Implant for substitution of bone defects

FIELD: medicine.

SUBSTANCE: invention relates to medicine, surgery and orthopedics. Implant for replacement of bone defects is made of carbon-carbon composite material. Material contains a porous matrix of crystalline carbon fibers with an interlayer distance of 3.58…3.62 angstrom, with a total amount of fiber 20…80 %. Further, the filler material consists of crystalline carbon with an interlayer distance of 3.42…3.44 angstroms in the amount of 50…70 % and amorphous carbon in the form of coke in an amount of 10…20 % of the total pore volume of the matrix. At the same time, carbon nanotubes are introduced into amorphous carbon in the amount of 0.05…1.0 % of the mass of amorphous carbon.

EFFECT: invention makes it possible to increase the efficiency of using an implant to replace bone defects by increasing the safety factor of bone strength when replacing its defect.

3 cl

 



 

Same patents:

FIELD: medicine.

SUBSTANCE: invention relates to medicine. Described is a medical device, containing a case which has an outer surface, forming an external profile of the device. The case contains a porous matrix, containing a group of interconnected macropores, formed by connected to each other spreaders, each of which has an internal cavity. A filling material fills at least a part of the group of interconnected macropores. The external surface of the case contains several holes, connected with the internal cavities of at least a part of the interconnected spreaders.

EFFECT: device is adapted for the stimulation of the bone and/or tissue integration, support of the bone remodelling processes due to the activity of osteoclasts and osteoblasts or for the stabilisation and stimulation of the bone consolidation and/or tissue consolidation in adjacent bones or bone tissues.

12 cl, 4 dwg, 1 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine. What is described is a two-phase bone filler material of calcium phosphate / hydroxyapatite (CAP/HAP) containing a sintered CAP nucleus and at least one uniform and closed epitaxial growing layer of nanocrystalline HAP coating the sintered CAP nucleus from above; the epitaxial growing nanocrystals have a size and a morphology identical to a human bone mineral, i.e. the length of 30 to 46 nm and the width of 14 to 22 nm. What is described is a method for preparing the bone filler material of CAP/HAP involving the stages as follows: a) making the sintered CAP nucleus, b) immersing the sintered CAP nucleus into an aqueous solution at 10°C to 50°C to initiate the process of CAP to HAP transformation to form the uniform and closed epitaxial growing nanocrystalline hydroxyapatite on the surface of the sintered CAP nucleus with the epitaxial growing nanocrystals have the size and morphology identical to the human bone mineral, c) terminating the transformation by separating the solid material from the aqueous solution in the presence of the uniform and closed coating of at least one HAP nanocrystalline layer, until the comprehensive completion of the transfomraiton process, d) optionally sterilising the material separated at the stage c), and using the above bone filler material as an implant or a prosthesis for osteogenesis, bone regeneration, bone repair and/or replantation at the site of injury in a human or animal.

EFFECT: preparing method for preparing bone filler material of CAP/HAP.

15 cl, 3 tbl, 6 ex

FIELD: medicine.

SUBSTANCE: invention relates to medicine, particularly to formulation of porous bioglassceramics containing fine soluble potassium, synthetic mineral granules - calcium phosphates that are parts of native bone tissue, wollastonite formed by crystallisation of soluble potassium, as well as addition of carbonate and carbon pore-former. The invention also refers to a method for making medical implant materials and devices of the presented formulation suitable for replacement of bone defects and deformities in maxillofacial surgery, dental surgery, neurosurgery, traumatology and orthopaedics.

EFFECT: bioceramics is gradually replaced by bone tissue and consists of the ingredients having no toxic, allergic, carcinogenic and mutagenic effects on human body.

3 cl, 2 tbl, 4 ex

FIELD: medicine.

SUBSTANCE: composite contains a reactive ceramic phase of triple-substituted calcium phosphate and an organic phase containing polyvinyl alcohol hydrogel. The mechanical properties and injectability of said material can be adjusted by varying the concentration of two phases.

EFFECT: preparation of the new injectable composite applicable as a bone filler.

