A method of treatment of psoriasis

 

(57) Abstract:

The invention relates to medicine, namely to dermatology, and can be used for the treatment of psoriasis. The invention consists in carrying out photochemotherapy 4-day method with taking pualina, with an hour before exposure to the areas affected are 5% ointment Akola on the basis of title. Treatment is not accompanied by side effects and complications.

The invention relates to medicine, namely to dermatology, and relates to a method of treatment of psoriasis.

There is a method of psoriasis treatment method photochemotherapy using photosensitizer pualina providing oral administration pualina a rate 0.6 mg per 1 kg of body weight for 2 h before irradiation and subsequent UVA-irradiation in a dose of 2.5 to 12 j/cm24 times a week, total dose of 300 to 600 j [1, 2]

However, the treatment in this way is long (an average of 25 sessions photochemotherapy), accompanied by frequent side effects (nausea, weakness, dizziness and other) caused by the action of furokumariny.

The closest in technical essence and the achieved result is the way l is p. 555 558).

The essence of the method consists in taking tigason 75 mg per day for 14 days followed by photochemotherapy 4-day method with the admission of the photosensitizer pualina and a simultaneous reduction in the dose of tigason to 50 mg per day to the state of clinical recovery.

The disadvantages of this method is its duration (6 to 10 weeks) and the presence of side effects (peeling of the skin, dryness of the lips, intermittent nasal bleeding, liver dysfunction and other) due to prolonged administration of tigason and a significant number of procedures photochemotherapy (Aromatic retinoids in the treatment of dermatoses, Shaftmaster I. I. Pokryshkin C. I. Pisarenko, M. F., and others, " Vestn. dermatol. 1984, No. 3, S. 26-31).

The aim of the invention is the reduction of terms of treatment, prevention of side effects and increased therapeutic efficacy, which is achieved by assigning photochemotherapy using photosensitizer pualina and parallel application to the lesions 5% ointment Akola, ointment prepared on the basis of TESOL.

Actual components ointments are vitamins A and E.

Clinical studies have shown that p nm) causes photodynamic effect has a positive effect on psoriasis. Vitamins A and E act as photosensitizers, thereby reducing the treatment time, to eliminate side effects, to increase the effectiveness of the treatment.

The method is as follows. According to the standard technique are photochemotherapy; after eating the patient is prescribed oral administration of a photosensitizer pualina a rate 0.6 mg per 1 kg body weight and 2 h carry out ultraviolet irradiation (wavelength 320 to 400 nm) in a single initial time dose of 3 min, with increasing time of irradiation for 3 min every 3 treatments up to 15 minutes; the irradiation intensity from 1.5 to 7.5 j/cm2. Irradiation is carried out 1 time per day 4 times per week. In parallel, 1 hour before irradiation, topically to the lesions on the skin cause 5% ointment ecola prepared on the basis of TESOL.

Positive clinical effect was observed with 3-4 treatments in the form of poslednee elements rashes, and their gradual flattening, reducing, peeling. Irradiation is carried out until full clinical recovery of the patient with psoriasis, which means the complete disappearance of psoriatic plaques, the appearance of clean, smooth in varying degrees pigmented skin. atom 23 years. The sharpening process was observed 1 to 2 times per year, with a duration of 2-3 months, not regressed against the background of traditional therapy. In the hospital the patient is treated by the proposed method. On the 4th day of therapy were observed blanching and flattening elements. The patient received 16 sessions photochemotherapy and the rate involving 5% ointment ecola issued on the 31st day of hospitalization in a state of complete clinical remission. Side effects, complications were noted. After treatment, the remission lasts 8 months.

Example 2. Patient W. 42 years. Suffering from psoriasis for 16 years. Relapses were observed 2 to 3 times a year, lasting 3 to 4 months, interspersed with very brief remissions 1 2 months. Traditional therapy desired effect is not exerted. During the last torpid exacerbation of psoriasis, patient had therapy with the proposed method. The regression was observed after 3 treatments photochemotherapy and use 5% ointment Akola. Treatment was not accompanied by side effects and complications. Remission lasts 9 months.

The proposed method was applied for the treatment of 18 patients with nodules, and often long-term recurrent forms normal, exudative psoriasis.

Clipsal clinically effective, it can be used in the outpatient setting.

A method of treatment of psoriasis, including photochemotherapy for the four-day method with the admission of the photosensitizer pualina, characterized in that hour of irradiation on the areas affected are 5% ointment askola based title.

 

Same patents:

The invention relates to veterinary medicine, namely the treatment of acute viral diseases (plague, parvovirus enteritis, and others) and can be used to treat dogs, Minks, foxes, foxes, etc

The invention relates to medicine, namely to the technology of medicines, and can be used to produce mercury-containing drugs with antitumor anti-infective activity

Antitumor agent // 2086261
The invention relates to anticancer remedies to treat some cancers: leukemia, adenocarcinoma, cervical cancer, melanoma, sarcoma, carcinoma Lewis, hepatoma and other diseases

The invention relates to drugs lipid nature of the polyunsaturated fatty acids
The invention relates to medicine, namely to obstetrics and gynecology, and can be used for treatment of miscarriage
The invention relates to medicine, namely to narcology and psychiatry, and can be used for the treatment of alcohol withdrawal syndrome

The invention relates to cosmetics, to compositions that reduce the depth of wrinkles on the skin as a result of natural or photoinduced aging

The invention relates to medicine, in particular to therapy and immunology, and for the treatment of chronic nonspecific lung disease

The invention relates to new derivatives of alkinoos acid, pyridine, or rather to new 1,3-dioxane-5-Illinois acids containing the residue of pyridine in position 4 1,3-dioxane rings

The invention relates to new pyridine containing heterocyclic compounds, in particular new 1,3-dioxane-5-silt derived alkenovich acids containing pyridyloxy residue attached to position 4 of the 1,3-dioxane ring

The invention relates to a method of obtaining new macrolide compounds of the formula I

The invention relates to 7-examinerlawrence heterocyclic Amida - analogues of prostaglandins, which are receptor antagonists AND thromboxane a2(THA2or combined receptor antagonists AND thromboxane a2(thromboxane synthetase inhibitors, and are used, for example, in the treatment of thrombotic disease and/or vascular spasm: have a long duration of action

The invention relates to medicine, namely to Virology
Up!