N-oxide 2-methyleneindoline (ii) chloride, exhibiting the properties of plant growth regulator
(57) Abstract:Usage: in agriculture. Product: N-oxide-2-methyleneindoline(2)chloride unidentified structure; exit 591,6 g (99%), decomposed, not melting. Reagent 1: N-oxide-2-methylpyridin in ethyl alcohol. Reagent 2: chetyrehpolnye chloride manganese. table 2. The invention relates to the derivatives of alkylpyridine, in particular to the complex N-oxide-2-methylenedianiline (II) chloride formula
unidentified structure having the properties of a plant growth regulator (productivity of spring wheat and having cytokinin activity).This property implies the possibility of its use in agriculture and biotechnology.The proposed connection is not described in literature. Known for a number of analogues with similar chemical structure and biological activity.1. The base object. Similar in effect for wheat, are permitted. The drug ROUND - 2-chloroethyltrymethylammonium [1,2].Used for seed treatment to improve grain yield of wheat. Disadvantages: high toxicity (670 mg/kg), large expenses and a lower activity than presenta only 2 g/t of seeds (2000 times less).2. A similar action (standard I) is the drug cartoon-2, which is recommended for use on wheat . Expenditure norm cartolina-2 250 times higher than for the proposed substance and yield increase below.3. Similar in structure and action is the drug Ivin-N-oxide 2,6-dimethylpyridine (standard II) [4,3] . For wheat Ivin less active (less yield increase) than the proposed substance.4. A similar action is kinetin-6-benzylaminopurine (standard III). Kinetin less active and exceeds the proposed substance on the cost and availability  . A big disadvantage of cytokines is their very poor solubility in water. The proposed substance, on the contrary, soluble in water.The aim of the invention is the synthesis of new highly effective and safe for the environment, plant growth regulator, as well as new substances with high cytokinin activity, soluble in water and able in practice to replace the well-known cytokinins.The objective is achieved by the synthesis of the substance akvo-N-oxide-2-methyleneindoline (II) chloride formula
Cl2H2O the Proposed connection is produced by interaction of the N-ocheskey structure, soluble in water, non-hygroscopic and non-explosive.The structure of the proposed compound is confirmed by elemental analysis and IR spectra taken on the spectrophotometer'S RECORD-M-80.The presence of absorption bands in the spectrum of the claimed connection: 1210 cm-1(NO); 1628 cm-1(C=C); 3360 and 3500 cm-1(OH); 1030 and 1070 cm-1(C-N-C), testifies in favor of this structure.P R I m er 1. The method of obtaining akvo-N-oxide 2-methyleneindoline (II) chloride.In a three-neck reactor, with a capacity of 2 l, equipped with a stirrer, dropping funnel and reflux condenser, dissolve 218 g (2 mol) of N-oxide of 2-methylpyridine in 200 ml of ethanol and rolled down at 20-25aboutWith the solution 379,68 g (2 mol) chetyrehletnego manganese chloride in 600 ml of ethanol. The reaction mass is heated to boiling, the solvent evaporated, the residue was washed with 60 ml of ether. Output akvo-N-oxide 2-methyleneindoline (II) chloride 591,6 g (99% ), the connection is not melting, decomposing. Found, %: C 28,3; H 3,6; N 5,7; Cl 27,7.C6H9NO2MnCl2.Calculated, %: C 28,49; H To 3.58; N Of 5.53; Cl 28,0.P R I m m e R 2. Effects of drugs on the productivity of spring wheat.The experience of the TA - Kurgan scientific research Institute of grain farming.The soil is leached Chernozem, medium, middle, heavy loam.The methodology of the experiment. Before sowing, seeds were treated with aqueous solutions of drugs by the method of semi-moist treatment. Solution solution, and in the control of water to 10 liters per 1 ton of seeds. Square plots 50 m2the fourfold repetition.Description of the experiment and the results are given in table.1. In the control variant used water as the base object taken the drug ROUND, as a standard I Kartalin-2 (similar in action, as a benchmark II - Ivin (similar in structure). Taken the recommended dose.Installed: proposed substance in all tested doses, increases the number of productive tillers, number of grains per spike and grain yield. The optimal dose of 2 g/t of seeds. With the increase and decrease of a dose effectiveness is reduced. In the optimal dose of the proposed substance on all indicators is superior to the control, the base object and