Antiparasitic agents (A61P33)

A   Human necessities(312083)
A61P33                 Antiparasitic agents(390)
A61P33/04 - Amoebicides(4)
A61P33/06 - Antimalarials(21)
A61P33/08 - For pneumocystis carinii(2)
A61P33/10 - Anthelmintics(163)
A61P33/12 - Schistosomicides(3)
Processing of fish population by lufenuron // 2642637
FIELD: veterinary medicine.SUBSTANCE: drug is applied by oral administration of daily doses of 1 lufenuron to 30 mg/kg of fish biomass within a period of 3 to 14 days, while the total number of lufenuron used during the specified interval of time is from 7 up to 350 mg/kg of fish biomass.EFFECT: invention is suitable for treating salmon and provides continued effective protection against sea lice in the sea.10 cl, 6 tbl, 2 ex
Complex preparation for treatment of acute and chronic otites of parasitary, bacterial and fungical origin in dogs, cats, fur-bearing animals and rabbits // 2642617
FIELD: veterinary science.SUBSTANCE: this invention relates to veterinary medicine and can be used in the treatment of acute and chronic otitis of parasitic, bacterial and fungal origin in dogs, cats, fur-bearing animals and rabbits. Complex preparation in the form of eardrops contains levofloxacin, clotrimazole, dexamethasone, moxidectin, and also targeted additives.EFFECT: invention provides 100 % therapeutic efficacy for parasitizing of ear mites and 98–100 % efficacy for otites of bacterial and/or fungal etiology.1 cl, 4 ex
Supramolecular complex of triclabendazole for treatment of animals in case of fascioliasis // 2640482
FIELD: veterinary medicine.SUBSTANCE: method comprises enteral administration of a supramolecular complex of triclabendazole and arabinogalactan in a ratio of 1:10 in the form of a powder of 0.1 to 10 microns in size, where the animals are received the complex in the form of an aqueous solution or in a dry mixture with food at a dose of 1-2 mg/kg.EFFECT: increased anthelmintic efficacy.4 ex, 4 tbl
Antiparastic means for pigs eimeriosis treatment and prevention // 2639133
FIELD: pharmacology.SUBSTANCE: invention is an antiparasitic means for pig eimeriosis treatment and prevention, which is a suspension comprising 5% of tolthrazuryl, characterized by additional content of sulfadimethoxin in an amount of 4%, trimetroprim in an amount of 0.8% and auxiliary substances in an amount of 90.2% as an intensification of the eimeriose and antibacterial action.EFFECT: increased effectiveness of pig eimeriosis treatment and prevention, physiological state stabilisation and optimisation of the digestive tract of animals.2 cl, 3 tbl, 3 ex
Application of aryl and hetaryl carboxamides as endoparasiticides // 2638830
FIELD: pharmacology.SUBSTANCE: invention relates to compounds of formula (Ib) in which Q is mono- or poly-M1 a substituted pyridyl, thienyl, furanyl or isothiazolyl; Y is hydrogen or cyclopropyl; W is oxygen or sulfur; L2 is -C(R21, R22)-; L3 is -C(R31, R32) - or a direct link; R21, R22 each independently is hydrogen, fluorine or, if necessary, mono- or poly-M2-substituted (C1-C4)-alkyl, (C2-C4)-alkenyl, (C2-C4)-alkynyl, (C1-C4)-haloalkyl, (C1-C6)-alkoxy, (C2-C4)-alkenyloxy, (C3-C4)-alkynyloxy, (C3-C4)-cycloalkyl-(C1-C4)-alkyl or (C3-C6)-cycloalkyl; R31, R32 each independently is hydrogen or (C1-C4)-alkyl; M2 each independently are chlorine, fluorine, formyl, cyano, nitro, (C1-C4)-alkyl, (C1-C4)-haloalkyl, (C1-C4)-alkoxy, (C1-C4)-haloalkoxy, (C1-C4)-alkylthio, (C1-C4)-haloalkylthio, (C1-C4)-alkylsulfonyl, (C1-C4)-haloalkylsulfonyl, (C1-C4)-alkylsulfanyl, (C1-C4)-haloalkylsulfanyl, (C1-C4)-alkylcarbonyl, (C1-C4)-haloalkylcarbonyl or (C3-C6)-cycloalkyl; M1 and M3 independently are halogen, cyano, nitro, OH, (C1-C10)-alkyl, (C1-C10)-haloalkyl, (C1-C10)-alkoxy, (C1-C10)-haloalkoxy, (C1-C10)-alkylthio, (C1-C10)-haloalkylthio, (C1-C10)-alkylsulfonyl, (C1-C10)-haloalkylsulfonyl, (C1-C10)-alkylsulfanyl, (C1-C10)-haloalkylsulfanyl, optionally substituted by halogen (3-14-membered cyclic group)-O-; n is an integer from 0 to 4; and to their use as medicines for controlling endoparasites in animals or humans.EFFECT: increased efficiency.16 cl, 29 tbl
ethod of increasing medical efficiency for cattle pyroplasmosis with neozidin-m in association with laserpuncture // 2638444
FIELD: veterinary medicine.SUBSTANCE: Neozidin-M is injected in association with irradiation with a semiconductor infrared pulsed laser of biological active spots with numbers 8, 9, 13, 17 and 22 according to the atlas written by Kazeev G.V. The laser is operated by the "Uzor" apparatus with a length of 890 nm with a pulse frequency of 1000, 1500 and 2000 Hz, in exposure of 0.5; 1.0; 1.5; 2.0 and 2.5 minutes after diagnosis and every 24 hours during the course of treatment.EFFECT: method provides high therapeutic activity of the disease treatment due to additional biostimulating effect.3 tbl, 1 dwg
ethod for increast of therapeutic efficiency of diminasin-70 in case of cattle pyroplasmosis // 2638433
FIELD: veterinary medicine.SUBSTANCE: invention can be used to increase the therapeutic efficacy of Diminazene-70 in case of cattle pyroplasmosis. For this purpose, the "Diminazene-70" preparation is administered in combination with irradiation of biologically active points 8, 9, 13, 17 and 22 according to the Kazeev G.V. atlas with a semiconductor infrared pulsed laser. Laser irradiation is carried out from the "Uzor" apparatus with a length of 890 nm, pulse frequency of 1000, 1500 and 2000 Hz, in exposures of 0.5; 1.0; 1.5; 2.0 and 2.5 minutes after diagnosis and every 24 hours during the treatment period.EFFECT: high therapeutic activity due to additional biostimulating effect.1 dwg, 3 tbl
ethod of increasing medical efficiency for cattle pyroplasmosis with pyro-stop medication in association with laserpuncture // 2638431
FIELD: veterinary medicine.SUBSTANCE: PYRO-STOP medication is injected in association with irradiation with a semiconductor infrared pulsed laser of biological active spots with numbers 8, 9, 13, 17 and 22 according to the atlas written by Kazeev G.V. The laser is operated by the "Uzor" apparatus with a length of 890 nm with a pulse frequency of 1000, 1500 and 2000 Hz, in exposure of 0.5; 1.0; 1.5; 2.0 and 2.5 minutes after diagnosis and every 24 hours during the course of treatment.EFFECT: increase of medical efficiency for cattle pyroplasmosis, high therapeutic activity due to additional biostimulating effect.3 tbl, 1 dwg
ethod for obtaining of supramolecular anthelmintic agent for group treatment of water birds in case of cestodiasis // 2637450
FIELD: veterinary medicine.SUBSTANCE: mehod includes obtaining of supramolecular antihelmintic agent and differs by niclosamide injection into propylene glycol in the ratio of 6:1, solvent temperature to 120-130°C and mixing thoroughly until complete dissolution of niclosamide, then polyvinylpolypyrrolidone (PVP) is added to the niclosamide solution in the ratio 14:1 with careful PVP stirring in the niclosamide solution until complete dilution, wheat bran in a ratio of 6:1 is added as a filler, and then ground chalk, salt and feed molasses are introduced at a ratio of 1:50:200:2, carefully stirred, the resulting mixture is subjected to pelletizing, pellet diameter is 5 mm.EFFECT: method allows to achieve savings of substances for drug preparation, lower therapeutic dose due to the drug bioavailability, reduce the toxicity of feed, environmental pollution, reduce drug cost and economize water birds treatment by the group method.3 ex
Drug for animal helminthosis treatment // 2635514
FIELD: veterinary medicine.SUBSTANCE: drug contains niclosamide, polyvinylpyrrolidone and ivermectin at the following ratio of ingredients, wt. pt.: niclosamide:ivermectin:polyvinylpyrrolidone - 1.0-2.0:0.005-0.015:7.985-8.995. The drug is obtained by mechanochemical activation for 5-7 hours in activators of shock-abrasive type at a ratio of the components weight and balls weight of 1:10, the volume of drum loading is 30-70% and the speed of its rotation is 60-80 rpm.EFFECT: wide range of action and high efficiency with a decrease in the concentration of active substances and increased safety during the manufacture.3 tbl, 4 ex
eans for animal arachnoses treatment // 2635191
FIELD: veterinary medicine.SUBSTANCE: ointment contains avermectins, isopropyl alcohol, dimexid, buckwheat melanins, polyhexamethyleneguanidine (PGMG), polyethylene oxide-400 (PEG-400) and polyethylene oxide-1500 (PEG-1500) as an active ingredient at a certain ratio of components, %: avermectins 0.06-0.1; isopropyl alcohol 8.0-9.0; dimexide 4.0-6.0; buckwheat melanin 0.01-0.02; polyhexamethyleneguanidine 0.005-0.006; PEG-400 45.0-80.0; PEG-1500 to 100.EFFECT: reduced treatment time and increased therapeutic effect in animal arachnoses.2 cl, 5 ex

