Syringe pen for large doses

 

(57) Abstract:

The syringe in the form of a handle for repetitive input individually set doses of medicine from the reservoir in the form of a cylindrical ampoule contains the element 10, 14, to set doses, which can be rotated to cause the rotary displacement of the metering element and a combined rotary and axial movement of the indicator element indicating the set dose, and item 22 of the actuator piston, which when rotated in one direction moves the piston inside a cylindrical ampoule. Between the metering element and the element 22 of the actuator piston is made one-way clutch, which is carried out using installed on these disks having a surface with a sawtooth teeth in the form of sectors, moving over each other, when the metering element is rotated in the direction of installation of the dose, and mating with each other when the metering element is rotated in the opposite direction corresponding to the direction of rotation, through which the piston moves inward of the cylindrical ampoule. Connection screw-nut 9, and 10 were made between the body of the syringe and the element 10, 14 to install doses, and predusmotrennoi by diversion of clutch plates from each other. 5 C.p. f-crystals, 7 Il.

The invention relates to a syringe in the form of a handle for repetitive input individually set doses of medicine from the reservoir into the syringe.

Such syringes-pen features are diabetes patients who must often enter a drug insulin to maintain blood glucose within acceptable limits.

With the advent of insulin preparations with delayed action, and mixed drugs that allow you to enter a drug that meets the urgent need for insulin, and medication, covering basic needs for a long time, the time interval between injections was increased, and therefore increased the dose injected at each injection.

Dose is mainly set by turning one part of the syringe handle relative to another portion of the syringe, and the numbers that make up the scale along the edge of one of the rotatable parts of the syringe is moved relative to the index mark on the other side of the syringe, to show the set dose. Thus, the dose is limited only by the fact that along the edge of the rotatable part can accommodate only a limited number of numbers, if at all possible the turn of her, thus instead of a circle, the number characterizing the dose can be positioned along a helical line, and you can also rotate, scale covering more than one turn.

Syringe pen should be made simple as possible to use, i.e. normal operations when used, must only be setting the dose and the input of the prescribed dose, and both of these operations must be simple in execution, and this condition meets the majority of the syringe-pens. However, not all syringes-stick represent the cancellation of the prescribed dose, so if there is a situation when you don't want to enter the set dose, the only way to return the syringe back into its original position to pour the dose. For syringes, which can be installed in large doses, this is unacceptable.

In a known type of syringe scale is made along a helical line having only one turn. The rod in the body of the syringe is in contact with a spiral groove on the surface of the cylinder element for installation doses so that when rotating the element to set doses axially shifted along its axis. Then, as it is axially displaced when setting the dose, the element to set the gate element for installation doses, when he pressed in the axial direction until it stops, and the rotation occurs in the direction opposite to the direction of rotation for setting the dose. The rotation of the element to set dose is transmitted to the mechanism of the screw-nut, causing the piston in the syringe to move forward by an amount proportional to the magnitude of the rotation.

The ends of the single-turn spiral grooves are connected by the axial groove. This gives you the opportunity to push an item to install doses in the axial direction of the back, making this element of the rotational motion in the case, if the angular position of the element such that the rod on the body of the syringe is in contact with the axial groove, and not spiral part of the groove. Thus, it is possible to cancel the set dose by further rotation of the element to set doses up until the rod does not come in contact with the axial groove. However, this cancellation option restricts the actual rotation for setting the dose of the element to set doses of a slightly smaller one turn, and, in addition, because the requirements are exactly the size of the input dose limit dosing amount per one rotation mechanism, the screw-nut, the magnitude of the dose, which can be installed in much the Ritz-stick, with the help of which you could set large doses, you can cancel the preset dose and the possibility of cancellation dose not affect the possible size of the set dose or the simplicity of normal use of the syringe.

