action of p is i.i.d. for reception painful effects. In subsequent hours (between 0.5 and 24 h) this effect is followed by inhibition, possibly due to the adaptive membrane resting potential (below -70 mB). May be a direct effect of active complexes of the drug on the nerve endings, which leads to their functional inadequacy. It is also clear that the effect of the drug on the nerve endings of non-specific and, therefore, not bound to specific receptors, such as, for example, in the case of classical analgesics and opiates.

Thus, in the experiment to study changes in the pain threshold temperature sensitivity based on the interpretation of the retention time of the tail in focus the heat of the beam after the local impacts of Balsam Vita shows nonspecific moderate dose-dependent analgesic effect. The development of analgesia lasts from 0.5 to 24 hours and is biphasic: weak stimulation (irritation) of nerve endings is replaced by a moderate braking.

The results of the study system analgesic drug action "Viturid B".

Oral for 10 days introduction "Viturid B" rats in doses of 4.2 and 0.42 ml/kg induced significant compared to control (p < 0.01) increased threshold temperature is independent character. The results confirm the known data about the effects of mercury compounds on the Central nervous system. Given the low concentration of mercuric chloride in the preparation "Viturid B", you can suggest that his active complexes, including mercuric chloride, nonspecific blocking either the ascending afferent impulses from nerve endings, subjected to painful thermal stress or downstream effector units responsible for responding to the stimulus of pain. This moderate blocking is possible at all levels of the reflex arc: from the nerve endings through senatorially paths of pain regulation of the reticular formation of the brain stem and mid-brain, and then ascending projections to ventrobasal and intralaminar nuclei of the thalamus and somatosensory cortex. There is no doubt that there are other phenomenological manifestations of Central action of small doses of mercury compounds.

Thus, in this experiment shows a systemic analgesic effect of the drug "Viturid B" dose, appropriate for therapeutic treatment of cancer at 0.42 mg/kg and ten times therapeutic dose. The mechanism of this phenomenon is the/P> Thus, the experiment showed that:

1. The Balsam Vita has analgesic effect of the local application of rats, causing a significant increase in pain threshold in dilutions of 1:10 (p < 0.05) and 1:1 (p < 0,01).

2. Breeding Balm Vita 1: 10 is the maximum, showing analgesic effect.

3. Action Balm Vita is biphasic: weak stimulation (irritation) of nerve endings is replaced by a moderate braking.

4. Drug Viturid B" has a systemic analgesic effect during repeated oral administration to rats at a dose corresponding therapeutic for humans in the treatment of cancer at 0.42 ml/kg

Conducted monitoring of patients in the clinic showed that regardless of the dosage form and methods of using drugs on the basis of mercuric chloride, which is blocked in a reversible state of sulfhydryl groups of proteins, with 3-4% sugar content, showed analgesia effect in various diseases. This decrease in pain occurred prior to the normalization of pathological tissue processes, causing pain that podtverjdau what about the office of the Republican hospital for infectious diseases in 15 patients with a diagnosis of Herpes Loster" in treatment were used topical application of drug Viturid. Analgesic effect was obtained in 10 patients, while it was mentioned that it will come much faster for the improvement of local manifestations of the disease.

In the thoracic Department of the Republican hospital SRK drug Viturid applied in 18 patients with immune diseases of the peripheral arteries by oral methods and topically in the form of applications for trophic defects. At the same time, patients with 2A-2B stages of chronic arterial insufficiency analgesic effect, reflected in significantly increasing the distance of "intermittent claudication" manifested itself in 5-7 days from the start of treatment. Pain reduction in the flow in patients with stage 3-4 disease marked by 3-5 days, complete relief for 10-12 days.

At the Department of hospital therapy of the medical faculty of the Petrozavodsk state University were treated 26 patients with rheumatoid arthritis by oral administration and local - in the form of application of Viturid. In 23 patients had a decrease in pain for 4-5 days. from the beginning of therapy while maintaining signs of inflammation. The overall clinical effect of treatment was observed not earlier than one month from the start of treatment.

The use of compositions on the basis of the dichloride of mercury that finds the as painkillers.

