The method of applying aseptic protective coatings and device for its implementation
(57) Abstract:Usage: in medicine, in particular for the application of bandages, plasters and coatings permeable to gas but impervious to microorganisms and dust. The essence of the invention: method of applying aseptic protective coating on the skin is that the solution containing 1 to 50 wt. % of fibre-forming polymer, aseptic drug and the solvent serves to protect the skin in the form of at least one jet. The coating formed in the electrostatic field of 1 to 5 kV/see This method is carried out using a device containing a tank filled with a solution, the microcompressor connected with the cavity of the container through the tube not reaching the level of solution in the tank, pressure cap installed on it forming a head with a capillary tube, one end of which is connected to the siphon tube, passed through the cover into the vessel and the other end is made free and taken out of the forming head. The device is provided with a source of high electrical voltage, one pole of which is connected to the capillary, and the other grounded. In the device cavity forming head may be the connection is and is installed with a clearance relative to the wall of the forming head. 2 S. and 1 C.p. f-crystals, 2 Il. The invention relates to medicine, and more precisely relates to a method of applying a protective aseptic coating and device for its implementation, which can be widely used for the application of bandages, plasters for medical establishments, veterinary hospitals and other industries that require coating is permeable to gas but impervious to microorganisms and dust.A known method of applying aseptic, therapeutic and protective coatings on the outer integument and the damage to the body by bandaging, and adhesion of these coatings adhesive patch, or medical adhesive. However, this method is not applicable in case of increased soreness and easy traumatized damaged surfaces, for example in the case of severe burns, extensive abrasions and the like.Widely used in medical practice, the method of coating by spraying solutions of film-forming substances containing drugs, such as from aerosol cans, of which the liquid is fed under the action created in the spray pressure of the gaseous environment.However, when this method is writenow surface, that does not preclude the irritant solvent until it dries. In addition, we obtain in this way the coverage is continuous and interfere with the normal gas exchange surface to be protected, which in some cases is unacceptable. A tight fit of these coatings to protect the surface hinders their subsequent destruction in case of increased soreness to the protected surfaces.Widespread technique has received a coating methods by air atomization of liquid material on a grounded product or surface in an electrostatic field, we then obtain highly dispersed aerosols transported in an electrostatic field, deposited on a grounded surface and form a continuous film coating. To obtain highly dispersed aerosols air flow serves under high pressure or liquid before atomization saturate any gas inert with respect to it 
In the devices performing such coating methods, in addition to the high voltage source connected to the electrode, the capacity for sprayable material and pressure source using the sophisticated design of the spray feed air stream 
However, such devices are bulky and require a powerful source for creating air flow, which effectively precludes their use in medical practice. In addition, the atomization of materials leads to the formation of a continuous film coating, which is inherent in the above-described disadvantages, which virtually eliminates the use of them as aseptic protective or therapeutic coating.The present of the invention is to create such a method of applying a protective aseptic coating and the device for its implementation, which will provide atraumatic coating, and its specified moisture and gas permeability, which in turn will help to create favorable conditions for healing of damage on the outer surface.The problem is solved in that in the method of applying aseptic protective coating by feeding on the protected surface of the mixture of solvent and aseptic drug as a mixture, use a solution of polymeric fibre-forming compositions containing the aseptic preparation of which is directly on the protected surface to form the coating layer microfiber or paroliciste 1-50 wt. moreover, the solution of polymer composition serves as at least one stream.Microfiber or porous structure of the coating layer of the stream of solution polymer composition is formed in the electrostatic field strength from 1 to 5 kV/seeThe problem is solved also by the fact that the device for applying aseptic protective coating containing a forming head placed in its hollow body by the capillary, mud tank, put on a grounded surface, the high voltage source, one pole of which is connected to the electrode for applying voltage to the applied solution, the microcompressor, reported hose capacity, according to the invention, the capacity installed