For the treatment of stomatitis
(57) Abstract:The invention relates to medicine and relates to a tool for the treatment of stomatitis. The aim of the invention is the reduction of treatment time, the acceleration of splitting and removal of necrotic masses and exudate from lesions. This is achieved using ointments containing (in wt. % ) piromekaina 3,0 - 8,0; benzoflavone 5,0 - 15,0; polyethylene oxide-400 30,0 - 70,0; polyethylene oxide-1500 5,0 - 15,0, glycerin else. The resulting composition reduces the period of epithelization of skin wounds in 1.5 times, the treatment of experimental ulcerative-necrotic stomatitis rabbits 2.5 times, experimental thermal burns of III degree in 1.4 times. 3 table. The invention relates to medicine, namely to the agent for the treatment of stomatitis.Closest to the claimed composition is an ointment containing antibiotics, the regulator of tissue metabolic processes methyluracil, local anesthetic, hydrophilic on the basis of the alloy oxides 400 and 1500.To reduce treatment time, accelerate the splitting and removal of necrotic masses and exudate of the lesions suggested ointment containing:
Benzoflavone the Oia obtain is the following.3.0 g piromekaina dispersed with 16.0 g of glycerin, parts added 16.0 g of glycerin. In a water bath alloys 36,0 g PEO 400 and 5.0 g of PEO 1500 and add portions to 5.0 g of benzoflavone. Then the parts are mixed with a suspension of piromekaina. The mixture is stirred until cooling and uniformity.Examples 2, 3, are given in table. 1, is prepared in the same way.Local anesthetic action of the ointment was studied on rabbits according to the method of Rainier. The inventive composition has a strong anesthetic action within 45-120 min, index Rainier is 987 3,1 - 1300 0,60. To study wound healing and anti-inflammatory action model is used by panolayou skin wounds.Rats of the same age and the same weight 20020 g under the General geksenalovy anesthesia was dissected full-layer skin flap area of 220 mm2the anterior shoulder. The bottom edge of the wound hurt toothed clamp. To avoid changing the original square to the edges of the wounds were attached to plastic frames, which were removed after 7 days. The rats were kept in individual cages on a normal diet. After 24 h, necessary for the development of the inflammatory process started treatment, evaluation of the effectiveness of which the initial composition reduces the period of epithelization in 1,5 times in comparison with untreated wound. Experiments were performed according to the method proposed by A. F. Nissinen (1979).About the nature of the inflammatory response and the dynamics of wound healing was judged visually daily examination and comparison of control and experimental groups of animals. In addition to visual observations conducted histological examination. Epithelialization of wounds in animals subjected to treatment, occurred at different times: in group 1 (treatment proposed composition) for 7-8 days, the control group on the 21st day.The results of the experiment are statistically processed and presented in table. 2.The study of reparative activity in rats.The study was performed on the model of thermal lesions in rats. Burn fixed intensity at a temperature of 250aboutWith an area of 300 m2caused by the device for the application of the Russian Academy of Sciences, developed in the laboratory of pharmacology NGOs "Vitamins".The activity of the reparative process was evaluated in the dynamics of the clinical observation of the state burns with regard to the inflammatory process, planimetrically with histological control.The treatment of experimental ulcerative-necrotic stomatitis rabbits showed that PR 1, 1984, S. 10-13. FOR the TREATMENT of STOMATITIS, containing a wound healing agent, a local anesthetic and alloy oxides 400 and 1500, characterized in that it contains benzoflavone, piromekain and glycerol at a ratio of ingredients, wt. % :
Benzoflavone 5,0 - 15,0
Piromekain 3,0 - 8,5
The polyethylene oxide 400 30,0 - 70,0
The polyethylene oxide 1500 5,0 - 15,0
FIELD: organic chemistry, biochemistry, biology.
