The method of prevention and treatment of gastrointestinal diseases calves

 

(57) Abstract:

Usage: veterinary medicine. The essence of the invention: enhancing the prevention and treatment of gastrointestinal diseases of calves through use as drugs 30% aqueous sodium thiosulfate solution and 0.1 to 1.0% aqueous solution of phenol. While the introduction of these drugs takes place simultaneously, with 30% aqueous sodium thiosulfate solution injected intravenously at a dose of 50 - 100 mg/kg weight of the animal, and 0.1 to 1% aqueous solution of phenol injected intramuscularly at a dose of 2 to 4 mg per 1 kg of weight of the animal 1 times in 1 day. within 5 days after birth for prevention and to recovery - therapeutic purposes. table 1.

The invention relates to veterinary medicine, in particular to methods for the prevention and treatment of gastrointestinal diseases in calves caused by conditionally pathogenic microflora and dietary factors.

There is a method of treatment of gastrointestinal diseases of calves.with. The USSR 1639656, class A 61 K 31/00, publ. 07.04.91), which consists in the introduction sulfatethen" containing tetracycline, thiamine chloride, ascorbic acid, sulfadimezin, fodder yeast. The drug is administered orally in a dose of 0.5 to 0.7 the characters are revealed only after a 7-fold giving the drug. In addition, included in multi-component drug antibacterial agents (tetracycline and sulfadimezin) often do not show bactericidal activity against pathogenic microorganisms in the gastrointestinal tract of calves due to acquired resistance of microorganisms to the above antibiotic and sulfanilamide.

Also known is a method of treatment of gastrointestinal diseases of calves (see RF patent 2010566, class A 61 K 31/00, publ. 15.04.94), lies in the oral introduction of Forasol and advanced preparation containing sodium chloride, potassium chloride, calcium chloride, magnesium chloride, ascorbic acid, thiamine bromide and glucose. When this drug is administered in the form of a 2.5% aqueous solution in a dose of 0.8 to 1.2 l 2 3 times a day.

However, the effectiveness of this method is also negligible due to the fact that drugs furazolidone of a number of pathogenic and conditionally pathogenic microflora in most cases insensitive. Also included in this composition of glucose in the gastrointestinal tract is a good nutrient material for the microbes. In addition, the components for the manufacturing of the drug is practically inaccessible.

Closest to saleemah sodium (and.with. USSR N 1782598, class A 61 K 35/00, publ. 23.12.92) containing sodium hydrogen carbonate, biogenic stimulator from the distillation Firth mud. The drug is administered intramuscularly in a dose of 2 ml and 4 ml Method helped to reduce the mortality of newborn calves to 8 20% and the incidence of gastrointestinal diseases 15 40%

However, the effectiveness of the method, as described above, is low, because it involves intramuscular injection of small doses of 2-4 ml or an average of 20 to 40 mg per 1 kg of body weight. However, the imposition of intramuscularly solutions of sodium thiosulfate at a concentration of 25 to 35% in these same doses leads to significant local reactions and inflammatory processes. In addition, the use of minor components of the structure (distillation Firth mud) can lead to unpredictable results. The method is economically disadvantageous because the source material for the preparation of the drug (the lime mud) is not available in all regions of the Russian Federation.

The invention is directed to solving the problem of increasing the effectiveness of prevention and treatment of gastrointestinal diseases of calves.

The problem is solved by using as drugs 30% aqueous solution thiosulfate 30% aqueous sodium thiosulfate solution injected intravenously at a dose of 50 to 100 mg/kg weight of the animal, and 0.1 to 1% aqueous solution of phenol injected intramuscularly at a dose of 2 to 4 mg/kg weight of the animal 1 times in 1 day. within 5 days after birth for prevention and to recovery for therapeutic purposes.

In the well-known author of the sources of patent and scientific and technical information not described method of treatment and prevention of gastrointestinal diseases of calves, based on intravenous calves 1 to 5 days of age 30-percentage aqueous sodium thiosulfate in doses of 50 to 100 mg per 1 kg of live weight for therapeutic and preventive purposes, as well as simultaneous parenteral injection of an aqueous solution of phenol at a dose of 2 to 4 mg per 1 kg of live weight.