standards. Increase in all indicators reliable.P R I m e R 3. Cytokinemia activity proposed substances.The experience of the laboratory.Under sterile conditions from the core of the stem of tobacco varieties Trebizond-62 cut out the cylinders with a diameter of 5 mm and a height of 2-3 mm Before incubation cylinders were weighed. Then they were placed in test tubes with sterile nutrient medium. In the control variant used only nutrient medium. In the variant with the standard on Wednesday added kinetin - 6-benzylaminopurine . In the variant with the proposed substance in the environment before the beginning of the experience added to the proposed connection.After adding substances and planting cylinders on a nutrient medium test tubes were placed in a thermostat at 34 days. For experience in a thermostat maintained the temperature of the 24aboutC. Illumination was 5000 HP at the length of day 16 hours after the experience, the cylinder was removed from the tubes and weighed. Largest weight gain were determined cytokinines activity.The results of the experiment are given in table.2.In the control variant, in the absence of kinetin weight fabric to the end of the experiment decreased 47.3% . This indicates that without kinetin, not only can not be growth, but also being degraded tissue.In the presence of kinetin in the medium insulated fabric is not only preserved, but its mass is significantly led the ILO to its significant growth. Compared to kinetin, increase tissue increased 4.9 times.Has revealed that the substance exhibits a distinct specific cytokinines activity. It is more active than kinetin. It has the best physical and chemical properties soluble in water. It is more accessible (less stages in the synthesis) and more cheaply.The proposed substance can replace kinetin as a component in various environments and to find application in the practice of agriculture in those cases when it is necessary to strengthen cytokinines activity in different tissues of a plant.P R I m e R 4. Acute toxicity of the compounds was determined on white mice - males and females weighing 19-21 g, the oral method of administration of aqueous solutions. As a demonstration of the toxicity of the value LD50- sredneseriynoe dose expressed in mg/kg of the animal. The account of the death of animals is carried out 24 h after the injection. The results of the experiments were statistically processed according to the method Litchfield and Wilcoxon signed in the modification of the Company . Has revealed that the compound belongs to the group srednetonnazhnyh drugs - LD50- 950 mg/kgTechnical and economic efficiency of offers plants with greater activity than the standards and analogues;
the proposed connection provides increased productivity of spring wheat on 16-21%;
a new substance has cytokinin activity and exceeds standard-kinetin, it can replace kinetin in the creation of various nutrient media and to find a practical application in agriculture;
the economic effect of the application of the proposed connection will be to increase the productivity of spring wheat 50-125 rubles/ha;
scope of implementation may be more than 5000000 ha;
the economic effect from implementation of the proposed solution can exceed 50 million rubles;
consumption of the drug is 2 g per 1 ton of seeds, 0.5 g per 1 ha, 50 kg on the proposed scope of implementation. N-OXIDE 2-METHYLENEINDOLINE (II) CHLORIDE, EXHIBITING THE PROPERTIES OF A PLANT GROWTH REGULATOR.N-Oxide 2-methyleneindoline (II) chloride formula
< / BR>the resulting interaction of the N-oxide 2-methylpyridine with manganese chloride in a molar ratio of 1 : 1 in the environment of aliphatic alcohol, exhibiting the properties of a plant growth regulator.
SUBSTANCE: composition preventing plant diseases including components I and II as active ingredients is described. Component I is (RS)-N-[2-(1,3-dimethylbutyl)thiophene-3-yl]-1-methyl-3-trifluoromethyl-1H-pyrazol-4-carboxamides. Component II is selected from tetrakonazol, flutriafol, imibenkonazol, triadimefon, simekonazol, oxpokonazol fumarate, protiokonazol, bupirimate, spyroxamine, metiram, dodine, anilazine, chlozolinate, oxicarboxine, ethaboxam, iprovalikarb, pirazophos, phtorimide, diflumetorim, fenhexamide, famoxadone, fenamidone, ciazofamide, zoxamide, ciflufenamide, boskalid, isopropyl bentyavalikarb, pikoxistrobine, piraklostrobine, fluoxastrobine or dimoxistrobine. Also, the method preventing plant disease is described.
