The method of obtaining an artificial eye lens

 

(57) Abstract:

Usage: when vision correction after cataract surgery. The inventive mixture of 100 wt. hours of polyorganosiloxane end of vinylsilane groups, 10 to 15 wt. hours of oligohydramnios, 5 - 14 wt. hours of oligomerisation, 0.2 to 0.5 wt. including inhibitors of premature vulcanization 0.001 0,010 wt. including platinum catalyst, in terms of platinum, pouring the obtained composition in the form of its curing by heating, cooling, removing the lens from the mold, heat is extracted from khrustalika to 260 - 270oand holding at that temperature for 10 - 15 minutes Strength of the lens 2.5 - 3.3 MPa, elongation at break 125 - 180%, resolution 310 - 380 min/mm, the optical density D400at a wavelength of 400 nm 0,27 is 0.55.

The invention relates to methods of producing artificial lens (IHG), which are used in ophthalmology to correct vision after cataract removal.

A method of obtaining IHG of organosiloxane compositions, including polysiloxan end of triphenylsilane groups, oligohydramnios and a platinum catalyst. In this way IHG of izgotavlivatsya from the form. Obtained in this way IHG has insufficient strength, which leads to a large number of defects in the manufacture and subsequent manipulation of the lens.

An object of the invention is to create a method of manufacturing a silicon lens, which significantly reduces the complexity of the process, increase opto-mechanical parameters IHG, reduced their biological reactivity.

This task is solved in that in the known method of obtaining IHG comprising a mixture of polyorganosiloxane end of vinylsilane groups, oligohydramnios and platinum catalyst, pouring the obtained composition in the form of its curing by heating, cooling, and removing the lens from the mold, part of the original composition further added oligophenylenes and inhibitors of premature vulcanization, and the components of the composition used in the following amount, wt.h.

Polyorganosiloxane-

San end

vinylsilane-group - groups of 100 Oligohydramnios 10-15 Oligophenylenes 5-14

Platinum rolled-

congestion, in terms of platinum 0,001-0,010

The inhibitor before

the time of volcanic mountain rage - ment of 0.2-0.5 when et is e 10-15 minutes

Introduction to composition for the manufacture of IgG of oligomerisation leads to an increase in the elastic modulus and strength of the lens, resulting in substantially increases the yield of lenses in their manufacture (less breaks at the notch of the lens from the mold, placing lenses in special containers for sterilization and so on), it reduces the risk of damage IHG during implantation. In addition, this is achieved by reducing the amount of unreacted cremiereana groups in the lens, which reduces its biological reactivity.

Additional heating can improve the biological inertness of IgG due to the removal of the Sol-fraction component of 6-8% by weight AG.

Quantitative intervals components of the composition are determined by the requirements to the parameters and properties ichg.

When the concentration of oligohydramnios least 10 wt.h. low strength silicone crystal; at a concentration no more than 15 wt.h. reduced stability of the material when additional heating and biological inertness due to unreacted Si-H groups.

When the concentration of oligomerisation, less than 5 wt.h. the smaller the value of the modulus of elasticity and defects in the fragility.

As inhibitors of premature vulcanization, intended to slow the reaction of the crosslinking of the composition at room temperature, use the diesters of maleic acid. The introduction of the inhibitor does not result in degradation of physical and mechanical properties of the material of the lens.

If the temperature is greater 200aboutWith, the inhibitor does not reduce the curing speed of the composition. At room temperature without inhibitor composition loses its fluidity 2-4 h, with inhibitor lifetime of the composition, measured at the time of increasing the viscosity of the half, tens of hours, which is sufficient for processing the prepared composition in the lens.

The inhibitors of premature vulcanization at a concentration of less 0.2 wt. including little reduces the rate of curing of the composition at room temperature and at a concentration higher than 0.5.h. slows the rate of curing at a temperature of 260-270aboutIn the process of manufacturing artificial lens.

As the vulcanization catalyst using 1% solution in oligoaniline complex compounds of PT, which is obtained by the interaction of the H2PtCl66N2About with tetravinylcyclotetrasiloxane. The catalyst Ho is dragoumis the effect on the eye. When using a platinum catalyst in a quantity less of 0.001 wt.h. the rate of curing at a temperature of 260-270aboutWith small, at a concentration of 0.001 wt.h. and more sufficient; at a concentration of 0.005 wt.h. the lens when heated at 260-270aboutWith slightly yellow, without any noticeable deterioration of optical characteristics; at a concentration greater 0,010 wt. hours when heated at 260 - 270aboutWith the optical density of the coloring IHG becomes too large, which significantly reduces its resolution.

P R I m e R 1. 100 wt.h. polymethylphenylsiloxane end of triphenylsilane groups (concentration units OSiC3WITH6H5equal to 33 mol. refractive indexD201,4830, viscosity = 's 112,000 cSt; 5 wt.h. oligomerisation (CSD) (D201,4850; = 910 cSt), 10 wt.h. oligohydramnios (CSOs) (D201,4858; = 1200 cSt), about 0.001 wt.h. platinum catalyst (in terms of platinum), 0.2 wt.h. diethylmalonate thoroughly mixed, pour into optical form and utverjdayut when heated at 2655aboutC for 10 minutes Then IgG extracted from optical form and additionally heated at 2655aboutC for 15 minutes weight Loss IHG when additional nahrawan the th capacity 320 l/mm; the optical density D400at a wavelength of 400 nm is equal to 0.27.

