Method for predicting the course of the initial choroidal melanoma

FIELD: medicine.

SUBSTANCE: invention relates to medicine, specifically to ophthalmology. To predict the course of the initial choroidal melanoma, before the treatment, optical coherence tomography is performed, the area and volume of exudate over the tumor are determined. With an exudate volume of more than 65.7 mm3 and area – more than 5.26 mm2 a heavy course id predicted.

EFFECT: method allows to predict the course of the initial choroidal melanoma in the early stages of the disease by identifying specific parameters that affect the course of the disease, for planning an adequate organ preservation treatment.

1 cl, 2 ex

 



 

Same patents:

FIELD: medicine.

SUBSTANCE: to determine density of otospongiosis focuses computer tomography of temporal bones with densitometry is carried out. Treatment duration is determined on the basis of obtained values of density. If density of otospongiosis focuses is less than 300 units HU, 4 courses of complex inactivating therapy are carried out. If density is 300-600 HU units -2 courses, if density is 600-900 units HU - 1 course. Duration of one course constitutes 3 months. During a year not more than two courses of therapy are carried out. Course of inactivating complex therapy includes intake of the following medications: bisphosphonates, sodium fluoride, calcium carbonate and vitamin D3. As bisphosphonates medication Bonviva is applied.

EFFECT: method makes it possible to increase efficiency of inactivating therapy in patients with different forms of active otosclerosis due to differential approach in selection of individual duration of carried out therapy.

3 ex

FIELD: medicine.

SUBSTANCE: curvature of a root canal of a tooth is investigated by means of Picasso Trio, cone-beam computerised tomography with Ezlmplant software. The computerised tomography processes an image and transmits it to the computer. The Ezmplant software contains four active windows of object images: upper and lower teeth in frontal (coronal view), sagittal (sagittal view), axial (axial view) projections, and an object 3D-reconstruction. A section thickness of the dentofacial tissues is specified at 1 mm for all active windows of the image; after that an image of the examined tooth is selected in the required active window. The mouse cursor is passed in the active window, and the button Enter on the keyboard is pressed to remove the axes; the primary mouse button is pressed in the Measure section of the menu on the left to activate the function Angle. That activates the section Tool Options in the menu automatically, wherein the angle 4-point measurement method 4-Point Click is selected. Then the mouse cursor is passed beyond the tooth being guided by a tooth canal orifice and the mort actual point of the root canal lumen curvature for display purposes; the mouse button is pressed beyond the tooth to display the first point of the first line. The first line is drawn approximately through an apex of a triangle to be constructed and extends behind the tooth to cover the root canal lumen. The mouse button is pressed again to mark the second point of the first line; line No. 1 is produced as one side of the determined curvature angle of the root canal of the tooth - points 1 and 2. The cursor is moved onto the expected apex of the angle of the triangle describing the root canal curvature with the lines being continuous. The mouse button is pressed to mark the first point of the second line that is the third point. The cursor is displaced towards the root apex by drawing a line through it behind the tooth. The function Angle is deactivated; all four points of the angular structure are activated; their position is specified to produce the final curvature angle in degrees to be calculated automatically. The root canal curvature is taken into consideration when choosing the instruments for the high-grade endodontal treatment of the root canal.

EFFECT: method enables measuring all the root canal curvature angles precisely by enabling the multiple activation of all the elements of the angular structure and correcting positions of the points and lines of the angular structure.

5 dwg, 2 ex

FIELD: physics, computer engineering.

SUBSTANCE: invention relates to computer systems for diagnostic imaging. Disclosed is a system for delineating anatomical features in images used for image-guided therapy planning. The system includes a processor which receives an initial image of an anatomical structure in a patient from an imaging device. Said processor also detects anatomical landmarks in the initial image and compares positions of the detected anatomical landmarks with reference landmarks in a reference contour corresponding to the anatomical structure. The processor also compares the detected anatomical landmarks with the reference landmarks.

EFFECT: high accuracy of identifying anatomical features on an image through automated delineation of said features.

20 cl, 5 dwg

FIELD: medicine.

SUBSTANCE: invention relates to the field of medical diagnostics and is aimed at the creation of an ultrasonic nonlinear tomograph, which contains a small quantity of receiving and transmitting transformers, mainly for mammography, defectoscopy and nondestructive testing of different objects. The ultrasonic tomorgaph includes a receiving-emitting device with receiving-emitting piezotransformers, to an inlet of which connected is a channel of the emitted signal formation, and to an outlet - a channel of the received signal analysis. The receiving-emitting device contains, at least, two emitting cylindrical piezotransformers with a broad band of emitted coded signals and, at least, one receiving cylindrical piezotrasformer with a broad band of the received signal, a longitudinal axis of which is located vertically, and a system of acoustic mirrors, which includes vertically located above each other lower smaller acoustic mirrors and an upper larger acoustic mirror, made in the form of coaxial truncated cones with an equal angle of conicity and height and a different mean radius. The emitting and accepting piezotransformers are placed at the level of the lower smaller acoustic mirror, and their height constitutes 0.8÷0.9 of the height of each of the acoustic mirrors.

EFFECT: application of the invention makes it possible to increase the resolving capacity of restoring an image of internal soft structures with the reduction of a quantity of the transformers.

4 cl, 3 dwg

FIELD: physics.

SUBSTANCE: disclosed is a method of obtaining a structural image of a biological object in optical coherence tomography. The method includes breaking down a source colour vide frame into non-overlapping spatial blocks consisting of more than one pixel. A structural image is obtained via small-angle raster scanning in the arm of an optical coherence tomography sample. The obtained image with a size of Piskh bytes is broken down into non-overlapping spatial blocks only on columns; adjacent column blocks are averaged pixel by pixel to form a new image with a size of Pstl bytes; the new image is broken down into non-overlapping spatial blocks only on rows; adjacent row blocks are averaged pixel by pixel to form a resultant image with a size of Pres bytes, and the averaging process is controlled based on an exponential relationship Pstl from the number of averaging column blocks Ustl and Pres from the number of averaging row blocks - Ustr.