EFFECT: composition has synergistic effect which is not expected for each separate components, is able to significant increase of preventive effect against different phytopathogens with lower quantity of chemicals and do not invoke phytotoxic lesion.
2 cl, 9 tbl, 6 ex
SUBSTANCE: invention relates to agriculture and is meant for increasing germination energy, germination capacity and yield of grain crops when using copper (II) bismalondiamiditrate of formula (I) Cu(NO3)2·2CH2(CONH2)2 as a growth stimulator for grain crops.
EFFECT: faster maturation of grain crops, increased yield, as well as wider range of agents for this purpose.
3 tbl, 1 ex
SUBSTANCE: invention relates to agriculture. The pre-sowing treatment of seeds is carried out with aqueous solution of copper bismalondiamidchloride (II) with a concentration of the active ingredient 0.001% at a dose of 1 liter per 1 kg of seeds. Table 3.
EFFECT: invention enables to increase viability and seed germination.
3 tbl, 1 ex
SUBSTANCE: invention relates to the field of agriculture. The interaction of copper chloride (II) and malonic acid diamide is carried out at molar ratio of 1:2 and the temperature of 18-22°C, followed by preparation of 0.001% aqueous solution of the resulting bismalondiamidchloride copper (II).
EFFECT: invention enables to increase germinating energy and seed germination, to speed up the ripening of grain crops.
3 tbl, 1 ex
SUBSTANCE: invention relates to agriculture. Copper (II) bis-malonediamide chloride of formula [CuCl2(C3H6N2O2)2] is used as a growth stimulant for grain crops.
EFFECT: invention increases germination power and germination capacity of seeds.
3 tbl, 1 ex
SUBSTANCE: invention relates to method of conserving water preparation of calcium compounds, which includes the following stages: (a) obtaining water preparation of at least one calcium compound; (b) addition to water preparation of stage a) of one or more sources of lithium ions in such quantity that the total quantity of lithium ions in water preparation constitutes from 750 to less than 3000 per mille , calculated relative to water in preparation; (c) addition to water preparation of stage a) of one or more sources of sodium ions and/or potassium ions in such quantity that the total quantity of sodium and/or potassium ions in water preparation constitutes from 3000 to less than 7500 per mille, calculated relative to water in preparation, where stages (b) and (c) can be performed simultaneously or separately in any order.
EFFECT: method improvement.
23 cl, 2 ex
SUBSTANCE: invention relates to the field of agriculture, namely to the technology of corn harvesting for grain. In the method of moisture reduction of corn grain when harvesting 8-10 days prior to panicle appearance the spraying of crops is provided with the mixture of Brexile-zinc and para-aminobenzoic acid in a ratio of 1:1, which is dissolved in water per hectare rate.
EFFECT: method enables to obtain grain with optimum moisture content when harvesting, reduction of the cost of agricultural receiving, final drying of grain, reduction of the growing season and saving the environment.
1 tbl, 1 ex
SUBSTANCE: biocide includes a zinc or copper (II) salt of general formula (1) , where M is Zn or Cu, R1 is selected from a group including hydrogen and methyl, R2 is selected from a group including hydrogen and OH, R3 is selected from a group including hydrogen, alkyl and a SO2OH group. Said biocide further contains a substance selected from a group including ionic and nonionic surfactants, water-soluble carboxylic acids and salts thereof with metals, phenols, zinc and inorganic acid salts, with the weight ratio of said substance to the copper or zinc salt of general formula (1) ranging from 1:200 to 1:0.7.
EFFECT: high efficiency of treatment.
