The treatment for infected wounds

 

(57) Abstract:

The invention relates to medicine, in particular to the surgery and the result they have proved. To enhance antibacterial activity and expansion of the spectrum of antibacterial action antibacterial contains streptocid and nitazol, the condensation product of propylene oxide and ethylene mol.m 13000 (proxanol is chosen-268), 1,2-propylene glycol (PEO-400) in the following ratio, wt. % : streptocid 2 - 6; nitazol 1 - 3; proxanol is chosen-268 20 - 30; 1,2-propylene glycol 37,5 - 42,7; PEO-400 18,0 - 37,5. table 2.

The invention relates to medicine, in particular to surgery and combustology.

Closest to the claimed object antibacterial substance of choice for the local treatment of wounds infected by Pseudomonas aeruginosa in Association with other microbes is the ointment mafenide acetate, which is the acetate salt of 4-aminoethylethanolamine. This drug chemical structure closest to sulfanilamide, in particular the streptocide, and selected as a prototype.

This is known ointments, wt.%: Mafenide acetate 10.0 polyethylene oxide-1500 40.0 polyethylene oxide-400 34,5 distilled Water 15.0 Sodium sulfate 0,5

The ointment mafenide what about it is necessary to apply very high concentration of 10%. Because of this, when applying the ointment on the burn or wound surface patients are effects local irritation, pain, burning. In severe pain even recommended the appointment of analgesics. In addition, you can priyanie dressing with ointment to the wound, which reduces the concentration of mafenide acetate directly on the wound surface, and in some cases may interfere with wound drainage and cause bleeding and damage to the wound surface when changing the dressing. For these reasons, 10% ointment mafenide acetate proved to be unsuitable for application to large areas of wounds and burns.

The aim of the invention is the enhancement of antibacterial activity and expansion of the spectrum of antibacterial action.

This goal is achieved by the fact that medicine as an antibacterial substances contains streptocid and nitazol, as polymer is a condensation product of propylene oxide and ethylene mol.m.13000 (proxanol is chosen-268), as a two - component solvent mixture of 1,2-propylene glycol and polyethylene oxide mol.m. 400 (PEO-400) in the following ratio, wt.%: Streptocide 4-6 Nitazol 1-3 proxanol is chosen-268 20-30 1,2-propylene glycol 37,5-42,7 PEO-400 37,5-18,3

P R I m e R s. In the Ola-268 and dissolution in the melt nitazola and streptocide, then gave to cool the composition to the 25aboutWith constant stirring. Ointment 100 g was packaged in bottles of dark glass.

The dynamics of the treatment of purulent-inflammatory process in the local treatment stratonicea rabbits are presented below.

Source on the 7th day after infection, animals bacteria: the wounds 4x4 - 5x6 see Around the edges of wounds hyperemic edematous skin. Edges of wounds nekrotizirovanne. Wounds filled with viscous blue-green purulent content. Made of surgical treatment of wounds. Imposed headbands with stratonicea. Inoculation of pus and esecanna necrotic tissue revealed Pseudomonas aeruginosa in the amount of 108-10101 g of tissue.

I-th day after the treatment of animals: the wounds 4x4 - 5x6 see Redness and swelling of the underlying tissue decreased. The wound edges and some parts of the wound depth infiltrated, there is necrotic tissue. Pus viscous, blue-green. Produced debridement. The bandage was applied with stratonicea. When planting necrotic tissue revealed Pseudomonas aeruginosa 106-108microbial cells in 1 g of tissue.

3rd day after treatment animals: rabbits active, good appetite, the wounds 3x4 - 4x4 1,

5th day after treatment animals: wounds dry 3x4 see the edges of the wound pink granulation Only in the depth of the wound serous secretion. Change bandages with stratonicea. Sowing tissue from the wound revealed Pseudomonas aeruginosa in the amount of 102-103microbial cells in 1 g of tissue.

7 days after treatment animals: wounds the size of 2-3 cm, dry, covered with crust. The entire surface wounds covered with pink granulation. At the edges of wounds observed epithelialization. Change bandages with stratonicea. When sowing tissue from the wound revealed a single colony of Escherichia coli.

10th day after treatment of animals: the wound dry, kapitalizirovana on a large surface area. Pseudomonas aeruginosa from fabrics not planted.

Thus, the claimed composition does not lose its activity when heavyline and exhibits antibacterial properties in experiments in vivo, reducing the level of bacterial contamination of the wound already to the third day of treatment 5 orders of magnitude; On the 5th day of treatment of microbial infection of wounds by Pseudomonas aeruginosa becomes below a critical level of development of inflammatory process (1051 g of tissue), and to the 7-10 day she wound almost no planted.

Antibacterial ointments are presented in table.1 and 2.

FOR the TREATMENT of INFECTED wounds, containing an antibacterial substance and a hydrophilic ointment base, characterized in that as an antibacterial substances it contains streptocid and nitazol and the base contains proxanol is chosen-268 (the condensation product of propylene oxide and ethylene (mol. m 13000), 1,2-propylene glycol and PEO-400 with a ratio of components, wt.%:

Streptocide 4 - 6

Nitazol 1 - 3

Proxanol is chosen-268 20 - 30

1,2-Propylene glycol 37,5 - 42,7

PEO-400 18,3 - 37,5

 

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