Wound healing and anti-inflammatory agent


(57) Abstract:

The invention relates to wound-healing and anti-inflammatory agent and can be used for the treatment of wounds, ulcers and burns of the mucous membranes and skin. To reduce the duration of treatment is used as anti-inflammatory and elitesoziologie component benzamycin in the form of ointment of the following composition, % benthaven of 5.0 - 15.0; piromekain of 3.0 - 8.0, polyethylene oxide 400 30,0 - D polyethylene oxide 1500 5.0 - 15ft glycerin - rest. The use of benzoflavone with - vitamin activity , a wide range of actions, including effects on lipid and carbohydrate metabolism, as a wound-healing and anti-inflammatory agent in the form of ointments can reduce the duration of treatment of wounds ulcers and burns of the mucous membranes and skin in 15 -2 times


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FIELD: organic chemistry, biochemistry, biology.

SUBSTANCE: invention relates to a pharmaceutical composition eliciting the inhibitory effect on activity of serine protease (caspase-3) in the form of tablet, capsule or injections placed into acceptable package, to a method for its preparing and a method for treatment of diseases associated with enhanced activation of apoptosis. The composition comprises compound 2,3-dihydro-1H-benzo[g]pteridine-4-one of the general formula (1) (1)

or its salt with pharmacologically acceptable acid as an active component taken in pharmaceutically effective amount wherein X means oxygen (O) or sulfur (S) atom; R1 and R2 represent independently of one another hydrogen atom, inert substitute taken among the group including low- or non-reactive and optionally substituted radical, such as (C1-C7)-alkyl, (C2-C7)-alkenyl, (C2-C7)-alkynyl, (C1-C7)-alkoxy-group, (C7-C12)-aralkyl, (C7-C12)-heterocyclylalkyl, (C7-C12)-alkaryl, (C3-C10)-cycloalkyl, (C3-C10)-cycloalkenyl, phenyl, aryl, heterocyclyl; optionally substituted hydroxy-(C1-C5)-alkyl group; R3, R4, R5 and R6 represent independently of one another hydrogen, halogen atom, -CF3, -CN, inert substitute taking among the group including low- or non-reactive and optionally substituted radical, optionally substituted hydroxyl group, optionally substituted hydroxy-(C1-C5)-alkyl group, optionally substituted amino-group, optionally substituted amino-(C1-C7)-alkyl group, optionally substituted carboxy-(C1-C7)-alkyl group, optionally substituted (C1-C6)-alkylcarboxy-(C1-C6)-alkyl group, optionally substituted carbamoyl group, optionally substituted (C1-C6)-alkylcarbamoyl group, optionally substituted sulfamoyl group. Also, invention relates to applying compounds of the formula (1) for preparing pharmaceutical composition and experimental study (in vitro and in vivo) processes associated with apoptosis.

EFFECT: improved preparing method, valuable medicinal and biochemical properties of composition.

7 cl, 1 dwg, 2 tbl, 5 ex

FIELD: veterinary science.

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EFFECT: higher efficiency of normalization.

2 ex, 4 tbl

FIELD: veterinary science.

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EFFECT: higher efficiency of therapy.

1 tbl

FIELD: medicine, pharmacy.

SUBSTANCE: invention relates to the development of medicines used for enhancing resistance of humans and animals to hypothermia. Agent for enhancing resistance of humans and animals to hypothermia comprises nicotinic acid, glutamic acid, riboflavin, ascorbic acid, uniquinone, succinic acid, polyethylene oxide and water taken in the definite ratio. Also, invention proposes a method for enhancing resistance of humans and animals to hypothermia involving administration of the abovementioned agent 30 min before works associated with hypothermia and after its termination for activation of vital essential biochemical processes. Invention provides enhancing resistance to overcooling under extreme conditions and using in surgery practice in cooling organs (in operations in heart and brain).

EFFECT: enhanced effectiveness and valuable medicinal properties of agent.

2 cl, 2 tbl, 1 dwg, 2 ex

FIELD: medicine, in particular veterinary.

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EFFECT: method with simultaneous antioxidant, antitoxic, metabolism stimulating, and liver function normalizing action.

2 ex, 3 tbl

FIELD: medicine, vitamins.

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EFFECT: enhanced medicinal effectiveness of vitamins.

13 cl

FIELD: pharmaceutical industry.

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EFFECT: vitamin-and-mineral complex of improved antioxidant properties.

6 cl, 1 ex

FIELD: pharmaceutical industry.

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6 cl

FIELD: medicine, ophthalmology.

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EFFECT: improved and effective method of treatment.

2 ex

FIELD: medicine.

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EFFECT: improved and valuable properties of composition.

19 cl, 1 tbl, 4 ex