This is achieved with a syringe in the form of a handle for repetitive input individually set doses of medicine from the reservoir in the form of a cylindrical ampoule and syringe contains the element to set doses, which can be rotated to cause the rotary displacement of the metering element and a combined rotary and axial movement of the indicator element indicating the set dose, the drive element of the piston by turning it in one direction moves the piston inside a cylindrical ampoule, unidirectional (perseverence) engages between the metering element and the drive element of the piston, and this engagement is made so, the rotation of the metering element for setting the dose is not transmitted to the drive piston, and the rotation in the opposite direction is transmitted, and the syringe is characterized by the fact that between the body of the syringe and the element to set doses made the connection type of the screw-nut, and the fact that means are provided on the Sabbath.">

Due to the mutual contact of the threaded surfaces of the connection screw-nut provides a more sustainable direction element for installation doses than the rod in contact with the groove. Since the cancellation mechanism is not based on axial groove as a guide return, then you can rotate the element to set doses for dispensing more than one turn, and thus can be set higher dose than that which can be obtained by rotation of the drive piston in one turn. A cancellation mechanism made in the form of gearing, which allows you to disconnect the metering element from the actuator piston, so that you can rotate the element to set doses and dosing item back, not transmitting rotation to the drive piston.

The threaded connection of the screw-nut of the metering element and the housing may have an angle of inclination greater than the angle of friction of the nut and screw. Thus the rotation of the element to set doses for dosing can be performed by simply pressing this element in the axial direction, thereby the screw will automatically carry out the screw offset relative to the nut and to provide a rotary displacement element for installation doses in the direction of dotirovana dosing element is limited by the head, which supports push button, and the button and head are mutually mating surfaces made of materials having a lower friction angle compared to the angle of friction of the screws and nuts.

In accordance with the exemplary embodiment of the invention the element to set doses can be a lead screw with an external thread, the metering element may be tubular and put on the screw and lead screw may have axial grooves which are appropriate axial transverse projections made on the inner side of the openings of the metering element. Thereby is provided a dosing element, which should only rotatable, but not axial movement of the element to set doses.

Unidirectional (non-reversing) the engagement between the metering element and the actuator piston can be provided with parts of the mesh with a circular surface, made with sector teeth with steeply and inclined lateral sides, and a circular surface under the action of the spring pressed toward each other so that the sloping side of a tooth on one surface in contact with the inclined side of the tooth on the other side. When an item is scored by the parties to each other, thus, the metering element is displaced in the axial direction against the force of the spring and bounce back every time, when there is a steeply side of the tooth. The user can hear and feel every bounce and step gearing may be selected so that the rebound occurs whenever the value of the set dose is increased by a given unit of dose adjustment.

Locking mechanism can be performed in a syringe having a tubular base element, the tubular element covering basic element coaxially him and with the possibility of axial displacement with respect to it against the force of the spring, forcing the tubular element to occupy a fixed position on the base element, and a lifting fork detail, mounted on a tubular member and a member in contact with an outer annular ledge on the dosing element to raise the associated part of the clutch to its disengaged from the part of the gearing associated with the actuator piston, when the tubular element is displaced in the axial direction on the base element against the force of the spring from its fixed position.

In Fig. 1 shows the syringe in the form of a handle according to izopet the Appendix); in Fig. 3 a cross section on line III-III according to Fig. 2; Fig. 4 is a side view in pen syringe according to Fig. 1, is divided into a part that contains a dispensing mechanism, the holder of the container and cap of Fig. 5, the syringe according to Fig. 4,in Assembly of Fig. 6 a side view of the syringe with the removed cap and a part containing the dispensing mechanism, and the holder of the cartridge is allocated from each other to make possible the abolition of the prescribed dose; Fig. 7 drives the gearing used in unidirectional mesh (shown schematically).

Syringe pen (Fig. 1-6) is assembled on a tubular base element 1 having at one end portion 42 with a larger diameter, and this part at the expense of the annular protrusion is divided into two sections the first section, made with thread that can nevinovate holder 2 of the container, and the second site on which there is mounted a tubular element 8. The holder 2 of the container is a tubular element intended to ensure that it was installed canister, and having on its side walls passing axially window through which you can monitor the contents of the canister. Along one of the Windows provided in the deep portion 4 of the side wall of Sulina. At its remote end of the holder 2 of the spray is invisible protrusions protruding inward from the wall of the holder of the cartridge to hold the cartridge in the holder, and cooperating with the cylinder 5 on the neck of the canister. This perceiving the spray head 5 is from the end of the holder 2 of the container and has an external thread onto which is screwed a sleeve 6 with the needle to secure the cartridge in the holder 2. When the syringe is not in use, the holder 2 of the cartridge may be worn tubular protective cap 3.