3 tbl, 65 ex
SUBSTANCE: invention relates to a zinc or copper salt of general formula (II) which is used as a biocide, wherein M is Zn or Cu, R1 is selected from a group which includes hydrogen and methyl, R2 is substituted C1-C5 alkyl, m=0-5, n=0-2, m+n=1-5. The copper and zinc (II) salts have high biocidal activity and a wide range of action on biological objects. Said salts can be used in disinfectant compositions for various purposes, coating compositions, paper and wood treatment compositions, polymer compositions with high fungal resistance, as well as in many methods of preventing negative effect on biological objects, particularly shellfish, on organisms and materials.
EFFECT: improved method.
2 cl, 28 ex, 4 tbl
SUBSTANCE: planting material is treated by soaking seeds prior to sowing for 24 hours. Soaking is carried out in an aqueous solution of magnesium and zinc complexonates with iminodisuccinic acid at a ratio of MgL:ZnL=1:1. The concentration of magnesium and zinc complexonates is 1.5·10-4 mol/l.
EFFECT: reduction of the agent consumption, and intensification of formation of pigments of photosynthetic apparatus.
FIELD: organic chemistry, medicine, physiology.
SUBSTANCE: invention relates to agents for regulation (maintaining or suppression) of physical working ability and/or adaptation to different variants represented by solvated complex compounds of the general formula (I): Katm+[L1 qEL2]Ann- x p.Solv (I) wherein L1 means aminothiols of the formula: R1NHCH(R2)(CH2)1-2SR3 wherein R1 means hydrogen atom (H), (C1-C20)-alkyl or RCO; R means (C1-C19)-alkyl; R2 means H or carboxyl; R3 means H, (C1-C20)-alkyl, (C2-C20)-alkenyl or benzyl; q = 1, 2 or 3; L2 means halogen atom, water and/or organic ligand. For example, bis-(N-acetyl-L-cysteinato)aquozinc (II) diheptahydrate suppresses physical working ability and in the dose 50 mg/kg increases reviving time of mice by 6 times and cats - by 2.8fold under conditions of acute hypoxia with hypercapnia, and increases reviving time of mice by 4 times under conditions of acute hypobaric hypoxia. Under the same conditions the known antihypoxic agents amtizol, acizol or mexidol are inactive or less active significantly by their activity. Bis-(N-acetyl-L-cysteinato)-ferrous (II) pentahydrate is more active as compared with the known antihypoxic agents and protects experimental animals in 4 variants of hypoxia. Bis-(N-acetyl-L-cysteinato)zinc (II) sulfate octahydrate is similar to enumerated compounds by its antihypoxic activity.
EFFECT: valuable medicinal properties of compounds.
4 cl, 1 dwg, 11 tbl, 33 ex
FIELD: catalyst preparation methods.
SUBSTANCE: invention relates to preparation of manganese (III) acetylacetonate, which can be used as catalyst as well as vinyl monomer polymerization initiator. Method is implemented in aqueous medium with ammonium acetylacetonate freshly prepared by mixing acetylacetone with aqueous ammonia solution. Hydrogen peroxide is used as oxidant and sodium bicarbonate is additionally introduced into reaction mixture. Following consecutive operations are carried out: reaction of manganese (II) chloride tetrahydraye with sodium bicarbonate; separating thus formed manganese (II) bicarbonate in the form of paste; adding ammonia acetylacetonate and then hydrogen peroxide aqueous solution to the paste; and recovering manganese (III) acetylacetonate with yield 95%.
EFFECT: improved economical and environmental characteristics of process.
FIELD: chemical technology.