To confirm the biological inertness of the lens are tested for cytotoxicity in vitro in tissue culture, "F2 transplantable tissue from cells ampion person, as well as biocompatibility method of tissue culture. The audit showed that the crystalline lens of the cytotoxic effect is not biologically reactive.

P R I m m e R 2. 100 wt.h. polymethylvinylsiloxane end of methyldiphenylamine groups (concentration units OSi(C6H5)2equal to 20 mol.D201,4910; = 19100 cSt), 9 wt.h. SVG (D201,4890, = 550 cSt), 15 wt.h. CSOS (D201,4850, = 910 cSt), of 0.003 wt.h. platinum catalyst (in terms of platinum), 0.3 wt.h. dipropylamine thoroughly mixed, pour into optical form and utverjdayut at a temperature 2655aboutC for 10 minutes Form cool, then IgG extracted from optical form and additionally heated at 265aboutC5aboutC for 10 minutes, the Loss of mass of the lens is 7.0 wt.

Get IHG with the strength of 2.9 MPA, elongation of 130% and a resolution of 380 l/mm Optical density D400equal to 0.28. Cytotoxics is dimetildisiloksana with terminal groups OSi(CH3)2CH= CH2(concentration units OSiC3WITH6H5equal

39 mol.D201,4910, = 680 cSt), 6 wt.h. oligomerisation (D201,4850, = 910 cSt), 14 wt.h. oligohydramnios (D201,4795, = 220 cSt), 0,006 wt.h. platinum catalyst (in terms of platinum), 0,25.h. bipropellant poured into optical form and heated at a temperature 2655aboutC for 10 minutes Remove IgG of optical shapes and additionally heated to 2655aboutC and maintained for 10 minutes, the Loss of mass of the lens is 6.5 wt. Received IHG has the strength of 2.5 MPa, elongation at break 150% resolution of 320 l/mm Optical density D400equal to 0.35.

P R I m e R 4. 100 wt.h. polymethylphenylsiloxane with terminal groups OSi(CH= CH2)3(concentration units OSiC3WITH6H5equal to 55 mol.D201,5070, = 43600 cSt), 12 wt.h. SVG (D201,5015, = 1920 cSt), 15 wt.h. CSOS (D201,4970, = 210 cSt), 0,008 wt.h. platinum catalyst (in terms of platinum) of 0.30 wt.h. dipropylamine stirred, poured into optical form and utverjdayut at 2655aboutC for 10 minutes Then remove IgG from opticana is 7.5 wt. The lens has a strength of 3.0 MPa, elongation at break 150% resolution 350 l/mm Optical density D400material IHG equal 0,46.

P R I m e R 5. 100 wt.h. polymethylphenylsiloxane with terminal groups OSi(CH= CH2)3(concentration units OSiC3WITH6H555 mol.), D201,5070, = 43000 cSt), 14 wt.h. SVG (D201,5015, = 1920 cSt), 15 wt.h. CSOS (D201,4970,= 210 cSt), 0,010 wt.h. platinum catalyst (in terms of platinum), 0.50 wt.h. diethylmalonate thoroughly mixed, pour into optical form and utverjdayut when heated at 2655aboutC for 10 minutes Remove IgG of optical shapes and heated at 2655aboutC for 10 minutes, the Loss of mass of the lens is 6.5 wt. IHG has the strength of 3.3 MPa, elongation at break 125% resolution 310 l/mm Optical density D400material IHG equal to 0.55.

P R I m e R 6 (by known means). 100 wt.h. polydimethylsiloxane with terminal groups OSiC3(CH=CH2)2(D201,4910, = 19100 FTAs, the concentration of groups OSi(C6H5)2equal to 20 mol.), 15 wt.h. GHS (D201,4850, = 910 cSt), of 0.003 wt.h. plahr>aboutC for 10 minutes Form cool, then IgG extracted from optical form. Received IHG has a strength of 1.0 MPa, elongation at break 220% resolution 250 Lin./mm

From the comparison of examples 1 to 5 and example 6 shows that the strength of the lens obtained by the method of the invention, 2.5-3.3 times higher than the strength of the lenses obtained in a known manner.

The METHOD of OBTAINING an ARTIFICIAL EYE LENS comprising a mixture of polyorganosiloxane with integral vinylcyclopropanes, oligohydramnios and platinum catalyst, pouring the obtained composition in the form of its curing by heating, cooling, and removing the lens from the mold, characterized in that the composition of the original composition further added oligophenylenes and inhibitors of premature vulcanization, and the components of the composition used in the following amount, wt. h

Polyorganosiloxane with integral vinylcyclopropanes 100

Oligohydramnios 10 15

The platinum catalyst based on platinum 0,001 0,010

Oligophenylenes 5 14

The inhibitors of premature vulcanization 0,2 0,5

after demolding the lens is heated to 2

 

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