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Biological chitosan coated pericardial valve prosthesis and method for making it What is described is a method for applying a chitosan coating on a pericardial surface of a biological heart valve prosthesis by direct chitosan application from a non-immunogenic solvent absolutely biocompatible with a human body and possessing antimicrobial properties, - high-pressure carbonated water, onto the pericardium of the biological heart valve prosthesis pre-processed with 0.625% glutaric aldehyde. The method for chitosan coating from high-pressure carbonated water enables providing higher effectiveness and prolonged functioning of the biological heart valve prosthesis ensured by avoiding formation of deposited calcium on the surface, providing better elasticity, enhancing antimicrobial properties enabled by the chitosan coating on the surface. |
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Osteoplastic composition (versions) What is described is an osteoplastic composition containing a mixture of hyaluronic acid, chondroitin sulphate and heparin in sodium chloride and an osteoconductive material presented by non-demineralised osseine or demineralised osseine in the following ratio of the ingredients, wt %: hyaluronic acid 0.1-4.0, chondroitin sulphate 0.1-4.0, heparin 0.1-0.5, non-demineralised osseine or demineralised osseine 25-94.0, sodium chloride 0.8-0.85, distilled water - the rest. According to the other version, the osteoplastic composition uses an osseous mineral ingredient as an osteoconductive material. |
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Histo-equivalent bioplastic material What is described is a histo-equivalent bioplastic material comprising a carrier in the form of a matrix that is presented by a native form of hyaluronic acid. The histo-equivalent bioplastic material is prepared by mixing 1.5% hyaluronic acid and 5% peptide complex in the following proportions: 80-90 ml and 10-20 ml, respectively to form a viscous elastic gel that is placed on a mould carrier and exposed to ultraviolet photopolymerisation in a laminar flow hood for 5-7 hours, and then transferred onto a perforation apparatus with the finished material being perforated and notched. |
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Hyaluronic acid gels containing analgesic agents Invention refers to medicine. There are described soft tissue fillers, such as cutaneous and subcutaneous fillers based on hyaluronic acids and pharmaceutically acceptable salts thereof. What is described is a hyaluronic acid composition which contains a therapeutically effective amount of at least one analgesic agent, e.g., lidocaine, and additionally non-cross-linked hyaluronic acid. There are also described the methods for preparing the hyaluronic acid compositions. |
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Biocompatible bone-substituting material and method of obtaining thereof Invention relates to medicine, namely to method of obtaining biocompatible bone-substituting material; powder of biological hydroxyapatite with particle size not more than 40 mcm is obtained from cattle bones, powder of hydroxyapatite is mixed with magnesium phosphate powder with particle size not more than 40 mcm with their ratio 1.0:0.25, water suspension of 2-amino-5-guanidine valeric acid is added to obtained mixture of powders with their further mixing for 40-50 minutes and drying at 50-60°C. Obtained mixture is combined with liquid, containing chitosane solution in 3% water solution of succinic acid and 2% water solution of sodium alginate with their ratio 0.3:0.7, ratio between liquid and powder mixture being 1.0:0.5. Before application hardening agent 5-10% water solution of calcium chloride is added to obtained plastic mass with ratio 1.0:0.3. |
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Artificial dura mater and method of its production Invention relates to chemical-pharmaceutical industry and represents artificial dura mater, produced from electrospinning layers by technology of electorspinning, with electrospinning layer, consisting of, at least, hydrophobic electrospining layer, which is produced from one or several hydrophobic polymers, selected from polylatic acid and polycaprolactone. |
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Micro-nanostructured bioplastic material Invention refers to medicine, namely combustiology, plastic surgery, cosmetology, and can find application as a bioplastic material for skin defect replacement and regeneration stimulation. What is described is a micro-nanostructured bioplastic material which is based on a nanostructured matrix formed of hyaluronic acid; it contains proteoglycans, glycoproteins, fibrous proteins and antiseptic in the following ratio (per 100 ml): hyaluronic acid - 30-20; proteoglycans - 20-30; glycoproteins -10-15, fibrous proteins - 10-15, antiseptic - 5-10; solvent (water) - the rest. |
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Medical implant and method of its manufacturing Invention relates to medicine and pharmaceutical industry, in particular to method of manufacturing elongated hollow body (1). Body, containing crystalline cellulose, has multiple projections (3, 4), which project into lumen of hollow body (1), on internal wall. Method of manufacturing elongated hollow body (1), includes stages: manufacturing hollow form (12), cultivation of cellulose-forming organisms in internal space, formed by hollow form (12), aimed at providing growth of hollow body (1) in internal space; operation of removal of hollow body from form (12). At the stage of removal from form (12), at least, part of hollow form (12) is irreversibly deformed. |
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Method for preparing biocompatible nanostructure conducting composite Invention refers to a method for preparing a biocompatible nanostructured conducting composite. The method involves preparing an ultra-disperse suspension of carboxymethyl cellulose and carbon nanotubes with the mechanical system of carbon nanotube structuring wherein nanostructuring is enabled by exposing the suspension to laser light in a continuous mode at generation wave lengths 0.81÷0.97 mcm and light intensity 0.5÷5 Wt/cm2. |
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Invention refers to medicine, namely combustiology, plastic surgery, cosmetology, and can find application as a bioplastic material for skin defect replacement and regeneration stimulation. In the bioplastic material containing a matrix base made of a native form of hyaluronic acid, a frame of the bioplastic material is prepared by the layered lyophilisation of the matrix material to form a space 0.5 to 10 cm thick with fibres of the native form of hyaluronic acid being directed in the porous order and their cells being enriched with thrombocytic lysate with thrombocyte count 1×109 thromb/ml. |