SUBSTANCE: invention relates to technology for synthesis of acetic acid inorganic salts. Method involves interaction of metallic manganese or its dioxide with acetic acid in the presence of oxidizing agent. Process is carried out in beaded mill of vertical type fitted with reflux cooling-condenser, high-speed blade mixer and glass beads as grinding agent loaded in the mass ratio to liquid phase = 1.5:1. Liquid phase represents glacial acid solution in ethylcellosolve, ethylene glycol, 1,4-dioxane, isoamyl alcohol and n-butyl alcohol as a solvent. The concentration of acid in liquid phase is 3.4-4 mole/kg. Then method involves loading iodine in the amount 0.025-0.070 mole/kg of liquid phase, metallic manganese and manganese dioxide in the mole ratio = 2:1 and taken in the amount 11.8% of liquid phase mass. The process starts at room temperature and carries out under self-heating condition to 30-38°C to practically complete consumption of manganese dioxide. Prepared salt suspension is separated from beads and unreacted manganese and filtered off. Filtrate is recovered to the repeated process and prepared precipitate is purified by recrystallization. Invention provides simplifying method using available raw and in low waste of the process.
EFFECT: improved method of synthesis.
3 cl, 9 ex
FIELD: chemical industry; methods of production of the bromine derivatives of fullerene С60.
SUBSTANCE: the invention is pertaining to the method of production of the bromine derivatives of fullerene С60. The process consists in the interaction of the bromoform and the tetra bromomethane with fullerene С60 at presence of the rhodium-containing catalyst - Wilkinson's complex [RhCl(PPh3)3] at the temperature of 100°С within 10-20 hours, at the molar ratio of [Rh]:[C60]:[CHBr3 or CBr4]= 1:100:100-500. The technical result of the invention is the increased output of the product, the reduced amount of the wastes, the insignificant consumption of the catalyst.
EFFECT: the invention ensures the increased output of the product, the reduced amount of the wastes, the insignificant consumption of the catalyst.
3 ex, 1 tbl
FIELD: organic chemistry, chemical technology.
SUBSTANCE: invention relates to an improved solid-phase method for synthesis of radioisotope indicators, in particular, for synthesis of compounds labeled with 18F that can be used as radioactive indicators for positron- emission tomography (PET). In particular, invention relates to a method for synthesis of indicator labeled with 18F that involves treatment of a precursor fixed on resin if the formula (I): SOLID CARRIER-LINKER-X-INDICATOR wherein X means a group promoting to nucleophilic substitution by a definite center of a fixed INDICATOR with 18F- ion for preparing a labeled indicator of the formula (II): 18F-INDICATOR; to compound of the formula (Ib):
and compound of the formula (Ih): ;
to radiopharmaceutical set of reagents for preparing indicator labeled with 18F for using in PET; to a cartridge for radiopharmaceutical set of reagents for preparing indicator labeled with 18F for using in positron-emission tomography.
EFFECT: improved method of synthesis.
13 cl, 1 sch, 3 ex
FIELD: chemical industry; methods of production of the manganese salts with the organic acids.
SUBSTANCE: the invention is pertaining to production of the manganese salts with the organic acids in particular, to the salt of the divalent manganese and formic acid. The method is exercised by interaction of manganese, its oxides in the state of the highest valence with the formic acid solution in the organic solvent in the presence of iodine as the stimulating additive. The production process is conducted in the bead grinder of the vertical type having the revertive cooler-condenser, the high-speed paddle stirrer and the glass beads of in the capacity of the grinding agent loaded in the mass ratio to the loading of the liquid phase as (1÷2): 1. The liquid phase consists of the formic acid solution in the organic solvent. The concentration of the acid is taken within the range of 3.5÷10.8 mole/kg. In the loaded liquid phase they dissolve the stimulating additive of iodine in the amount of 0.025-0.100 mole/kg of the liquid phase. The ratio of the masses of the liquid phase and the total of the metallic manganese and the manganese oxide are as(4.9÷11):1. The molar ratio of the metal and the oxide in the loading is as (1.8÷2.,2):1. The metal and the oxide are loaded the last. It is preferable in the capacity of the dissolvent to use the butyl alcohol, ethyl acetate, ethylene glycol, 1.4-dioxane, dimethyl formamide. The production process is started and conducted at the indoor temperature up to practically complete(consumption of the whole loaded manganese oxide. Then the stirring is stopped, the suspension of the salt is separated from the beads and the nonreacted manganese and after that conduct filtration. The filtrate and the nonreacted manganese are returned into the repeated production process, and the filtered out settling of the manganese salt is exposed to purification by recrystallization. The technical result of the invention is - simplification of the method at usage of accessible reactants.
