The method of treatment of mastitis

 

(57) Abstract:

The invention relates to medicine and can be used in the treatment of diffuse extrasensitive mastitis. Effect: the elimination of the side effects of the drug and reduce the period of treatment of mastitis. The essence of the invention: method for the treatment of mastitis, including the introduction of tamoxifen, tamoxifen is administered in the amount of 0.5 to 3.0 wt.% in someway the basis of similar water-lipid balance to sebum, is applied directly on the mammary gland and is subjected to the action of low-frequency magnetic induction with an amplitude value of 1.5 - 0.5 MT at the geometric center of the solenoid intermittent two inductors within 10-20 min, and the procedure is repeated 4-8 times every night. The proposed method for the treatment of mastitis promotes rapid stabilization process (5-7 days versus 84), eliminates surgery and side effects of the drug on the body.

The invention relates to medicine and can be used in the treatment of diffuse estrogensensitive mastitis.

There is a method of topical treatment of lesions, including the application of the ointment on the affected area, and then layer LECHEBNO CLASS="ptx2">

There is a method of treatment of limited scleroderma breast cancer, including the introduction of tamoxifen oral within 1-3 months 10 mg twice a day. The disadvantage of this method is the duration of treatment and the presence of side effects on the body.

There is a method of treatment of mastitis using tamoxifen orally for 12 weeks 10-20 mg per day.

The disadvantage of this method is the duration of treatment and the occurrence of side effects, developing almost 10-20% of patients (impaired blood pressure, sugar and platelets in the blood, nausea, vomiting, and others).

The main aim of the invention is to eliminate the side effects of the drug and reduce the period of treatment of mastitis.

This objective is achieved in that in the method of treatment of mastitis, including the introduction of tamoxifen, tamoxifen in the amount of 0.5-3.0 mass. enter in the ointment base, similar water-lipid balance to sebum, is applied directly on the mammary gland and is subjected to the action of low-frequency magnetic induction amplitude value 1,50,5 MT in the geometric center of the solenoid intermittent two inductors within 10-20 min, and the procedure Powai tamoxifen blocker oestrogens receptors eliminating the effect of female sex hormones and inhibits the growth of breast cells. With the introduction of tamoxifen oral only a small part of it gets into the mammary gland, whereas most of it is broken down in the gastrointestinal tract and excreted from the body. The increase in dose leads to adverse changes in the body: changes in blood pressure, blood sugar, platelets, etc.

The method of introduction of the drug tamoxifen in ointment form directly through the skin into the tissue of the breast. Local injection of tamoxifen gives the ability to block oestrogens receptors directly in the tissue of the gland without side effects on the entire body.

It is known that as the basis for ointments plays a crucial role in the uptake of the drug and its action on the skin. Rubbing therapeutic agents using ointments it penetrates deep into the tissue through the pores and intercellular space. Water-soluble substances basics ointment dissolved in aqueous solutions, tissue, and fat-soluble, respectively, in tissue fat of the skin, constituting 1/3 of the water-lipid balance of the skin. The proposed materials, which entered tamoxifen, a copy of the part of cognasso vegetable 15-17% emulsifier 7-9 wt. lanolin 2-4 wt. beeswax 1-3 wt. glycerin 2-4 wt. borax 0.2-0.4 wt. benzyl alcohol 0.5. ethyl alcohol of 0.5-2.0 wt. tamoxifen 0.5 to 3.0 mass. perfume 0.3 to 0.5% purified water rest.

In the treatment of mastitis is offered in conjunction with topical treatment to use magnetic therapy effects of low-frequency magnetic field. Low-frequency magnetotherapy is manifested in anti-inflammatory and analgesic actions. Low-frequency magnetic field enhances inhibitory processes in the Central nervous system and improves the General condition, sleep. It is not accompanied by the formation of endogenous heat and temperature rise in tissues, is not irritating to the skin, easily passes through the skin and tissue, improves circulation and accelerates the diffusion of Masi cloth.

For therapeutic effects of the magnetic field in physical therapy offices use the Device for low-frequency magnetotherapy portable" "pole-101" (passport pelvis.293.061 PS with Instructions on its use, approved 1.06.84 year).

