Anthelminthic agent for the treatment of sheep nematodes
(57) Abstract:Use: animal health, in particular in medical products - anthelmintic for the treatment of helminthiasis in sheep. The inventive anthelminthic agent for the treatment of nematodosis sheep includes nilverm or tetramisole and highly dispersed silica, taken in an amount of 3-15 wt. 1-2 wt. activitiesthese substances. table 2. The invention relates to agriculture, in particular for veterinary use, namely preparations for anthelminticum.Helminthiasis animals are still common and cause significant losses of meat, milk, wool and other animal products. The success of deworming depends on the availability of high-efficiency low-emission public and affordable anthelmintica, easy to use.Among Anthelmintics distinguish inorganic arsenic, tin, lead, cadmium, copper, having a relatively high toxicity, poorly flushed out of the body, although having a high therapeutic activity in the complex protivogelmintny events.Drugs are organic, usually expressed anthelminthic properties, Udovichenko practice.Known anthelmintic organic structure nilverm. He srednerussian, easy to use. Nilverm first released by the English company "ICI". Nilverm is a 2,3,5,5'-tetrahydro-6-phenylimidazo-2,1-b-thiazole and is intended for the treatment of lung and other nematodosis animals 
The closest to the technical nature of the claimed tool is anthelmintic nilverm intended for oral administration in the treatment of nematodosis sheep or similar action tetramisole. For the treatment of sheep commonly used aqueous solutions of these drugs as effective against Mature gamehouse and strongest these Anthelmintics evident when orally administered in doses of 10-15 mg/kg twice 
The aim of the invention is to achieve a high therapeutic effect while reducing the dose activitiesthese anthelminthic tool by extending its impact on the body of the animal.For this anthelminthic agent for the treatment of nematodosis sheep containing nilverm or tetramisole, further comprises highly dispersed silica in the following ratio, wt.h.Nilverm or tetr composition, formulations (see table.1), as well as methods of using the inventive anthelminthic drug for treatment of nematodosis sheep respiratory disease caused by pulmonary strangulate.P R I m e R 1.50 g tetramisole (20% granules) are dissolved in 100 ml of water, add 75 g of highly disperse silica (GOST 14922-77 Aerosil). This forms a pasty mass, which after stirring for 15-30 min, dried at 140-150aboutWith in a drying Cabinet. After drying the resulting product is ground in a ball mill, after which used in the treatment.P R I m m e R 2. 50 g of tetramisole (20% granules) in aqueous solution is mixed with 150 g of highly disperse silica. Further processing is done according to example 1.P R I m e R 3. 25 g of nilverm dissolve in water and add 150 g of highly disperse silica. Processing the resulting pasty substances behave similarly to example 1.P R I m e R 4. 25 g of nilverm pulverized in a ball mill, add 100 g of highly disperse silica and then continue rubbing in the same mill for 2.5 hours Obtained in powder form of the drug is further used in experimental testing in the treatment of nematodosis sheep.P R I m e R 6. 50 g of tetramisole (20% water granulate) and 75 g of highly disperse silica is ground in a ball mill, then according to example 4. The composition contains 40 h nilverm 150 hours of highly disperse silica (example 11). You can obtain a positive effect, but in this case, the consumption nilverm the same as without the addition of silica. In this case, no reduction of the dose active substance.With a ratio of 1:17 is an excess of highly dispersed silica in the composition. Therefore, for a rate needed to treat the number of active substances (nilverm), you must enter an animal such amount of the composition by volume, which creates discomfort for him. In short, difficult to oral administration of the composition to the animal. The compositions according to the formulations 7-12 were prepared by the techniques described in example 1 (the main method).Below is the method of treatment of nematodosis sheep with the use of the claimed composition.It should be noted that in groups of sheep were used compositions prepared by different technologies, namely: in groups 1,3 and 4 sheep received drugs, cooked was technogical drugs obtained by immobilization of nilverm or tetramisole by liquid-phase layering on highly dispersed silica (see example 1).The experimental technique.Experiments on the treatment of nematodosis sheep conducted in January and February on the Crimean scientific-research veterinary stations using animal farm "Precepts of Ilyich" Simpara - Polish area.Before performing experience on the farm of the inventive compositions were tested for emissions on sheep vivarium nivs. Preparations in the form of a suspension in distilled water was injected once by mouth in doses three times higher than therapeutic. Monitoring the clinical condition of the animals (behavior, appetite), thermometry conducted prior to the introduction of drugs, after 2 h, 24 h and 7 days after injection of the inventive composition. As it turned out, the animals have not detected changes of physiological parameters of the body, side effects have been noted.For testing sheep are divided into groups of 4 heads in each one of them control 9 has not received any drugs, and another received nilverm (prototype) (8).Before the experiment, sheep were examined clinically and helminthophobia is: cough, mucopurulent expiration of the nose. The extensiveness of invasion pulmonary strangulate was high: dictyocaulus 100% protostrongylus ranged from 25 to 75%