 

Same patents:

The invention relates to medicine, namely to the technology of medicines, and can be used to produce mercury-containing drugs with antitumor anti-infective activity

The invention relates to medicine and can be used in the pharmaceutical industry to obtain funds with antitumor and antiviral activity

The invention relates to medicine, in particular technology of drugs, and can be used in the pharmaceutical industry to obtain mercury-containing drugs intended for use in experimental studies and in clinical practice
The invention relates to medicine and can be used for the treatment of patients with tumors of the uterus, ovaries and vulva
The invention relates to medicine, in particular to cancer and can be used for the treatment of patients with breast tumors
The invention relates to medicine, in particular to cancer, and can be used for the treatment of patients with breast tumors
The invention relates to medicine and can be used to treat patients with benign and malignant tumors of the uterus, ovaries and vulva

The invention relates to medicine, in particular to the technology of medicines, and can be used to produce mercury-containing drugs with antitumor activity

The invention relates to medicine and can be used to treat patients with benign and malignant diseases irrespective of their origin and localization, immunodeficiency different origin and radiation diseases, as well as for conflict prevention incompatible transplant, for pain relief and wound-healing
The invention relates to medicine and can be used to treat patients with cancer, immunodeficiency different origin, viral, microbial, parasitic, radiation diseases, and as a means for conflict prevention incompatible transplant, analgesic and prevention of various diseases

FIELD: pharmaceutics.

SUBSTANCE: the suggested preparation for treating chronic urological diseases contains perforated St. John's wort grass, common horsetail grass, dog rose fruits, meadow clover grass, flax, elecampane roots at certain ratio of components. The method for preparing the preparation for treating chronic urological diseases deals with washing the raw material, reducing and mixing the components mentioned, removing surface cuticular compounds due to treating the mixture with liquefied carbon dioxide mixture followed by drying and packaging, moreover, the raw material: perforated St. John's wort grass, meadow clover grass, flax seeds, dog rose fruits, elecampane roots, common horsetail grass should be treated under certain conditions. The preparation obtained due to the technique mentioned above is of higher activity for treating chronic urological diseases.

EFFECT: higher efficiency of therapy.

2 cl, 3 ex, 3 tbl

FIELD: medicine; veterinary.

SUBSTANCE: for prevention cows in pre-labour period are introduced mercury nitrate "Mercurius solubilis Hahnemmanni" in dose 0.2 g per 100 kg of weight, for treatment dose is doubled.

EFFECT: increase of animal resistance to mastitis disease, considerable reduction of treatment terms.

FIELD: medicine.

SUBSTANCE: said medicine contains Mercurius solubilis C 6, Apis C 3, Belladonna C 3, Pulsatilla C 3, Calcarea carbonica C 6. All medicinal components are taken in the same ratio. The medicine represents sugar granules. Means allows improving clinical effectiveness in treatment for conjunctivitis, quickly managing subjective symptoms (within several hours) and reducing time of treatment due to the integrated effect on all links of the disease process.

EFFECT: medicine is available, reasonably priced, has no contraindications, does not cause an allergic response, can be applied both as a single-drug therapy, and in combination with other medical preparations.

2 cl, 2 ex

FIELD: medicine.

SUBSTANCE: The invention relates to pharmacology, in particular, to medication for preventing or treating herpes labialis or herpes genitalis. The homeopathic medication or biologically active additive with anti-viral effect or preventing or treating herpes labialis or herpes genitalis contains: Nisylen, Cepa, Euphrasia, Belladonna and Mericulis Solubilis, furthermore, the components are present with a certain dilution and amount. The combination of the said components is used for production of homeopathic medication or biologically active additive with anti-viral effect or preventing or treating herpes labialis or herpes genitalis.

EFFECT: production of medication which effectively treats herpes labialis or herpes genitalis.

14 cl, 1 ex

FIELD: chemistry.

SUBSTANCE: invention relates to a method of producing concentrates of nanodispersions of zerovalent metals such as silver, gold, copper, palladium, platinum and mercury, which have antiseptic properties. Said method involves mixing a solution of a soluble metal salt in a solvent with ammonia to obtain a complex which is then mixed with alkalnolamine to form a solution. The obtained solution is mixed with a solution of a polymer stabiliser to obtain a stabilised metal cation which is then reduced by adding to the solution an organic or inorganic reducing agent to form a stable dispersion of metal nanoparticles. The disclosed method is realised at a defined ratio of components for 10-60 minutes in an air atmosphere at temperature of up to 100C.

EFFECT: invention is aimed at obtaining metal dispersions with high sedimentation and chemical resistance and high antiseptic power, which are compatible with a physiological NaCl solution; the method also cuts duration of synthesis and considerably simplifies the process, increases efficiency and complete conversion of cationic metal into a zerovalent metal.