on the main body of the forming head, tightly connected with him and has two nozzles, one of which is connected to the microcompressor, and the open end of the pipe connected to the capillary, placed in the vessel below the level of its solution. The tank is provided with an additional pipe, one end of which is placed in the body cavity of the forming head, and the other end is placed in the vessel above the level of its solution.Thanks spoets on the healing of damaged surface. In addition, the supplied stream of polymeric fibre-forming composition under the action of the electrostatic field is extruded into a thin thread, the pressure which when laid on the damaged surface during formation of the layer is almost not felt, since during the movement of the thread from the capillary to the protected surface is drying yarn from the solvent and the protected surface reaches the fiber diameter of 0.1-10 μm, which provides atraumatic coating and creates a structure, impervious to dust and micro-organisms. While the coating structure can apply through his pores additional amount necessary medication.The possibility of filing a polymeric fibre-forming composition in the form of a stream, pulling the thread, and not its atomization, allowed to exclude the formation of a continuous film and the need to use air flow supplied under pressure in the direction to the damaged surface, which in General can serve as a source of delivery to it of microorganisms and dust. In addition, eliminates the need to use air flow supplied under pressure, has greatly simplified the design of the device, the th head. As a result, the device for applying aseptic protective cover compact, convenient and reliable in operation.In Fig. 1 shows schematically a General view of the proposed device for applying aseptic protective cover of Fig. option 2 implementation capacity of the installation.The proposed method of applying a protective aseptic coating is that the protective coating formed from a solution of known polymeric compositions capable of fiberizing, for example, polystyrene of high molecular weight, perchlorovinyl, rizal and so forth, and containing aseptic, for example iodine, brilliant green, the drugs.The polymeric fibre-forming composition is contained in solution in the amount of 1-50 wt. that depends on the properties of the polymer to the fiberizing, and its interaction with drugs, the type of lesion on the protected area, and so forth. For example, when used as a polymeric fibre-forming compositions of polystyrene of high molecular weight or high molecular weight methacrylate each of them is contained in the solution from 1-2 wt. cellulose acetate and perchlorovinyl 5-20 wt. Risala (without additives) 30-50 wt. or from the components of the TV can be used ethyl alcohol or other admitted to the medical use of solvents.Such a solution polymer composition serves as one or more jets, of which an electrostatic field strength from 1 to 5 kV/cm on the surface to be protected form the coating layer microfiber or porous structure of a given thickness, and the thickness of the coating depends on the type and size of the lesion surface. The jet of polymer solution composition can be fed continuously or intermittently through a capillary or to be extruded through the die plate for forming fibre-forming polymers or porous structure that depends directly on the use of the proposed method and type of the applied coating.For applying aseptic protective coating microfiber or porous structure is used, the device containing the forming head 1, the container 2 is applied to a grounded surface 3 solution of 4 fibre-forming polymer compositions containing aseptic preparation source 5 high voltage, one pole of which is connected to the electrode for applying voltage to the applied solution, the microcompressor 6 reported hose 7 with a capacity of 2. The second pole of the source 5 high voltage grounded. Forming head 1 contains a hollow to what aprovada 10, moreover, through the capillary 9 is a solution that is in the tank under pressure. The tank 2 is installed on the housing 8 forming head 1 and hermetically connected with him through the famous split node 11 as needed to change capacitance with the applied solutions.The tank has a cover 12, which is equipped with nozzles 13 and 14, the pipe 13 is connected to the hose 7 microcompressor 6. For compactness of the device, the hose 7 passes through the housing 8 forming head 1. The pipe 14 is connected to the capillary 9, and the open end of the pipe 14 is placed in the vessel below the level of the inside of the solution 4. The open end of the pipe 13 can also be placed below the level in the vessel solution, as shown in Fig. 2.In accordance with a variant of execution of the device in the lid of the vessel 2 has an additional pipe 15, one end of which is placed in the cavity of the housing 8 forming head 1, and the other end is placed in the vessel 2 above inside solution that allows couples solvent released into the vessel 2 from the solution to pass through the additional pipe 15 and to accumulate in the cavity of the housing 8 