Subjects received oral freshly prepared aqueous suspension of anthelminthic means at a dose of 5-7 mg/kg wet weight (calculated as active substance (ADV)). As a rule, it was 3-5 g claimed anthelminthic funds for sheep with an average weight of 40 kgAfter injection, the animal 1-8 groups was satisfactory. Sheep were clinical observation, samples of faeces were taken after 5 days and again after 14.The results are presented in table.2.It should be noted that in groups 1,2,6 and 7 achieved 100% effectiveness of the proposed anthelminthic funds, while the doses were 2-3 times lower than recommended (group N 8).The intensity of infection by dictyocaulus in experimental groups is almost zero (only one sheep in the group found 2 larvae that when counting by 4's head gave average 0.5 larvae).Thus, anthelminthic tool at a lower dose of active beginning exhibits a high therapeutic activity. When the drug is not used, what is required when using pure silvery or tetramisole. A single use of the composition can achieve savings of expensive imported medicines and to reduce the cost of carrying out secondary injection.The drug is non-toxic and has no side effects, has no smell. ANTHELMINTHIC agent FOR the TREATMENT of NEMATODOSIS SHEEP, including nilverm or tetramisole, characterized in that, to improve therapeutic efficacy means, it additionally contains highly dispersed silica in the following ratio, wt. hNilverm or tetramisole 1 2
Highly dispersed silica 3 15
FIELD: medicine, in particular composition for quick-disposable in buccal cavern tablets.
SUBSTANCE: claimed composition contains granulated product of fine dispersed long releasing particles, comprising drug and fillers selected from group including sugars and sugar alcohols together with binder, wherein content of non-granulated fine dispersed long releasing particles is 0-15 %. Method for production of such tablets is also disclosed.
EFFECT: pharmaceutical composition with accelerated degradation.
24 cl, 9 ex, 3 dwg
FIELD: medicine, pharmacy.
SUBSTANCE: invention relates to a pharmaceutical composition that comprises internal lipophilic matrix and external hydrophilic matrix in the mass ratio of lipophilic and hydrophilic matrices from 100:0.5 to 100:20. The internal lipophilic matrix consists of substances with melting point below 90oC and comprises at least partially an active component as globules. As an active component the composition comprises mesalazine - 5-aminosalicylic acid in the concentration up to 95 wt.-%. Lipophilic matrix is dispersed in external hydrophilic matrix. The composition can comprise optionally other excipients. Also, invention describes a method for preparing the composition. Invention provides sustained-release of mesalazine from first phases after administration and more homogenous pattern of release as compared with conventional systems.
EFFECT: improved properties of composition.
11 cl, 5 ex
FIELD: medicine, pharmacy.
SUBSTANCE: invention relates to a medicinal formulation with the constant rate for releasing a medicinal substance, core of medicinal formulation and to a method for providing relieved release of medicinal substance. Medicinal formulation comprises medicinal substance-containing layer and semi-permeable wall and expanding layer. A layer promoting to moving forward is placed between semi-permeable wall and medicinal substance-containing layer and the content of medicinal substance is at least 20% of the total layer mass containing a medicinal substance. Invention provides releasing practically all amount of medicinal substance from medicinal formulation to medium for it applying.
EFFECT: improved and valuable medicinal and pharmaceutical properties of medicinal formulation.
12 cl, 13 dwg, 8 ex
FIELD: medicine, cardiology, pharmacy.
SUBSTANCE: invention relates to carvedilol-containing pharmaceutical composition that is used for treatment and/or prophylaxis of hypertension, cardiac insufficiency or stenocardia. The composition comprises carvedilol or its pharmaceutically acceptable salt and one or some adjuvants. Carvedilol is distributed in adjuvants as a molecular dispersion. Adjuvants are not surface-active substance and/or non-ionogenic surface-active substance. The concentration of adjuvants exceeds 5 wt.-%. Also, invention describes a method for preparing the composition and pharmaceutically acceptable solid formulation for oral administration. Compositions of the present invention provide the enhancing solubility of carvedilol and level of its absorption in lower regions of intestine.