It is known the use of aqueous solutions of sodium thiosulfate in veterinary medicine as an anti-toxic and anti-inflammatory drugs intravenously and orally with the compounds of mercury poisoning, arsenic, lead and other heavy metal salts in a concentration of 25% at a dose of 75 to 100 ml per 1 injection.

As desensitization funds it is recommended intravenously and orally in allergic diseases, dermatitis, arthritis, ketonuria sheep, neuralgia, and also burns to reduce acidosis, prevention of further coagulation proteins, the Nera. M. Kolos, 1977, S. 399 400).

Known application of a 10% aqueous solution of sodium thiosulfate for the treatment of gastroenteritis piglets, which is administered intramuscularly at a dose of 180 to 200 mg per head (see U.S. Pat. RF N 2014833, class A 61 K 31/00, publ. 30.06.94). This drug helps to normalize the immune protection of newborn piglets.

However, the properties of 30% of the energy of aqueous solutions of sodium thiosulfate to stabilize the energy metabolism, the natural factors of nonspecific resistance of the body to normalize the functions of the endocrine system were not known to the researchers.

On the other hand, is known for use in veterinary aqueous solutions of phenol 0,1 0,5% concentration for canning molozivnyi serum (see B. N. urban, I. L. Naiman. Diseases of young animals in the cattle industry. M. Kolos, 1984, S. 187). It is known the use of a 5% solution of phenol as a preservative in the preparation for the treatment and prevention of colibacillosis piglets (see and.with. USSR N 1785692, class A 61 K 39/108, publ. 07.01.93).

However, the solutions of phenol 0.1 to 1% concentration as an antibacterial drug was not used.

Thus, the unknown intramuscular mogo solution of sodium thiosulfate, stimulating, in turn, the neuroendocrine system of the animal body and regulating the level of hormones and enzymes, allows to make a conclusion about the presence in the invention of the criterion of "Inventive step".

Sodium thiosulfate (sodium hyposulphite, Chernovetskiy sodium) is a colorless, transparent crystals odourless, salty-bitter taste, soluble in water (1:1), insoluble in alcohol. Comes in powder form and in the form of a 30% solution in ampoules of 5, 10 and 50 ml.

Phenol (carbolic acid, oxybenzone) is a colorless thin long needle crystals or colourless crystalline mass a distinctive smell. Soluble in water (1:20), easily soluble in alcohol, ether and fatty oils. Keep on list B in a well-corked banks (bottles) in a dark place.

The method is as follows.

As drug use 30% aqueous sodium thiosulfate solution and 0.1 to 1% aqueous solution of phenol. With 30% aqueous sodium thiosulfate solution injected intravenously at a dose of 50 to 100 mg/kg body weight of the animal and simultaneously injected intramuscularly with 0.1 to 1% solution of phenol is their preparations carried out for the first five days of life the calf, and in the treatment of gastrointestinal diseases, the introduction of drugs is carried out until recovery.

Experimental studies of the drugs was performed on calves profilaktornoe of age and older groups (1 to 6 months of age) in several districts of the Saratov region.

Example 1. Rationale doses of intravenous injections of phenol and radiation Toxicological action. Was conducted local and General reaction of the organism calves on the introduction of various doses of solutions of phenol.

With the introduction of 4 calves 5 to 7 days of age intramuscularly 0.1 to 1% solutions of phenol in doses greater than 4 mg/kg body weight was apparent toxic effect was observed local inflammatory response within 3 to 4 days with symptoms of swelling and pain at the injection site, there was a General depression of the body. Marked reaction took place without consequences, weight calves remained the same, the clinical signs of gastrointestinal diseases disappeared.

Introduction calves 5 to 7 days of age 0.1 to 1% solutions of phenol in doses less than 4 mg/kg body weight showed no toxic effect. The introduction of the drug in doses of less than 2 mg/kg of body weight had no considerable is at a concentration of less than 0.1% does not lead to effective prevention and treatment, and concentrations of more than 1% cause painful local reaction in the animal.

Example 2. Justification of methods, doses and frequency of intravenous injections of sodium thiosulfate and phenol.

