The method of producing drug that prevents premature ejaculation

 

(57) Abstract:

Usage: the invention relates to the field of sexual pathology, namely the method of producing drug that prevents premature ejaculation, which can be used in the treatment of impotence and other sexual disorders in men. The inventive method of producing a drug that prevents premature ejaculation is that the aqueous solution of the drug "Prozac", which is a hydrochloride (-N-methyl-3-phenyl-3-[(, , --trifter-n-tolyl)oxy] -Propylamine, mixed with an aqueous solution of hyaluronic acid, the mixture is alkalinized to pH 8.0 to 8.5, and incubated for 2 - 4 h, then acidified to pH 3.5 - 4.5, the precipitate was separated, washed with water to pH 6.5-7.0 and dried, "Prozac" and hyaluronic acid take in a mass ratio of 1:0,2 - 0,6. A new drug is non-toxic and has a pronounced and quickly manifested effect.

The invention relates to the field of sexual pathology, namely the method of producing drug that prevents premature ejaculation (servislerini), which can be used in the treatment of impotence and other sexual disorders in men.

Known medikamente drug "Prozac", the basis of which is a chemical compound hydrochloride ()-N-methyl-3-phenyl-3 - [,,,, trifter-n-tolyl)oxy] Propylamine and used in a variety of oral, parenteral or external dosage forms. Thanks to the use of "Prozac" in men normalizes the ejaculation coming after 1.5 to 2 minutes after the beginning of coitus, whereas without treatment, ejaculation occurs either when introitus (1 to 2 fractions), or not later than 10 to 20 C.

Known drug has, however, the disadvantage that its use necessitates the appointment of "Prozac" in high doses (20 to 80 mg / day) for a long time (3 to 6 months), what increases the risk of toxic effects.

The invention solves the problem of obtaining non-toxic drug that prevents premature ejaculation, has a marked and rapid onset of the effect.

This goal is achieved by creating a method of producing drug for preventing premature ejaculation, according to which an aqueous solution of the drug "Prozac", which is a hydrochloride ()-N-methyl-3-phenyl-3 - [,,,, trifter-n-tolyl)oxy] Propylamine, mixed with an aqueous solution hyaluron separated, washed with water to pH 6.5 to 7.0 and dried, "Prozac", and hyaluronic acid take in a mass ratio of 1:(0,2 0,6).

To test the effectiveness of the obtained drug studies have been conducted involving 10 volunteers, men between the ages of 18 and 45 years, who came to the doctor with the relevant complaints. Patients were asked to replace the timing of ejaculation, and obtain an average value 3 4 coitus, and to submit to the clinic assembled disposable ejaculate after Masturbation, in which known methods was determined by the content of the spermatozoa and the proportion of sperm.

The volunteers were divided into two equal groups (5 people); each patient the first group were given the drugs in the form of tablets containing 20 mg of Prozac" in the tablet, and the second group of patients - tablets containing 5 mg of the drug according to the invention. Weekly all patients presented sperm samples to the laboratory in sterile test tubes for further analysis.

A survey of patients and the results showed that treatment with the drug "Prozac" led to the achievement of the desired effect only in 3 patients (out of five) after 5 to 6 months. after the start of treatment, while in the l to 2 to 6 ml; the content of the spermatozoa and the proportion of sperm was restored to normal.

The second group of patients receiving the drug according to the invention, a similar effect was achieved in all five men already 1 month after starting treatment with the drug at a dose of 5 mg/day, i.e. 4 times less.

It is important to emphasize that the use of hyaluronic acid, a high molecular weight polysaccharide not only provides the prolongation of therapeutic action "Prozac": a study of UV spectra of both drugs ("Prozac" and claimed) showed that in contrast to the "Prozac" with maximum absorption at 250 nm and hyaluronic acid, not absorbing in this region, claimed the drug shows a maximum absorption at 263 nm, which indicates the formation of a new connection.

However, to obtain a new drug requires strict adherence to the described process and its parameters, because the increase or decrease of mass ratios interact ingredients, and changing the pH and time of incubation does not allow to obtain the target product.

Example 1. 1 g "Prozac" (company "Sigma", USA) dissolved in 100 ml of water, to relax salacious 1 n NaOH to pH 8.0, incubated for 2 h with periodic stirring, then acidified with 1 n Hcl to pH 3.5, the formed precipitate was separated by centrifugation, washed with water to pH 6.5 and dried in vacuum. Obtain 1.07 g of the powder (yield of 89.2%), which direct the production of different dosage forms.

Example 2. 1 g "Prozac" is dissolved in 100 ml of water, add a solution of 0.4 g of hyaluronic acid in 100 ml of water (ratio 1:0,4), the mixture is alkalinized 1 g NaOH to a pH of 8.25, incubated for 3 h with periodic stirring, then acidified with 1 g Hcl to pH 4.0, the precipitate was separated by centrifugation, washed with water until the pH of 6.75, dried in vacuum and obtain 1.28 g of powder (yield 91,4%).

Example 3. 1 g "Prozac" is dissolved in 100 ml of water, add a solution of 0.6 g of hyaluronic acid in 100 ml of water (ratio 1:0,6), the mixture is alkalinized 1 n NaOH to pH 8.5, and incubated for 4 h with periodic stirring, then acidified with 1 n Hcl to pH 4.5, the precipitate was separated by centrifugation, washed with water until pH 7.0, dried in vacuum and gain of 1.46 g of the powder (yield of 91.7%).

The method of producing drug that prevents premature ejaculation, namely, that an aqueous solution of the drug "Prozac", which is a hydrochloride()-N-methyl-3-facepalm to pH 8.0 to 8.5, incubated for 2 to 4 h, then acidified to pH 3.5 to 4.5, the precipitate was separated, washed with water until a pH of 6.5 to 7.0 and dried, "Prozac", and hyaluronic acid take in a mass ratio of 1 0,2 0,6.

 

Same patents:
The invention relates to chemical technology and concerns of chitosan
The invention relates to the field of chemistry of natural compounds and biotechnology and can be used in medicine, textile, paper and food industry

The invention relates to the production of low molecular weight oligosaccharides from chitin, which can be used independently or as an intermediate product, separately or in a mixture with inorganic or organic compounds of different structure

The invention relates to oligomer of chitin and chitosan, and the method of its production, allowing a high yield of chitin or chitosan oligosaccharide of chitin, which is a mixture of oligomers of chitin or chitosan oligosaccharide, which is a mixture of oligomers of chitosan
The invention relates to a method of producing hyaluronic acid, belonging to the class of glycosaminoglycans, which is used in the production of perfumes and cosmetic products, and can also be used as the basis for obtaining high-purity preparation for medicine and as a substrate in the quantitative determination of enzymes hyaluronidase actions

The invention relates to the chemistry of natural compounds and can be used to prevent depolymerization of solutions of hyaluronic acid during sterilization by ionizing radiation
The invention relates to medicine, namely preparations for the treatment of diseases of the joints

The invention relates to medicine and can be used in the departments of pulmonology and neurology
The invention relates to medicine and can find application in the treatment of myocardial infarction
The invention relates to medicine, cardiology

The invention relates to medicine, in particular to pharmacy

The invention relates to medicine, in particular to the treatment of viral diseases caused by herpes virus

The invention relates to chemical-pharmaceutical industry, in particular, to methods for drugs, namely paracetamol, intended for the treatment of gout, migraines, and also used as an analgesic and antipyretic
Up!