The powder dispenser
(57) Abstract:Usage: refers to the dosing devices, in particular, injection of the powdered dielectric biological drugs in the pharmaceutical industry. The inventive dispenser includes a housing made in the form of a pipe that has one inlet and two discharge openings, a hopper, a carrier of tanks and shaken the following elements. Medium tanks are made in the form of a hollow cylinder that is installed with the possibility of reciprocal leg movements of rotation and translation relative to the longitudinal axis. The carrier has three measuring device, each of which is formed a lateral surface of the carrier with a number of end-to-end axial grooves along its perimeter and dead-ends. Standard elements are in the form of a number of elastic rods, one ends fixed to the body and hopper, respectively, over the charging hole and is made in the case Windows. The free ends of the rods interact with the lateral surface of height during the rotation of the carrier. 3 Il.
FIELD: medicine, pharmacy.
SUBSTANCE: invention relates to a tablet decomposing rapidly in the buccal pocket and comprising a medicinal agent, excipient and saccharide with relatively lower melting point than that of a medicinal agent and excipient. Tablet is made by uniform mixing saccharide with low melting point with tablet mass to form bridge between particles of named medicinal agent and/or excipient through melting product followed by hardening mentioned saccharide with low melting point. Except for, invention relates to a method for making tablet decomposing rapidly in buccal pocket and comprising a medicinal agent, excipient and saccharide with relatively lower melting point than that of medicinal agent and excipient. Method involves: (a) the parent components of tablet comprising a medicinal agent, excipient and saccharide with relatively lower melting point that that of a medicinal agent and excipient are pressed under low pressure to provide the required tablet form; (b) pressed product obtained after stage (a) is heated to temperature when saccharide with low melting point is melted; (c) melted product obtained after stage (b) is cooled to temperature when melted saccharide with low melting point is hardened. Invention represents a tablet decomposing rapidly in buccal pocket and having the tablet strength providing its using in tablet-making machines for dosed formulations and giving the possibility for making tablet using common tablet-making machines, and to a method for making tablets. Except for, invention represents a tablet decomposing rapidly in buccal pocket being this table as compared with common tablets has enhanced tablet strength and improved frangibility without prolonged decomposing time in buccal pocket, and a method for tablet making.
EFFECT: improved making method.
63 cl, 4 tbl, 1 dwg, 21 ex
FIELD: pharmaceutical industry branch.
SUBSTANCE: installation includes housing jointly secured to telescopic struts. Inside housing driven latticed drum with pouring-over helix is mounted in hollow perforated shaft. Drive unit of drum is provided with unit for regulating rotation frequency. Installation is communicated with compressed air source and aspiration system. In order to set operation mode, inclination angle of drum axis is regulated due to changing height of struts and desired revolution number of drum is set.
EFFECT: enlarged functional possibilities of installation due to controlling its operation mode.
4 cl, 2 dwg
FIELD: medicine; medical engineering.
SUBSTANCE: method involves supplying target materials and core materials, carrying out target materials ablation with washed-out particle materials being produced and coating core materials with the washed-out particle materials. The method is applied under pressure of approximately equal to 10 torr or higher. Coating of thickness from one to several nm is applied at atmospheric pressure with pseudo-fluidized particle substance state, achieved by means of pneumatic pseudo-fluidization, being used.
EFFECT: improved pharmacokinetic drug properties.
22 cl, 22 dwg
SUBSTANCE: the present innovation deals with pharmaceutical composition of bactericidal action. The composition suggested contains ciprofloxacin in the form of hydrochloride monohydrate, maltodextrin as a binding substance, sodium carboxymethyl starch as a disintegrating agent, silica gel, a lubricant at quantities mentioned in its formula. Ciprofloxacin tablets should be obtained due to pressing technique by applying the stage of moisture granulation. If necessary, the surface of tablets should be covered with a hydroxypropylmethylcellulose-based water-soluble membrane. Simultaneous application of maltodextrin as a binding substance and sodium carboxymethyl starch as a disintegrating agent enables to obtain ciprofloxacin-containing tablets of sufficient strength and quick release of active ingredient.
EFFECT: higher efficiency of application.
6 cl, 6 ex, 9 tbl
FIELD: medicinal industry.
