The substance which shows choleretic effect

 

(57) Abstract:

The invention relates to medicine. The essence of the invention lies in the fact that offer potassium salt of glutamic acid as a substance exhibiting choleretic activity. 8 table.

The invention relates to a means to stimulate the physiological functions of the organism, in particular bile secretion, and can be further used in clinical practice.

In recent years in clinical practice in place a number of cholagogue, among which there are tools that stimulate bile production and synthesis of bile salts (hollow) in the liver (the so-called true haeretici) and drugs that increase bile secretion due to only the water component (hydrocholoric). Typical representatives of the latter are the sodium salicylate and its derivatives, preparations, Valerian, ginseng, and many mineral water.

The action of hydropolitical limited influence on the diffusion process of choleresis. They do not increase cholatocholesterol factor and are therefore not fully choleretic agents.

To choleretic means, in logol, holenzim and holesin;

synthetic drugs: vicodin, oxygenated, Cigalon, ibota, salts and esters of salicylic acid and other

drugs of vegetable origin, obtained from sandy immortelle, Bupleurum, corn silk, peppermint, tansy, wild rose and other plants (for example golosas).

However, most known drugs or insufficient, such as cholelithiasis and golosas, or limited usable, for example the sodium salt of dehydrocholic acid, due to accumulation in the body of sodium, or the drug allohol because they evoke long-term use side effects.

The aim of the invention is to develop effective cholagogue with broad pharmacological action.

This goal is achieved by the fact that as a cholagogue apply potassium salt of glutamic acid in doses of 50 to 500 mg per 1 kg of body weight.

Potassium salt of glutamic acid, a natural metabolite of the human body contributes to the concentration in the body potassium is the main intracellular ion, which plays an important role in maintenance of homeostasis, actively especta potassium salt of glutamic acid (synonyms: potassium glutamate, kaputa), previously used in a mixture with monomagnesium salt of the same acid, became possible as a result of established pronounced pharmacological activity of Kalutara resulted in strengthening both the diffusion and secretory processes jelcheobrazovanie liver, stimulating the process of helatoobrazutee and excretion of bilirubin and cholesterol in the bile. The described action is found in the research conducted on animals.

Part of the preparation examples 1 to 3, wt. potassium 22; glutamic acid 78.

P R I m e R 1. Studies performed on 32 passported rats male 6 8 months 10 adults 12 months. The study drugs were administered once daily orally.

All animals were divided into following groups:

1. Treated with saline control group.

2. Kaguta at a dose of 500 mg/kg for 14 days.

3. Kaguta at a dose of 500 mg/kg for 52 days.

4. Kaguta dose of 50 mg/kg for 52 days.

Evaluated:

the influence of Kalutara on the intensity of bile secretion (results are presented in table. 1);

the influence of Kalutara on the secretion of bile acids (see table. 2);

influence carlosm. table. 4).

In accordance with the above table. 1 the results of the experiments the intensity of bile secretion in animals treated with kaputa, significantly higher than that in control animals.

As evidenced by the results of the experiments, kaputa has a marked stimulating effect on the secretion of Khalatov: under the influence of the drug at a dose of 50 mg/kg and 500 mg/kg in the vast majority of the time portions concentration of Khalatov increased.

There is a clear stimulating effect on the excretion of cholesterol in the bile.

P R I m m e R 2. Comparative studies choleretic action of Kalutara and allohol. As is well known in medical practice, drug allohol, which along with other ingredients include dry bile of animals, causes an increase in bile secretion, increase the content of bile acids.

The results are shown in table. 5, 6, 7, 8.

As follows from the data of experiments kaputa has more pronounced stimulating effect on the secretion of bile, than allohol when approximately equal to other parameters.

P R I m e R 3. The drug was tested for toxicity. Acute toxicity was determined on white mice-female 9.4 g/kg

When intraabdominal administration LD50to 1.9 g/kg

Therefore, the drug has very low toxicity.

Thus, the claimed as bile substances, potassium glutamate has a pronounced pharmacological activity and can be recommended in the future to widespread clinical practice.

The use of potassium salt of glutamic acid as a substance exhibiting choleretic effect.

 

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