Local anaesthetics (A61P23/02)

A   Human necessities(312083)
A61P23        Anaesthetics(281)
A61P23/02                     Local anaesthetics(150)
Gel including nifedipine and lidocaine hydrochloride (versions), application of gel including nifedipine and idocaine hydrochloride (versions), method for preparation of gel including nifedipine and idocaine hydrochloride, using nanotechnology // 2641570
FIELD: pharmacology.SUBSTANCE: method for gel preparation consists in preparation of two separate solutions and a nifedipine suspension, followed by mixing of the solutions and suspension at a temperature of 20-37°C for 1-9 hours with further filtration and gel preparation by addition of a gelling agent.EFFECT: invention implementation allows to obtain a gel with a high stability of gel properties, transparency, stability of properties for up to 2 years, the use of which allows to reduce the clinical symptoms of hemorrhoids up to their complete elimination, anal fissure healing and relief of pain after hemorrhoidectomy.3 cl, 1 tbl
ethod for subdural analgesia as method for analgesia in first delivery period // 2633933
FIELD: medicine.SUBSTANCE: in the first delivery period, the puncture site is anesthetized with a solution of bupivacaine 0.5%. The subdural space is then punctured with a spinal needle at the level L3-4, L4-5 by median access, using an isobaric solution of bupivacaine 0.5% in doses of 0.8-1.2 ml as a local anesthetic. At that, the woman after the puncture remains lying on her side for 2-3 minutes, then turns to the opposite side for 2-3 minutes.EFFECT: decreased drug effect on the maternal and fetal organism, ensured rapid onset of qualitative and prolonged analgesia of the first delivery period.1 ex
Application of lidocaine derivative with local anesthetic activity, for terminal anesthesia // 2628811
FIELD: medicine.SUBSTANCE: invention can be used for application of a lidocaine derivative - N-acetyl-L-glutamate 2-diethylamino-21,61-dimethyl phenylacetamide of the general formula (1) with local anesthetic activity, for terminal anesthesia.EFFECT: invention allows to reduce acute toxicity, increase the breadth of therapeutic action, increase the depth and duration of terminal local anesthesia without a local irritant effect compared to lidocaine.3 tbl, 3 ex
ethod for epidural catheter installation for conduction of epidural analgesia in young mothers // 2626909
FIELD: medicine.SUBSTANCE: aseptic treatment and local anesthesia of the puncture site is performed, inserting the Tuohi needle No. 16-18G in the sagittal plane between spinous processes L2-L3. The mandrel is removed after sensation of a dip, a low-pressure syringe with saline is attached and the needle is moved till the loss of resistance for the saline in the syringe. The syringe is disconnected, then the catheter is inserted into the needle and pushed through the needle. A syringe with a 5-7 mm of saline is attaced to the outer end of the catheter. The catheter is slowly and continuously advanced in the cranial direction. Simultaneously, the connective tissue of the epidural space is infiltrated together with the epidural veins with saline, the catheter is placed at a depth of 4-5 cm.EFFECT: method allows to reduce the risk of epidural hematoma and unintentional injection of local anesthetic into the bloodstream for young mothers.1 cl
Agent for application anaesthesia with antiseptic, optical-keratoprotective properties and method for use thereof in ophthalmology // 2624901
FIELD: medicine.SUBSTANCE: group of inventions relates to medicine and pharmacology, and can be used to produce an agent form of gel for application anaesthesia in ophthalmic surgeries. Agent contains following components, wt%: hydroxyethyl cellulose 1.2–1.8, glycerol 17–25, lidocaine hydrochloride 1.8–2.4, chlorhexidine dihydrochloride 0.03–0.07, water- balance up to 100. Also disclosed is a method of application anaesthesia in ophthalmic surgeries.EFFECT: group of inventions enables to produce an agent possessing antiseptic, optical-keratoprotective properties without preservatives, use of which enables to achieve complete anaesthesia with no complications.4 cl, 4 ex
Gel with oximethyluracyl, chlorohexidin and lidocaine for diagnostic and treatment endourethral procedures // 2624866
FIELD: medicine.SUBSTANCE: invention can be used for diagnostic and therapeutic procedures (cystoscopy, bladder catheterization, urethral expansion) as an anti-inflammatory antimicrobial anesthetic regeneration stimulating antioxidant antiviral agent with prolongation effect. The agent contains oxymethyluracyl, lidocaine and chlorhexidine bigluconate as active ingredients, contains polyethylene glycol 400, glycerin, lutrol F-127 and purified water as the gel basis at a certain ratio of components.EFFECT: creation of a new therapeutic and diagnostic antimicrobial anesthetic anti-inflammatory regenerative antioxidant antiviral agent, with good fixation, spreadability, pronounced and prolonged action, convenient in application.2 tbl, 5 ex

