Method of correction of psychophysiological state of a person
(57) Abstract:The invention relates to medicine, namely to methods for management of psycho-physiological parameters of the individual using biofeedback, and can be used in various fields of medicine for treating a wide spectrum of diseases. The result of the invention is to increase the efficiency of correction of psychophysiological state of a person at the expense of increasing the degree of uniqueness of the transformation of the EEG signal biofeedback. The method includes the modulation of the audio signals, the signals pneumogram of man and the transformation of EEG signals into sound by the transpose of the spectrum of the EEG signals in the frequency range of the sound signals, which then affected person through the organization of biological acoustic feedback and the effects transposed signals begin at the stage of decay modulated pneumogram audio signals barefoot. While the transportation spectrum of EEG signals in the frequency range of the sound signals is performed by the decomposition of EEG signals in a series of quasi-periodic signals and their tracking. 3 Il. The invention relates to medicinema using biofeedback, and can be used in various fields of medicine for treating a wide spectrum of human diseases, for example, from hypertension to dysregulatory disorders due to organic lesions of the brain and cardiovascular system.There is a method of correction of psychophysiological state of a person described in device for bioadaptive regulation, in which the recorded biological signals, including signals, electroencephalogram (EEG) is converted into the signal biofeedback (BFB), also containing pre affecting the rights of the audio signal 
In this way the creation of a biological signal feedback, including audio signal to provide "traditional biofeedback"  through which man, as a device, consciously monitors and corrects some variations in their psychophysiological state by establishing individual threshold.The disadvantage of this method is low efficiency correction due to the low degree of uniqueness of the transformation of the true biological signal, in particular of the EEG signal in the signal ASS="ptx2">There is also known a method of correction of psychophysiological state of a person described in the device for the correction of human functional state in which the preparatory mode empirically produce selection parameters of the external environment, such as light or sound, providing a comfortable condition, and in the correction mode perform discrete change of selected parameters at which the patient suffers minimum deviation biosignal, including EEG signal, and adjust the deviation of the latter from the empirical parameters by organizing signal biofeedback, including sound or light signals 
This method is compared with the previous improves the efficiency of the correction functional (physiological) state of a person due to the additional influence on human emotional factor, which in this way prevails over technocratic and consists in optimizing the parameters of the external environment in the process of correction.The disadvantage of this method is the relatively low degree of uniqueness of the transformation of the true biological signal in the signal barefoot, voltage doctor (operator), to learn how to manage the bio-measurement in the process of conducting signals the OS that repeated and tedious. All this complicates carrying out this method.Known selected as a prototype method of control and correction of psychophysiological state of a person, in which the recorded signals on the electroencephalogram (EEG) transform using the synthesizer in the modulated sound (music) signals, and the converted signals affect the individual through the organization of biological acoustic feedback (BOS) after a time delay, calculated so as to change the phase of the feedback, with musical sounds contain at least one tone that follows the envelope changes of EEG in real-time 
In this way, the prototype musical feedback signal (OS) has psychoacoustic and music properties, forcing the brain to produce primarily a specific type of EEG activity, while the physiological response of the brain to the music of feedback actively changes the current EEG activity, bringing it into resonance with the music to loop circuit physiological feedback that leads to snigdha musical feedback. In addition, the use of a musical signal in the signal biofeedback provides also increase the emotional effect sound signal barefoot, which reduces the monotony and utomitelnoj process.All this ultimately increases the efficiency of the control and correction of psychophysiological state of a person in comparison with the previous analogues, where used "traditional feedback".The disadvantage of the prototype method is the relatively low degree of uniqueness of the transformation of information about the true signal of the body (EEG) due to the presence of a musical signal in the loop biofeedback, which reduces the effectiveness of the correction of psychophysiological state of a person. In addition, the presence in the way of "forcing" operator to the patient correction algorithm leads to decreased emotional effect sound signal, acting on the patient under the influence of biological acoustic feedback during the session, which also reduces the effectiveness of the control and correction of psychophysiological state of a person.The technical result of the invention is ovisnosti conversion true biological signal of the organism in the biological signal feedback while ensuring the required level of emotional effect sound signal biofeedback.The technical result is achieved in that in the method of correction of psychophysiological state of a person, in which the recorded signals on the electroencephalogram (EEG) is converted into audio signals, which then affect the individual through the organization of biological acoustic feedback )BAOS), according to the invention, the conversion of the EEG signals in the audio signals is carried out by tranceonjeroen spectrum of EEG signals in