9 cl, 2 tbl

FIELD: biomedical engineering.

SUBSTANCE: device has composite materials containing biologically active microparticles stimulating human bone tissue regeneration. Silicon, calcium and phosphorus particles combination is used in given carcasses as biologically active substance stimulating human osteoblast proliferation and differentiation and promoting osteogenesis and new bone calcification. Beside that, organic polymer is used in given carcasses as carrier having three-dimensional structure and external anatomical shape. It shows several properties compatible with bone regeneration and blood vessel neogenesis.

EFFECT: enhanced effectiveness of treatment; improved safety and cost-effectiveness.

27 cl, 6 dwg, 1 tbl

The invention relates to medicine, in particular to methods for biological coatings for wound closure in the treatment of patients with burns and mechanical damage to the skin

FIELD: medicine.

SUBSTANCE: invention relates to medicine, in particular to the field of composite materials for manufacturing endoprostheses. A composite material for replacement of bone tissue contains a porous matrix from crystalline carbon fibres with an inter-plane distance 3.58…3.62 angstrom with a content of fibres 20…80 of its total volume and a filling material, which contains crystalline carbon with an inter-plane distance 3.42…3.44 angstrom. In creation of the composite material for bone tissue replacement with an elasticity modulus, corresponding to the human bone tissue, the filling material contains obtained by Bakelite carbonisation amorphous carbon in the form of coke in an amount of 10…20% and obtained by methane decomposition crystalline carbon in an amount of 70-50% respectively of the total volume of the matrix pores.

EFFECT: composite material has the elasticity modulus, corresponding to the elasticity modulus of the human bone tissue.

1 tbl

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to orthopaedic dentistry. A method for making an intraosseous dental implant involves sand-blast finish of an implant surface by alimunium oxide particles, plasma-based layer-by-layer deposition of a system of biocompatible coatings containing mixed titanium or titanium hydride or calcium hydroxyapatite powders onto an implant carrier. The first layer consists of titanium or titanium hydride of dispersity 3-5 mcm at spraying distance 70-80 mm and thickness 5-10 mcm. The second layer is titanium or titanium hydride of dispersity 50-100 mcm at spraying distance 100 mm and thickness 50-115 mcm. The third layer represents mixed titanium or titanium hydride of dispersity 40-70 mcm and calcium hydroxyapatite of dispersity 5-10 mcm in ratio 60-80 and 20-40 wt % respectively, at spraying distance 80 mm and layer thickness 15 -20 mcm. The forth layer consists of calcium hydroxyapatite of dispersity 40-70 mcm at spraying distance 70 mm and layer thickness 20-30 mcm. Thereafter, the multilayered system of the biocompatible coatings is covered by a metal film consisting of a ferric triad (iron, cobalt or nickel) of thickness 20-35 nm by magnetron sputtering. A carbon nanocoating of thickness up to 1 mcm is prepared thereon. The carbon nanocoating represents carbon nanotubes and carbon nanofibres of diameter 50-200 nm.

EFFECT: method provides making the implant coated so that to promote the active growth of bone tissue.

3 cl, 1 tbl, 4 dwg

FIELD: medicine.

SUBSTANCE: invention refers to a method for preparing a biocompatible nanostructured conducting composite. The method involves preparing an ultra-disperse suspension of carboxymethyl cellulose and carbon nanotubes with the mechanical system of carbon nanotube structuring wherein nanostructuring is enabled by exposing the suspension to laser light in a continuous mode at generation wave lengths 0.81÷0.97 mcm and light intensity 0.5÷5 Wt/cm2.

EFFECT: invention provides preparing the high-conductivity bio-composite.

1 tbl, 1 ex

FIELD: medicine.

SUBSTANCE: invention relates to medicine, in particular to orthopedics, and can be applied in production of endoprosthesis of human joints and other products, as well as in different fields of technology. Carbon-carbon compositional material (CCCM) with filler in form of carbon tissue layers has pyrocarbon matrix, which additionally contains boron. Components in its matrix are in the following ratio, wt % boron - (1-19); pyrocarbon - the remaining part. In addition, into CCCM filler layers of titanium mesh can be additionally introduced between carbon tissue layers.