The tubular element 8 is attached by its end to the second area portion 42 with a larger diameter at one end of the base element 1 and rests with its edge on the annular ledge 7. The other end of the tubular element 8 has a reduced diameter and fits over the base element 1 and has on its outer end portion 9 with a diameter, which is even less, and this part 9 internal thread which engages with an external thread of the tubular lead screw 10.

Spring 11 rests with one end on an annular internal ledge 12 in the hole of the base element 1 and pressed the other end to the sleeve 41, a pressure-transmitting group raises villabona at some distance from each other along the perimeter of the element 8, and transmit the pressure element 8, while holding its edge in contact with the protrusion 7 on the base element 1. Through the slots 43 in the wall of the tubular base element 1 lifting fork parts 13 extend into the hole of the base element and can be displaced in the axial direction in these slits.

Lead screw 10 at its end extending over part 9 attached to the head 14 to install doses and can be rotated with the rotation of the head 14. When turning in one direction lead screw 10 and, therefore, the head 14 is displaced in the axial direction relative to the tubular element 8.

The indicator sleeve 15 is attached to the head 14 and forms a casing associated with the cylinder 14 and is placed in the cavity between the element 8 and the tubular housing 16 mounted on the side of the element 8 having a larger diameter. The window in the tubular housing 16 is equipped with a magnifying glass 17, through which you can observe the sleeve 15 along a helical line, when it rotates and simultaneously moves along the axis with the cylinder 14. Number characterizing the set dose, plotted along the helix, so that through a magnifying glass 17 was visible the actual dose.

The rotation of the lead screw 10 pesu lead screw 10, with one or more passing in the axial direction of the grooves of the thread are held in the axial direction transverse protrusions 19, made from the inner side of the metering element 18. Thus rotary motion is transmitted, and the axial offset no.

At its end opposite the head 14, the metering element 18 has a part 20 of the unidirectional engagement with which the element 18 is connected with the actuator piston, which is part 21 of the gearing and the drive nut 22 having an internal thread, which engages with the external thread on the piston rod 23, which in its allotted position is placed in the hole of the tubular lead screw 10 and which is designed so that it cannot be rotated relative to the base element 1 through the locking projections 24, installed without a possibility of rotation relative to the base element 1 and is fixed in axial slots in the threaded part of the piston rod 23.

Unidirectional engagement is provided a metering element 18 and nut 22 of the actuator piston having a correspondingly shaped mating parts 20 and 21, on the surface of which, facing each other, made the teeth, each of which is schematically shown in Fig. 7. The toothed surfaces are pressed together by the spring 25, the compressed between the wall 26 on the upper end of the tubular element 8 and the outer flange 27, is made at one end of the sleeve 28, having at the other end an internal flange 29 resting on the upper edge of the metering element. When the metering element is rotated in the direction in which the head come unscrewed outward sloping sides of the teeth slide over each other, shifting mating elements from each other against the force of the spring 25 until, until it reaches the steeply side, and one part of the clutch is shifted back until it stops under the action of the spring to start a new slide along the inclined sides. This breakthrough prevents transmission of the rotation of the nut 22 of the actuator piston when the cylinder is turned in the direction of installation of the dose, but the transfer of rotation occurs when the head is turned in the opposite direction as steeply hand on the parts of the gearing in this case will be in contact with each other. The rotation can be performed by pressing the head in the axial direction until it stops, and thread on the carriage bolt has a step to convert the axial pressure in turn. To abinaya the surface of the button rests on the top surface of the head, and the mating surfaces are made of materials that provide a slight friction.

The rotation is transmitted to the portion 21 of the actuator piston participating in the engagement, and, consequently, to the nut 22 of the actuator piston. When the nut 22 is rotated due to the transmitted rotation, it will cause the non-rotating piston rod 23 in the movement in the axial direction of the cylindrical ampoule 31, and through the base 32 of the piston, the piston rod will push the piston 33 in the cylindrical ampoule 31.

Part 21 of the actuator piston, participating in engagement at its periphery has elastic teeth 34, which communicate with the internal teeth 35 in the tubular element 36, rigidly mounted in the base element 1, in order to ensure fixation, allowing rotation of the nut 22 of the drive piston in the direction of injection, but prevents rotation of the nut 22 in the opposite direction.