Parasiticide compositions containing several active agents, methods and their applications // 2633751
FIELD: veterinary medicine.SUBSTANCE: group of inventions relates to a veterinary composition for punctual external application to treat or prevent parasitic infections or invasions in an animal. The composition comprises: (a) a combination of four active agents comprising i. two topically active agents, where one of the topically active agents is fipronil, and the other is a regulator of insect growth; and ii. two systemically active agents where one of the systemically active agents is praziquantel and the second is an avermectin or milbemycin active agent; and (b) a pharmaceutically acceptable carrier comprising glycerolformal, dimethyl isosorbide or a combination thereof. A method for treatment or prevention of parasitic invasions or infections in an animal is also provided.EFFECT: group of inventions ensures destruction, control and prevention of parasitic infections and invasions in an animal.21 cl, 1 dwg, 7 tbl, 5 ex
ethod for treating pyroplasmosis in cattle // 2631417
FIELD: agriculture.SUBSTANCE: against the backdrop of antiparasitic therapy, biologically-active points with numbers 8, 9, 13, 17 and 22 in the atlas of Kazeev GV are irradiated twice at 24 hour intervals. The irradiation is carried out by a semiconductor infrared "Uzor" laser with a wavelength of 890 nm. The pulse frequency and exposure are selected depending on the used drug, namely: when Diminazine-70 is received, the pulse frequency is 1000 Hz, the exposure is 3 minutes; when Neozidin-M is received, the pulse frequency is 1500 Hz, the exposure is 2 minutes; when Pyro-Stop is received, the pulse frequency is 1500 Hz, the exposure is 2 minutes.EFFECT: increased effectiveness of pyroplasmosis treatment due to biostimulating effects of laser radiation on biologically-active points.6 tbl, 1 dwg
Complex anthelminthic for treatment and prevention of strongylatosis of gastrointestinal tract of horses // 2629318
FIELD: veterinary medicine.SUBSTANCE: complex anthelmintic includes albendazole, fenbendazole and pegassin (zeolite) at the following ratio of components (%): albendazole - 20, fenbendazole - 20, pegassin - 60.EFFECT: drug is non-toxic, provides a high therapeutic effect.3 tbl, 4 ex
eans for nematodosis and eimeriosis treatment in veterinary // 2629316
FIELD: veterinary medicine.SUBSTANCE: means contains n-hexadecyltriphenylphosphonium bromide as an active ingredient and sunflower oil at a weight ratio of 1:99.EFFECT: drug is low-toxic, has high therapeutic efficacy at low therapeutic doses.5 tbl, 5 ex
Anthelminthic for treatment and prevention of delafondiosis, alfortiosis, oxyuriasis, strongylosis and trichonematosis of horses // 2629203
FIELD: veterinary medicine.SUBSTANCE: anthelminthic for treatment and prevention of horse strongylatoses includes 10% avertine powder, fenbendazole and shivyrtuin at the following component ratio (%): 10% avertine powder - 25, fenbendazole - 20, shivyrtuin - 55.EFFECT: agent is highly effective for treatment and prevention of horse strongylatoses.3 tbl, 4 ex

