The method of treatment of inflammatory processes

 

(57) Abstract:

Usage: in medicine, refers to methods for treating various inflammatory processes. The inventive method of treatment is that in addition to NSAIDs or glucocorticoids, appoint antidiabetics - biguanides. This method of treatment can be applied in the treatment of various inflammatory diseases: radiculitis, myositis, myocarditis, polyarthritis, collagen.

The invention relates to medicine, namely to methods for treating various inflammatory processes.

In medical practice, the number of known methods of treatment of inflammation with non-steroidal anti-inflammatory drugs (Mashkovsky M. D. Medicines, 1987, I. 1, pp. 187-202, 566-577). The disadvantage of these treatments is often noted low efficacy or lack of efficacy in the treatment of inflammatory diseases.

The aim of the invention is to accelerate anti-inflammatory effect in the treatment of patients with inflammatory process.

The essence of the proposed technical solution is, h is ecogov appoint a biguanide - antidiabetics in the usual therapeutic doses approved by farmkomiteta. This allows to significantly accelerate and enhance the anti-inflammatory effect in the body compared to previously used drugs.

Anti-inflammatory effect from the first day from the start of the reception of patients, which has not previously been the effect of the drugs listed in the prototype.

The decision about the appropriateness of technical solutions have emerged based on the fact that anti-inflammatory drugs lose their effectiveness when insulin is compromised (which is very well demonstrated in decompensated diabetes mellitus type I, but restore its efficiency at full compensation of diabetes insulin).

It is therefore proposed for the treatment of inflammatory processes in the body combined application of previously known anti-inflammatory drugs (described in the prototype), and medications group of biguanides, improves insulin security, by neutralizing kontrinsuljarnye of Titel, improve the sensitivity of tissue cell receptors to insulin, reduce blood cholesterol, which reduces the phagocytic function of whether the Lin - the activator of the immune system.

Contraindications - correspond to those specified in the annotation, approved Farmkomiteta.

The combined effective use of drugs conducted in 20 patients with inflammatory processes in the body, when the prototype was not given effect.

Examples

Patient R., 48 years old, diagnosis: rheumatoid arthritis, worsening.

Sick 3 years. Recent exacerbation of 1 month. Pain and swelling interphalangeal and large joints of the extremities. The temperature of 37.6oC. Treatment within 2 weeks of prednisolone at a dose of 20 mg per day effect is not given. The concomitant use of prednisone 20 mg and glibutida 1 t 2 p/d steadily shone with pain and swelling of the joints. Temperature 36,6oC in the blood count erythrocyte sedimentation rate decreased from 50 to 23 mm/h, CRP++++.

2. Patient S., 35 years old, diagnosis: bronchial asthma, infectious-allergic. Chronic bronchitis, aggravation.

Sick 5 years. Deterioration 1 month - daily asthma with difficult access, cough. Use within 3 weeks of prednisolone 15 mg daily effect is not given. The concomitant use of prednisone 15 mg per day, Adelita 1 t 2 p/d off asthma attacks in 1 day. In the analysis of blood ESR reduced">

Sick 2 years. Exacerbation of the disease 1 month. Temperature - 38oC, epigastric pain shingles character daily. The use of indomethacin on 1 t 3 R/d within 5 days effect on gave. The combined use of indomethacin 1 t 3 p/d and glibutida 1 t 2 p/d for one night - shot of pain, temperature 36,6oC ESR in blood decreased from 35 to 20 mm/h

The proposed solution may have wide application in various inflammatory diseases, acute and chronic: radiculitis, myositis, myocarditis, polyarthritis, collagen and many others.

The method of treatment of inflammatory processes, including the use of nonsteroidal means or glucorticoids, characterized in that it further designate the biguanides.

 

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