A method of obtaining a substance that prevents nocturnal diuresis in young animals

 

(57) Abstract:

Usage: the invention relates to the field of veterinary medicine, in particular to a method of obtaining the substance of prolonged action, preventing nocturnal diuresis in young animals. The essence of the invention lies in the fact that the use of atropine sulphate in tablet form, and before the introduction of tablet matrix 1 wt.h. atropine sulphate is mixed with 2-3 wt.h. hyaluronic acid and the mixture is dissolved in 10-20 wt.h. water, acidified to pH 3.0 to 4.0, with 80-100oC for 20-30 min, then the solution is cooled at 4-6oC for 2-4 h, add 3-4 volume of ethanol and the resulting precipitate is dried, as a filler to obtain tablets use lactose. table 1.

The invention relates to the field of veterinary medicine, particularly to a method of obtaining the substance of prolonged action, preventing nocturnal diuresis in young animals.

It is known that puppies, kittens and other Pets during the first year of life emit per night urine up to 5-7 times.

There are various technical solutions aimed at creating drugs that prevent nocturnal diuresis young home is Oia.

Closest to the claimed adopted for the prototype, is the composition in the form of tablets against bedwetting in young animals [5] containing as the active ingredient antimuskarinovoe act occurs substances, mainly sulphate of atropine in doses of 0.1-1.2 mg per tablet with a total weight of 0.3 g

The disadvantages of this drug lies in its multi-component nature (including, in addition to atropine sulphate, dried liver, glucose, yeast and cellulose), low efficiency (urine in animals for the night there 3-4 times), and its toxicity, expressed in dilated pupils, accommodation disorder, sleepiness, etc., due to individual sensitivity to atropine, present in the drug in free form [6]

The invention solves the problem of achieving prolonged effect of preventing nocturnal diuresis in young animals without any side effects.

This result is achieved in that in the method of obtaining a substance that prevents nocturnal diuresis in young animals, including the use of atropine sulphate in the form of tablets, before introduction into the tablet matrix 1 wt.h. with the pH 3,0-4,0, at 80-100oC for 20-30 min, then the solution is cooled at 4-6oC for 2-4 h, add 3-4 volume of ethanol and the resulting precipitate is dried, as a filler to obtain tablets use lactose.

The inventive method has the advantage over known in part to the fact that the use as an active ingredient proprietary atropine and its compounds with high molecular polysaccharide hyaluronic acid (GUK) can significantly improve the effectiveness of this alkaloid (urination in young animals for 8-10 hours a night time not noted), with the resulting substance is effective in lower doses (0.03 to 0.05 mg pills instead of 0.1-1.2 mg) and does not occur in animals inherent in the free atropine toxicity or side effects.

It is important to emphasize that upon receipt of the substances according to the claimed method, atropine fully associated with the molecule GUK, as evidenced by the negative reaction to this alkaloid, and its release from the matrix occurs gradually over a long period of time (8-10 hours) in the gradual hydrolytic cleavage of the links between atropine and HUK under deystvitelnoe acid dissolved in 10 ml of water, acidified with 0.1 G. of HCl to pH 3.0, when heated at 80oC for 20 min, the solution is cooled at 4oC for 2 h, then diluted with water pH 3.0 to the original volume (10 ml), add 30 ml (3 volume) of ethanol, the precipitate is separated by filtration through a filter paper, dried at 40oC in vacuum and get 3 g (yield 100%) of powder contains 1 g of atropine sulfate, every 0.09 mg which is mixed with 299,1 mg of lactose and subjected to direct compression. Get 33333 tablets (atropine sulphate per tablet 0.03 mg), feeding them on one piece of young puppies or kittens prevents urination for 8-10 hrs of the night time without side effects.

Example 2. A mixture of 1 g of atropine sulfate and 2.5 g of hyaluronic acid are dissolved in 15 ml of water, acidified with 0.1 G. of HCl to pH 3.5, at 90oC for 25 min, the solution is cooled at 5oC 3 h, adjusted to 15 ml water, pH 3.5, add to 52.5 ml of ethanol (3.5 volume), the precipitate was separated by filtration, dried at 40oC in vacuum and obtain 3.5 g (yield 100%) of powder contains 1 g of atropine sulfate, 0.14 mg every which mixed with 299,86 mg of lactose and subjected to direct compression. Get 25000 tablets (atropine sulfate in tablets is about time without side effects.

Example 3. A mixture of 1 g of atropine sulfate and 3 g of hyaluronic acid was dissolved in 20 ml of water, acidified with 0.1 G. of HCl to pH of 4.0 at 100oC for 30 min, the solution is cooled at a 6oC 4 h, adjusted to 20 ml water, pH to 4.0, add 80 ml of ethyl alcohol (4 volume), the precipitate was separated by filtration, dried at 40oC in vacuum and get 4 g (yield 100%) of powder contains 1 g of atropine sulfate, every 0.2 mg which is mixed with 299,8 mg of lactose and get 20000 tablets by direct pressing (the content of atropine sulfate per tablet 0.05 mg), feeding them one tablet of young animals prevents urination for 8-10 hrs of the night time without side effects.

Comparative analysis of technical and economic performance of the proposed method and the known method presented in the table.

Thus, the proposed method allows to obtain a substance that prevents nocturnal diuresis in young animals 3.3-3.4 times smaller doses than by a known method, and does not cause toxic or side effects.

As filler lactose has the advantages over starch and dextrins that, first, it has a more pleasant taste and, secondly, it outsa (not worse) during processing and storage.

The sources of information.

1. U.S. patent N 2594296, 1952.

2. U.S. patent N 3062720, 1962.

3. U.S. patent N 3063901, 1962.

4. U.S. patent N 3923990, 1975.

5. U.S. patent N 5075312, 1991 (prototype).

6. Mashkovsky M. D. Medicines. M. Medicine, 1984, T. 1, 233.0 sec.

A method of obtaining a substance that prevents nocturnal diuresis in young animals, including the mixing of sulphate of atropine with filler followed by manufacture of tablets, characterized in that before the introduction of tabletow matrix 1 wt.h. atropine sulphate is mixed with 2 to 3 wt.h. hyaluronic acid and the mixture is dissolved in 10 to 20 wt.h. water, acidified to pH 3 to 4, when 80 100oC for 20 to 30 minutes, after which the solution is cooled to 4, 6oC for 2 to 4 hours, add 3 to 4 volumes of ethanol and the resulting precipitate is dried, and the filler used lactose.

 

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