ethod of production of a combined antihelmint tablet with a symbiotic treatment for treatment of a small cattle // 2627893
FIELD: veterinary medicine.SUBSTANCE: invention is a method for producing a combined anthelmintic tablet with a symbiotic for treating small cattle containing a first and second layer comprising the steps of: adding a first powder mixture to a mould plate. Mentioned first powder mixture contains a pharmaceutically active substance and a binder, a second powder mixture is added to said mould plate. Mentioned second powder blend comprises a binder and the composition of mentioned second powder blend is different from the composition of mentioned first powder mixture, the first powder mixture and the second powder blend are pressed on said plate of the mould to form a tablet form and subjected to said tableted form with radio frequency emission for a period of Time sufficient to activate said binder within said tablet mould to fuse mentioned tableted Th form into said tablet, such that the density of mentioned tablet is less than about 0.8 g/cm3, characterized in that a bacterial concentrate is prepared for the preparation of the first powder mixture comprising a bifidobacterium adolescentis B-1 and Lactobacillus acidophilus LH-1 consortium with a titre of 108-1010 CFU/g sorbed on a carrier in a ratio of 1:1:12, which Is concentrated by filtration or centrifugation to a suspension containing 5 billion bacteria per ml, followed by mixing them in equal volumes. As the carrier, flour or bran is used at the rate of 12 parts of the support per part of a mixture of concentrated cultures, and then the obtained dry powder mass is mixed with lactulose, and to obtain the second powder mixture, ivermectin, praziquantel and at least one pharmaceutically acceptable excipient microcrystalline cellulose MCC is used, then the substances ivermectin, praziquantel and excipient are mixed in dry kind. The components in the tablet are in a certain ratio in wt %.EFFECT: invention provides high anthelmintic activity, intensification of treatment and prevention of a number of helminthic invasions, nonspecific correction of the immune response of the animal organism, normalization of hepatoprotective and reparative liver functions.6 ex, 1 tbl, 1 dwg
ethod of prophylaxis and treatment of repair young chickens of egg breed with coccidiosis // 2627612
FIELD: veterinary medicine.SUBSTANCE: as an anticoccidial drug appoint toltrazuril 2.5% with water at a dose of 1 ml per 1 l Drinking water continuously for 48 hours in five stages: in 9-10-, 16-17-, 23-24-, 37-38- and 56-57-days of age, ascorbic acid is prescribed in a dose at the rate of 0.05 g on 1 l, And glucose is prescribed in a dose 40 grams on 1 l Drinking water without restrictions under the scheme: in 8-10-, 15-17-, 22-27-, 36-38- and 55-57-day-old age.EFFECT: use of the claimed method is highly effective for the treatment and prevention of coccidiosis in the repair of young chickens of egg breeds.4 tbl, 4 ex
Bicyclic heterocyclic derivatives, their production and application // 2627269
FIELD: pharmacology.SUBSTANCE: invention relates to compounds of general formula (I) , as well as to a method for their preparation, pharmaceutical compositions based thereon, and their application.EFFECT: new compounds have been obtained that can be used to treat or prevent pathology for which it is necessary to inhibit the mTOR kinase.20 cl, 4 tbl, 30 ex
Derivatives of 5-substituted quinazolinone, compositions containing them and methods of application thereof // 2617989
FIELD: pharmaceutics.SUBSTANCE: compounds of formula (I) R1 is halogen atom; (C1-C6) alkyl, optionally substituted with one or more halogen atoms; (C1-C6) alkoxy group, optionally substituted with one or more halogen atoms, or -(CH2)nNHRa, where Ra represents hydrogen atom; -C(O)-(CH2)n-phenyl or -C(O)-(CH2)n-pyridyl, where phenyl is optionally substituted with one or more substitutes of halogen atom; -SCF3; (C1-C6)alkyl, optionally substituted with one or more halogen atoms, or (C1-C6)alkoxy group, optionally substituted with one or more halogen atoms; -C(O)-(C1-C8)alkyl, where alkyl is optionally substituted with one or more halogen atoms; -C(O)-(CH2)n-(C3-C10-cycloalkyl); -C(O)-(CH2)n-NRbRc, where Rb and Rc are hydrogen atoms independently of each other; (C1-C6)alkyl; or phenyl, optionally substituted with one or more substitutes of halogen atom or (C1-C6)alkyl; -C(O)-(CH2)n-O-(C1-C6)alkyl; or -C(O)-(CH2)n-O-(CH2)n-phenyl; R2 is hydrogen atom; OH; phenyl or (C1-C6) alkyl, optionally substituted with one or more halogen atoms; R3 is hydrogen atom; or (C1-C6) alkyl; and n takes values 0, 1 or 2.EFFECT: method is disclosed of treating or controlling diseases or disorders, such as cancer involving administering 5-substituted quinazoline compound of formula (I) or its pharmaceutically acceptable salt, solvate or stereoisomer.32 cl, 59 ex