and out of the cavity in it the cleaning of the capillary. When forming the protective coating from multiple jets of the solution of the latter serves multiple forming heads or devices.The operation of the device is as follows. For coating the patient and the device are connected to a common wire 17 to ground and the spray device is positioned at a distance of 100-300 mm to the protected surface 3, is connected to the voltage source and the microcompressor. Under the pressure developed by the microcompressor 6, the solution of one of the fibre-forming polymers and aseptic drug is delivered through the pipe 14 to the capillary 9, which voltage is 10-100 kV generator 5 high voltage.In an electrostatic field arising between the capillary 9 and the surface to be protected 3, the solution is supplied in the form of a stream, is extruded in a thin charged thread 18, which under the action of electrostatic attraction is transported to the protected surface 3. During movement of the thread 18 of the capillary tube 9 to the surface 3 of the patient is drying yarn from the solvent and the protected surface 3 reaches the microfiber diameter of 0.1-10 μm. This fiber does not traganou the surface of the fibers under the influence of the same charge of the electrostatic field and the mutual repulsion between randomly distributed over the surface, forming a coating of a given thickness.Small diameter fibers forms a structure that is impermeable to microorganisms and harmful dusts, but not impeding gas exchange surface to be protected or the penetration of moisture.High speed fiberizing allows to obtain a protective coating within 2-20 minutes After which the device is disconnected from the power source and the microcompressor and removed from the patient. therapeutic effect is introduced into the solution aseptic preparations and simultaneously formed in the process of negative air ions. Electrical current process is 1-20 mA, is completely safe and the patient is not felt. The boost protective cover is retained on the surface due to the electrostatic field created in the process of formation of the coating.P R I m m e R. On the surface of human skin by application was applied artificial nutrient medium from cultures of microorganisms. These applications were brought by the proposed method protective coating microfiber structure with a thickness of 1 mm from a solution having a viscosity of 1 PZ, conductivity 210-5Ohm/cm and containing, by weight. rizal 5% polyvinyl butyral 5% iodine 1% ethyl sa three strains of bacteria (Staphylococcus, Salmonella and esherichia), three strains of fungi (penicilli, aspergilli and debris) and four strains of imperfect fungi (Candida, Trichophyton, epidermofitony and microsporon). The protective cover is retained on the surface of the skin within 24 hoursThe test results showed that the applied protective coating has antimicrobial properties (observed suppression of reproduction almost all used strains) and does not cause bio - logical skin-irritating.Thus, the proposed method of applying a protective coating can be widely used for protection and treatment of people and animals from the surface of microbial processes (abscesses, fungal infections, and so forth), especially for ringworm, the components of the actual medical problem. 1. Method of applying protective aseptic coating by feeding on the skin of a solution of aseptic preparation, characterized in that the solution further comprises a fibre-forming polymer in quantities of 1 to 50 wt. the solution serves as at least one stream, and the coating formed in the electrostatic field of 1 to 5 kV/see2. A device for applying casinoportalen on it forming a hollow head with capillary, one end of which is connected to the siphon tube, passed through the cover into the vessel, and the other is made free, characterized in that the device is provided with a source of high electrical voltage, one pole of which is connected to the capillary, and the other grounded, the free end of the capillary taken out of the forming head, and the pressure source in the form of microcompressor connected to the cavity of the container through the tube not reaching the level of solution in the tank.3. The device according to p. 2, characterized in that the cavity forming head is connected with the cavity of the tank through a pipe, not reaching the level of solution in the tank, and the free end of the capillary is installed with a clearance relative to the wall of the forming head.
FIELD: medicine, pharmaceuticals.
SUBSTANCE: invention relates to new method for production of granules containing 5-aminosalicylic acid, as well as to new method for production of peroral pharmaceutical composition for treatment of non-specific ulcerative colitis and Cron's disease. Said composition includes 5-aminosalicylic acid as active ingredient, and granulation is carried out by using water as solvent.
EFFECT: granules containing 5-aminosalicylic acid with increased strength, glib surface and narrow granule size distribution.
24 cl, 3 ex, 12 tbl, 9 dwg
FIELD: medicine, chemical-pharmaceutical industry, pharmacy.