Aminoindane compounds and use thereof in treating pain // 2612959
FIELD: chemistry.SUBSTANCE: invention relates to novel aminoindane compounds of formulae (I) or (II): , where: A is phenyl or a monocyclic aromatic 5- or 6-member ring containing 1 or 2 heteroatoms selected from N and S; R1 and R4 are independently C1-C6 alkyl or CH2CH2OH; or R1 and R4 are combined to form a 4-6-membered carbocyclic or saturated 5- or 6-member monocyclic group containing one additional ring heteroatom, such as O; R2 is independently selected from a group consisting of halogen; R3 is independently selected from a group consisting of halogen and C1-C-6 alkyl; or q equals 2, and two R3 groups are bonded to form a saturated 5- or 6-member monocyclic group containing 1–2 oxygen atoms; m is ranges from 1 to 3; n ranges from 1 to 3; p ranges from 0 to 2; q ranges from 0 to 2; and X- is a halogen, trifluoroacetate, sulphate, etc, as well as methods of producing and using said compounds. Methods involve administering a compound of formula (I) or (II) and a TRPV1 receptor activator.EFFECT: said compounds can find application in treating pain and/or itching.14 cl, 8 tbl, 11 dwg, 59 ex
ethod of anesthesia for transrectal prostate biopsy // 2608604
FIELD: medicine.SUBSTANCE: invention relates to medicine, namely to oncourology. Before introduction of ultrasonographic probe into rectum in tessellated space between fascia Denonvile and prostate capsule 20 ml of 0.5 % solution of novocaine is introduced with standard needle of disposable syringe at distance of thumb width from anus at 10–12 hours of conditional clock face to the right and at 12–2 hours of conditional clock face to the left.EFFECT: method allows to safe and quickly relieve pain for transrectal prostate biopsy,without expensive consumables, including patients with chronic diseases of rectum and anal canal.1 cl, 2 tbl, 2 ex

Agent for treating pyoinflammatory processes in soft tissues and mucous membranes // 2601897
FIELD: medicine.SUBSTANCE: invention refers to medicine, namely to agents possessing antimicrobial, sorption, analgesic and wound healing action on local pyoinflammatory processes in soft tissues and mucous membranes, used in surgery, dermatology, obstetrics and gynecology, otorhinolaryngology. Declared agent for treating pyoinflammatory processes in soft tissues and mucous membranes is a film and contains as therapeutic ingredients antiseptic chlorhexidine bigluconate 0.05 % and stimulator of regeneration methyluracil, comprises the base polyethylene oxide with molecular weight 400 (PEO-400) and carboxymethyl cellulose sodium salt (Na-CMC), also as a therapeutic component-metronidazole, as anaesthetic contains lidocaine hydrochloride, as a stabilizer - glycerine in the amounts specified in the patent claim.EFFECT: technical effect consists in creation of effective remedy in the form of film, possessing antimicrobial, sorption, analgesic and wound healing action.1 cl, 3 tbl
ethod of high spinal anaesthesia in operations on top floor of abdominal cavity // 2599044
FIELD: medicine.SUBSTANCE: invention refers to medicine, namely to anaesthesiology. In a patient side position performed is a middle or a paramedian access. After local anaesthesia puncture is performed at the level of LIV-LV with a needle of diameter 25 G and less. Introduced into the subarachnoid space are 40 mg of 2 % lidocaine solution, herewith the edge of the needle during puncture of the dura mater and verification of the subarachnoid space is directed sagittally right or left. Then introduced is an isobaric marcaine solution in the total dose of 15-20 mg, while placing the needle edge maximum cranially, herewith the time of a single-stage introduction of marcaine with bubbling liquor in the amount of up to 5-10 ml is equal to 1-2 minutes. Further regulation of the block development and control over the block is done by inclination of the head end of the table to 45-60° and controlled by noninvasive measurement of blood pressure and heart rate.EFFECT: method enables to combine positive properties of subarachnoid anaesthesia meaning simplified, fast start, prolonged analgetic and myorelaxing effect, besides, softer and easier postoperative period, faster postoperative rehabilitation of patients, no need for a long myoplegia (intraoperative and postoperative), no period of postanesthetic depression, no need for an artificial pulmonary ventilation.1 cl, 3 ex
ethod of pelvic diseases therapeutic block in animals and offering obstetric aid during pathological delivery // 2596725
FIELD: veterinary science.SUBSTANCE: invention refers to veterinary science and concerns pelvic diseases therapeutic blockade in animals or offering obstetric aid during pathological delivery. Method involves determining needle stick point and introduction of 0.25-0.5 % novocaine. Needle is stuck to right or left side along inner edge of iliac bone to its stop at inner surface of iliac bone wing. At that, end of needle is pulled up and novocaine solution is introduced in amount of 0.5 ml per 1 kg of animal body weight. For 0.5 ml of introduced solution added 0.1 mg of dexamethasone, 0.1 ml of polyglucin and 10 mg of ceftriaxone or gentamycin. Similarly acting on opposite side of pelvis.EFFECT: method provides fast and stable elimination of pain and inflammatory reaction.1 cl, 4 ex
ethod of anesthesia on an outpatient basis in patients dental profile // 2591638
FIELD: medicine.SUBSTANCE: prior to surgery by intravenous infusion using the infusion device controlled within 10 minutes of dexmedetomidine injected to a concentration of 4.0 mcg/ml in a dose of 1.0 mcg/kg of patient body weight, then the rate of infusion of the drug was reduced to 1.0 mcg/kg/h. Spend local infiltration anesthesia of the surgical solution of articaine hydrochloride 40.0 mg/ml. Next, a surgical intervention, upon completion of dexmedetomidine infusion was stopped. At the same time, before, during and after the induction of anesthesia and surgery, as well as to the full recovery of consciousness of the patient is carried out continuously monitor observation of blood pressure, pulse, oxygen saturation, respiratory rate, ECG.EFFECT: method allows you to improve the quality of anesthesia on an outpatient basis in patients dental profile.1 cl, 1 ex
ethod of personalised intraoperative contact local hyperthermia for treatment of locally advanced malignant tumours // 2565810
FIELD: medicine.SUBSTANCE: heating of bed of ablated or resected tumour is performed with application of intraoperatively made individual tissue-equivalent applicator copying tumour bed shape. Applicator is made from self-polymerising material, in which ferromagnetic filler is introduced at stage of manufacturing. In the process of manufacturing surface of tissue-equivalent applicator is covered with protective film from self-absorbable polymer material. Antibiotics, anti-tumour preparations and anaesthetics are preliminarily added into polymer base of protective film.EFFECT: elimination of possibility of direct contact of ferromagnetic filler with tissues, located in operation field zone, intensification of dissolution of active substances, reduction of number of pyoinflammatory complications, reduction of tumour recurrences, including due to creation of high concentration of preparations in operation field zone and in bed of ablated tumour.2 cl, 1 ex