Crystalline forms of 1-(5'-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3'h-spiro[azetidine-3,1'-isobenzofuran]-1-yl)-2-(methylsulfonyl)ethanone // 2614978
FIELD: chemistry.SUBSTANCE: invention relates to a crystalline form of A (S)-1-(5'-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3'H-spiro[azetidine-3,1'-isobenzofuran]-1-yl)-2-(methylsulphonyl)ethanone.EFFECT: technical result is obtaining a crystalline form of A (S)-1-(5'-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3'H-spiro[azetidine-3,1'-isobenzofuran]-1-yl)-2-(methylsulphonyl)ethanone, as well as a veterinary composition and a method of treating parasitic infection or infestation with parasites in an animal in need thereof is described.13 cl, 7 dwg, 5 tbl, 3 ex
Complex antiparasitic "azinal plus" - 3 compound for chemotherapy and prevention of trihotsefaleze, hookworm and echinococcosis for dogs // 2614711
FIELD: veterinary medicine.SUBSTANCE: preparation contains Azinoks, Alvet, Mepatar and Gerpegezhsky field bentonite of 10% humidity, in the following proportions, wt %: Azinoks - 10, Alvet - 20, Mepatar - 15, bentonite - 55.EFFECT: increased efficiency of chemotherapy of trihotsefaleze, hookworm and echinococcosis mono-infestations for dogs, can be offered for chemotherapy and prevention of mixed infestations, gastrointestinal and nematosis cestodosis.3 tbl, 4 ex
ethod of cattle thelaziosis treatment // 2613145
FIELD: veterinary medicine.SUBSTANCE: preparation comprising in wt %: 0.2-0.3 of ivermectin;. 0.9-1.1 of azithromycin; 0.5-1.0 of carbomer; 8.0-12.0 of water; to 100.0 of monopropylene glycol, is injected into the conjunctival sac cavity of the affected eye once daily for five days, one dose is 0.5-1.0 g.EFFECT: method exhibits high therapeutic efficacy in cattle thelaziosis treatment, no signs of toxicity or other side effects were observed after treatment.3 tbl, 3 ex
Anthelmintic agent for treatment and prevention of fascioliasis, dicroceliosis and paramphistomatosis of cattle // 2612013
FIELD: agriculture.SUBSTANCE: invention relates to the field of veterinary medicine and is intended for treatment and prevention of trematode infections of liver (fascioliasis, dicroceliosis) and of proventriculi (paramphistomatosis) in cattle. The claimed anthelmintic agent comprises albendazole 10%, phenbendazol-(5-phenyl-thio-2-benzimidazole carbamate), an energy and bactericidal component - mepatar, the filler - propylene glycol iodised table salt, 10%), the fresh dead lime suspension, a filler and a prolongator - aqueous 20% suspension of bentonite. The agent is characterized in the fact that it is made in the form of a suspension.EFFECT: proposed agent is highly effective for treatment and prevention of fascioliasis, dicroceliosis and paramphistomatosis of cattle.3 tbl, 3 ex
ethod for production of antiparasitic long acting preparation for animals // 2611387
FIELD: veterinary medicine.SUBSTANCE: praziquantel, ivermectin, copolymer of lactic and glycolic acids are mixed with a solvent with the following ingredient ratio (in wt %): praziquantel - 1.0-15.0, ivermectin - 0.5-8.0, copolymer of lactic and glycolic acids - 6.0-16.5, solvent - the rest. At that,praziquantel and ivermectin are the first to be dissolved in the solvent. The solution is then purged with argon or nitrogen and placed in an ultrasonic bath. The mixture is kept in the ultrasonic bath for 50-60 minutes till complete dissolution of the components. Then the copolymer of lactic and glycolic acids is added. For complete copolymer dilution, the obtained mixture is kept for 4-5 hours with occasional stirring at the rotation speed of 1600-2000 rpm. Then, the resulting solution is subjected to sterile filtration, dispensed into vials and sealed.EFFECT: method can reduce loss of active ingredients during manufacture and provide a harmless, non-toxic, sterile and effective long-acting drug for treating animals against a wide range of parasitic infections.5 cl, 8 ex
Personal hygiene agent with acaricidal activity on mite demodex // 2611347
FIELD: pharmaceutics.SUBSTANCE: invention relates to pharmaceutical industry and represents personal hygiene agent with acaricidal activity on mite Demodex, containing water as solvent, foaming agent sodium laureth sulphate, preservative, biologically active component – birch tar, flavoring agent, consistence amplifier and extracts, characterized by, that device additionally contains detergent Chegina K 40GLO, as amplifier of foam and thickener Emanon XLf, emulsifier, thickener and fatter Amidet N and Amidet B 112, as preserving agent – Mikroker DN, Apricot perfume as flavoring agent, as plant extracts – extract of Chamomile, tickseed herb extract, tansy herb extract, verbena herb extract, wherein ingredients in preparation are taken in certain proportions, wt%.EFFECT: invention provides care of hair and human body, as well as high acaricide therapeutic effect on mites Demodex.1 cl, 2 ex, 1 tbl
ethod of treating demodectosis // 2611346
FIELD: pharmaceutics.SUBSTANCE: invention relates to pharmaceutical industry, namely to method of treating demodecosis. Method consists in application of care and prevention agents, means of local and systemic therapeutic agent. As agent for care and prevention and local therapy shampoo is used, containing following ingredients in wt%: sodium laureth sulfate 8.0–10; Chegina K 40GLO 1.5–2.0; Emanon XLf SAS 2.1–2.5; Amidet N 2.1–2.2; Amidet B 112, 1.0–1.5; Mikroker DH 1.4–1.7; Sodium chloride 2.0–2.5; Apricot perfume 2.4–2.6; Chamomile extract 2.9–3.1; tickseed herb extract 2.9–3.1; birch tar 0.28–0.32; tansy extract 0.28–0.32; verbena extract 0.28–0.32 and water to 100, and antibiotics and/or metronidazole are used as system agent. Shampoo is applied daily on problem skin areas, as well as hair and skin of face, neck and low neck zone, in external auditory passages rubbed in processed sections, kept 1–2 minutes, and then washed with warm water.EFFECT: invention provides obtaining of high therapeutic effect in form of reducing length of treatment due to higher acaricide effect.1 cl, 1 tbl, 2 ex

