A method of obtaining a water-soluble antiseptic polymer

 

(57) Abstract:

The invention relates to the synthesis of polymeric materials and can be used in medicine, veterinary medicine, food industry, etc. as an antiseptic and disinfectant. Water-soluble polymer with a stable antiseptic properties are obtained by copolymerization of 15-20 wt.h. N-vinylpyrrolidone and 30-45 wt.h. N,N-dimethyl-N,N-diallylammonium chloride under the action of radiation with a dose of 10-30 kGy in 35-55 wt.h. alcohol-water mixture with a volume ratio of alcohol and water as 1:1. table 2.

The invention relates to the synthesis of polymeric materials with antimicrobial properties, and can be used in medicine, veterinary medicine, food industry, etc. as antiseptic disinfectant.

A method of obtaining water-soluble cleansing of the polymer by copolymerization of N-vinylpyrrolidone with N,N-dimethyl-N,N-diallylammonium chloride in an organic, aqueous-organic or aqueous media [and.with. USSR N 1587056, CL 08 F 226/10, 1990]

The disadvantages of this method include the duration of the copolymerization process (onset 6 to 48 h), the need for real copolymerization initiator (AIBN) and its breakdown products limit the scope of the resulting copolymer. In addition to being obtained by this method, the copolymer has insufficient antiseptic properties.

The invention solves the problem of creating a more technologically advanced method of obtaining water-soluble polymer material with high antiseptic properties and finding copolymerization conditions.

The objective is achieved by obtaining a water-soluble antiseptic polymer by copolymerization of 15-20 wt.h. N-vinylpyrrolidone and 30-45 wt.h. N,N-dimethyl-N, N-diallylammonium chloride under the action of radiation with a dose of 10-30 kGy in 35-55 wt.h. alcohol-water mixture with a volume ratio of alcohol and water 1:1.

In the process of radiation synthesis under certain conditions (absorbed dose, solvent, concentration of monomers and their ratio) to obtain a stable water-soluble copolymer with a linear non-branched structure formed by strong covalent bonds.

As a medium for synthesis is suggested to use the alcohol-water mixture (with a volume ratio of alcohol and water as 1:1), which allows to obtain a homogeneous reaction mixture of monomers and inhibits the processes of structuring of the copolymer.

The lower boundary of oligonu are determined based on the preservation of the antiseptic properties of the copolymer and its water solubility, and the upper bound concentration of N,N-dimethyl-N,N-diallylammonium chloride and correspondingly lower limit of the concentration of N-vinylpyrrolidone are defined so that at relatively higher contents of N,N-dimethyl-N, N-diallylammonium chloride, and, consequently, a lower content of N-vinylpyrrolidone receive insoluble copolymer.

The lower bound concentration of the solvent is determined by the fact that at lower concentrations of solvent impossible to obtain a homogeneous reaction mixture of monomers due to insolubility N,N-dimethyl-N,N-diallylammonium chloride in N-vinyl pyrrolidone, which in turn leads to the production of homopolymers and the upper bound concentration of the solvent is determined by the adaptability and efficiency of the copolymerization process.

The lower boundary of the absorbed dose is determined by the output of the copolymer, and the upper limit is determined by the fact that at higher absorbed radiation dose get spatial-cross-linked copolymer.

The method is as follows: 30-45 wt.h. N,N-dimethyl-N,N-diallylammonium chloride dissolved in 35-55 wt. including a mixture of alcohol and water (density 0,897 g/cm3and add to the resulting solution was 15-20 wt.h. N-view g-radiation with a dose of 10-30 kGy on installing the MPX g -20 C Co60as the source. The copolymer is recovered from the reaction mixture and purified by presidenial in acetone.

Example 1. In the flask 350 ml prepare a solution of 135 g (45 wt.h.) N,N-dimethyl-N, N-diallylammonium chloride in 134 ml (40 wt.h.) a mixture of alcohol and water (density 0,897 g/cm3and after complete dissolution of the monomer added to the resulting solution was 41 ml (15 wt.h.) N-vinylpyrrolidone (density 1,0847 g/cm3). After mixing, the solution is filtered, poured into ampoules, vacuum and sealed. Then the ampoule is subjected to at 20-25oC the effect of g-radiation for 2.0 hours to achieve the absorbed dose of 10 kGy. As the radiation source use the installation MPX - g -20 C Co60the dose rate of 5 kGy/h Copolymer is recovered from the reaction mixture and purified by presidenial in acetone. After drying obtain 126 g of water-soluble target product (70.0% of theoretical) in the form of small granular granulate white.

The absence of homopolymers of N,N-dimethyl-N,N-diallylammonium chloride and N-vinylpyrrolidone in the resulting product copolymerization prove the Sol-gel and differential thermal analyses. The structure of the copolymer prove the results of elemental analysis and IR spectroscopy.

Pimkie test 1% solution of the copolymer are shown in table.2.

From table.2 it follows that the copolymer obtained by the proposed method, has a high bactericidal properties (within days observed 100% mortality of the microorganisms Staphylococcus and group of bacteria Escherichia coli, which is in solution in the pathological concentrations). Using the proposed method allows to obtain a water-soluble copolymer and detergent-disinfectants based on it with stable properties and a long shelf life, do not have negative impacts on humans and animals into force of the macromolecular structure of the resulting substance. Radiation technology for producing copolymer determines the particular product purity, the absence of impurities and sterility without additional special handling. In addition, because the proposed method of obtaining the target product is carried out in one stage from the initial low molecular weight reagents and under the influence of g-radiation, the total time the final product is reduced to 2-4 hours against onset 6 to 48 h of the prototype.

A method of obtaining a water-soluble antiseptic polymer by copolymerization of N-vinylpyrrolidone with N,N-dimethyl-N,N-diallylammonium and 30 to 45 wt.h. N,N-dimethyl-N,N-diallylammonium chloride under the action of gamma-radiation with a dose of 10 to 30 kGy 35 to 55 wt.h. spirtovodnogo mixture with a volume ratio of alcohol and water 1 1.

 

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