The way to obtain 6-methoxy-9,10-seco-3,5-cyclogest-7, 10(19)-dien-25-ol

 

(57) Abstract:

Use: for the production of active metabolites of vitamin Oz. The inventive product - 6-methoxy-9,10-SECO-3,5-cyclogest-7,10 (19)-Dien-25-ol. Output 60-71%. Reagent 1: trimethylsilyloxy ether 4-chloro - 2-methylbutanol-2. Reagent 2: toilet 6-methoxy-23,24-bisnor-9.10-SECO-3,5-cyclohe La-7.10 (19)-Dien-22-ol. Reaction conditions: condensation of the Grignard reagent in the presence of salts si(1) when 70-30°C in tetrahydrofuran and subsequent alkaline hydrolysis.

 

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FIELD: organic chemistry, steroids, medicine, pharmacy.

SUBSTANCE: invention relates to 3-methylene-steroid derivative of the general formula (1):

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EFFECT: valuable medicinal properties of compounds, improved method for treatment.

38 cl, 1 tbl, 18 ex

FIELD: organic chemistry, medicine, pharmacy.

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EFFECT: valuable medicinal properties of compounds.

22 cl, 7 tbl, 41 ex

FIELD: organic chemistry, chemistry of steroids.

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EFFECT: improved preparing method.

2 cl, 3 ex

FIELD: medicinal industry, sterols.

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EFFECT: improved producing method.

2 cl, 3 ex

FIELD: chemistry.

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EFFECT: production of polyaminosteroid derivatives, possessing bactericidal activity which can be used for prevention of bacterial infections.

27 cl, 31 ex, 1 tbl, 2 dwg

FIELD: chemistry.

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19 cl, 38 ex, 12 tbl

FIELD: chemistry.

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EFFECT: method is highly selective and single-stage.

2 cl, 1 ex

FIELD: chemistry.

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EFFECT: application in therapy.

31 cl, 127 ex, 5 tbl

FIELD: production processes.

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EFFECT: increase of environmental safety and method effectiveness.

6 cl, 4 ex, 3 dwg

FIELD: medicine.

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9 cl, 3 ex

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