Compositions containing 2-arylpirazole alone or in combination with formamidine for treating parasitic infections // 2608906
FIELD: veterinary science.SUBSTANCE: declared group of inventions relates to veterinary science and is intended for destruction of parasites in animals. Declared composition for treating or preventing parasitic invasion in animal includes at least one compound of 1-arylpirazole in first veterinary acceptable carrier, at least one compound of formamidine in second veterinary acceptable carrier and optionally at least one inhibitor of crystallization, where compound(s) 1-arylpirazole and first veterinary acceptable carrier are compartmentalized together and have no contact through liquid with compound(s) of formamidine and second veterinary acceptable carrier. Method of treating or preventing parasitic invasion in animal is disclosed involving administration of effective amount of said composition.EFFECT: declared group of inventions is high effective for destruction, monitoring and preventing parasitic invasion in animal.14 cl, 13 dwg, 28 tbl, 17 ex

Esters of pentamidine-amidoxime acids as prodrugs and their application as medicinal agents // 2608388
FIELD: chemistry.SUBSTANCE: invention relates to pentamidine prodrugs, namely to compound of formula given below, where n equals to 2, as well as to its pharmaceutically acceptable salts, solvates, salts of solvates, which have improved properties, such as solubility and bioavailability, compared to existing prodrugs.EFFECT: invention also relates to method of producing said compound, various versions of therapeutic agents for treating and/or preventing diseases, selected from oncological and tumor diseases, leishmaniasis, trypanosomiasis, pneumocystis pneumonia and malaria, including this compound, and methods of treating above diseases. 13 cl, 7 dwg, 5 tbl
New anthelmintic preparation for treating and preventing ostertagiasis in cattle and small cattle // 2608132
FIELD: veterinary science.SUBSTANCE: invention relates to veterinary science and is intended for treating and preventing ostertagiasis in cattle and small cattle. Anthelmintic preparation for treating and preventing ostertagiasis in cattle and small cattle includes albendazole 10 % and additionally contains fenbendazole, propylene glycol, iodized table salt, soluble streptocid, soluble norsulfazole, oxytetracycline, fructose, 10 % suspension of fresh slaked lime and 20 % aqueous suspension of bentonite with following ratio of components, wt %: albendazole 10 % – 5, fenbendazole – 10, propylene glycol – 20, iodized table salt – 3, soluble streptocid – 0.2, soluble norsulfazole – 0.2, oxytetracycline – 0.1, fructose – 1.5, 10 % suspension of fresh slaked lime – 10, aqueous 20 % suspension of bentonite – 50.EFFECT: invention is highly effective for treating and preventing ostertagiasis in cattle and small cattle.1 cl, 3 tbl, 3 ex
Pyrrolidinyl urea and pyrrolidinyl thiourea compounds as trka kinase inhibitors // 2606131
FIELD: pharmaceutics.SUBSTANCE: invention relates to compounds of formula I given below, or to their stereoisomers, tautomers or pharmaceutically acceptable salts thereof. R1, R2, Ra, Rb, Rc, Rd, X, Y, B, and ring C are as defined by the invention formula. Wherein the Y-B moiety and the NH-C(=X)-NH moiety are in the trans configuration.EFFECT: compounds of formula I are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation, neurodegenerative diseases and certain infectious diseases.56 cl, 31 tbl, 649 ex

Complex method of treating theileriosis in small cattle // 2603622
FIELD: veterinary science.SUBSTANCE: invention relates to veterinary science and aims at treating theileriosis in sheep and goats. Water solution of DAZ is introduced to animals in combination with antimalarial preparation delagil in following proportions, mg/kg: DAZ in dosage 2.5 mg/kg in 5 %-aqueous solution once a day for 1-2 days, in amount of 0.5 mL/kg of body weight, intramuscularly, delagil in dose of 25 mg/kg with water, once a day for two days. Symptomatic therapy is carried out simultaneously.EFFECT: invention provides higher clinical effectiveness, while treating theileriosis in sheep and goats.1 cl, 1 ex, 1 tbl

ethod of pasturable prevention of fascioliasis in ruminant animals // 2602679
FIELD: agriculture.SUBSTANCE: invention relates to agriculture. Animals are raised on pasture, plant formation of which consists of 70 % and more of plants, containing main active substances of 2 classes (phenolcarboxylic acids class, higher fatty acids class) and ascorbic acid (vitamin C) and auxiliary reactants of 2-3 classes (class of aromatic carboxylic acids class of lipid acids, class of triterpenic acids, class of sesquiterpene acids, class of organic acids and class of tanning substances), nicotinic acid and amino acid canavanine.EFFECT: use of declared method reduces the rate of multiple invasion during herd season, improves therapeutic and preventive effect.1 cl, 8 tbl, 2 ex

