A method of treating bronchial asthma

 

(57) Abstract:

Usage: medicine, pulmonology for the treatment of bronchial asthma. The inventive temporary electrical locking facility conducted by the vagus nerves by passing through them DC voltage 1-3, amperage 30-80 mA. The electrical locking facility is due implanted under the nerves of electrodes connected to the receiver, containing the constant current source. The receiving device is implanted in the subcutaneous tissue of the upper part of the chest. The electrical locking facility is activated remotely by radio frequency method using a transmission device, and the inclusion can be made both at the time of the attack, directly to patients, and prevention of attacks of bronchospasm is periodically and automatically in the interictal period. On the background of operation automatic mode electrolocation nerves and possibly an extraordinary inclusion, if necessary, electroplater yourself. To proactively prevent attacks by electromotively vagi transmitting device includes a programmable timer inclusions lock during the day. The time of day on which Astapov during the day in a particular patient. During electrical lockout allows for more accurate selection of the current mode using the appropriate authorities of the sending device to achieve the optimum effect in a particular patient. 1 Il.

The invention relates to medicine, namely to methods for treating bronchial asthma.

There is a method of treatment of bronchial asthma by the intersection of the vagi. This method is effective, but has a significant drawback: wandering nerves go fibers not only to light but also to most of the internal organs of the abdominal cavity, and therefore the intersection of nerves leads to serious consequences, and sometimes the death of the patient.

The closest entity is a method of treatment of bronchial asthma, which consists in the intersection of only those branches stray nerves that go to the roots of the lungs. However, this method has some significant drawbacks. For denervation of the root of the lung is required to produce the opening of the chest, and it is very traumatic than surgery stem vagotomy where nerves cross at the neck. In patients with bronchial asthma usually have chronic inflammatory lung disease and bronchogenic for life complications. In addition, denervation of the root of the lungs often gives only temporary effect due to the fact that over time, the innervation of the lungs is restored.

The goal of the invention: 1) the achievement of the lock conductivity vagi only temporarily, for a period of bronchospasm attack, 2) the achievement of stability, repeatability of the blocking effect, regardless of the time elapsed since the operation, 3) the possibility of preventive temporary locks conductivity of the vagi to prevent asthma attacks.

This is accomplished by the fact that blocking conduction in nerves is not by surgical crossing and electrically, for which under the nerves implanted two electrodes connected to a constant current source, which is included in the receiving device, implanted in the subcutaneous tissue of the upper part of the chest. The inclusion of the blocking voltage is remotely radio-frequency method using a transmission device. The enabling electrical lockout can be implemented either in the time of the kinks, and in the interictal period automatically with the preventive purpose. For this purpose, the transmitting of the mouth is moved such that so it preceded the development of seizures in an individual patient during the day. On background of electrical lockout nerves in automatic mode it is possible extraordinary inclusion blocker directly by patients if necessary.

The comparative analysis of patent literature selected prototype with the proposed method revealed that a common feature among them is to block conduction through the vagus nerves.

Revealed the following differences:

blocking nerve conduction electric method is carried out temporarily for the period of the attack. This eliminates harmful for the patient lock conductivity of the vagi in the interictal period, because wandering nerves are vital nerve fibers to most of the abdominal organs. In the prototype, the same and similar transection vagi leads to irreversible consequences, which further worsens the health condition of the patient;

e/lock to prevent attacks, periodically, in automatic mode, depending on the frequency of asthma attacks during the day and their duration in the patient;

after orcluseridattribute does not require disturbing the integrity of the vagi (electrodes implanted under the nerves) while in the prototype make the crossing fibers of the nerves surgically;

the electrical locking facility, regardless of the duration of time elapsed since the operation, effectively temporarily blocks the conductivity of the nerves. In the prototype because recovery innervation few months for possible resumption of attacks of breathlessness;

the invasiveness of the surgery to implant electrodes and the receiving device is smaller than a partial denervation of the roots of the lungs, as in the first case, open the chest with two sides, there is no need (electrodes implanted in the cervical part of the vagi).

The drawing shows a diagram of the method for the treatment of asthma: 1 light, 2 right vagus nerve, 3 left vagus nerve, 4 - blocking electrodes to the right the wandering nerve, 5 locking the electrodes to the left wandering nerve, 6 receiver 7 transmitting device.