SUBSTANCE: invention relates to a pharmaceutical composition eliciting the inhibitory effect on activity of serine protease (caspase-3) in the form of tablet, capsule or injections placed into acceptable package, to a method for its preparing and a method for treatment of diseases associated with enhanced activation of apoptosis. The composition comprises compound 2,3-dihydro-1H-benzo[g]pteridine-4-one of the general formula (1) (1)
or its salt with pharmacologically acceptable acid as an active component taken in pharmaceutically effective amount wherein X means oxygen (O) or sulfur (S) atom; R1 and R2 represent independently of one another hydrogen atom, inert substitute taken among the group including low- or non-reactive and optionally substituted radical, such as (C1-C7)-alkyl, (C2-C7)-alkenyl, (C2-C7)-alkynyl, (C1-C7)-alkoxy-group, (C7-C12)-aralkyl, (C7-C12)-heterocyclylalkyl, (C7-C12)-alkaryl, (C3-C10)-cycloalkyl, (C3-C10)-cycloalkenyl, phenyl, aryl, heterocyclyl; optionally substituted hydroxy-(C1-C5)-alkyl group; R3, R4, R5 and R6 represent independently of one another hydrogen, halogen atom, -CF3, -CN, inert substitute taking among the group including low- or non-reactive and optionally substituted radical, optionally substituted hydroxyl group, optionally substituted hydroxy-(C1-C5)-alkyl group, optionally substituted amino-group, optionally substituted amino-(C1-C7)-alkyl group, optionally substituted carboxy-(C1-C7)-alkyl group, optionally substituted (C1-C6)-alkylcarboxy-(C1-C6)-alkyl group, optionally substituted carbamoyl group, optionally substituted (C1-C6)-alkylcarbamoyl group, optionally substituted sulfamoyl group. Also, invention relates to applying compounds of the formula (1) for preparing pharmaceutical composition and experimental study (in vitro and in vivo) processes associated with apoptosis.
EFFECT: improved preparing method, valuable medicinal and biochemical properties of composition.
7 cl, 1 dwg, 2 tbl, 5 ex
FIELD: veterinary science.
SUBSTANCE: about 20-25 d before calving one should introduce intramuscularly 0.5%-sodium selenite solution for cows at the dosage of 10 ml. Twice before and twice after calving at 10-d-long interval - tetravit at the dosage of 10 ml at the content of 50000 IU vitamin A, 25000 IU vitamin D, 20 mg vitamin E and 5 mg vitamin F per 1 ml. Succinic acid should be introduced 20-25 d both before and after calving at the dosage of 1.0 g. The method provides efficient correction of the main values of homeostasis in cows after calving.
EFFECT: higher efficiency of normalization.
2 ex, 4 tbl
FIELD: veterinary science.
SUBSTANCE: one should introduce endovit complex preparation once daily for dogs. Moreover, during the first 5 d endovit should be introduced at the dosage of 30 mg/kg, during the next 10 d - 25 mg/kg and during the last 5 d 20 mg/kg body weight. The suggested innovation provides normalization of myocardial trophic nature, interrupts dystrophic processes in it, improves functional state of cardiac conductory system and, thus, provides the chance to treat both the main and secondary disease by the mentioned scheme without applying any additional cardiological remedies.
EFFECT: higher efficiency of therapy.
FIELD: medicine, pharmacy.
SUBSTANCE: invention relates to the development of medicines used for enhancing resistance of humans and animals to hypothermia. Agent for enhancing resistance of humans and animals to hypothermia comprises nicotinic acid, glutamic acid, riboflavin, ascorbic acid, uniquinone, succinic acid, polyethylene oxide and water taken in the definite ratio. Also, invention proposes a method for enhancing resistance of humans and animals to hypothermia involving administration of the abovementioned agent 30 min before works associated with hypothermia and after its termination for activation of vital essential biochemical processes. Invention provides enhancing resistance to overcooling under extreme conditions and using in surgery practice in cooling organs (in operations in heart and brain).
EFFECT: enhanced effectiveness and valuable medicinal properties of agent.
2 cl, 2 tbl, 1 dwg, 2 ex
FIELD: medicine, in particular veterinary.
SUBSTANCE: invention relates to method for treatment of cattle intoxicated with Cynoglossum officinalis containing in feed hey as admixture. Claimed method includes administration perorally of sorbent, namely healthy feed supplement containing in dose of aluminum silicate in dose of 0.15 g/kg of body mass; saccharose in dose of 0.5-1.0 g/kg of body mass; and beta-carotene comprising 10-20 mg/ml of active ingredient in dose of 2 ml 1 time per day; administration intramuscularly of 1 % riboflavin mononucleotide solution 3 ml; 1 % pyridoxine hydrochloride solution 1 time per day; tetravit in dose of 3 ml 2 time during treatment course with interval for 5 days, wherein total treatment course includes 10 days.