The piston rod 23 is made non-rotating due to the fact that he has an axial groove, which includes locking tabs 24, performed on the element 37 of the fixing of the piston rod. This element of the upper edge of the cylindrical ampoule 31 is pressed against the end of the basic element 1, and the clamp is against the efforts progenie cylindrical ampoule 31, removed by unscrewing the cap 3 from the base member 1, the spring 38 will hold the element 37 fixing the piston rod regardless of the base element 1, and then the piston rod can be rotated, because the locking element 37 may now be rotated together with him. Thereby, the piston rod can be screwed back into its allotted position through the nut 22 of the actuator piston. When the holder of the cartridge with the new vial is screwed on the base element 1, the locking element 37 is pressed back to the base element, in contact with which the rotation is impossible, and the ability to rotate the piston rod is again excluded.

From the above steps, it is seen that the dose can be set by turning the head 14 in the direction of the calling release relative displacement of the parts 20 and 21 gears. Parts 20 and 21 coupled appropriately so that each of the sudden audible displacements at the end of the inclined sides of the pair of teeth sliding over each other, corresponds to, for example, one unit. When the head 14 is screwed in until it stops, which can be executed by clicking the button 30, the rotation is transmitted to the nut 22 of the actuator piston, causing the displacement of the piston forward by an amount appropriate to the by-entrainment (hands) of the holder 2 of the container, which is attached to the base member 1 and the tubular housing 16, which is attached to the tubular element 8, and by retraction (pulling) of the holder 2 of the container and the tubular body 16 in the axial direction from each other. Thus the tubular element 8 is displaced in the axial direction relative to the base element 1, and further compression of the spring 11 retaining the tubular element 8 in its position on the base element 1. Due to this displacement of the lifting fork parts 13, inserted in the window in the tubular element 8, shift up until the lower end of their teeth 39, passing inward through the slots in the base element 1, no abuts the annular shoulder 40 on the metering element 18. Upon further displacement against the force of the spring 11 the metering element 18 will be displaced against the force of the spring 25, and displays the parts 20 and 21 of the clutch of their mutual engagement. Now the metering portion of the syringe can be freely dovorachivat without transmitting rotation to the nut of the actuator piston, and hence the set dose can be checked by turning the head 14 to install the dose back to its original position, possibly by way of releasing until it stops.

When the element 8 is released, under the action of the spring 11 ATO in its position, in which he carries out the involvement of nuts.

1. The syringe in the form of a handle for repetitive input individually set doses of medicine from the reservoir in the form of a cylindrical ampoule containing an element for installation doses mounted can be rotated to provide a rotary displacement of the metering element and a combined rotary and axial displacement of the indicator element indicating the set dose, the element of the actuator piston, which when rotated in one direction moves the piston inside a cylindrical ampoule, unidirectional engagement between the metering element and the drive element of the piston and engages performed can be rotated to set a dose metering element and without transmitting rotation to the drive piston, but with the transmission of rotation in the opposite direction, characterized in that between the body of the syringe and the element to set doses connected to the screw nut, and that means are provided for separation of the unidirectional engagement between the drive piston and the metering element.

2. The syringe under item 1, characterized in that the threaded connection of the screw nut has an angle of inclination greater than the angle of friction nut the head, which supports push button, and the button and head are mutually mating surfaces made of materials having a lower friction angle compared to the angle of friction of the connection screw nut.

4. The syringe on the PP.1, 2 or 3, characterized in that the element for installation doses contains lead screw with an external thread that the metering element is made tubular and mounted on this lead screw, that screw Assembly has an axial grooves, which are held in the axial direction transverse projections made on the inner side of the openings of the metering element.

5. The syringe under item 4, characterized in that the unidirectional engagement between the metering element and the actuator piston is provided with parts of the mesh with a circular surface, which holds the teeth in the form of sectors with steeply and inclined sides, and under the action of the spring these surfaces are pressed together, and the sloping side of the teeth on one surface adjacent to the inclined side of the teeth on the other side.

6. The syringe under item 5, characterized in that it comprises a tubular base element, the tubular element covering basic element, coaxially with it since installation is emant to engage them fixed position on the base element, and lifting fork detail, mounted on a tubular element and incoming fork detail, mounted on a tubular member and a member in contact with an outer annular ledge on the dosing element for lifting part of the gearing associated with it, with the aim of taking it out of engagement with a part of the gearing of the drive piston displacement of the tubular element in the axial direction on the base element against the force of the spring from its fixed position.

 

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