The method is based on the well-known physiological phenomenon electrical lockout conductivity of the nerve by passing through it a constant electric current. The vagus nerve plays an important role in the implementation of bronchospasm. We offer the camping electrodes, two for each nerve. The distance between electrode contacts on each nerve about 0.3 see Locking the electrodes from each nerve is connected to the receiving device, which is implanted in the subcutaneous tissue of the upper part of the chest. During an attack of bronchospasm include transmitting device, which is remotely radiofrequency method comprises the constant current source contained in the receiving device. While wandering through the nerves starts to go direct electric current, causing the electrical locking facility conduction of nerve impulses, including pathological supporting spasm of the bronchioles. Bronchospasm docked. Settings current when the lock: voltage 1-3, the current 30-80 mA. After cupping attack transmitting device off. When this disappears, the current in the circuit vagi and conductivity of the nerves quickly resumes. To prevent attacks, the electrical locking facility can be performed in automatic mode, for which the transmitting device has a programmable timer inclusions of electrolocation during the day. If necessary, the patient may include electrical locking facility and independently on the background of the auto mode.

Example 1.

141,7; MOS2531,4; MOS5038,6; MOS7534,4 violation of function of external respiration by mixed type. A significant reduction of bronchial patency throughout. For therapeutic purposes the patient implanted pacemaker vagi, started blocking nerve current of 38 mA, 1 In, the duration of 2 minutes in accordance with the circadian rhythm of asthma attacks. After a month lacenet average was at least 30-40 minutes, after a month's course of electrolocation vagi 10-20 minutes. Decreased the dose of medication needed to treat: polcortolon 4 mg x 3 times aminophylline 0.15 g x 2 R. teofedrin cancelled, birotica began to use rare-no more than 0.2 mg per attack. The number of attacks per day has decreased from 9 to 3. The attacks were well stopped and electrolocation. Improved pneumotachometer: VC 71,2; FEV156,3; MOS2550,4; MOS5052,6; MOS7548,3 a moderate reduction of bronchial patency throughout. Viewed through the year after surgery. Duration of remission of the disease has increased not less than 3 times. The exacerbation of asthma was observed only in the winter due to exacerbation of chronic pneumonia. Inpatient treatment was not required. After a course bronchodilator antibiotic therapy was again achieved stable remission of the disease. The patient is in need of medical drugs remained the same as one month after initiation of treatment, i.e. significantly lower than before surgery. The number of attacks per day averaged 2-3. The attacks were easily stopped or electrolocation vagi, either by inhalation beroteka (0.2 mg). The show is/SUB> 57,7; MOS7551,4 a slight decrease in the permeability of the bronchi.

Example 2.

Patient I. 62 HP suffered from bronchial asthma for 7 years. Diagnosis: bronchial asthma mixed, moderate. Ischemic heart disease. The disease developed after trauma and is characterized by a progressive course. The frequency of asthma in remission of the disease was 4-5, and in the period of exacerbation of up to 8 per day. Took the following medications: aminophylline 0.3 x 3 R. teofedrin 0.5 x 3 R. salbutamol up to 3-4 inhalation on the attack (up to 160 mg). The survey results before surgery: pneumotonometry (from due.): VC 58,8; FEV140,8; MOS2539,9; MOS5043,3; MOS7535,7 violation of function of external respiration by mixed type, a significant reduction of bronchial patency throughout. Due to the prolonged exacerbation of the disease and the inability to achieve stable remission conservative methods have been implanted with electrolocation vagi. 2 weeks after the operation started electrical lockout current of 40 mA, 1.6 V, up to 2-3 minutes. Asthma effectively stopped. One month after such treatment, the attacks began to acquire significantly more Les is not more than two inhalations on the attack (up to 80 mg). Was achieved stable remission of the disease. The number of attacks per day has decreased from 8 to 4. Improved pneumotachometer: VC 67,8; FEV1< / BR>
54,6; MOS2540,2; MOS5046,4; MOS7553,3 - moderate reduction of bronchial patency. The patient was treated with electrolocation vagi. Her condition through the year: duration of remission of the disease has increased from 30-40 days 120-150. Bronchial asthma exacerbation was easily stopped by the rate of bronchodilator therapy (inhaled mucolytics are presented, injection of aminophylline) in the outpatient setting. The patient reported relief of flow and coronary heart disease: heart pain became less frequent. Of drugs one year after the start of treatment took only aminophylline 0.15 g at night and salbutamol one inhalation on the attack (40 mg). Indicators of pneumotachometer through the year: VC 72,0; FEV156,6; MOS25- 54,6; MOS5054,4; MOS7558,6 a slight decrease in the permeability of the bronchi all over. The number of attacks per day through the year not more than three.

