The treatment for infected wounds

 

(57) Abstract:

The invention relates to medicine and can be used to enhance antibacterial activity and expansion of the spectrum of antibacterial action. Antibacterial contains streptocid and nitrosol as polymer - monoalkyl ether glycol and the primary fatty alcohols of the formula C18H37O(C2H4O)20(preparation of OS-20), as a two - component solvent mixture of 1,2-propylene glycol and water, and optionally contains vaseline oil and primary alcohols fatty fraction C16-C21formula CnH2n+1HE, where n = 16 and 21, with the following ratio of components, wt.% streptocid 4 - 6; nitazol 1 - 3; vaseline oil 10 - 30; preparation of OS-20 of 1.2 - 1.6; primary alcohols fatty fraction C16-C216,4 - 6,8; 1,2-propylene glycol 20-40; water - the rest. Good and satisfactory effect is obtained from 90,9% of patients. 3 table.

The invention relates to medicine, in particular to the surgery and the result they have proved.

Closest to the claimed is an antibacterial drug for the topical treatment of wounds - ointment mafenide acetate, which according to its chemical structure namenda acetate prepared on a hydrophilic base, containing polymer is a polyethylene oxide mol.m. 1500 and mixed two-component solvent consisting of polyethylene oxide mol.m. 400, and distilled water.

The composition of the ointment. wt. %: Mafenide acetate 10.0 polyethylene oxide-1500 40.0 polyethylene oxide-400 34,5 distilled Water 15.0 Sodium sulfate 0,5

However, the ointment mafenide acetate has the disadvantages associated with low antibacterial activity of the main active substances, consequently, it is necessary to apply very high concentration of 10%. As a result, when applying the ointment on the burn or wound surface patients are effects local irritation, pain, burning, causing the necessity of prescription analgesics. For these reasons, 10% ointment mafenide acetate is unsuitable for application to large areas: wounds and burns.

The aim of the invention is the enhancement of antibacterial activity and expansion of the spectrum of antibacterial action.

This goal is achieved by the fact that medicine as an antibacterial substances contains streptocid and nitazolom as polymer - monoalkyl ether glycol and the primary fatty alcohols of the formula C18H3716-C21formulanH2n+1HE, where n = 16-21, with the following ratios, wt. %: Streptocid 4-6 Nitazol 1-3 vaseline Oil 10-30 Drug OS-20 1,2-1,6 primary Alcohols, grease - ing fraction16-C216,4-6,8 1,2-Propylene glycol 20-40 distilled Water To 100

P R I m e R 1. The tool contains, %: Streptocid 4-6 Nitazol 1-3 vaseline Oil 10-30 Drug OS-20 1,2-2,0 primary Alcohols fatty fraction16-C216,8-6,0 1,2-propylene glycol 20-40 distilled Water To 100

The composition was prepared as follows. At a temperature of 75aboutWith vaseline oil floated the preparation of OS-20 and the primary alcohols of the fatty fraction16-C21and poured with stirring, heated to the same temperature water (by weight). Was emulsiable turbomaschinen, cooling the emulsion to 45aboutC. In 1,2-propylene glycol (or vaseline oil) using a rotary pulsation apparatus was dispersively streptocid and nitazol so that the temperature of the suspension does not exceed 45aboutC. the Suspension with stirring, poured into the emulsion and the resulting mixture was cooled to 25aboutWith the continued parameterarray activity of the compounds was determined by the method of diffusion in agar with respect to the reference strains of bacteria, recommended by who and obtained from gisk named after.L.A. Tarasevich, and freshly isolated bacteria strains from patients with infected wounds.

In table. 1 shows the antibacterial activity of compounds 1-9, prototype - ointment mafenide acetate 10% and analogues (liniment of streptocide 5% and suspensions nitazola 2%) against Pseudomonas aeruginosa.

The combined use of streptocide and nitazola with such components in such proportions leads to unexpected synergistic effect of character - a strong antibacterial action against Pseudomonas aeruginosa.

In table.2 shows information about zones delays the growth of bacteria optimal composition 2 and prototype - ointment mafenide acetate 10%.

As is seen in table.2 data on the effects on Pseudomonas aeruginosa inventive composition effectively ointments mafenide acetate. Its advantage lies in the significantly higher zones of growth inhibition of other pyogenic bacteria (Staphylococcus, E. coli, clostridia), and in the case of asporogenic anaerobic-peptococcus and bacteroids.