the frequency range of the sound signals, in this first produce modulation affecting the rights of sound signals systems pneumogram, and the impact transposed the EEG signals begin at the stage of decay modulated pneumogram audio signals.In addition, the transportation spectrum of EEG signals in the frequency range of the sound signals is carried out by decomposition of EEG signals in a series of quasi-periodic signals using comb filters, the write periods of the received signals in the memory with subsequent accelerated reading and add last.The transformation of EEG signals by transposition of the spectrum of the latter in the audio frequency range allows you to save the frequency and the amp is about biological signal EEG biofeedback signal, and therefore, improves the accuracy of the information transmission by the person about him wave brain activity compared to the prototype. This ultimately increases the efficiency of correction of psychophysiological state of a person. In addition, the transformation of EEG signals eliminates the "imposition" of a certain wave activity of the patient, which increases its independent role in conscious control of his psycho-physiological state.The implementation of modulating the audio signals biofeedback signals pneumogram (GHG) allows to provide the required degree of susceptibility of the EEG signal, due to the fact that the breath of man is the only function that includes conscious and unconscious control signals barefoot.The inclusion tranceonjeroen EEG signals at the stage of decay modulated pneumogram audio signals makes it possible to ensure a smooth transition to the perception of the EEG signal, which eliminates the stress condition of the patient when the perception of the transposed audio signal barefoot. All this guarantees the preservation of the desired emotional effect sound signal impinging on the patient.The implementation of tranceonjeroen spec is laud and the frequencies of the harmonics of EEG signals while maintaining the absolute values of the phases.Comparison of the proposed method with the method of the prototype shows that it differs from the latter by the fact that the transformation of EEG signals in the audio signals carried by the transpose of the spectrum of the EEG signals in the frequency range of the sound signals, in this first produce modulation affecting the rights of the audio signals, the signals it pneumogram, in effect transposed the EEG signals begin at the stage of decay modulated pneumogram audio signals.Therefore, the proposed method meets the criteria of the invention of "novelty."Comparison of proposed method with other known in the field of technical solutions allows us to conclude that it follows from them in subtle ways and, therefore, meets the criterion of "inventive step".The implementation of this method in devices, medical equipment provides him with the criterion "industrial applicability".The invention is illustrated by the following drawings, where Fig.1 shows a temporal diagram of the session the impact of biofeedback to the patient; At the volume level, dB; Fig.2 graphical representation of the process Proc. of the true EEG signal, (2) transposed the EEG signal; (b) the same spectrum phases of EEG signals: 1 - the true EEG signal, 2 - transposed the EEG signal; And the signal amplitude, In phase, deg. F - frequency, Hz Fig.3 block diagram of the device for implementing the proposed method.The proposed method is as follows.Session impact BAOS patient is carried out in three stages (see Fig.1). The session is conducted in a darkened sound-proofed room 1 (see Fig.3), the patient sits in a comfortable chair. At first, preparatory stage, the patient receives from the operator (physician psychophysiology) oral statement about their behavior and explanation about the nature of BAOS, abridged from his pneumogram and recommendations for listening to signals BOOS from the EEG, which basically consist in maximum focus on the most pleasant it sounds. Throughout the preparatory period (a,b) Fig.1), which lasts 10 minutes, the patient hears through the synth-balanced sound, for example, the sound of the organ, which is modulated by the signal from the respiration sensor, located on the chest of the patient. As the breath is fully consciously controlled by the function of the person, the patient almost immediately "feel"for euphony sound.At the transition stage (see Fig.1) duration 2 minutes modulated pneumogram audio signals BAOS decrease to zero, and the transposed signals BOOS from the EEG, which is connected to the patient at the stage with, increase the set value of the volume on stage and fade on the stage.This eliminates abrupt sound effects on patient transported EEG signal. The duration of preparatory and transitional periods (a,b,C) provides for any patient.During the third stage, 30 minutes the patient hears only transported the EEG signals in the signal BAOS (e, K,Fig.1) and should be received instructions. The impact of transported EEG signals on the patient creates as close to a natural condition for conscious control of physiological state.The inventive method implements with the help of the device ("Sync"), shown in Fig. 3. The device comprises a speaker system 2, system 3.4 the EEG sensors and pneumogram accordingly, the system of the microphones 5, blocks 6 and 7 of acoustic and visual control (e.g., audio amplifier and respectively oscilloscope) blocks 8, 9 convert the s EEG and pneumogram is connected to the unit 7 visual inspection, unit 8 conversion EEG and unit 9 conversion breathing. The blocks 8,9 conversion EEG and respiration connected to the control unit 11 through the unit delays of 10, the output of which is connected to the power amplifier 12 which is connected to the loudspeaker 2.System sensors breathing is a system based on infrared optoelectronic pairs. These sensors are located on the breast (in women) or stomach (in men).The system of the EEG sensors made in the form of strictly two fixed and one movable electrode. The latter provides the forehead-vertex-occiput. In the EEG sensors are built-in