Example 3.

Patient L., 51, suffered from bronchial asthma for 8 years. Diagnosis: bronchial asthma, atopic asthma, moderate. The patient was pronounced polyallelic operations received the following treatment: every year 2 session hemosorption ultraviolet irradiation of blood and plasmapheresis. Daily aminophylline 0.15 g x 3 times teofedrin 0.5 g x 3 times Estefan 0.25 g x 2 R. salbutamol 2-3 inhalations on the attack (up to 120 mg), intravenous injection of aminophylline 2,4% 10,0 with heavy attacks. The frequency of asthma in remission of the disease was 3-5, and at exacerbation-up to 9-11 per day. The survey results before surgery: pneumotonometry (from due. ): VC 69,8; FEV158,2; MOS2544,5; MOS5042,1; MOS7539,9 violation of respiratory function in obstructive type. A significant reduction of bronchial patency throughout. For therapeutic purposes the patient implanted with electrolocation vagi, started applying it for attacks. Applied mode: 45 mA, 1.8 V, 2 minutes. Asthma satisfactorily were stopped. In the postoperative period, the patient developed severe asthma smell of penicillin. Applied electrical locking facility vagi every 10 minute break 2 minutes lock for 40 minutes asthmatic condition cropped. Any other drugs were not used at that. After a month of starting treatment in patients electromotively vagi her condition has improved. H is for drugs: aminophylline 0.15 g x 2 R. teofedrin cancelled, asthafen 0.25 g, salbutamol no more than 1 inhalation on the attack (40 mg). Improved pneumotachometer: VC - 73,3, FEV162,4; MOS2556,6; MOS5062,4; MOS7551,1 a slight decrease in the permeability of the bronchi. Viewed through the year. The condition is satisfactory. Acute illness was not. The frequency of attacks is not more than 4 per day. Attacks stymied by electrolocation one or inhalation of salbutamol (40 mg). The demand for drugs significantly decreased compared to preoperative: aminophylline, teofedrin - cancelled, asthafen 0.25 was due To the fact that severe attacks was not not used intravenous aminophylline for edema. Indicators of pneumotachometer through the year: VC 72,3; FEV159,7; MOS25- 50,2; MOS5046,8; MOS7553,4 a slight decrease in the permeability of the bronchi. Asthmatic conditions in the course of the year was not.

Before introduction into the clinic method was developed in experiments on Guinea pigs. To simulate bronchial asthma animals were senzibilizirani horse serum, and then in conditions of acute experience in the development of experimental bronchoconstriction conducted electrical locking facility vagi. Tonawanda bronchospasm. These data are fully consistent with the General view of the fact that wandering nerves regulate the tone of bronchi.

The method of treatment of bronchial asthma, in which the lock conductivity vagi, characterized in that, in order to reduce the morbidity and negative side effects, and prevention of attacks and increase the reliability of their edema lock is carried out by electric, temporarily, by passing through the wandering nerves using implanted under these electrodes DC voltage 1 3 In force 30 80 mA, and the electrical locking facility is carried out as in the time of the attack and prophylactic periodically in an automatic mode, in interictal period.

 

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FIELD: medicine.

SUBSTANCE: method involves carrying out transcranial micro polarizations once a week during 4-6 weeks in 15-20 min long sessions with 80-200 mcA large current over 2 electrodes. Anode is applied to the boundary of posterior region of superior temporal convolution and inferior parietal zone of the left hemisphere. The electrode is applied in later sessions to the boundary of inferior frontal region and anterior regions of superior temporal convolution and to projection of motor area of the left hemisphere cortex. The cathode is applied to the inferior regions of the left occipital area. Logopedic lessons are combined with psychological training during and between the transcranial micro polarization sessions. The treatment course is repeated when needed not more than 2-3 times a year.

EFFECT: enhanced effectiveness of treatment.

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