Pharmaceutical composition with analgesic activity in injection form (versions) // 2563211
FIELD: medicine, pharmaceutics.SUBSTANCE: pharmaceutical composition with kappa-opioid agonistic activity, demonstrating an analgesic effect in accordance with the first version contains 9-(2-morpholinoethyl)-2-(4-fluorophenyl)imidazo[1,2-α]benzimidazole dihydrochloride as an active component, and an isotonicity corrigent, selected from salts of organic and inorganic acids, polyols, amino acids, as auxiliary substances. The composition can additionally contain a co-solvent, a corrigent of the solution pH, a cryoprotector, and an antioxidant. In accordance with the second version the pharmaceutical composition contains 9-(2-morpholinoethyl)-2-(4-fluorophenyl)imidazo[1,2-α]benzimidazole dihydrochloride as an active component, and a co-solvent, selected from ethyl alcohol, glycerol, propylene glycol, benzylbenzoate, benzyl alcohol, ethyloleate and fatty oils, including olive oil and peach oil as auxiliary substances. The composition can additionally contain an isotonicity corrigent, a corrigent of the solution pH, a cryoprotector, and an antioxidant.EFFECT: invention provides the pharmaceutical composition in an injection form with kappa-opioid agonistic activity without narcogenic potential, demonstrating the fast relief of pain syndrome.12 cl, 5 dwg, 3 tbl, 4 ex
ethod for anaesthesia in extended partial mastectomy with axillary-subcapular lymphadenectomy in senior patients // 2559278
FIELD: medicine.SUBSTANCE: after a surgical site has been treated from three points at a breast base: superior internal and superior external, superior and inferior external, inferior external and inferior internal quadrants junctions, the skin is infiltrated with 0.25% Novocaine solution. Further, a long needle is used to inject 0.25% Novocaine 40 ml from the marked points into the retromammary space on either side. Besides, from the fourth point: axillary subcutaneous fat is infiltrated along a border of a greater pectoral muscle with smoothly changing the needle direction. That is followed by the infiltration anaesthesia of the skin and underlying tissues along the outline of the quadrant to be removed. What is also required is a Novocaine block of separated thoracodorsal nerve and long thoracic nerve.EFFECT: enabling the lymphadenectomy with no general anaesthesia required, which is ensured by the infiltration anaesthesia combined the retromammary Novocaine block and the additional anaesthesia of the thoracodorsal nerve and long thoracic nerve.1 ex

ethod for managing neuropathic pain // 2554494
FIELD: medicine.SUBSTANCE: invention refers to chemical-pharmaceutical industry and represents a pain control formulation containing 4 wt % to 10 wt % of Lidocaine and 4 wt % to 10 wt % of Tetracaine, 10 wt % to 40 wt % of polyvinyl alcohol, water and sorbitan monostearate (Span 60) as an emulsifier, wherein water/PVA mass ratio makes more than 2.5, wherein the formulation provides the transdermal delivery of Lidocaine and Tetracaine, and wherein the delivery is terminated or considerably slows down when water evaporates completely, and wherein the formulation possess an initial viscosity from approximately 28,000 centipoise to approximately 828,000 centipoise, and shows a after 3 freeze-thaw cycles at least 2 times as much as the initial viscosity; the freeze-thaw cycle is determined by placing the formulation into the environment of temperature -18°C to -22°C for the time period of 48 hours and thawing the formulation at room temperature (approximately 25°C) for the time period of 48 hours.EFFECT: invention provides the improved long-term storage of the compositions.16 cl, 9 ex, 7 tbl, 2 dwg
ethod for retrobulbar anaesthesia in oncological eye diseases with use of b-ray applicator // 2553193
FIELD: medicine.SUBSTANCE: catheter is inserted into the retrobulbar space and used to introduce 2% lidocaine 1 ml and 0.5% marcaine 1 ml 15-20 minutes before applicator anchoring. The catheter is left in the retrobulbar space for 1-7 days. 10-15 minutes before removing the applicator, 2% lidocaine 0.5-1 ml and 0.5% marcaine 0.5-1 ml are introduced through the catheter. 4-6 hours after anchoring and removing the applicator, 2% lidocaine 1 ml and 0.5% marcaine 1 ml are introduced respectively additionally.EFFECT: achieving adequate and prolonged anaesthesia in a combination with reducing a risk of a retrobulbar haematoma, eyeball puncture and visual nerve damage by eliminating the retrobulbar space re-puncture.2 ex

