The antidote carbon monoxide

 

(57) Abstract:

The invention relates to medicine and for the production of the antidote. The proposal is that, as an antidote carbon monoxide used bis-(1-vinylimidazole)-(Aziza). 5 table.

The invention relates to a new medicinal and preventive tool, namely, the antidote carbon monoxide (carbon monoxide) azizoglu drug in the form of 1 ml of 6% aqueous solution of alzola 0.5% aqueous solution of novocaine.

This tool can be used for protection of armed forces personnel and population from poisoning lethal doses of carbon monoxide emitted during fires, the action of some types of modern weapons and in extreme situations in the chemical, petrochemical, metallurgical and mining and other industries.

As an antidote for acute carbon monoxide poisoning azizol has no analogues on the activity and structure among the famous antihypoxic drug. Currently, the most effective for carbon monoxide poisoning are hyperparasitaemia and exchange transfusion. Drugs used in medicine for the new connection (alzola) and tested as antidote carbon monoxide. Primary research is that of the properties showed that the priming carbon monoxide at a concentration of 1.2% on white mice weighing 18-22 g dose of 30-60 mg/kg connection ensures the survival of animals 62,5%

Preliminary results was a prerequisite for further in-depth study of the drug.

The aim of the invention is the creation of medicinal and prophylactic treatments for poisoning lethal doses of carbon monoxide.

This objective is achieved in that azizol at a dose of 60 mg (1 ml of 6% solution in 0.5% aqueous solution of novocaine) is well tolerated and necessary efficiency in carbon monoxide poisoning.

The essence of the proposed invention is that a new drug, azizol at a dose of 60 mg (1 ml of 6% solution in 0.5% aqueous solution of novocaine) has the necessary antidote for action effectiveness criteria changes the characteristics of oxyhemoglobin. The drug does not cause changes in the functional state of the human body according to objective clinical observations of changes in blood pressure and heart rate, functional sedenii with the original data and the control group.

In accordance with the order of Ministry of health of the USSR, No. 157 since 1986 and the decision of the Pharmacological Committee of the USSR Ministry of health (Protocol No. 3 from 10.06.86) specialists of the Military medical Academy. S. M. Kirov (Department of military field therapy) and the research Institute of Military medicine of the USSR conducted clinical trials on the tolerability and efficacy of the drug arizol. The investigated drug in the dosage form for injection 6% solution in 0.5% aqueous solution of novocaine, ampoules of 1 ml, and diluted solutions of the drug in concentrations of 2.4% participated In the trials of 24 healthy men aged 18-40 years. The subjects were hospitalized groups of 6 people each. The tests were carried out in two stages with the aim of:

1) the dosage of the drug according to the criteria of portability;

2) evaluation of the tolerability and efficacy of selected dose of the drug "blind" using placebo (calcium gluconate). The following examples illustrate the subject matter.

P R I m e R 1. The manufacture of dosage forms alzola. Legform drug arizol, the substance is synthesized in Iriah SB as USSR on author. St. N 125532, 1978, made by the technology of sterile filtration and asepticsure 0.5% aqueous solution of novocaine. Before filtering the water-procaine solution of the preparation process for 5-10 min Aerosil for removing small opalescence and filtered through a filter paper under technical vacuum on a Buechner funnel. The prepared solution is colorless and transparent according to the project VFS on lectora of arizola. Sterilizing filtration of the solution alzola put through a filter Millipore" (diameter of pores 0,22 MK), mounted in a special coil connected to the installation of filtration under pressure of purified nitrogen. After careful filtering (solution 4 times filtered) system hose with filter cut off from the flask with the solution and attach it to the sterile burette for bottling. The filling of the drug is carried out in a sterile and carefully conducted purity ampoules of 3 ml, which is then sealed. Ampoules with lekforma next view on the content of mechanical impurities and burns on the control table GF-42 with the aim of rejection. Certification legform of alzola in accordance with VFS performed by the technical control Department of the Kiev chemical-Pharma - citiescape plant them. M. C. University. Storage dosage form of the drug at 20-23aboutWith showed that within 2 years what Tracia 2 and 4% was prepared directly before introduction, mixing 6% alzola with sterile 0.5% aqueous solution of novocaine.

P R I m m e R 2. Research on the effectiveness of drug arizol. Studied solutions alzola in concentrations of 2,4,6% 0.5% aqueous solution of novocaine. The necessary antidote for the actions of efficiency has a dose of 60 mg alzola in the form of a 6% solution in 0.5% aqueous solution of novocaine volume of 1 ml In this regard, further studies performed using the specified dose and drug concentrations. Research on the effectiveness of alzola as antidote carbon monoxide conducted a study of the oxygen binding function of hemoglobin with the construction of the dissociation curve of oxyhemoglobin (BWW), by definition of P50and constants hill.

The evaluation of the effectiveness of the drug arizol found that its introduction in the dose and dosage form causes a distinct decrease value, i.e. cooperativity subunits of hemoglobin, which should reduce the effect of Holden, and consequently, to increase tolerance of high concentrations of carboxyhemoglobin.

P R I m e R 3. Study of tolerability of the drug arizol.

It is established that doses of alzola 15 mg (2% solution), 3 is reavley common side effects of the drug. As the necessary antidote action efficiency has a dose of 60 mg alzola in the form of a 6% solution in 0.5% aqueous solution of novocaine volume of 1 ml, and further studies performed using the specified dose and drug concentrations. According to clinical observations of changes in blood pressure and heart rate, functional cardiovascular samples Rufe, and ECG results revealed no changes as compared to background characteristics within groups and between groups in terms of average values. Objective clinical data, biochemical and physiological studies are presented in table.2-5.

Thus, the results of the test drug arizol performed in the inpatient clinical study involving healthy volunteers allow us to draw the following conclusions:

1. A single intramuscular injection of the drug arizol at a dose of 60 mg in 1 ml of 6% solution in 0.5% aqueous solution of novocaine practically does not cause changes in the functional state of healthy volunteers assessed by clinical, laboratory and physiological parameters, in comparison with the original dantogo action effectiveness criteria changes the characteristics of oxyhemoglobin and recommended farmkomiteta the USSR Ministry of health for use in medical practice.

The use of bis-(1-vinylimidazole)-alzola as antidote carbon monoxide.

 

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