EFFECT: by means of invention increase of physical and mechanical properties of carbon-carbon composition materials is achieved.

2 cl, 2 tbl, 3 ex

FIELD: nanotechnologies.

SUBSTANCE: invention relates to laser equipment used for the purposes of nanotechnologies, particularly, to the methods of nanostructurisation of bulk bio-compatible nanomaterials by laser radiation. Nanostructurisation of the aforesaid materials is performed by laser irradiation of colloidal water-protein solution of carbon nanotubes till evaporation of the solution liquid component.

EFFECT: varying the properties of produced materials in a wide range and remote irradiation provides for biological purity of products.

3 dwg

FIELD: medicine; maxillofacial surgery.

SUBSTANCE: coal-plastic composition for bone defects elimination includes carbonic material "ТГН-2М" and polyamide film 12/10. The novelty consists in additional introduction of titanium powder; the ingredients proportion being as follows, in wt %: carbonic tissue "ТГН-2М" 57.5-62.5, titanium powder 2.5-7.5, polyamide film 12/10 the rest. Titanium powder particles size is 20 to 50 mcm.

EFFECT: radiodensity and biocompatibility increase, toxicity and carcinogenicity lowering.

2 cl, 1 tbl

FIELD: medicine; maxillofacial surgery.

SUBSTANCE: coal-plastic composition for bone defects elimination includes carbonic material "ТГН-2М"and polyamide film 12/10. Silver powder is additionally introduced; the ingredients proportion being as follows, in wt %: carbonic tissue "ТГН-2М" 57.5-62.5, silver powder 2.5-7.5, polyamide film 12/10 the rest. Silver powder particles size is 20 to 50 mcm.

EFFECT: radiodensity and biocompatibility increase, toxicity and carcinogenicity lowering, gaining anti-inflammatory and antiseptic properties.

2 cl, 1 tbl, 3 ex

FIELD: medicine.

SUBSTANCE: composition of black-reinforced plastic for bone defect correction contains carbon-base material "ТГН"-2M and polyamide film 12/10. Additionally composition contains powdered titanium and silicon at following ratio of components, wt %: carbon-base material "ТГН"-2M 60-64.5, powdered titanium 1.25-3.75, powdered silicon 1.25-3.75, and polyamide film 12/10 - the rest. Particle size of powdered silicon and titanium is 20-50 mcm.

EFFECT: higher radiopacity and biocompatibility, reduced toxicity and carcinogenicity of material.

3 cl, 1 tbl, 3 ex

FIELD: medicine.

SUBSTANCE: composition of black-reinforced plastic for bone defect correction contains carbon-base material "ТГН"-2M and polyamide film 12/10. Additionally composition contains powdered silicon at following ratio of components wt %: carbon-base material "ТГН"-2M 57.5-62.5, powdered silicon 2.5-7.5, and polyamide film 12/10 - the rest. Particle size of powdered silicon is 20-50 mcm.

EFFECT: higher radiopacity and biocompatibility, reduced toxicity and carcinogenicity of material.

2 cl, 1 tbl, 3 ex

FIELD: medical engineering.

SUBSTANCE: method involves precipitating pyrocarbon layer on graphite substrate surface by carrying out carbonaceous gas from gas flow in flow reactor, separating pyrocarbon layer from the substrate and mechanically manufacturing cusp with paired supporting projections. Constant graphite substrate orientation is provided with relative to gas flow direction in the reactor during the whole pyrocarbon layer sedimentation process. The paired supporting projections are arranged in a way that their imaginary axis remains coinciding with carbonaceous gas flow direction when precipitating pyrocarbon layer. Graphite substrates are mainly shaped as plates placed into flow reactor along its lateral walls without spaces available between them. Six and more plates are placed into the reactor. The most convenient carbon compound for producing pyrocarbon by decomposition is methane. Propane and trichloroboron availability in gas flow is desirable. Additional inert carrier gas like nitrogen is available in the gas flow in addition to active ingredients. Pyrocarbon sedimentation and its final characteristics are controlled by varying nitrogen and active substances proportion in the gas flow.

