Method p. i. fedorischeva obtain drugs having wound healing properties

 

(57) Abstract:

The essence of the invention: prepare a mixture of copper acetate (1 wt.h.), sodium hydrogen carbonate (from 0.4 to 0.8 wt.h.) and talc (from 0.01 to 0.05 wt. h ), hydratious her, dried and crushed to powder. The resulting product is used in the form of lotions for the treatment of burns, frostbite, erysipelatous inflammations. table 1.

The invention relates to medicine, namely to methods for drugs.

A method of obtaining a medicinal product by mixing formalin, glycerin, ascorbic acid and distilled water /1/.

This method is quite simple to implement, but its scope is limited to profilaktika suppuration around the spokes.

The prototype of the proposed technical solution is the method of obtaining effective drug, developed by P. I. Fedorishin /2/. The method consists in preparing a mixture of 5 wt.h. copper acetate

Cu(CH3COO)2H2O and 3 wt.h. sodium bicarbonate - NaHCO3after hydrating with water at a ratio of 1:1 by weight. Upon completion of the hydration of a dried mixture of a CR in the treatment of burns, frostbite, erysipelatous inflammations. However, the method of obtaining the drug of ethnological, as the necessary conditions for its exercise are: fixed value of the ratio of water and a mixture of hydration (1:1 by weight); limit temperature drying (not more than 35oC).

In addition, the lotion prepared on the basis of the drug retains its effectiveness is not more than eight days if stored in a dark place at room temperature.

The aim of the invention is to improve the workability and effectiveness of the method.

The objective is achieved by the proposed method comprising preparing a mixture of 1 wt. including copper acetate, 0.4 to 0.8 wt.h. of sodium bicarbonate and from 0.01 to 0.05 wt.h. talc. The resulting mixture hydratious water at a ratio of components, M, is equal to from 1.0 to 1.5 wt.h. water 1.0 wt.h. of the mixture. Upon completion of the hydration wet mass is dried at a temperature T.

Improving the processability of the method is achieved by expanding the range of variation of the mass ratio of the mixture and water when hydrating and removing restrictions on the temperature of drying, increasing efficiency by extending the storage is and the mixture additionally contains talc, representing the magnesium silicate approximately the following composition 4SiO23MgOH2O. This is a very soft white or slightly grayish powder without smell and taste. In medicine is used for powders and as indifferent filler for cooking pastes and tablets.

The adaptability of the method was evaluated by comparing the duration of the drying drug LW, h

The effectiveness of the method was assessed by the ability of lotions, prepared on the basis of a medicinal product, to restore the homogeneity after a certain length of storage. To do this, prepare a lotion from 0.25 g drug and 500 g of distilled water and kept it in a dark place during the time of HHS day. During storage lotion exfoliates, i.e., forms a transparent portion and sediment. A lotion which was for 5 min, poured into a graduated cylinder and left to rest for 10 minutes Then determined the volume of the clarified part lotions 0, less Than 0, the higher the homogeneity (uniformity) of lotion.

An example of the method. The addition of copper acetate with a weight of 100 g was mixed with 60 g of sodium bicarbonate and 3 g of talc. The resulting mixture was mixed with 163 g Aadnoy the consistency of the mass. Then propertybase the mixture was dried at a temperature of T=60oand grind to powder.

The results of the study drug, prepared in accordance with the foregoing example, when different modes of implementation of the method is given in the table.

The table shows that when carrying out the known method (experiment 1), the duration of drying is 12 h, the volume of the clarified part lotions after 8 days of storage 10 and after 16 days 45 (experiment 7). When the temperature drying to 60o(experiment 8), the duration of drying is reduced to 8 h, however, the properties of the lotions, the estimated volume of the clarified layer deteriorate.

For the proposed method (experiments 2, 3, 4, 5, 6) the reduction in the duration of the drying occurs while restoring the original properties of a lotion after storage. Thus, this goal is achieved only when declared essential features.

The resulting implementation of the way the drug is used in the form of lotions for the treatment of burns, erysipelatous inflammations, frostbite.

The analysis of the proposed technical solutions pokazyvaet specialist is not obvious from the prior art. This method is industrially applicable, as confirmed by the examples of its implementation. Thus, the proposed technical solution meets all the required criteria for the recognition of his invention.

The method of obtaining drugs having wound healing properties, including the preparation of a mixture of copper acetate and sodium bicarbonate, with subsequent hydrating, drying and grinding, characterized in that in the preparation of the mixture into it further added talc, 1 wt.h. copper acetate take 0,4 0,8 wt.h. of sodium bicarbonate and 0.01 to 0.05 wt.h. talc.

 

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6 ex, 1 tbl

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