Isoxazoline compositions and their use as antiparasitics // 2602308
FIELD: veterinary science.SUBSTANCE: invention refers to veterinary science and can be used for controlling parasitic infestations of the environment where an animal is held. For this purpose it is applied the isoxazoline, salt of the isoxazoline, solvate of the isoxazoline or a salt of a solvate of the isoxazoline, wherein the isoxazoline has a structural formula (11-1).EFFECT: invention provides control of chicken mite in the environment where poultry is held.8 cl, 1 dwg, 10 tbl, 7 ex

Topical localized isoxazoline formulation comprising glycofurol // 2602189
FIELD: veterinary science.SUBSTANCE: group of inventions refers to veterinary science, namely to a method of treating and preventing parasite infestation in animals by compositions for external and local application. For this purpose, the composition containing 1-50 % wt/vol. of an isoxazoline compound (I) and veterinary acceptable liquid carrier vehicle containing 15-20 % wt/vol. of glycofurol and 5-95 % wt/vol. of auxiliary solvents mixture, such as dimethylacetamide, acetone and N,N-diethyl-3-methylbenzamide. Compound I is a 4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-2-methyl-N-[(2,2,2-trifluoro-ethylcarbamoyl)-methyl]benzamide. Composition can also contain an effective amount of macrocyclic lactone compound.EFFECT: group of inventions provides a cosmetically acceptable formulations for external and local application effective for a long period of time in treating ectoparasite infestation in animals.8 cl, 3 tbl, 3 dwg, 4 ex

ethod of cattle theileriosis treating // 2601915
FIELD: veterinary science.SUBSTANCE: invention refers to veterinary science and aims at cattle theileriosis treating. For therapeutic effect animals are treated with “Neozidinum” aqueous solution in combination with antimalarial preparation “Delagil”. Symptomatic therapy is carried out simultaneously. Following components ratio is used, mg/kg: “Neozidinum” in 7 % aqueous solution in dosage of 5 mg/kg once a day for 2-3 days in amount of 0.8 ml per 10 kg of body weight intramuscularly, “Delagil” in dosage of 100 mg/kg in amount of 10 g per 100 kg of body weight inside with water once a day for five days.EFFECT: disclosed method is highly effective in treating of cattle theileriosis.1 cl, 1 tbl, 1 ex

ethod of miliary dermatitis and otodectic mange treating in carnivores // 2600161
FIELD: veterinary science.SUBSTANCE: invention refers to veterinary science and is applicable for treating otodectic mange in and miliary dermatitis in carnivores. Method involves use of pine tar oil solution. Tar pine is mixed with vegetable oil in dilution of 1:2.EFFECT: preparation is instilled into auricle with subsequent light massage once a day in a day, at least 4 times, until recovery.1 cl, 1 tbl, 1 ex

Endoparasite control agent // 2596788
FIELD: pharmaceutics.SUBSTANCE: invention relates to a composition for oral or enteral administration for control endoparasite, containing a carboxamide derivative of general formula (I):, or its salt as an active ingredient, and to an endoparasite control method, comprising oral or enteral administration of composition for endoparasite control.EFFECT: endoparasite control.8 cl, 8 ex, 7 tbl

Control of ectoparasites // 2596494
FIELD: veterinary science.SUBSTANCE: invention refers to veterinary science and is intended for protection of animals against ectoparasites. Method involves treating non-human mammal, infected with ectoparasites or at risk of infection by ectoparasites, with composition containing 4-chloro-3-ethyl-1-methyl-N-[4-(n-tolyloxy)benzyl)pyrazole-5-carboxamide or its salt, where non-human mammal is selected from the livestock, domestic animals and experimental mammals.EFFECT: invention is highly effective for protecting animals against ectoparasites.20 cl, 2 tbl, 1 ex

N-heteroaryl compounds // 2596185
FIELD: pharmaceutics.SUBSTANCE: invention relates to N-heteroaryl compounds and pharmaceutically acceptable salts, solvates or N-oxides of general formula (I), where R1: halogen, C1-C6-alkyl, C1-C6-alkyloxy, C1-C6-alkylthio, C2-C6-alkenyl, C2-C6-alkynyl, C1-C6-alkoxy-C-1-C6-alkyl, C1-C6-alkyl-carbonyl, SF5, C1-C6-alkylsulphonyl, wherein each carbon-containing radical is optionally substituted with one or more halogen atoms, R2: hydrogen, C1-C6-alkyl, R3, R4 and R7 hydrogen, C1-C6-alkyl, R5: hydrogen, C1-C6-alkyl, C1-C6-acyl or C1-C6-alkyloxycarbonyl, R6: hydrogen, C1-C6-alkyl, C1-C6-alkyloxycarbonyl, phenyl, phenyl-C1-C6-alkyl, n=1-3, X: carbonyl, thiocarbonyl or sulphonyl group, A is a bond, E is a bond or NR9, where R9 - hydrogen, B is N, D is N or CR11, where R11 - hydrogen, Y1 is C or N, where C is substituted with R12, which is hydrogen, C1-C6-alkyl, C1-C6-galoalkilom, nitro, Y2 is C or N, where C is substituted with R13, which is hydrogen, halogen, C1-C6-alkyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1-C6-haloalkoxy, nitrilo, di(C1-C6-alkyl)amino, N-pyrrolidinyl, C1-C6-alkylthio, C1-C6-alkylcarbonyl, aminocarbonyl, C1-C6-alkylamino-carbonyl, C1-C6-alkoxycarbonyl, Y3 is C, where C is substituted with R14, which is hydrogen, C1-C6-alkyl, C1-C6-alkoxy, amino, N-pyrrolidinyl, N-piperidinyl, N-morpholinyl, C1-C6-alkylcarbonyl, 1,3-dioxolane, which is unsubstituted or substituted with C1-C6-alkyl, Y4 is C or N, where C is substituted with R15, which is hydrogen, C1-C6-alkyl, wherein two of Y1, Y2 and Y4 can represent N, or Y3 and Y4 are bonded to form a ring system, selected from phenyl, thiophene, imidazole, pyridine, furan, 1,4-dioxane, triazole, and where at least one of B and D is a nitrogen atom. Invention also relates to a pharmaceutical composition based on compound of formula (I), intermediate compounds of formulae (1-IV), (3-IV), (4-II), method of treating helminth infection, compounds of formula (Ia), use of formula (I) and (Ia).EFFECT: obtaining novel compounds effective in treating parasitic infections.23 cl, 3 tbl, 18 ex