ethod of anaesthetics and prevention of inflammatory complications after median sternotomy // 2553178
FIELD: medicine.SUBSTANCE: after performing median sternotomy pericardial and mediastinal drainages are installed and sternum is sutured. After suturing sternum for length of its entire front surface, catheter is installed through skin counterpuncture, with 1.0-2.0 cm indent from lower wound edge. proximal end of catheter is fixed to subcutaneous-adipose cellular tissue with absorbable suture material, and distal part of catheter with cannula is fixed by suturing to skin with non-absorbable suture material. Local anaesthetic is introduced through installed catheter every 6 hours, with antibiotic being introduced every 8 hours. Introduction of medications is performed for 3-5 days.EFFECT: method provides effective anaesthetics with simultaneous drainage of front sternum surface and skin wound due to introduction of anaesthetics and antibiotics via catheter into said zone, which additionally reduces quantity of exudative inflammatory complications in post-operative period.2 dwg, 1 ex

ethod for spinal anaesthesia in pregnant women suffering concomitant cardiovascular pathology // 2548510
FIELD: medicine.SUBSTANCE: spinal anaesthesia is followed by catheterisation of an epidural space at the level of L1-L2. The spinal anaesthesia is performed at the level of L4-L5 by administering 0.5% bupivacaine. Bupivacaine is administered in a dose of 5-6 mg if the pregnant woman's height is less than 165 cm, and the dose is 6-7 mg if the pregnant woman is from 165 to 175 cm high. After the local anaesthetic is administered into the epidural space, normal saline is introduced. If the intra-abdominal pressure is ≤16 cm H2O, normal saline 15 ml is administered; if the intra-abdominal pressure is 17-21 cm H2O, an amount of normal saline is 10 ml, whereas the intra-abdominal pressure of 22-28 cm H2O requires an amount of 5 ml.EFFECT: performing the effective spinal anaesthesia combined with reducing a probability of hypertension by dilating the epidural space preliminary in accordance with the intra-abdominal pressure.1 tbl, 1 dwg, 2 ex

Pharmaceutical composition in solid form with analgesic activity // 2545861
FIELD: chemistry.SUBSTANCE: as active component pharmaceutical composition contains dihydrochloride of 9-(2-morpholine ethyl)-2-(4-fluorophenyl)imidazo[1,2-α]benzimidasol, and as additional substances - fillers, binding, sliding and film coatings, in quantities, given in the invention formula. Composition can be made in form of solid medication form, mainly in form of tablets and capsules.EFFECT: obtained solid medication forms satisfy the requirements of the State Pharmacopoeia.7 cl, 2 dwg, 3 tbl, 14 ex
Percutaneously absorbable preparation // 2543639
FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to a percutaneously absorbable layer having a base and an adhesive layer which is placed on the base and which comprises an adhesive agent and a therapeutic ingredient. The adhesive agent contains a mixture of resins containing 100 portions by weight of an acrylic copolymer (A) and 0.1 to 30 portions by weight of an acrylic copolymer (B) or 0.05 to 2 portions by weight of a low-molecular polyamine compound having at least two amino groups in one molecule and non-polymerising with a polymer or an oligomer formed. The adhesive layer additionally contains an organic acid. The acrylic copolymer (A) represents an acrylic copolymer, which contains acrylic ester of (meth)acrylic acid as a main monomer ingredient and contains 3 to 45 wt % of diacetone acrylamide as a target monomer ingredient, but free from a free carboxylic group. The acrylic copolymer (B) represents an acrylic copolymer, which contains acrylic ester of (meth)acrylic acid as a main monomer ingredient and contains a primary amino group and/or carboxyhydrazidase group on side chains, but free from a free carboxylic group.EFFECT: reducing the aging period of the adhesive layer considerably.7 cl, 8 tbl, 39 ex
Antiseptic and analgesic therapeutic agent in form of gel for processing and lubricating catheters used in examining and treating urogenital system // 2540921
FIELD: medicine.SUBSTANCE: therapeutic agent contains hypromellose, boric acid and a consistency base; it additionally contains anesthesin or lidocaine as an analgesic in an amount of 0.00001-0.5 g.EFFECT: fixing a lubricating agent on the catheter enabling preventing mucosal injuries accompanying a drainage procedure, and eliminating side effects.3 cl, 6 ex
ethod for prolonging anterior chamber anaesthesia and pupil dilatation experimentally // 2540007
FIELD: medicine.SUBSTANCE: anterior chamber anaesthesia and pupil dilatation accompanying anterior eye segment surgeries experimentally involve a preoperative administration of a composition in an amount of 0.1-0.2 ml representing 0.005% 1-(3-pyrrolidinopropyl)-2-phenylimidazo[1,2-a]benzimidazole dihydrochloride into the anterior eye segment. The composition is prepared in 1% viscoelastic solution, visiton PEG.EFFECT: prolonging anaesthetic effect and pupil dilatation with no mydriatics used.2 ex
ethod of intramesovarian blockade of ovarian and cranial uterine nerves in dogs and fur-bearing animals of canine family // 2539425
FIELD: veterinary medicine.SUBSTANCE: intramesovarian blockade of ovarian and cranial uterine nerves is carried out by laparotomy and administration in the mesovarium of 0.5-1% solution of novocaine or lidocaine. Blockade is carried out by inserting the needle of the syringe into the mesovarium in the vicinity of the ovarian bursa and uterine horn at an acute angle to the surface of the ovarian mesenterium to a depth of 3-4 cm. At that 3 ml of anaesthetic is administered to small breeds of dogs and fur-bearing animals, and from 3 to 9 ml of anaesthetic is administered to large and giant breeds of dogs as from one and from the opposite side of the body.EFFECT: effective implementation of intramesovarian blockade by taking into account the anatomical and the breed features of the animal category.1 tbl