SUBSTANCE: the present innovation deals with manufacturing medicinal preparation containing drotaverin hydrochloride to be applied for interrupting spasms of smooth musculature. Mass for tableting should be prepared due to mixing the powder of drotaverin hydrochloride with that of dyed granulate at the ratio of 1:3 to 2:1. One should obtain the dyed granulate by moisturizing inert pharmaceutical filler with binder's solution dyed with quinoline yellow dyestuff. Then comes drying up to 0.1-2.5% followed by granulation and tableting. The innovation enables to obtain tablets of drotaverin hydrochloride upon industrial equipment at its degradability being below 15 min, being stable during manufacturing and at storage. Quality of tablets meets all the requirements of pharmacopoeic article.
EFFECT: higher efficiency of manufacturing.
2 cl, 4 ex, 3 tbl
SUBSTANCE: the innovation deals with manufacturing remedies to prevent wound suppuration based upon polymeric matrix and antimicrobial substance due to mixing components in solution, forming the film to obtain a powder-like medicinal form by providing the safety of antimicrobial activity of medicinal preparation. The obtained remedy is completely biodestructed in the body and requires no repeated operation on its removal after the end of tissue regeneration processes.
EFFECT: higher efficiency of manufacturing.
1 cl, 3 ex, 1 tbl
FIELD: heat-exchanging equipment used in medicine, in particular, in blood transfusion stations.
SUBSTANCE: apparatus has screened working chamber and cylindrical vessel made from dielectric material and located inside working chamber for rotation by means of electric engine, and temperature sensors connected to control unit. Netted container of dielectric material is provided with openings formed in bottom and wall. Dielectric used has low melting temperature and is adapted for filling of cylindrical vessel, netted container and for surrounding non-metal container filled with bioproduct to be defrosted. Temperature sensors are located inside netted container in the vicinity of non-metal container. Additional emitter with microwave energy source is positioned at opposite side with respect to first emitter and is connected to control unit. Control unit output is coupled to temperature regulator, which is connected to heating members placed inside dielectric material in lower part of cylindrical vessel.
EFFECT: increased efficiency and provision for uniform distribution of temperature through the entire volume of bioproduct under defrosting process.
4 cl, 1 dwg
FIELD: medicine, pharmacy, pharmaceutical industry.
SUBSTANCE: invention relates to tablets covered by envelope for masking taste of active substance. The core pharmaceutical composition comprises ciprofloxacin as an active component and the following accessory substances - microcrystalline cellulose, crosspovidon, magnesium stearate, lactose, talc, and maize starch. The core envelope comprises hydroxypropylmethylcellulose, titanium dioxide, collidone, propylene glycol, polyethylene oxide and talc. Also, invention describes a method for preparing the sold dosed formulation. Invention provides satisfactory technological properties of tableted mass, preparing plastic, luster core envelope not delaying the release of ciprofloxacin.
EFFECT: improved and valuable properties of composition, improved method for preparing formulation.
3 cl, 5 ex
FIELD: medicine, pharmacy.
SUBSTANCE: invention relates to a new composition of benzimidazole (omeprazole) and a method for its preparing. The benzimidazole composition comprises a benzimidazole compound in common with compound with acid reaction and includes inert core with applied benzimidazole, inert and external layer having enteral coating, pH 6.6-6.95. Also, invention relates to a method for preparing the composition wherein layers are applied in a device used for applying coatings in moving layer. Proposed compositions elicit the enhanced stability and biological availability.
EFFECT: improved and valuable pharmaceutical properties of compositions.
15 cl, 2 ex
FIELD: medicine, pharmacy.
SUBSTANCE: invention proposes a medicinal formulation consisting of a core and the stomach-dissolving envelope. The core comprises trimetazidine dihydrochloride as an active component, and starch, mannitol, povidone, magnesium stearate, croscarmelose and microcrystalline cellulose as accessory substances. The envelope comprises hydroxypropylmethylcellulose, polyethylene glycol, titanium dioxide, magnesium stearate and acid red as a dye. Also, invention describes a method for making the trimetazidine medicinal formulation. Trimetazidine tablets show high mechanical strength in the low pressing strength (3.5-5 kH). The composition of the medicinal formulation provides releasing 80% of trimetazidine for 30 min.
EFFECT: improved and valuable properties of formulation.
3 cl, 1 tbl, 1 ex