EFFECT: the invention ensures simplification of the method at usage of accessible reactants.
16 ex, 2 tbl
SUBSTANCE: invention is related to improved method for preparation of manganese oxalate (II) by means of direct interaction of metal with acid in bead mill in presence of liquid phase, in which manganese and oxalic acid are loaded into bead mill in stoichiometric ratio in amount of 0.75-2.4 mole/kg of load at mass ratio of load and glass beads of 1:1.2, liquid phase dissolvent used is water or organic substance, or mixture of organic substances; loading is carried out in the following sequence: liquid phase dissolvent, acid, then metal; process is started at room temperature and is carried out under conditions of forced cooling in the temperature range of 18-39°C with control over procedure by sampling method to practically complete spend of loaded reagents for product making, afterwards mixing and cooling are terminated, suspension of reaction mixture is separated from glass beads and filtered, salt deposit is sent for product cleaning from traces of non-reacted metal, and filtrate is returned into repeated process.
EFFECT: method makes it possible to produce target product in absence of manganese dioxide and stimulating additive at temperatures close to room temperature.
2 cl, 13 ex, 2 tbl
SUBSTANCE: invention refers to chelating agents and their technetium complexes to be used as radiopharmaceuticals and characterised by formula I where X is -NR-, -CO2-, -CO-, -NR(C=S)-, -NR(C=O)-, -CONR- or Q; Y represents amino acid, -CH2-, -CH2OCH2-, -OCH2CH2O- or X; Z is an aggregation from peptides, their analogues, substrata, antagonists or enzyme inhibitors, receptor-bonding compounds, oligonucleotides, oligo-DNA- or oligo-RNA-fragments; n is a number 1 to 8; m is a number 0 to 30; R represents H, C1-4alkyl, C2-4alkoxyalkyl, C1-4hydroxyalkyl or C1-4fluoroalkyl; Q represents remains of succinimide , A is a pharmaceutically acceptable anion.
EFFECT: production of new chelating agents applicable for making the technetium complexes.
22 cl, 12 ex, 3 dwg, 2 tbl
SUBSTANCE: invention relates to an improved method of producing manganese (II) fumarate from manganese metal and its oxide (III) through direct reaction of the metal and its oxide Mn2O3 with an acid in the presence of a liquid phase and a stimulating iodine additive in a vertical type bead mill with glass beads as grinding agent. The metal and its oxide are loaded in molar ratio (2±0.1):1 in total amount of 7.87 to 10.93% of the mass of the load. Acid is added with 15 to 25% excess of the calculated value, equal to the number of moles of metal and twice the number of moles of metal oxide in the load. The base of the liquid phase is isoamyl alcohol, in which the iodine stimulating additive is dissolved in amount of 0.02 to 0.05 mol/kg. Glass beads are loaded first, in mass ratio to the reaction mixture of 1.35:1, and then later the liquid phase solvent, acid and stimulating additive, and after brief stirring, metal oxide and metal, stirring all the while. Taking this moment as the beginning of the process, forced cooling is introduced right away. Operating temperature is stabilised in the range 33 to 45°C and in this mode, the process is carried out until virtually quantitative conversion of metal and its oxide to the target salt, after which stirring and forced cooling are stopped. The reaction mixture is separated from the glass beads, cooled to temperature 5 to 6°C and kept at that temperature for 1 to 2 hours. The solid phase of the target salt is filtered off and washed with isoamyl on a filter cooled to approximately the same temperature, after which it is taken for purification by recrystallisation. The filtrate and the cleaning solvent, containing excess acid, the bulk of the stimulating additive and a certain amount of dissolved target salt, are returned for loading in the repeated process. The process is carried out in light temperature conditions. The target substance can be easily separated.
EFFECT: design of a low-waste method, which allows for obtaining target product from available manganese oxide with an easy to implement process.