ethod for novocaine block // 2536283
FIELD: medicine.SUBSTANCE: patient is laid on his/her side opposite a block region. A guide mark is a vertical line in a projection of Petit's triangle from the twelfth rib to a wing of ilium. A needle is pricked into the skin on the vertical line at 1.5-2.5cm above the wing of ilium. 0.25% Novocaine is administered in layers into the skin and subcutaneous fat. The needle is advanced into the lumbar region from back to front in the medial direction along the lateral edge of broadest muscle of back at 6-8cm. Novocaine 120ml is administered into the lower order of the lumboiliac fossa formed in this region.EFFECT: effective and safe pain management in the given category of patients by providing the required Novocaine concentration in the retroperitoneal space.1 dwg, 1 ex

icrocolloidal solution of propofol for anaesthesia // 2535001
FIELD: biotechnology.SUBSTANCE: aqueous composition for anaesthesia is proposed, which comprises propofol as an active agent, the PEG-660-12-hydroxystearate as a solubiliser, benzyl alcohol, or chloroethanol or parabens as preservative, the tocopherol and arginine or glycine at a specific content of components wt %. The GABA agonists can be additionally added to the composition, e.g. aminophenyl-butyric acid, local anesthetics such as lidocaine, alpha-2-adrenoceptor agonists such as xylazine. The method is proposed for implementing anaesthesia comprising administering to a patient of an effective amount of the claimed composition.EFFECT: invention provides low toxicity of dosage form and high efficiency.5 cl, 3 tbl, 1 ex

ethod for assessing limb distal circulation reserves // 2530764
FIELD: medicine.SUBSTANCE: radionuclide indicator is administered to record the dynamics of its distribution in limb tissues by a radionuclide method. The examination is performed at rest and during a load test. The load test represents an epidural block by gradual administration of bupivacaine 25-30 mg between L2-L3 vertebrae for 5-7 minutes. That is followed by measuring a blood flow as a percentage of its value to the same level in an analogous segment of a collateral limb.EFFECT: qualitative assessment of the circulation reserve in various categories of patients, including disabled ones by inhibiting sympathetic and minimally sensory activity with maintaining the patients' motor activity.2 dwg, 2 ex

ethod for preperitoneal block following median postoperative ventral hernioplasty // 2529412
FIELD: medicine.SUBSTANCE: invention refers to medicine, namely to abdominal surgery and anaesthesiology, and can be used where it is necessary to anaesthetise after the prosthetic hernioplasty for median postoperative ventral hernias. That is ensured by placing an endoprosthesis under the aponeurosis, a polyvinylchloride catheter is placed into the formed spaced around the periphery of a postoperative wound in the form of an oval above the endoprosthesis plane at 2.5-3 cm from its edges. Along its full length, the catheter has multiple side holes. Single openings are created in a projection of a lower corner of the wound, and the catheter ends are brought out onto the skin. An inlet of the catheter is attached to a local anaesthetic dosage device by means of a cannula. That is followed by a controlled prolonged irrigation with 2.5% Ropivacaine 20 ml every 6-8 hours during 2-3 days.EFFECT: method enables the adequate postoperative anaesthesia, as well as the length of the postoperative intestinal distention by providing the uniform controlled administration of the local anaesthesia solution.7 dwg, 1 ex

ethod of anaesthesia after herniorrhaphy by inguinal access in case of inguinal hernias // 2521836
FIELD: medicine.SUBSTANCE: invention relates to medicine, namely to anaesthesiology and surgery, and can be used in case of anaesthesia necessity in patients after herniorrhaphy with inguinal access in case of inguinal hernias. For this purpose after the main stage of operation - hernioplasty, before suturing of the aponeurosis of the external oblique abdominal muscle, through subcutaneous adipose cellular tissue a puncture of 1 cm more medially and 1 cm higher than the anterior-superior iliac spine is made. A multiperforated catheter is introduced through the puncture under finger and visual control in such a way that its distal end is near the pubic tubercle. The catheter is placed under the aponeurosis of the external oblique abdominal muscle in the inguinal canal above and parallel to the spermatic cord in men or the round ligament of uterus in women. All the side holes of the catheter must be located in the subaponeurotic space. The first 48 hours of the post-operation period the local anaesthetic is continuously introduced by drop infusion at a rate of 2-4 ml/h or by bolus introduction in a dose of 10 ml each 4-6 hours through the catheter. After 48 hours the catheter is removed.EFFECT: method provides adequate anaesthesia in the said category of patients in the post-operation period without application of additional anaesthetic preparations due to blockade of ilioinguinal, ilioceliac and hollow branch of genitofemoral nerves.2 dwg, 2 ex

ethods for reducing pain and drug delivery devices // 2513219
FIELD: medicine.SUBSTANCE: group of inventions refers to medicine, and may be used in treating the patients suffering headaches and facial pains. There are presented versions of a drug delivery device comprising an injector a first end of which is left outside patient's nasal passages. Another end of the injector comprises one or more holes for spraying a drug upwards, and/or to the side, and/or to the front towards a sphenopalatine ganglion, an input device interacting with a patient's nostril and comprising a canal for receiving the injector. Additionally, the device can comprise a handle connected to the input device and provided for receiving the canal of the input device. The injector can move between a storage position before the interaction, and an interaction position related to the interaction. There are also presented versions of the method of using the above device that involve introducing the injector through the nasal passage into median and/or posterior and/or inferior region in relation to the patient's sphenopalatine ganglion, and spraying the drug.EFFECT: group of inventions provides faster and more effective headache and facial pain relief by safe and accurate drug delivery of the therapeutic substances blocking the sphenopalatine ganglion.49 cl, 4 dwg, 30 ex