EFFECT: method with simultaneous antioxidant, antitoxic, metabolism stimulating, and liver function normalizing action.
2 ex, 3 tbl
FIELD: medicine, vitamins.
SUBSTANCE: invention proposes a composition of vitamins riboflavin and nicotinic acid (niacin) or nicotinamide for treatment of primary headaches representing usual migraine, classic migraine, migraine combined with "histamine" headache. The composition comprises the combination of 0.5-750 mg of nicotinic acid (niacin or nicotinamide) and 0.1-250 mg of riboflavin. Also, the invention involves the corresponding method for treatment. Proposed treatment provides body with necessary NAD/NADP and FAD/FMN in order to modulate activity of mast cells when changes in their secretion results to migraine. Method provides disappearance of all migraine symptoms during the next 20 months of dispensary observation.
EFFECT: enhanced medicinal effectiveness of vitamins.
FIELD: pharmaceutical industry.
SUBSTANCE: claimed complex contains vitamins such as B1, B2, B3 (nicotineamide), B5 (calcium pantothenate), B6, B9 (folic acid), B12, A, C, D3, E, beta-carotene, lycopitin, and minerals such as magnesium, copper, iodine, iron, molybdenum, selenium, calcium, phosphorus, chromium, zinc, and manganese. Complex is separated into two solid formulations taken at different time. The first solid formulations contains B1, B2, B3 (nicotineamide), B5 (calcium pantothenate), B6, B9 (folic acid) and minerals such as magnesium, copper, iodine, iron, molybdenum in specific component ratio; the second one contains A, C, D3, E, beta-carotene, lycopitin, and minerals such as selenium, calcium, phosphorus, chromium, zinc, and manganese in specific component ratio.
EFFECT: vitamin-and-mineral complex of improved antioxidant properties.
6 cl, 1 ex
FIELD: pharmaceutical industry.
SUBSTANCE: invention relates to creation of therapeutical and prophylactic balsams, which can be used as generally restorative and tonic agents to increase resistance of organism to reduced levels of atmosphere oxygen (increase of hypoxia resistance) as well as to prevention and correction of functional disorders associated with stress and exhausting environmental factors affecting organism. Invention proposes two variants of therapeutical-prophylactic balsam producing generally restorative and tonic effects, each containing vegetable oils, vitamins, amino acids, hepatic implant cells (Hepatosan), adaptogen (Astragerm), antioxidant, odorant, and thickener.
EFFECT: achieved normalization of vitality in exhausted organism.
FIELD: medicine, ophthalmology.
SUBSTANCE: after termination of surgery operation as to strabismus the method involves catheterization of Tenon's space by using the irrigative system for the successive fractional administration of preparations of riboflavin, cerebrolysin, dicynone, caffeine, emoxipine and taufon in the dose 0.3 ml for each drug. Also, method involves carrying out the computer training by designation of the complex "Shooting range/gallery" and "Pursuit" wherein the patient combines color symbols that change colors and sizes in cyclic change of positions, 1 séance for each type of exercise every day. Administration of drugs and computer trainings are carried out for 10 days. Such performance of the method provides the effective treatment of strabismus and recovery of binocular vision based on the complex effect on all links of coordination activity of sensor and motor eye apparatus. Invention can be used in treatment of strabismus.
EFFECT: improved and effective method of treatment.
SUBSTANCE: invention relates to polyvitamin composition comprising complex of vitamins A, B1, B2, B6, B12, C, E, nicotinamide and calcium pantothenate and, optionally, folic acid, biotin, chlorocalciferol, phytomenadione and sorbitol, lactose, lubricating agent, taste and/or odor corrector as special supplements, and, optionally, microcrystalline cellulose and/or aerosil, and to a method for its preparing. The composition shows the enhanced stability.
EFFECT: improved and valuable properties of composition.
19 cl, 1 tbl, 4 ex