For the treatment of chronic prostatitis

 

(57) Abstract:

The invention can include means for the treatment of chronic nonspecific prostatitis in the form of reactive suppositories based on lipid complex of the pulp of the fruit of black currant, obtained by degreasing pulp food grade gasoline "Nevrax". When using candles as part of complex therapy in patients with chronic parenchymal nonspecific prostatitis etiology identified explicit therapeutic activity suppositories, in particular their anti-inflammatory effect. In any case, clinically or laboratory does not identify any local or General adverse reactions or complications. Candle safe, easy to use and can be recommended for wide use in urological practice.

The invention relates to medicine, in particular to the means for the treatment of chronic inflammatory diseases of the prostate.

Know the use for the treatment of chronic prostatitis non-steroidal anti-inflammatory drugs, i.e. indomethacin [1] Indometacin assign inside depending on tolerability at a daily dose of 100 to 150 mg (3-4 hours)are the need for long-term treatment with a drug, because premature discontinuation may lead to the resumption of the pain, the possibility of side reactions, in particular indomethacin may have ulcerogenic action. The drug also has some contraindications.

Know the use for the treatment of chronic inflammatory diseases of the prostate rectal suppositories weighing 0.5-1 g, prepared on the basis of sea-buckthorn oil and containing the herb celandine, the fruit of Sophora japonica flowers chamomile. [2] Candle was administered daily for 9 to 15 weeks, with the first 2 candles were introduced in the morning, and the third candle 10-14 hours First and last 3-5 weeks first and second candles were introduced after prostate massage.

The disadvantages of this tool are the duration and complexity of the treatment process.

The purpose of the invention is the reduction of treatment time.

This goal is achieved using rectal suppositories based on the lipophilic fraction of the pulp of the fruit of black currant, introduced on 1 suppository 2 times a day for 10-12 days.

Candles were prepared in accordance with GF-XI ed. vol. 2. C. 151-153 Art. "Suppositories" method of pouring. With the and the ratio of components in wt.

Lipophilic fraction 17-20;

Lipophilic suppozitornoj bases to 100.

The mass of the candle 3,0,

Lipophilic fraction of the pulp of the fruit of black currant obtained by degreasing pulp food grade gasoline "Nevrax in the ratio of raw materials extractant 1:10 for 6 h followed by distillation of the solvent.

Example 1. To 25,0 g of melted cocoa butter add 5.0 g of lipophilic fraction of the pulp of the fruit of black currant and stirred with an anchor stirrer until a homogeneous mass, and then hot suppozitornyj the Foundation is poured into a special form and cool. Get 10 suppositories weight of 3.0 g

Example 2. To 24,0 g melted basics "Witepsol" add 6.0 g of lipophilic fraction of the pulp of the fruit of black currant and get suppositories as described in example 1.

Candles were used as part of complex therapy in 16 patients suffering from chronic parenchymatous prostatitis nonspecific etiology. The patients ' age from 21 to 52 years.

Criteria for diagnosis and evaluation of treatment effectiveness have served the objective of the study, hematological and immunological tests, urinalysis, prostate secretion and ejaculate, bacteriological Control group comprised 20 patients about identical in structure with the main group, comprehensive treatment which preclude the use of any rectal suppositories.

The course of treatment in the main group consisted of antibacterial drugs, biogenic stimulators, physical therapy, local procedures introduction 1 rectal suppository containing lipophilic fraction of the pulp of the fruit of black currant, 2 times a day for 10-12 days.

All patients tested drug is well tolerated. In any case, clinically or laboratory not identified any local or General adverse reactions or complications. At the same time reliably identified therapeutic activity of subjects of candles in chronic prostatitis, in particular their anti-inflammatory effect.

The subjects of the main group there has been more rapid and persistent decrease or complete disappearance of pain and dysuria, decrease or complete data normalization objective research, laboratory, ultrasound and endoscopic tests.

Example 1. Patient C. 31. Diagnosis: Chronic bacterial (nonspecific urethritis), chronic lung prostate in the phase of active inflammation. The disease duration of 6 years. Held earlier courses of standard therapy is ineffective. In article physiotherapy, local effects, rectal suppositories with black currant oil (0.5 g) and 1 twice a day for 12 days. During the control study in 20 days was marked by almost complete disappearance of pain and dysuria, improving data palpation and ultrasound, data normalization of urine and prostate secretion.

Example 2. Patient A. 49 years. Diagnosis: Chronic bacterial lung prostate in remission with pronounced symptoms of pelvic sympathalgias. The disease lasts 8 years, the clinical picture was dominated by complaints of pain and paresthesia in the area of the perineum and rectum. The treatment included vegetotherapy and ganglioblokirute funds, physiotherapy, subjects candles with oil content of black currant 0.6 g 1 twice a day for 10 days. During the control study after 22 days showed a significant decrease in pain, disappearance of paresthesia. Data palpation of the prostate and ultrasound revealed a clear positive trend.

Thus candles containing oil of black currant in the amount of 0.5-0.6 g, have obvious therapeutic effect on chronic nonspecific prostatitis. They are safe, easy to use and can be recommended for wide use is Irina, 1993. -T. 1. S. 199-200.

2. Boichenko C. M. Borysenko Century A.//ABT. Mon. N 169819 published in Bulletin 46. (1991) a Method of treatment of chronic prostatitis.

For the treatment of chronic prostatitis, consisting of lipophilic suppozitornoj bases and active substance of plant origin, characterized in that the active substance it contains lipophilic fraction of the pulp of the fruit of black currant in the following ratio, wt.

Lipophilic fraction of the pulp of the fruit of black currant 17 20

Lipophilic suppozitornyj basis Until 100i

 

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