2,6-dimethylanilide of n-cyclohexylpyrrolidine-2-carboxylic acid hydrochloride, having surface, infiltration and conduction anaesthesia activity // 2504538
FIELD: chemistry.SUBSTANCE: invention relates to a novel biologically active 2,6-dimethylanilide of N-cyclohexylpyrrolidine-2-carboxylic acid, having surface, infiltration and conduction anaesthesia activity, considerably better than bupivacaine and ropivacaine with the same or less toxicity.EFFECT: improved compounds.2 tbl

Pharmaceutical composition of pediphene for treating damage by non-lethal irritants // 2496485
FIELD: medicine, pharmaceutics.SUBSTANCE: what is presented is a pharmaceutical composition in the form of a spray for treating a damage by non-lethal irritants (e.g. pelargonic acid morpholide), containing pediphene in the following proportions, wt/volume %: pediphene hydrochloride 0.01-10.0; sodium chloride 0.1-10.0; water for injections up to 100 ml. What is shown is the efficacy of pediphene in compliance with the declared application ensured by the local anaesthetic effect of the drugs.EFFECT: drug preparation has no allergenic and immunotoxic properties.3 dwg, 40 tbl
ethod for prevention of developing acute postoperative pancreatitis accompanying endoscopic transpapillary interventions // 2477153
FIELD: medicine.SUBSTANCE: invention refers to medicine, namely anesthesiology, intensive therapy and endosurgery, and may be used in patients in need of endoscopic transpapillary intervention. That is ensured by an intravenous infusion therapy with crystalloid solutions in the amount of 800-1200 ml. An epidural space is punctured and catheterised at the level of Th VIII - Th IX with the catheter moved by 4-5 cm in the cranial direction. A local anaesthetic solution and Clopheline 100 mcg are introduced through the epidural catheter at the level of Th V - Th X 20 minutes before the endoscopic transpapillary intervention. It is followed by pre-medication enabled by introducing 0.1% atropine 0.5-1 ml and 0.5% relanium 1-2 ml, and the patient is wheeled into a catheterisation laboratory. After the endoscopic transpapillary intervention completed, the patient is transferred into an intensive therapy unit wherein prolonged epidural analgesia is enabled by introducing 0.5-1% lidocaine 10 ml into the epidural space every 4 hours. If observing no clinical manifestations of postoperative pancreatitis, the epidural catheter is removed, and the patient is transferred into a department of surgery for symptomatic treatment.EFFECT: method enables preventing acute postoperative pancreatitis following such interventions due to action of a general mechanism of pathogenesis of the given pathology.1 ex

Vaginal antiarrhythmic drugs for managing pelvic pain // 2476212
FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to a pharmaceutical vaginal composition for reducing or relieving uterine dysrhythmia. The composition contains an antidysrhythmia drug in the concentration of 1 wt % to 12.5 wt % and a pharmaceutically acceptable carrier providing prolonged release. The carrier contains a bioadhesive, water-swellable, water-insoluble, cross-linked polycarboxylic acid polymer such as polycarbophil. The drug is specified in prilocaine, mepivacaine, bupivacaine, ropivacaine, ethidocaine, mexiletine, procainamide, moracizin, propaphenone and flecainide.EFFECT: invention provides reducing or relieving uterine dysrhythmia with prolonged release of said drugs with creating adequate local concentrations and low blood concentrations.9 cl, 33 ex
ethod of anesthetics in abdominal surgery after laparoscopic or video-assisted appendectomy // 2469747
FIELD: medicine.SUBSTANCE: after performing main stage of surgery, under visual control needle puncture is performed into retroperitoneum space of right iliac fossa perpendicularly to skin, 1 cm inward from anterior superior iliac spine. Needle is passed inward, downward and frontward to the depth 6-8 cm, sliding on internal surface of iliac bone. Conductor is introduced through needle lumen and polyethylene catheter, through which after the end of operation, after 4-6 and 10-12 hours introduced is naropin in dose 2.5 mg/ml in 0.9% sodium chloride solution, is installed.EFFECT: method makes it possible to ensure adequate and safe anesthetics in post-operative period due to accuracy of introduction of anesthetic directly in the zone of surgery.2 ex
ethod of subdural anaesthesia as anaesthetic management of cervical suturing surgery // 2466751
FIELD: medicine.SUBSTANCE: puncture point is anaesthetised by 0.5% bupivacaine. It is followed by puncture of a subdural space with the use of a spinal needle at the level of L3-4, L4-5 from a medial approach. A local anaesthetic is presented by hyperbaric 0.5% bupivacaine 0.8-1.2 ml. The patient is kept seating for 10 minutes.EFFECT: method enables adequate anaesthesia with ensured maximum perineal myorelaxation combined with decreased drug-induced load on mother's and foetus's bodies.1 ex
Pharmaceutical composition for treating damage by non-lethal irritants // 2466721
FIELD: medicine.SUBSTANCE: spray composition contains, wt/vol %: lidocaine hydrochloride 1.0-10.0; benzethonium chloride 5.0·10-4 - 5.0·10-3; sodium chloride 0.1-10.0; water for injections to 100 ml.EFFECT: use of the declared composition is effective for treating damages by non-lethal irritants.1 ex
ethod for retrobulbar anaesthesia in vitreoretinal surgeries // 2462278
FIELD: medicine.SUBSTANCE: invention refers to medicine, namely anaesthiology in ophthalmosurgery, and may be used in vitreoretinal surgeries, including those terminated by the stage of introducing silicone oil. For this purpose, 40-45 minutes before the operation, the retrobulbar introduction of a mixture of 2% lidocaine and 0.75% ropivacaine in proportions 1:1 in the amount of 4-5 ml is prescribed. It is followed by the intraoperative intravenous titration introduction of 0.01% nitroglycerine starting with 1 ml 1-2 minute before the introduction of silicone oil in response to a surgeon's signal. The nitroglycerine introduction is terminated when patient's systolic blood pressure becomes lower than the initial values by 10-20%.EFFECT: method provides adequate anaesthesia combined with a reduced risk of developing complications due to blood pressure correction at the specific stage of surgery.1 ex
ethod for simulating prevention of hospital strain formation // 2458138
FIELD: medicine.SUBSTANCE: method involves the intramuscular introduction of the preparations Galavite 200 mcg/mouse and Lidocaine 8 mcg/kg of body weight once a day for three days running every 24 hours to experimental animals CBA line mice suffering a burning injury with underlying mycotic and bacterial infections accompanied by anti-infectious protection suppression.EFFECT: invention enables creating a model of hospital strain formation which is applicable for studying the variations of the properties of opportunistic microorganisms to increasing virulence and antibiotic resistance.2 tbl