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Bone prosthesis material and method for preparing it Invention refers to medicine. What is described in a method for preparing a bone prosthesis material which involves producing precursor particles of tricalcium phosphate (TCP) particles; pre-caking the TCP-particles at temperature within the first temperature range to produce the TCP-particles of the diameter within the preset diameter range range; granulating the TCP-particles and caking the granulated bodies at temperature within the second temperature range. The second temperature range includes temperatures exceeding those of the first temperature range. A first gap 100 to 400 mcm is formed in the bone prosthesis material between two caked particle group neighbours. Each caked particle group contains the tricalcium phosphate (TCP) particles which are caked to form a second gap 5 to 100 mcm between two TCP neighbours. The first gap and the second gap are connected. Each caked particle group has a connection portion connecting the TCP-particle, and said connection portion is 5 to 20 mcm wide. |
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In-situ system for intra-articular regeneration of cartilaginous and bone tissues Invention refers to medicine. What is described is an implanted multilayer chondral reparation flap showing biological compatibility and physiological resorption, and what is also described is a method providing surgical management in situ for intra-articular regeneration of cartilaginous tissue in joint damages and/or defects. The chondral reparation flap comprises a first external cell-impermeable layer and a second external cell-permeable layer adapted for placement in an immediate proximity from a subchondral bone on a wound portion, and also a cartilage-forming matrix located between the first and second layers. The cartilage-forming matrix represents an accepting medium for diffusion of autologous stem cells and contains chemical components promoting formation of a hyaline-like cartilage in the presence of said autologous stem cells. The method prevents a fibrous cartilaginous replacement tissue from forming within the injury region. |
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Gel of hyaluronic acid for intracutaneous injection Invention relates to medicine. Described is implant, which can be injected in subcutaneous or intracutaneous way in form of monophase hydrogel, which contains gel, obtained from cross-linked hyaluronic acid and one of its physiologically acceptable salts. |
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Present invention refers to medicine, more specifically to use of a polymer containing thiol groups, for producing a tissue extension implant where a base polymer is polysaccharide. |
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Method of making construct containing crystal cellulose What is offered is a method of making a construct containing crystal cellulose. Cellulose-forming organisms are grown at least partially in a hollow template made by means of a three-dimensional printer. What is offered is a method of making the hollow template by means of the three-dimensional printer which grows portions of the hollow template in layers from a modelling material. |
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Nanostructured bioplastic material In a nanostructured bioplastic material containing a native form of hyaluronic acid, a base is nanostructured hyaluronic acid produced by photochemical cross-link and having a cellular texture in the range of 50 to 100 nm. |
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Medical devices covered with quickly-dissolvable biocompatible coating Invention relates to medicine, namely to medical device, which includes biocompatible medical coating, glued to it, in which coating includes at least one of non-linked water-soluble salts (i) of alginic acid, (ii) hyaluronic acid or (iii) chitosane, coating being completely dissolved in at least one physiological fluid of human organism for less than 3 hours. |
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Composition includes chitosan gel, which has bactericidal properties, representing matrix for including in it of water solution for "Adgelon" injection, which contains serum glycoprotein from blood of livestock, possessing biological activity in supersmall doses 10-9-10-15 mg/ml, and calcium salt - preparation "Adgelon". In obtaining composition medicine "Adgelon" is immobilised on chitosan gel. |
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Membrane to be used in targeted angiogenesis Membrane to be used in targeted angiogenesis comprises a plate made of undemineralised or demineralised type I collagen prepared from spongy bone tissue and saturated with sulphated glycosaminoglycans, heparin and chondroitin sulphate. In dental implantation, it includes at least one hole. |
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Complex matrix for medico-biological application Complex matrix consists of at least one biologically compatible polymer of natural origin, structured with sewing agent, which represents two- or multi-functional molecule, selected from epoxides, epihalohydrines and divinyl sulphone, on said polymer inoculated are chains with molecular weight less than 50000 daltons, selected from polymers of natural origin of small size, preferably, derivatives of cellulose or other biological polymer derivatives which naturally are not present in human organism, and/or non-polymerised chains with properties of oxidation inhibitors or ability to inhibit reactions of matrix decomposition, preferably, vitamins, enzymes or molecules, consisting of one or several cycles, degree of inoculation, expressed as ratio of moles of inoculated molecules and quantity of moles of polymer units, constitutes from 10 to 40%. Also described are method of obtaining such matrix and its application for separation, replacement, filling or addition of biological fluid or tissues. |
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Composition for stimulation formation of osseous tissue and bone joining Invention relates to a composition used for stimulation of formation of osseous tissue and bone joining. The composition is prepared by addition of material stimulating formation of osseous tissue and bone joining, namely to a mixture of tripolyphosphate and water-soluble chitosan. Invention provides preparing the composition used for stimulation of bone joining in early phase. The composition is inexpensive and useful for using in humans. |
Another patent 2528494.