38 cl, 3 tbl, 104 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to chelated mercury complexes with cysteine of formula C6H13O4N2S2HgCl or methionine of formula C10H21O4N2S2HgCl which show anticancer, antiviral, antiparasitic and immunomodulating action. The invention also concerns a method for preparing the complexes specified above which involves conducting a reaction of mercury dichloride and an aqueous solution of cysteine or methionine, keeping the mixture at temperature 35-40C for 60-90 min, cooling the reaction mixture to 18-20C and setting at this temperature for one day. The invention also refers to a drug preparation that is an apoptosis modulator of showing anticancer, antiviral, immunomodulating and antiparasitic action which contains the chelated mercury complex with cysteine or methionine 0.38-0.52 wt % and distilled water.

EFFECT: invention provides preparing the new chelated mercury complexes showing anticancer, antiviral, antiparasitic and immunomodulating action, and also the simplified method for preparing them at lower temperatures.

6 cl, 8 tbl, 8 ex

FIELD: medicine.

SUBSTANCE: for treatment of postimmobilization contractures, pharmacopuncture of homeopathic drugs Traumeel S and Zeel T is carried out at acupuncture points located around the affected joint, 0.2-0.3 ml of the drug per each point. Introduction of medications is alternated - Traumeel S is introduced during one session, and Zeel T - during the next one. The following points are used: for elbow contractures treatment - GI11, P5, TR10, IG8, for wrist contractures - C7, GI5, IG5, TR5, P7, for ankle contractures - V60, V62, E41, VB40, R6. After the pharmacopuncture session vibratory massafe is performed using "HIVAMAT-200". Exposure is performed with a manual applicator in the affected joint area by the labile method using the following exposure modes: 5 minutes - 190 Hz frequency, 50% intensity, pulse width/pause length ratio - 1:1, then 5 minutes - 50 Hz frequency, 50% intensity, pulse width/pause length ratio - 1:1. Then joint development is carried out by exercises performed in the water with the Dead Sea salt, 100 g salt per 1 liter of water at water temperature of 37-41C. At that, the corresponding distal part of the limb is immersed in a bath of saline, and passive and active movements are made with increasing amplitude, 5-15 repetitions of one type of exercise for 10-15 minutes before fatigue.

EFFECT: reduced time of treatment due to the possibility to provide the desired range of motion without expressed pain at the extremes of motion, elimination of damaged limbs muscle atrophy, full range of joint motion within a shorter time.

2 cl, 3 ex

FIELD: medicine.

SUBSTANCE: invention can be used as a preventive and therapeutic agent with anti-inflammatory and antibacterial properties, intended for external use, for treatment of all kinds of chronic dermatoses: dermatitis, neurodermatitis, furunculosis, eczema, fungal diseases, parasitic skin diseases, acne, and method for its production. The external agent for treatment of chronic dermatitis in the form of an aqueous suspension of mercuric monochloride is prepared by a process comprising premixing of powdered mercury monochloride with nitric acid at the following ratio of components, wt %: mercury monochloride 0.3-0.6; nitric acid 0.6-1.0, at a temperature of 70-90C, stirring for 1 hour. Then the obtained solution is mixed with water of high mineralization from the "Belaya Gorka" mineral source to 100 wt %. At that, the pH of the obtained suspension is adjusted to 1-2 with nitric acid.

EFFECT: increased efficiency of treatment.

2 cl, 7 ex

FIELD: pharmacology.

SUBSTANCE: method for production of sulfur-containing organomercury compounds of the formula RS-Hg-SR, where R is

,

or

,

or

,

respectively, by reacting an aqueous solution of mercuric diacetate with cysteine, or glutathione, or acetylcysteine, followed by isolation of the product obtained by filtration, washing with water and drying at a room temperature to the constant weight. The reaction is carried out at a molar ratio of mercury and cysteine or glutathione or acetylcysteine of 1:2, and the reaction mixture is kept at a room temperature for 45-90 minutes.

EFFECT: increased yield of the desired product with a significant simplification of its production method.

3 cl, 4 tbl, 3 ex

FIELD: medicine.

SUBSTANCE: at the first treatment session, a mixture containing 1 ml of diprospan suspension and 2 ml of a 2% lidocaine solution is injected into the tender points in the projection of the medial meniscus of knee joint which are determined by palpation. 3 ml of the mixture is divided into the identified tender points and injected into the points in equal amounts. After the mixture is injected, acupuncture is performed at points Rp 9, Rp 10, E 36 with steel needles for 20 minutes. At the second session, 2.2 ml of Traumeel C preparation is injected into the tender points in the projection of the medial meniscus of knee joint, which are divided in equal amounts into the number of detected tender points, and then this acupuncture is performed.

EFFECT: reduction of treatment time due to rapid relief of pain syndrome, inflammatory phenomena, improvement of trophism of tissues and normalization of blood circulation in the area of the affected limb and increase in functional activity in the affected joints.

5 cl, 2 ex

Up!