amplifiers that form the signal for conversion.Modulation sound signals pneumogram implement with the help of block 9, which allows to represent the pneumogram in the form of a readily perceptible changes of the audio signal in real time. Transportation spectrum of EEG signals in the audio signal using the block 8 is carried out by decomposition of the original process in a number of quasi-periodic signals using comb filters (analysis), writing periods of the received signals in the memory unit 8 with subsequent accelerated reading (by multiplying the n-times) and the addition of Polozov EEG (1) sound signal (2) is maintaining relations of amplitudes and frequencies of the harmonics of the EEG signal (1) while maintaining the absolute values of the phase (v). During the session the impact of biofeedback on the subject ("S" in Fig.3) the EEG signals and pneumogram output system 3 and 4 of the EEG sensors and pneumogram patient are displayed to a workplace of the operator and served on the block 7 visual control by which the operator can judge the quality and condition of the patient (S). Parallel to these signals to the respective blocks 8 and 9 of the inverter. After converting the signals of the EEG sensors and pneumogram sound (acoustic) signal is supplied to the control block 11, providing a passive level control signals during the session. Next, the audio signal is supplied to the unit delay 10, providing the necessary protection and reverb to compensate for the acoustic properties of the room. In the block of output amplifier 12, the signal is amplified to a value necessary for the operation of the acoustic system 2. System 6 acoustic control allows the operator to hear what the patient.P R I m m e R.At the Institute of experimental medicine, laboratory of physiological studies have been conducted a series of studies testing the proposed method of correction of psychophysiologic the ski healthy men and women aged 10 to 60 years, and the second from patients with functional neurological disorders. The whole procedure effects included a series of 4-5 sessions held through the day under the supervision of a physician, neurologist and operator of psychophysiology. The duration of each session was 40-45 minutes. We measured the following physiological parameters: heart rate (heart rate), blood pressure (blood pressure), the frequency and depth of respiration (PG), tremor of the limbs, the level of reactive anxiety, etc.The results showed that in healthy subjects, 75% of cases, significantly reduced heart rate ( 10-15%), the frequency and depth of breathing, the level of reactive anxiety (15-20%), and significantly improved psychological indicators on projective techniques.The results of the research in the group of patients subjects showed a positive clinical effect, which was accompanied by more pronounced changes above psychophysiological indicators, and was reduced emotional lability, fixity at its pathological condition and fatigue, normalization of sleep and appetite, improve mood and health, as well as in removing bol is otation allows to increase the degree of uniqueness of the transformation of EEG signals in the signal biofeedback, this improves the accuracy of the information transmission by the person about him wave brain activity while ensuring the required level of emotional effect of the biofeedback signal. This ultimately improves the efficiency of correction of psychophysiological state of a person.The use of the proposed method without the use of drugs to treat a certain range of mental and psychosomatic disorders (neuroses of various etiologies, predzirroticalkie state, reactive psychosis, depression and so on), as well as to enhance the action of pharmaceuticals used in psychotherapy. Healthy people this way will give the possibility to optimize mental activity, relieve psychological stress, and increase efficiency (which is confirmed by the results of a two-year practice in more than 100 patients. In addition to the purely medical institutions of the method can be recommended for use in various health-handling centres, especially useful for persons with occupations associated with increased fatigue, risk and overloads. 1. Method of correction of psychophysiological state of a person, which registered the m organization of biological acoustic feedback characterized in that the conversion of electroencephalogram signals in the audio signals carried by the transpose of the spectrum of the electroencephalogram signals in the frequency range of the sound signals, in this first produce modulation affecting the rights of the audio signals, the signals it pneumogram, and the impact of the transposed signals electroencephalogram begin at the stage of decay modulated pneumogram audio signals.2. The method according to p. 1, wherein the transposition signal spectrum of the EEG in the frequency range of the sound signals is carried out by decomposition of electroencephalogram signals in a series of quasi-periodic signals using comb filters and recording periods of the received signals, electroencephalogram with subsequent accelerated reading and add last.
FIELD: medicine, neurology, psychopathology, neurosurgery, neurophysiology, experimental neurobiology.
SUBSTANCE: one should simultaneously register electroencephalogram (EEG) to detect the level of constant potential (LCP). At LCP negativization and increased EEG power one should detect depolarizational activation of neurons and enhanced metabolism. At LCP negativization and decreased EEG power - depolarized inhibition of neurons and metabolism suppression. At LCP positivation and increased EEG power - either repolarized or hyperpolarized activation of neurons and enhanced metabolism. At LCP positivation and decreased EEG power - hyperpolarized suppression of neurons and decreased metabolism of nervous tissue. The method enables to correctly detect therapeutic tactics due to simultaneous LCP and EEG registration that enables to differentiate transition from one functional and metabolic state into another.
EFFECT: higher accuracy of diagnostics.
5 dwg, 1 ex, 1 tbl