acrocyclic compounds as trk kinase inhibitors // 2594742
FIELD: chemistry.SUBSTANCE: invention relates to compound of formula I or its pharmaceutically acceptable salts, which are inhibitors of Trk kinases and are useful for treating pain, malignant oncological disease, inflammation, neurodegenerative diseases and Trypanasoma Crusi infections. Invention also describes versions of methods of producing compound of formula I. In Formula I (I) ring A is selected from A-1, A-2, A-3, having structure , where wavy line marked 1 indicates connection point of ring A to ring B, and wavy line marked 2 indicates point of connection ring A to W; X is N or CH; Y is H or F; R1 is H or halogen; ring B is selected from rings B-1 and B-2, having structure , where wavy line marked 3 indicates point of connection to ring A, and wavy line marked 4 indicates point of connection to pyrazolo[1,5-a]pyrimidine ring of formula I; W is O, NH or CH2, wherein, when ring A is A-2, then W is CH2; m is 0, 1 or 2; D is carbon, R2 and R2a independently represent H, F, (1-3C)alkyl or OH (provided that R2 and R2a are not simultaneously OH), and R3 and R3a are independently H or (1-3C)alkyl, or (D) is carbon or nitrogen, R2 and R3 are absent, and R2a and R3a together with atoms to which they are bonded, form 5-6-member heteroaryl ring containing 1-2 heteroatoms ring; Z is *-NR4aC(=O)-, *-ONHC(=O)-, *-NR4bCH2- or *-OC(=O)-, where asterix indicates connection point of Z to containing carbon R3; R4a is H or (1-6C)alkyl; R4b is H, (1-6C)alkyl, ((1-6C)alkyl)C(O)-, HOCH2C(O)-, ((1-6 C)alkyl) sulfonyl, HO2CCH2- or ((1-6C)alkyl)NH(CO)-; and R-5 and R6 independently represent H, halogen, OH or (1-6C)alkyl.EFFECT: useful for treating pain, malignant oncological disease, inflammation, neurodegenerative diseases and Trypanasoma Crusi infections.73 cl, 1 tbl, 45 ex
Novel composition of active ingredient(s) of vegetable origin or synthetic analogues thereof and extract(s) of vegetable origin containing same and lecithin // 2593949
FIELD: biochemistry. SUBSTANCE: present invention relates to a composition containing 10-20 wt% vegetable active ingredient (clove oil and/or eugenol), 20-30 wt% lecithin, 15-30 wt% ethanol, 10-20 wt% of one or more sugars: sucrose, glucose, fructose or mannose. Clove oil and/or eugenol are encapsulated with lecithin. Said composition is used for preventing or treating human or animal intestinal parasites, including as an active ingredient in medicinal agent. Furthermore, said composition is used for insecticidal treatment. Present invention also discloses a method for preparing said composition, a method of encapsulating active ingredient of vegetable origin with lecithin, as well as a method of treating with insecticide. EFFECT: present invention improves solubility of lecithin in composition and provides different coating by microencapsulation. 10 cl, 4 ex

ethod of sheep nematodosis treating and preventing // 2592236
FIELD: veterinary science. SUBSTANCE: invention refers to veterinary science and aims at sheep strongylatoses treating and preventing. Method involves using antiparasitic preparation “Praziver” orally individually in dosage 0.4 ml per 10 kg of animal body weight, together with triple (every 72 hours) intramuscular introduction of “Ajsidivit” immunomodulator in a dose of 3 ml per animal. EFFECT: method provides 100 % efficiency of the declared method of treating sheep strongylatoses, as well as allows to accelerate therapeutic effect antiparasitic preparation. 1 cl, 2 tbl, 2 ex
Anti-parasitic composition containing macrocyclic lactone and levamisole, and method of treating parasitic infestation // 2591082
FIELD: veterinary science.SUBSTANCE: group of inventions refers to veterinary science and aims at treating animals against parasitic infestation. Disclosed is veterinary anti-parasitic dissolved composition consisting of macrocyclic Lactone or its pharmaceutically equivalent of salt and levamisole or its pharmaceutically equivalent salt, characterised by that pH of composition ranges from 2.0 to 5.0 and where composition contains at least 15 % of weight/volume of surfactant. Also disclosed is method of treating animals against parasitic infestation, characterised by stage of administering declared veterinary composition.EFFECT: declared group of inventions is high effective in parasitic infestation in animals.17 cl, 11 tbl, 1 ex