In the experiment conducted on 4 calves 2 of 10 days old, it is shown that the optimal method for the introduction of a 30% aqueous sodium thiosulfate solution is intravenously because intramuscular and subcutaneous methods cause severe painful reaction.

To determine the effective doses of intravenous injections of sodium thiosulfate in the experiment was used 39 calves 2 to 10 days of age with syndromic diarrhea. Calves were divided into 13 groups of 3 calves in each group. Calves 12 experimental groups were administered the drug intravenously in increasing doses ranging from 10 mg per 1 kg of live weight in the 1st group and up to 200 mg/kg in 12-th group within 2 to 5 days. The calves of the control group was injected intravenously 10 ml of saline throughout the experiment.

For the calves were clinical and physiological observations: measured body temperature, counted the number of respiratory movements, heart rate, observed overall health, appetite, changes in the nervous system.

The results of the experiments showed, Thu who walked faster disappearance of clinical signs of disease, improved the General condition compared with calves that were administered the drug in doses of 10 to 40 mg/kg and from 110 to 200 mg/kg

The introduction of the drug in doses less than 50 mg/kg did not lead to a significant preventive and therapeutic efficacy, i.e. does not lead to solving the problem.

Higher doses of sodium thiosulfate solution cause tachycardia, weakness of the body, increased respiration, discoordination traffic passing within 1 2 h

Therefore, when establishing the boundaries of the optimal doses of sodium thiosulfate most acceptable were taken 50 to 100 mg per 1 kg of live weight.

The drug 1 time in 1 day. was chosen for economic reasons, because the number of injection drug more than once per day did not lead to significant results and has increased the overall consumption of the drug and increased time spent veterinary specialists.

Example 3. The rationale for therapeutic efficacy of the method.

The experience was used 64 calf 2 10 days of age with syndromic diarrhea.

The drugs were injected together 1 time in 1 day. 30% aqueous sodium thiosulfate solution at a dose of 50 to 100 mg/kg and 0.1 to 1% aqueous rastenij in the treatment of calves with clinical diarrhea by sharing drugs, by using only sodium thiosulfate solution and by using only the phenol solution.

The results of the study are presented in the table, from which it follows that the effectiveness of the treatment by the use of sodium thiosulfate solution without phenol solution 12.5% lower than in case of joint application of both drugs. Respectively below and the effectiveness of the treatment using only the solutions of phenol (18.8%).

Example 4. The rationale for prophylactic effectiveness of the method.

The method used on 104 calves 1 20 days of age in comparison with 104 control animals.

Newborn calves during the first five days of life 1 times in 1 day. injected intravenously with 50 to 100 mg/kg of 30% aqueous sodium thiosulfate solution and in parallel intramuscularly 0.1 to 1% solution of phenol in a dose of 2 to 4 mg/kg

The results of the experiment showed that in the control group ill Zhashkov stud farm 87 calves (83.6 percent), and experienced 32 calf (30,1%). Fell in the control group 14 goals (13,7%) experienced 4 head (3,8%).

Thus, the method can reduce the mortality of calves 3 times.

Thus, on the basis of experimental data it is possible to conclude that high routine 30% aqueous sodium thiosulfate solution as a treatment drug, reducing impaired immune systems, endocrine systems, normalizing the level of enzymes and hormones, neutralizing endo - and exotoxins bacteria in combination with directional bacteriostatic and bactericidal action nizkobonitetnyh solutions of phenol.

This therapeutic effect of the method occurs within a short period of time.

The method allows to increase the level of safety calves 2 to 3 times in comparison with the same indicators when using traditional methods of treatment and prevention of gastrointestinal diseases.

The method of prevention and treatment of gastrointestinal diseases of calves, which consists in the introduction of a medicinal product on the basis of sodium thiosulfate, characterized in that it additionally used as a drug of 0.1 to 1.0% aqueous solution of phenol, and medicine on the basis of sodium thiosulfate used in the form of a 30% aqueous solution, when the drugs administered simultaneously, with 30% aqueous sodium thiosulfate solution injected intravenously at a dose of 50 to 100 mg per 1 kg body weight of the animal, and of 0.1 to 1.0%aqueous solution of phenol injected intramuscularly at a dose of 2-4 mg per 1 kg of alive with curative intent.

 

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