For part 2 were highly sensitive in 98% of cases (49 strains of 50) viewed the diversified processes, who have MDR to antibiotics.

As can be seen from the data presented in table.3, the inventive composition 2 on the effectiveness of antibacterial action significantly outperform their counterparts - ointment polioksidony and gentamitsinovoy, which in most cases, Pseudomonas aeruginosa and Staphylococcus were not sensitive. Ointment of levocin containing the antibiotic chloramphenicol and sulfadimetoksin comparable with the composition 2 performance impact on staphylococci and less effective against Pseudomonas aeruginosa.

The study of therapeutic properties of composition 2 on animals carried out in a series of model experiments on rabbits of the chinchilla breed by weight of 2,5-3,0 kg

The treatment composition 2 was started on day 7 after infection, i.e., after the stage of hyperemia and education inflammatory infiltrate. The abscess was opened, if it has not been opened spontaneously and produced primary surgical processing of wounds. Bleeding was stopped by 3% hydrogen peroxide solution and applied a bandage with part 2 called stratonica. The amount of fungicide applied daily to the wound, amounted to 5-10 g

Below are the dynamics of the flow of pus is e infected animals bacteria: the wounds 4x4 - 5x6 cm, around the edges of wounds hyperemic edematous skin edges of wounds nekrotizirovanne; wounds filled with viscous blue-green purulent contents. Made of surgical treatment of wounds. Imposed headbands with stratonicea. Inoculation of pus and esecanna necrotic tissue revealed Pseudomonas aeruginosa in the amount of 108-10101 g of tissue.

1st day after treatment of animals: the wounds 4x4 - 5x6 cm; redness and swelling of the underlying tissue decreased; the wound edges and some parts of the wound depth infiltrated, there is necrotic tissue, pus viscous, blue-green. Produced debridement. The bandage was applied with stratonicea. When planting necrotic tissue revealed Pseudomonas aeruginosa in the amount of 106-108microbial cells in 1 g of tissue.

the day 3 after treatment animals: rabbits active, good appetite. The wounds 3x4 - 4x4 see a Weak pus. Change bandages. Sowing tissues revealed Pseudomonas aeruginosa in the amount of 103-1051,

5th day after treatment of animals: the wounds are dry, their size 3-4 cm along the edges of the wound pink granulation. Only in the depth of the wound serous secretion. Change bandages with stratonicea. Sowing tissue izadi after treatment of animals: wounds the size of 2-3 cm dry, covered with a crust; the entire surface wounds covered with pink granulation; the edges of wounds observed epithelialization. Change bandages with stratonicea. When sowing tissue from the wound revealed a single colony of Escherichia coli.

10 days after treatment animals: wounds dry; kapitalizirovana on a large surface area. Pseudomonas aeruginosa from fabrics not planted.

Thus, the claimed composition does not lose its activity when heavyline and exhibits antibacterial properties in experiments in vivo, reducing the level of bacterial contamination of the wound already to the third day of treatment 5 orders of magnitude. On the 5th day of treatment of microbial infection of wounds by Pseudomonas aeruginosa becomes below a critical level of development of inflammatory process (1051 g of tissue), and by the 7th-10th day she wound almost no planted.

The proposed antibacterial agent in the form of ointments can improve the effectiveness of treatment of purulent-inflammatory processes caused by Escherichia coli in the form of monocultures and in multicomponent associations with obligate and facultative anaerobes, which are resistant to antibiotics. It can be used on the sociology for the prevention and treatment of purulent complications.

FOR the TREATMENT of INFECTED wounds, containing an antibacterial substance and a hydrophilic ointment base, characterized in that as an antibacterial substances it contains streptocid and nitazol and the base contains liquid paraffin, drug OS-20 (monoalkyl ether glycol and the primary fatty alcohols of the formula C18H37(C2H4O)20the primary fatty alcohols fraction16- C21formula CnH2n+1OH , where n is 16 - 21, 1,2-propylene glycol and water in the following ratio, wt.%

Streptocide 4 - 6

Nitazol 1 - 3

Liquid paraffin 10 - 30

Preparation of OS-20 of 1.2 - 1.6

The primary fatty alcohols fraction16- C21the specified formula 6,4 - 6,8

1,2-propylene glycol 20 - 40

Water The Rest

 

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