ethod of treating myofascial pain accompanying spine osteochondrosis // 2452493
FIELD: medicine.SUBSTANCE: invention refers to medicine, namely neurology, orthopaedics, reflexotherapy, physiotherapy exercises, recreation therapy and is applicable in integrated treatment of myofascial pain accompanying spine osteochondrosis. Pain management procedures are followed by a complex of exercises with using the HUBER apparatus consisting of seven staticodynamic exercises aimed at strengthening and activation of muscles of upper limb girdle, greater pectoral muscle, pelvic floor muscles and gluteal muscles. It is combined with loading and coordination improvement of left broadest muscle of back, left obliques, left lumbar quadrate muscle. Upper shoulder anchors, broadest muscle of back and rhomboid muscle are relaxed, and postural muscles are coordinated. Lumbar spine muscles are relaxed. Tone in upper extremity and back muscles is strengthened. It is followed by making exercises for activation of muscles of upper limb girdle, pectoral muscles, pelvic floor muscles, gluteal muscles. Then, the exercises for strengthening of lumbar muscles for the purpose of improving the body position coordination, relaxation of back ground of femoral and hip muscles, strengthening of abdominal wall muscles.EFFECT: method improves support ability of feet, normalises position of the centre of gravity, forms an optimum motor conditions.3 ex, 7 dwg
ethod of combined anesthesia in resecting operations on lungs // 2448743
FIELD: medicine.SUBSTANCE: invention relates to medicine, namely to anesthesiology and thoracic surgery, and can be used as anesthetic aids in surgery on lung resection. For this purpose carried out is general anesthesia with microrelaxants and artificial lung ventilation in combination with blockades. Before anesthesis induction subpleural blockade is performed. After intubation of patient vagosympathetic blockade is carried out. As local anesthetic, in carrying out said blockades 0.2% ropivacaine solution is used.EFFECT: method makes it possible to ensure adequate blockade of pain impulse at stages of transduction and transmission in carrying out operation on patients with reduced reserve heart possibilities.1 ex
ethod of brachial plexus block in upper extremity surgeries // 2430752
FIELD: medicine.SUBSTANCE: invention refers to medicine, namely to anesthesiology, and can be used where block brachial plexure anaesthesia required in upper extremity surgeries. For this purpose, a first needle stick point is arranged on a periphery edge of a subclavian artery 1 cm above a posteromedial edge of a clavicle. A second needle stick point is located in an axillary cavity below an axillary pulsation over a head of humerus.EFFECT: method enables safe adequate block anaesthesia in appropriate surgeries due to additional ulnar nerve block.2 ex

Succinate of n-(2,4,6-trimethylphenyl)amide 2-(beta-n,n-diethylamino ethylamino)-4-oxo-4-(4-methyylphenyl)-2-butenoic acid // 2428412
FIELD: chemistry.SUBSTANCE: novel compound relates to amine derivatives of pyruvic acid amides and is biologically active - succinate of N-(2,4,6-trimethylphenyl) amide 2-(β-N,N-diethylamino ethylamino)-4-oxo-4-(4-methyl-phenyl)-2-butenoic acid of formula .EFFECT: compound has marked local anaesthetic and antimicrobial activity.1 cl, 1 ex, 3 tbl
ethod of infraorbital block // 2427393
FIELD: medicine.SUBSTANCE: invention refers to medicine, namely, to anaesthesia in dentistry, and can be used if maxillary anaesthesia is needed. For this purpose, in a region of an alveolar process of an upper jaw between juga alveolaria 12 and 13 or teeth 22 and 23 respectively depending on a side of the jaw, at level of a projection of root ends, intraosseous injection of an anaesthetic solution is performed.EFFECT: method provides safe adequate maxillary anaesthesia ensured by blocking the conduction of peripheral branches of an infraorbital nerve due to spongy bone impregnation with the anaesthetic solution to penetrate into an infraorbital canal.