Supramolecular complex with niclosamide and preparation method thereof // 2588368
FIELD: veterinary science.SUBSTANCE: invention can be used for treating cestodaria in animals. Said technical result is achieved by proposed composition of supramolecular complex of niclosamide with vinyl pyrrolidone polymer at ratio of 1:5 by weight and disclosed production method which consists in combined mechanochemical treatment in roller ball mill with addition of 700 g of metal balls within 2 hours during drum rotation at speed of 90 rpm to produce supramolecular complex with particles size up to 10 microns.EFFECT: invention is aimed at higher water solubility, bioavailability and anthelmintic effect of niclosamide when lowering dose by more than 10 times after mechanochemical treatment of niclosamide and vinyl pyrrolidone polymer substance in ball mill of impact-abrasive type.1 cl, 6 ex, 3 tbl

High penetration compositions or prodrugs of antimicrobials and antimicrobial-related compounds // 2586287
FIELD: pharmaceutics.SUBSTANCE: group of inventions refers to chemical-pharmaceutical industry and represents compound with high penetration ability, which is HCl salt of 1-piperidine ethyl ether 4,4-dioxide [2S-(2alpha, 3beta, 5alpha)]-3-methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl) -4-tia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid (tazobactam-REE), HCl salt of N,N-diethylaminoethyl ether of 4,4-dioxide (2S,5R)-3,3-dimethyl-7-oxo-4-tia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid (sulbactam-DEE), HCl salt of 4-piperidine ethyl ester of (2R,5R,Z)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid (clavulanic acid-REE) , HCl salt (4-nitrophenyl) (N, N-diethylaminomethyl)-ether[(N-benzyloxyicarbonilamino) methyl]-phosphonic acid, HCl salt (3-pyridinyl) (1-piperidinethyl)-ether [(N-benzyloxyicarbonilamino)methyl]-phosphonic acid, HCl salt of 4-(4-dimethylaminobutiril) amidobenzolsulphonamide (DMAB-sulfanilamide), HCl salt of N,N-diethylaminopropil ether 6-oxo-3-(2-[4-(N-pyridine-2-ylsulfamoil)phenyl] hydrazone) cyclogexa-1.4-diencarboxylic acid (sulfasalazine-DEPE), HCl salt of butyl ether 1-cyclopropyl-6-fluoro-4-oxo-7-piperazine-1-yl-quinoline-3-carboxylic acid (ciprofloxacin-VE), HCl salt of N,N-diethylaminoethyl ether 1-ethyl-7-methyl-4-oxo-[1,8] naphtirydine-3-carboxylic acid (nalidixic acid-DEE).EFFECT: pharmaceutical composition containing effective amount of such compounds and pharmaceutically acceptable carrier.4 cl, 19 ex, 9 tbl, 6 dwg
Soluble pharmaceutical composition based on fipronil and uvemon for treating arachkoentomoses // 2585384
FIELD: pharmaceutics.SUBSTANCE: invention relates to pharmaceutical industry, veterinary science and medicine and represents a multicomponent soluble pharmaceutical composition for treating arachkoentomoses characterised by that it contains fipronil, yuvemon, prednisolone, chlorhexidine or myramistine, lidocaine, dimethyl sulphoxide, 2-hydroxypropyl-β-cyclodextrin and solvent: water and alcohol component, including isopropyl or ethyl alcohol and propylene glycol, in volume ratio 1:3-1:5, ingredients of composition taken in certain proportions, wt%.EFFECT: invention provides high level of anti-parasitic activity and therapeutic efficiency at lower concentrations fipronil, reduced toxicity and local irritant action, high stability and shelf life and higher biological availability of components.4 cl, 3 ex, 3 tbl

utant polypeptides suaa and polypeptide derivatives suitable for delivery of immunogenic molecules in cell // 2585216
FIELD: biotechnologies.SUBSTANCE: group of inventions relates to biotechnology. Disclosed is a mutant polypeptide containing or representing a fragment of adenylyl cyclase, corresponding to SEQ ID NO: 1, 7, 8 or 9. Also disclosed is recombinant polypeptide representing said polypeptide, which is additionally combined with one or more molecules of interest, capable of launch immune response. Disclosed is pharmaceutical composition containing one of above polypeptides.EFFECT: group of inventions allows to induce t-cell and/or b-cell immune response in host organism for preventing or treating disease selected from neoplasia, cancer and infectious diseases caused by virus, retrovirus, bacterium of parasite or fungus.21 cl, 16 dwg, 1 tbl, 1 ex

Integrated method for therapy of fasciola cattle // 2584212
FIELD: veterinary science.SUBSTANCE: invention is intended for therapy of bullocks Fasciola. Proposed method comprises using politrema ac and immunomodulator - ribotana according to scheme: politrem as in dose of 0.2 g/kg of animal body weight orally with concentrated fodder once, ribotan subcutaneously into middle one-third of neck for 5 days running in dosage of 5.0 ml per head.EFFECT: use of method provides more effective therapeutic and preventive dehelmintisation at fascioleze, stimulates non-specific immune resistivity, normalises metabolism of proteins, fats, microelements and other synthetic hepatic functions.1 cl, 5 tbl, 3 ex

ethod for prolonged chemoprophylaxis of hemosporidial infections of cattle // 2583139
FIELD: veterinary science.SUBSTANCE: invention relates to veterinary medicine and is intended for prevention of piroplasmoses in cattle. Animals are administered a solution consisting of neosidine - 7 g, glycerine - 20 ml and distilled water - 73 ml.EFFECT: method improves safety of cattle from piroplasmoses.1 cl, 1 tbl, 1 ex
 
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