EFFECT: improved and valuable pharmaceutical properties of composition.
17 cl, 9 ex
FIELD: pharmaceutical industry.
SUBSTANCE: invention provides oral-administration beta-histin-based controlled-release solid preparation prepared by granulating active ingredient from melt with fat component added followed by mixing thus obtained granulate with hydrophilic polymer and conventional excipients. Invention enables preparation of pharmaceutical dosage form with appropriate beta-histin release profile allowing reduction of daily drug intake to single dose, whereas concentration of active ingredient is kept constant within therapeutical dose limits.
EFFECT: facilitated therapeutical treatment.
4 cl, 14 ex
SUBSTANCE: the present innovation deals with pharmaceutical composition of bactericidal action. The composition suggested contains ciprofloxacin in the form of hydrochloride monohydrate, maltodextrin as a binding substance, sodium carboxymethyl starch as a disintegrating agent, silica gel, a lubricant at quantities mentioned in its formula. Ciprofloxacin tablets should be obtained due to pressing technique by applying the stage of moisture granulation. If necessary, the surface of tablets should be covered with a hydroxypropylmethylcellulose-based water-soluble membrane. Simultaneous application of maltodextrin as a binding substance and sodium carboxymethyl starch as a disintegrating agent enables to obtain ciprofloxacin-containing tablets of sufficient strength and quick release of active ingredient.
EFFECT: higher efficiency of application.
6 cl, 6 ex, 9 tbl
FIELD: pharmaceutical industry, medicine.
SUBSTANCE: invention relates to human insulin drug with activity of 100 IU/ml, including cartridge forms. Drug contains active ingredient, glycerol as isotonic agent, conserving agent and water, wherein it contains human insulin substance of high purity with residual proteolysis activity not more than 0.005 adsorption units, sodium chloride as additional isotonic agent, m-cresol as conserving agent, and additionally sodium dihydrogenphosphate dihydrate or disodium hydrogenphosphate heptahydrate as substance with buffer capacity and pH 6.9-7.8.
EFFECT: human insulin drug of short action with increased physiological activity and physical and chemical storage stability.
6 ex, 1 tbl
FIELD: pharmaceutical industry, medicine.
SUBSTANCE: invention relates to human insulin drug of durable action. Drug contains human insulin substance of high purity, protamine sulfate, zinc chloride, glycerol, m-cresol, phenol, sodium dihydrogenphosphate dihydrate or disodium hydrogenphosphate heptahydrate, sodium chloride, and water and has residual proteolysis activity not more than 0.005 adsorption units.
EFFECT: human insulin drug of durable action with increased physiological activity and physical and chemical storage stability.
4 ex, 1 tbl
FIELD: pharmaceutics, medicine.
SUBSTANCE: the present innovation deals with cardiotherapy for treating and preventing coronary deficiency. The preparation is designed as a plate (film) consisted of three layers, each of them is manufactured out of co-polymer of vinyl pyrrolidone, acrylamide and nitroglycerin-containing ethylacrylate; moreover, internal layer additionally contains solid fat - cacao oil, and weight ratio for the sum of external layers to internal corresponds to 1 : 1. The suggested preparation could additionally contain brilliant green dyestuff. The preparation should be manufactured out of pre-obtained mixture of nitroglycerin and copolymer in solution of alcohol and water followed by layer-by-layer forming three-layer film due to spreading the mixture onto solid bottom plate and drying at 30-50 C. The innovation provides higher adhesion to gingival mucosal surface, decreased side action, improved bioavailability and stability of therapeutic effect.
EFFECT: higher efficiency of therapy.
3 cl, 3 ex
FIELD: pharmaceutical industry.
SUBSTANCE: invention discloses solid oral dozed pharmaceutical form of hydrocodon with controlled release. Pharmaceutical form comprises analgetically effective amount of hydrocodon or pharmaceutically acceptable salt thereof and controlled-release material. Pharmaceutical forms of hydrocodon are suitable to be administered once a day and provides early commencement of therapeutical effect, which lasts at least about 24 h.
EFFECT: enhanced analgetic action.
44 cl, 3 tbl, 3 ex