The unit operates on AC current with frequency of 50 Hz and voltage 220 10% of the Device consists of an electronic unit and two inductors 1 and 2, representing srchastt current power inductor 1 is 1000100 Hz, and frequency of the current supplied to the inductor 2 700100 Hz. The device provides continuous and discontinuous modes of operation of one inductor and intermittent operation of the two inductors. In intermittent mode, the duration of the parcel is equal to 1,50,3 with, the duration of a pause 1,50,3 C. Regulation of the magnetic induction is carried out in four stages. Magnetic induction (peak value) on the 4-th stage is 1,50,3 MT at the geometric center of the solenoid.

The influence of the magnetic field over time, a smaller lower limit,

ineffective, and over time more than 20 minutes too, because the process of penetration of the drug into the tissue is completed.

Part of antimuscarinic ointment is tamoxifen in the amount of 0.5-3.0 mass. The introduction of tamoxifen in the amount of < 0,5, ineffective, and more than 3 wt. the cost of the product without significant effect.

Treatment with magnetic therapy with antimuscarinic ointment includes 4 to 8 treatments at intervals through the day. Courses with less than 4 procedures, provide incomplete therapeutic action, and the course of treatment, including more than 8 procedures, does not increase the effectiveness of the treatment.

The method is as follows.

Les is Gnanou induction, mode, the time of treatment, the concentration of ointment. The physiotherapist palpation causes the skin of the breast evenly, and the injured area with the most concentrated layer antimuscarinic ointment "Marmaton and latching solenoids puts the mammary gland in the center of the solenoids 1 and 2 of the "pole-101", working in discontinuous mode. Magnetic induction (peak value) at the 4th level is 1.5 to 0.3 MT. The duration of the treatment 10-20 min, treatment 4-8 sessions every day.

The proposed method for the treatment of mastitis promotes rapid stabilization process (5-7 days versus 84), eliminates surgery and side effects of the drug on the body.

Example 1. The test antimuscarinic ointment "Marmaton" with a content of 1 wt. tamoxifen was conducted on 129 patients estrogensensitive diffuse mastopathy. All patients were expressed signs of activity of the pathological process: pain in the breast, coarse-grained structure of the gland, tenderness to palpation. After the course of magnetotherapy with antimuscarinic ointment in 116 patients (90%) showed a positive therapeutic effect: no pain in the breast, the breast structure gel mastopathy treatment had no effect (preserved signs of an active process). Side effects were not identified.

Example 2. Patient P. 33 years, there is about diffuse fibroadenomatosis right breast since may 1991, he Conducted a course of treatment using iodotope potassium, aevit, 17-PCR. The effect of the treatment is negligible. In September 1992, conducted a sectoral resection concerning localized fibroadenomatosis right breast. In January 1993, he turned again with complaints of pain in the right breast. Clinically there were signs of fibrous mastopathy. Conducted 5-day course of magnetotherapy with 1% antimuscarinic ointment "Marmaton" within 15 minutes of action of low-frequency magnetic induction amplitude value 1,50,5 MT in the geometric center of the solenoid in the intermittent mode of operation of the two inductors. After 11 months conducted visual inspection: no complaints, the structure of the breast is normal.

Example 3. Patient S. 37 years, there is about a bilateral fibrous mastopathy with 09.90 was Periodically treated using iodotope potassium, aevit, 17-PCR. The effect of treatment unstable. IN IX.91 were lumpectomy about localized fibroadenomatosis both Breasts. 01.93, addressed gelobet palpation. A course of magnetic therapy with 2% antimuscarinic ointment "Marmaton" within a 20 - minute action of low-frequency magnetic induction amplitude value 1,50,5 MT in the geometric center of the solenoid in the intermittent mode of operation of the two inductors. Conducted 6 treatments. XII.93 was held in check. No complaints. The structure of the mammary gland normal.

The method of treatment of mastitis, including the introduction of tamoxifen, wherein tamoxifen in the amount of 0.5 to 3.0 wt. enter in the ointment base, similar water-lipid balance to sebum, is applied directly on the mammary gland and is subjected to the action of low-frequency magnetic induction amplitude value (1,5 0,5) MT at the geometric center of the solenoid intermittent two inductors within 10 to 20 min, and the procedure is repeated 4 to 8 times every night.

 

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FIELD: medicine, anesthesiology, resuscitation.

SUBSTANCE: one should perform puncturing of epidural space at Th12-L1 level. Through the lumen of puncture needle one should introduce catheter to move it cranially at the depth of 3 cm. After that one should inject 10 ml 05%-marcaine solution to perform repeated injections per 5.0 ml every 4 h during 1-8 d. The effect is achieved due to unloading minor cycle of circulation.

EFFECT: higher efficiency of therapy.

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