The remedy of potato virus diseases


(57) Abstract:

Usage: agriculture, plant protection against viral diseases. 4-Methyl-3,3-dioxo-1,2-dihydrothieno[3,2-a] napthine has a protective effect with the defeat of potato virus diseases and can be used as a tool for potato protection from viral diseases. table 1.

The invention relates to agriculture, particularly to the field of protection of plants against viral infections.

Practical application for disease control and phytopathogenic fungi in a series of quinone compounds of the type obtained 2,3-dichloro-1,4-naphthoquinone (Dylan), formulas

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It is used for spraying of green plants. The disadvantages of this drug are fitotecnia properties at elevated concentrations, severe skin irritation and high toxicity for fish (0,12-0,34 mg/kg). Even more powerful antiviral properties in viral diseases of plants (sugar beet, tomatoes) have a 2-chloro or 2-bromo-3-alkyl substituted 1,4-naftochinona with alkyl WITH4-C5and quinoline-5,8-diones, which are not found practical application in connection with high toxicity and high irritable spasmophilia from viral diseases selected widely used in agriculture retardant chloroindole (product TOUR) formula lCH2CH2N+(CH3)3Cl-.

Processing plants carried out by spraying the green plants in the budding stage, water 67% solution of the drug. LD50for experimental animals is 600 mg/kg the consumption rate of the drug from 1.8 to 4.0 kg/ha Disadvantages funds are its toxicity, increased consumption rates, as well as its retardant properties associated with impaired biosynthesis of gibberellins and thereby cause the formation of short plants.

The aim of the invention is a highly efficient means of potato protection against viral diseases.

This goal is achieved using 4-methyl-3,3-dioxo-1,2-dihydrothieno[3,2-a] naphthoquinone (I) as a means of potato protection against viral diseases.

The compound 4-methyl-3,3-dioxo-1,2-dihydrothieno[3,2-a] naphthoquinone known.

The method of obtaining the compound (I) is in the cycloaddition reaction of 2-Isopropenyl-2-thiolen-1,1-dioxide with benzoquinone in acetic acid (boiling) and subsequent oxidation of the obtained substituted hydroquinone action suryamaninagar in acetonitrile. The yield of compound (I) in two stages is 65-68%.

2the number of accounts 45 plants, three replicate samples of each variant. Processing plants affected by filoviruses, carried out in the budding stage by spraying plants with solutions of the test substances in a concentration of 0.005%. During the growing season was determined by the intensity of the lesions viral disease control (untreated) and pilot plants, as well as the concentration of viruses in potato leaves by the method of limiting dilution of juice. At the end of the vegetation period was held the record harvest of control and test plants. The results presented in the table.

From the table it is seen that in the field, on the plots treated with cyanonaphthalene (I) and widely used in agriculture reference drug TOUR of the disease of viral etiology appear weaker than in the control. The number of visually healthy bushes on the plots treated with cyanonaphthalene (I) amounted to 20.9%, which is 2.3 times more than in moormani viral diseases (twisting of leaves, sources of resistance to which almost no) using the proposed connection is to 37.9%, which is 2 times lower than in the control group. The yield of potato tubers using substituted cyanonaphthalene (I) increased by 13.4%, or 45 grams for each hive. The use of the drug ROUND in these conditions increases the yield of 7.2%, or 25 g per Bush, in 2 times less than when using the compound (I).

On known data using partially affected potatoes, drug ROUND was led to an increase in yield 17-22 kg/ha, which amounts to 4.5-7.5 percent. The incidence of viral diseases has decreased 2.5-3.0 times against raw potato (control). In this case, when using the completely amazed potato prevalence decreased by 10.8-18.5 percent, the productivity has increased by 18.2-25.8 per cent.

Acute toxicity of 4-methyl-3,3-dioxo-1,2-dihydrothieno[3,2-a]naphthoquinone determined by the method of Cerberus, 800 mg/kg of the Compound belongs to the third class of mild-hazard substances. LD50the similar properties of the drug ROUND (67% aqueous solution) was 640 mg/kg, i.e., the toxicity of the studied compounds 1.3 times lower than the viral diseases of potato. The main advantage of this drug are small active dose of a substance - 0.005 wt.% and effectiveness against diseases Curling of leaves, strong development which have been observed in recent years in different regions of the country. The use of the drug leads to increased yield of potatoes in 2 times in comparison with the known tool TOUR, which is also used in thousands of doses, compared with the use of the drug (I). The toxicity of the proposed tools 1.3 times lower than that of the reference drug ROUND. This invention is illustrated in the examples.

P R I m e R 1. Synthesis of 4-methyl-3,3-dioxo-1,2-dihydrothieno[3,2-a]naphthoquinone. A solution of 1.0 g of benzoquinone and 1.6 g of 2-Isopropenyl-2-thiolen-1,1-dioxide was boiled in 20 ml of acetic acid 12 p.m cooling and evaporation at the watch glass was provided 1.7 g (70%) of 4-methyl-6,9-dihydroxy-3,3-dioxo-1,2,5,9 in-tetrahydrothieno[3,2-a] Naftali (II). The remaining mother liquor after evaporation was chromatographically on SiO2(eluent - chloroform, chloroform-methanol, 10: 1) provided 0.5 g (20%) of the substance (II). So pl. 279-282aboutC (from ethanol). IR spectrum (cm-1): 780, 810, 1080, 1130, 1290, 1310, 3360, 3460.

Found, %: C 59,7; N 5,0; S 12,0.


IR spectrum (cm-1): 750, 1100, 1125, 1140, 1315, 1675, 1680.

Range PMR ( , memorial plaques, CD Cl3): 2,82 C (CH3), 3,55 D. D. D. (2N, N1, J 17,2; 4,5; to 7.6 and 2.8 Hz), 3.75 to D. D. D. (2N, N2, J = 2,7; 6,5; 14,8; and 4.5 Hz); 6,99 C (2N, N7,8), to 8.20 (1H, H5).

Found, %: From 59.8; H 4,0; S 12,5.


Calculated, %: C Of 59.5; H 3,9; S 12,2.

P R I m m e R 2. Study of antiviral action of the substance (I) was performed on purified preparation of virus tobacco mosaic using isokeraunic leaves plant-indicator Nicotiana glutinosa. Determination of virus concentration in the leaves was performed by the method of limiting dilution of juice. The size of the experimental plots 3 m2the number of accounts - plants 45, each repeated 3 times. The concentration of the test compound is 0.005% of bourazani bushes - 41,3%, selenorganic to 37.9%, respectively.


The use of 4 - methyl-3,3-dioxo-1,2-dihydrothieno(3,2-a) naphthoquinone of the formula

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as a means of potato protection against viral diseases.


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