Of an acyclic saturated carbon skeleton (C07C321/14)

Method of obtaining ketoacids and their derivatives

Invention relates to a method of obtaining α-ketoacids, as well as their derivatives of general formula or , where R1 stands for either a branched or linear C1-C18alkyl group and, where R1 is optionally substituted with -SH or -SCH3, R2 stands for -OR"', where R"' represents a hydrogen atom or a branched or linear C1-C8alkyl group, both residues R3 together represent C2-C8alkanediyl and together form a ring or both residues R3 and R"' together represent a part of a C3-C8alkanetriyl group of general formula -R3(CH-)R"'- and together form a bicyclic group, consisting in the following: a) aldehyde R1 CHO is subjected to interaction with similar or different thiols of formula R4-S-H, where R4 stands for a branched or linear, optionally substituted C1-C6alkyl group, with obtaining respective dithioacetal, b) formed dithioacetal is subjected in the presence of a strong base to interaction with carbonyl-containing electrophile and further hydrolysis with obtaining α,α-(dithio)carboxylic acid or its derivatives of formula , where R5 represents a hydrogen atom or a branched or linear C1-C6alkyl group, and residues R4 and R1 have values given above, and c) α,α-(dithio)carboxylic acid or its derivatives of formula are converted by solvolysis carried out at acid catalysis in the presence of at least 1 molar equivalent of water into α-ketoacid or its derivatives of general formula (I) or (II) with the separation of thiols of formula R4SH. The invention also relates to an intermediate product of formula .

Composition based on organic sulphide with masked odour

Invention relates to masking the odour of organic sulphides and more specifically to alkyl or dialkyl sulphides, particularly dimethyl sulphide, as well as oxides thereof and particularly dimethyl sulphoxide by adding to said organic sulphides at least one odour masking agent which contains at least one monoester, at least one di- or triester, at least one alcohol, at least one ketone and optionally at least one terpene.

4-hydroxybenzamide drug derivatives

There are presented drug derivatives wherein said derivatives contain a H2S-releasing fragment of 4-hydroxythiobenzamide which is either covalently bond with the drug, or forms a pharmaceutically acceptable salt with the antilipidemic drug.

Method of producing 1a-methyl-1a-(3'-thioalkylprop-2'-yl)-1ah-1(9)a-homo(c₆₀-i_h)[5,6]fullerenes

Invention relates to organic chemistry, and specifically to a method of producing sulphur-containing homofullerenes of general formula (1): R = Am (pentyl), Cy (cyclohexyl), which is characterised by that C60-fullerene reacts with sulphur-containing diazoalkanes, produced in situ via oxidation of corresponding hydrazones of ketosulphides with MnO2, of general formula N2C(Me)CH(Me)CH2S-R, where R = Am (pentyl), Cy (cyclohexyl), in the presence of a three-component catalyst {Pd(acac)2:2PPh3:4Et3Al}, taken in molar ratio C60 : diazocompound : Pd(acac)2 : PPh3 : Et3Al=0.01:(0.01-0.03):(0.0015-0.0025):(0.003-0.005):(0.006-0.01), preferably 0.01:0.02:0.002:0.004:0.008, in o-dichlorobenzene as a solvent at temperature 20°C for 0.25-1.0 hours.

Method of producing dimethyl sulphide

Invention relates to methods of producing sulphur-containing compounds, specifically dimethyl sulphide which is used as an odorant and starting material for synthesis of dimethyl sulphoxide which is used as a medicinal agent, solvent and extractant. Described is a method of producing dimethyl sulphide by converting dimethyl disulphide in the presence of methanol at atmospheric pressure and temperature 300-380°C using a catalyst containing gamma-aluminium oxide and 0.73-7.3 wt % chromium oxide. The weight ratio of methanol to dimethyl disulphide is equal to 0.8-0.9 g/g and contact time is 0.1-0.35 s.

Prodrug 1,3-diamino-2-hydroxypropane derivatives

Invention relates to the compounds of the formula and their pharmaceutically acceptable salts used as inhibiting agent in the relation of fermentative beta-secretase and it also relates to pharmaceutical compositions based on the formula. In general formula one of RN and RN' represents hydrogen, and another represents - C(=O)-(CRR')0-6R100, or where R4 is chosen from the group including H; NH2; -NR50CO2R51; -(C1-C4)-alkyl-NR50CO2R51; where n7 is equal to 0, 1, 2 or 3; R50 represents H or C1-C6alkyl; R51 is chosen from the group including phenyl-(C1-C4)-alkyl and (C1-C6)-alkyl; X is chosen from the group including -(C1-C6)-alkylidenyl optionally substituted with 1, 2 or 3 metal groups; Z is chosen from the group including bond, SO2, SO and S; Y stands for (C1-C10)-alkyl; R1 represents -(C1-C6)-alkylphenyl where phenyl ring is optionally substituted by 1, 2, 3 or 4 halogen atoms; R and R' independently represent hydrogen or (C1-C6)-alkyl; R2 represents hydrogen; R3 represents hydrogen; Rc represents - (CR245R250)0-4-aryl; where aryl is optionally substituted by 1, 2 or 3 R200; R200 is chosen from the group including (C1-C6)-alkyl optionally substituted with 1, 2 or 3 groups R205; halogen; C=N; R205 stands for halogen; R245 and R250 in each case stands for H; either R245 or R250 are taken together with carbon atom whereto attached to form carbocycle from 3, 4, 5, 6 or 7 carbon atoms; R100 represents 5-6-merous heteroaryl with 1-2 heteroatoms chosen from nitrogen and sulphur, -phenyl-W-heteroaryl where heteroaryl is 5-6-merous ring containing 1-2 heteroatoms, chosen from nitrogen and oxygen and where cyclic parts of each group are optionally substituted by 1, 2 or 3 groups independently chosen among C1-C6alkyl, -(CH2)0-4-CO2-NR105R'105, -(CH2)0-4-SO2-NR105R'105, -(CH2)0-4-N(R150)-CO-R105, -(CH2)0-4-N(R150)-SO2-R105; W represents -(CH2)0-4; R105 and R'105 independently represent (C1-C6)-alkyl optionally substituted with -NH2 or halogen; R150 represents hydrogen.

Method for modifying paraffins

Invention relates to modification of oil paraffins, namely, to preparing sulfurous compounds used as additives in manufacturing bitumen in petroleum chemistry. Method involves interaction of paraffin with sulfur in the presence of alkaline metal persulfate or alkaline-earth metal persulfate, or ammonium persulfate. Invention provides preparing modified paraffins for a single step.