ethod of conduction anesthesia of foot // 2425649
FIELD: medicine.SUBSTANCE: invention relates to medicine, namely to traumatology and orthopedics and can be used in operations on Achilles tendon, ankle joint and foot. For this purpose block of tibial nerve is performed by introduction of anesthetic through point, located on the middle of the distance between internal ankle and internal edge of Achilles tendon. Additionally performed is block of common paroneal nerve by introduction of anesthetic through point, located behind fibular bone head.EFFECT: method makes it possible to provide adequate anesthesia of foot for long term due to more accurate determination of reference points for additional block of paroneal nerve.2 dwg, 2 ex
ethod of local anesthesia of mandbular molars with no periodontium pathology // 2424002
FIELD: medicine.SUBSTANCE: invention refers to medicine, namely, to anaesthesiology and dentistry, and can be used as an anaesthesia care of dental interventions. That is ensured by infiltration anaesthesia as follows. In the middle of each gingival papilla adjoining a tooth to be anaesthetised, a short-needle syringe is pricked in from a vestibular side at an angle 90 degrees to a surface of a mucous membrane of the medial and distal gingival papilla. The needle is moved forward firmly to a bone. Then an anaesthetic drug 0.2 ml of 4 % articaine and adrenaline of various concentrations is introduced from each side.EFFECT: method provides the adequate and prolonged anaesthesia ensured by the most exact delivery of the anaesthetic drug and vasoconstrictive agent to nerve fibres.1 ex
Ointment for treatment and prevention of alveolitis // 2423103
FIELD: medicine.SUBSTANCE: invention relates to field of medicine, namely, surgical dentistry and maxillofacial surgery and can be used for treatment and prevention of alveolitis. Ointment for treatment and prevention of alveolitis contains lanolin-vaseline base, crystalline iodine, water solution of potassium iodide, solcoseryl dental adhesive paste, anesthesin, polysorb MP, distilled water, with the following component ratio: lanolin-vaseline ointment 40.5-42.5; crystalline iodine 0.1-0.3; water solution of potassium iodide 0.4-0.5; solcoseryl dental adhesive paste 40.5-42.5; anesthesin 3.8-5.8; polysorb MP 0.3-0.5; distilled water - the remaining part.EFFECT: invention makes it possible to accelerate healing of bone wounds, prevent development of inflammatory complications and reduce period of recovery of patients with alveolitis.2 ex
ethod of complex rehabilitation of patients with central spastic paresis of upper extremities // 2422167
FIELD: medicine.SUBSTANCE: invention refers to medicine, namely to neurology, and can be used in complex rehabilitation of the patients with central spastic paresis of upper extremities. For this purpose, first under block anaesthesia of branches of a brachial plexus, hand bracing is performed from an axillary approach. In bracing, a rigid bandage is applied to a level of the lower one-third of forearm 2 cm higher than a wrist joint. It is followed with physioprocedures every 15-30 minutes in the following order: paraffin-ozokerite applications or cryotherapy during 20 min, electrical myostimulation of extensor muscles of hand and fingers, massage of the affected extremities, physiotherapy exercises, mirror therapy. Thereafter, the hand is placed in the brace and fixed with an elastic bandage. The bracing time is 3-4 hours 1-2 times a day. A number of the physioprocedures of each type makes 15-20 procedures in the course. The bracing period is 3 weeks to 3 months, and the brace is used till muscle tone recovery, and also active finger extension. For one year after the suffered stroke, the rehabilitation courses are repeated for 3-4 times a year, further the therapeutic courses are performed 2 times a year.EFFECT: method allows ensuring considerable recovery of motor functions disordered by a local brain damage and activation of neuroplasticity mechanisms of the central nervous system for a shorter period of time in the given category of patients due to optimal selection of a therapeutic regimen and more effective bracing.2 ex
ethod of funicular anesthesia // 2422164
FIELD: medicine, pharmaceutics.SUBSTANCE: invention relates to medicine, namely to urology, andrology and anesthesiology, and can be used in necessity of performing blockade of spermatic cord. For this purpose in place of supposed puncture in visible, ultrasonic and infrared spectra of radiation state of tissues is determined and nearest to epididymis section of spermatic cord is selected. Spermatic cord is lifted, forming deflection of posterior wall above selected section, and fixed. After that into spermatic cord under US control with cut downward needle is introduced on anterior-external surface of scrotum and moved through subcutaneous fatty cellular tissue and anterior wall of spermatic cord on descending radius towards scrotum on minimal distance. After that angle of needle inclination with respect to anterior surface of cord in place of its puncture is reduced to 5-0°, and needle is moved inside cord at the distance equal to length of its cut with further introduction of 1-1.5 ml of solution of 2% lidocain hydrochloride and 1% cefazolin sodium salt at temperature +37°C. After that, correctness of needle introduction is estimated by ultrasonic visualisation of place and form of obtained drug infiltrate and entire procedure is repeated, after which solution is introduced until drug infiltrate of desired shape and size is not formed in cord canal. Needle is removed, skin in point of injection is processed with antiseptic and sterile bandage is applied.EFFECT: method makes it possible to increase efficiency and safety of performing blockade of spermatic cord due to increase of accuracy of medications solution introduction.1 ex
Pharmaceutical composition in form of spray for wound surface treatment // 2416394
FIELD: medicine, pharmaceutics.SUBSTANCE: invention relates to field of medicine, namely to chemical-pharmaceutical industry, in particular to production of medications intended for external application for treatment of wounds of various etiology including those which occur after burns. Pharmaceutical composition contains active substances - lidocaine, acemine, ofloxacine, auxiliary substances: preservative - nipagine, solvent - propyleneglycole and shape-former - purified water.EFFECT: activation of skin granulation tissue growth, regeneration stimulation, acceleration of affected tissue healing and reduction of edema.3 ex
 
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