EFFECT: high reliability of design.

3 cl, 2 dwg

FIELD: medicine.

SUBSTANCE: invention relates to composition materials used in making endoprosthesis and in using the composition material for replacement of osseous tissue. The composition material for replacement of osseous tissue comprises a porous matrix made of carbon fiber and carbon material - a filling agent filling pores of matrix partially and wherein the interplanar distance d002 in carbon material crystal is 3.58-3.62 Å, and the interplanar distance d002 in carbon crystal-a filling agent is 3.42-3.44 Å in the total amount of carbon fiber 20-80%. Invention provides enhancing strength and safety of junction of endoprosthesis material with osseous tissue due to creature of the composition material for replacement of osseous tissue with the elasticity modulus equal with the human and animals elasticity modulus in the range 14-28 hPa.

EFFECT: improved and valuable properties of material.

1 tbl

FIELD: medical engineering.

SUBSTANCE: method involves precipitating pyrocarbon layer on graphite substrate surface by carrying out carbonaceous gas from gas flow in flow reactor, separating pyrocarbon layer from the substrate and mechanically manufacturing cusp with paired supporting projections. Constant graphite substrate orientation is provided with relative to gas flow direction in the reactor during the whole pyrocarbon layer sedimentation process. The paired supporting projections are arranged in a way that their imaginary axis remains coinciding with carbonaceous gas flow direction when precipitating pyrocarbon layer. Graphite substrates are mainly shaped as plates placed into flow reactor along its lateral walls without spaces available between them. Six and more plates are placed into the reactor. The most convenient carbon compound for producing pyrocarbon by decomposition is methane. Propane and trichloroboron availability in gas flow is desirable. Additional inert carrier gas like nitrogen is available in the gas flow in addition to active ingredients. Pyrocarbon sedimentation and its final characteristics are controlled by varying nitrogen and active substances proportion in the gas flow.

EFFECT: high reliability of design.

3 cl, 2 dwg

FIELD: medicine.

SUBSTANCE: composition of black-reinforced plastic for bone defect correction contains carbon-base material "ТГН"-2M and polyamide film 12/10. Additionally composition contains powdered silicon at following ratio of components wt %: carbon-base material "ТГН"-2M 57.5-62.5, powdered silicon 2.5-7.5, and polyamide film 12/10 - the rest. Particle size of powdered silicon is 20-50 mcm.

EFFECT: higher radiopacity and biocompatibility, reduced toxicity and carcinogenicity of material.

2 cl, 1 tbl, 3 ex

FIELD: medicine.

SUBSTANCE: composition of black-reinforced plastic for bone defect correction contains carbon-base material "ТГН"-2M and polyamide film 12/10. Additionally composition contains powdered titanium and silicon at following ratio of components, wt %: carbon-base material "ТГН"-2M 60-64.5, powdered titanium 1.25-3.75, powdered silicon 1.25-3.75, and polyamide film 12/10 - the rest. Particle size of powdered silicon and titanium is 20-50 mcm.

EFFECT: higher radiopacity and biocompatibility, reduced toxicity and carcinogenicity of material.

3 cl, 1 tbl, 3 ex

FIELD: medicine; maxillofacial surgery.

SUBSTANCE: coal-plastic composition for bone defects elimination includes carbonic material "ТГН-2М"and polyamide film 12/10. Silver powder is additionally introduced; the ingredients proportion being as follows, in wt %: carbonic tissue "ТГН-2М" 57.5-62.5, silver powder 2.5-7.5, polyamide film 12/10 the rest. Silver powder particles size is 20 to 50 mcm.

EFFECT: radiodensity and biocompatibility increase, toxicity and carcinogenicity lowering, gaining anti-inflammatory and antiseptic properties.

2 cl, 1 tbl, 3 ex

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