SUBSTANCE: invention proposes a composition possessing anti-hypertensive and diuretic activity with prolonged release of an active component. The composition comprises an envelope-covered core comprising indapamide as an active component and ludipress, hydroxypropylmethylcellulose, aerosil and stearate as accessory components. The core is covered by a film-forming envelope that is based on hydroxypropylmethylcellulose preferably and comprising additionally polyethylene glycol, glycerol, talc, titanium dioxide and lactose. Method for preparing the novel composition involves mixing indapamide and accessory components followed by forming the prepared mixture to form the core of required configuration and size and applying the envelope. The composition is characterized by continuous release of indapamide, high fracture and abrasion strength, stability of active component during storage with the fitness time above 2 years.
EFFECT: improved preparing method, improved and valuable properties of composition.
9 cl, 2 tbl, 4 ex
FIELD: medicine, pharmacy, chemical-pharmaceutical industry.
SUBSTANCE: invention relates to a medicinal formulation of tramadol with delayed-release. Proposed medicinal formulation possesses the high effectiveness in treatment of pains of different etiology and can be used in treatment of diseases chosen from the following group: enuresis, cough, inflammatory processes and/or allergic responses, depression states, abuse and/or alcoholism, gastritis, diarrhea, cardiovascular diseases, diseases of respiratory ways, psychic diseases, epilepsy.
EFFECT: improved and valuable medicinal and pharmaceutical properties of formulation.
38 cl, 11 tbl, 4 dwg, 11 ex
FIELD: medicine; chemical and pharmaceutical industry.
SUBSTANCE: invention in the field of pharmaceutical forms, in particular relates to a regulated delivery tablet held in the stomach containing: a) a centre regulating medicine release which contains medicine, well expanding polymer, generating gas-agent, and b) a composition of fast releasing coating with the same medicine as in the centre and pharmaceutically accepted accipients, where the coating envelops the centre which ensures two-phase medicine release in the gastro-intestinal fluid. Besides, the invention is associated with once a day therapy, which includes centre with baclofen released in a regulated manner and coating of fast release composition made of baclofen or its pharmaceutically acceptable salt and pharmaceutically accepted filling material and means for holding the tablet in the stomach for longer periods.
EFFECT: holding tablets in the stomach for longer periods; two-phase medicine delivery in a regulated manner.
14 cl, 1 dwg, 6 tbl, 4 ex
FIELD: medicine; pharmacology.
SUBSTANCE: invention refers to solid dosed composition for pain treatment, containing: nucleus including active pharmaceutical ingredient and matrix, an coating including physical compound of polyvinyl acetate, polyvinyl pyrrolidone and active pharmaceutical ingredient, where active pharmaceutical ingredient and matrix are interconnected in such a way that release of pharmaceutical ingredient placed within nucleus from matrix is controlled, and release of composed active ingredient placed within nucleus occurs more slowly than release of active pharmaceutical ingredient placed in coating matrix. Yet nucleus and coating active pharmaceutical ingredient is the same and considered to tramadole or its stereoisomer or pharmaceutically acceptable salt. Invention also refers to tablet containing specified composition. Composition under invention provides pain relief not later than 2 hour after primary introduction in one dosage; pain relief lasts within at least 24 hours after introduction.
EFFECT: agent is characterised by high efficiency.
14 cl, 7 dwg, 9 tbl, 6 ex
SUBSTANCE: invention concerns the solid medicinal composition, including flupirtin or its physiologically comprehensible salts as biologically active substance. At least, one part of flupirtin exists as preparative ready form with the slowed down liberation of the active component. The preparative ready form contains the pressed forms flupirtin, which are preferably in regular intervals covered by a prolonging component. Form pressing of flupirtin is characterised by the size of particles of 160-800 mcm, in bulk volume less than 5 ml/g and preferably are spherical or close to spherical. The prolonging component provides diffused-controllable flupirtin release and preferably includes polymer or a copolymer from acrylic acid, derivatives of acrylic acid, methyl-acrylic acid and-or derivatives of the methyl-acrylic acid, or their admixtures.
EFFECT: new flupirtin composition provides uniform and long release of active substance during long time, frequency of reception to two times day, more rare implication of side effects and a risk exception of a "dose dumping".
16 cl, 3 dwg, 3 ex