EFFECT: high quality of the structural image of a biological object in optical coherence tomography.

7 dwg

FIELD: medicine.

SUBSTANCE: invention refers to medical diagnostics, namely to ultrasonic non-linear tomographs. The tomographic scanner comprises a receiving emitter with a receiving-emitting electroacoustic transducer with a signal forming channel connected to an input thereof, and a signal analysis channel connected to an output thereof. The receiving emitter comprises emitting plane electroacoustic transducers with an emitted coded ultrasonic signal broadband, and a receiving plane electroacoustic transducer with a received signal broadband. The working surface of the transducers is arranged in a tangential plane to a circle which encloses a scanned organ, and orthogonal to the circle plane, while its diameter is 1.5÷2.0 times more than a width of the working surface of the plane transducers. An angle of acoustic axes perpendicular to the working surface of the plane electroacoustic transducers for each pair of the adjoining plane electroacoustic transducers is within the range of 30° to 90°.

EFFECT: using the device provides high resolution of recovery and visualisation of internal structures of soft tissues and internal defects of various objects with a low noise level.

3 cl, 2 dwg

FIELD: medicine.

SUBSTANCE: complete echocardiography is performed to determine a dyssynergia index and the presence of mitral regurgitation. The findings are used to detect the presence of hemodynamically relevant coronary artery stenosis by the value of function F that is calculated by the original formula. If F=1.95, the presence of hemodynamically relevant coronary artery stenosis is diagnosed, while F=-0.766 shows the absence thereof.

EFFECT: technique enables high accuracy detection of ischemic heart disease in the patient with using no invasive method, eg coronary angiography, which ensures the lower risk of developing intraoperative complications.

2 ex, 1 tbl

FIELD: medicine.

SUBSTANCE: invention relates to field of medicine, namely to optic methods of biological tissue analysis. To carry out differential diagnostics of nail plate diseases analysis of patient's nail plates, preliminarily processed with 25% glycerol solution, is performed by optic coherent tomography. Nail plate is analysed in its middle part in direction from posterior wall to free edge, step-by-step with overlapping previous probe position by approximately 1/3 of probe working diameter. Image of five horizontally oriented layers of nail plate are analysed on tomograms. If the first layer is unchanged, height of the second layer is increased, signal intensity increases in the second, third and fourth layers, inhomogeneity appears within the second, third and fourth layers, contrast decreases and boundary between the third and the fourth layers disappears, inhomogeneous change of the fifth layer takes place, with irregular arch-like elements, characterised by high and low signal, psoriatic affection of nails is diagnosed. If signal intensity decreases in the first layer, thickness of the second, third and forth layers increases, signal intensity decreases within the third layer, contrast decreases and boundary between the second and third and the third and fourth layers decreases, as well as linear zones, horizontally oriented, parallel to each other, with high intensity signal appear, onychomycosis is diagnosed.

EFFECT: method provides possibility of non-invasive assessment of pathological process in nail plate.

4 ex, 4 dwg

FIELD: medicine.

SUBSTANCE: invention relates to field of medicine. To perform dynamic assessment of structural changes of pancreatic (P) parenchyma comparison of successive indices of X-ray density in its different parts is carried out by means of multispiral computed tomography. Absolute X-ray density (AXRD) and the largest thickness in head, body and tail of pancreas are determined on the basis of obtained tomogram. Specific density of each part of pancreas in dynamics is calculated by formula: SD1,2…n=AXRD/thickness of examined part of pancreas (mm), where SD1 is initial value of specific density of each part of pancreas, SD2n are values of specific density of each part of pancreas in dynamics. Induration index (II) of each part of pancreas in dynamics is calculated by formula: II= SD2…n/SD1, the value of which is used to assess structural changes of pancreatic parenchyma.

EFFECT: increased accuracy and self-descriptiveness of dynamic assessment of course of inflammatory process in pancreatic parenchyma due to taking into account structural and morphological shifts in pancreatic tissue with application of dynamic computed tomography monitoring.

5 ex, 5 dwg

FIELD: medicine.

SUBSTANCE: invention relates to field of medicine. In method realisation bone density in the area of tibia and femur condyles is determined by method of computed tomography. Range of scanning is determined by topogram. Axial cuts and multiplanar reconstructions are obtained. Measurements of density are carried out by Haunsfield scale in 8 points, marked on multiplanar reconstructions of knee joint in frontal plane. In case if density in points 5, 6 constitutes 351-450 HU, in points 3, 4 351-400 HU, in point 8 up to 220 HU, in point 7 up to 140 HU, in point 1 221-250 HU, in point 2 171-190 HU, data correspond to the first stage of disease under condition of their coincidence in six points of eight. In case if in the said points density constitutes: 251-350 HU, 301-350 HU, 221-240 HU, 141-170 HU, 191-220 HU, 141-170 HU, data correspond to the second stage of disease under condition of their coincidence in six points of eight. In case if in the same points density is: to 250 HU, to 300 HU, 241-260 HU, 171-200 HU, to 190 HU and to 140 HU, data correspond to the third stage of disease, under condition of their coincidence in six points of eight.

EFFECT: method makes it possible to reduce labour consumption in estimation and facilitate comparative interpretation of treatment results.

5 dwg, 2 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to ophthalmology. A confocal scanning laser retinal tomography is used to measure an oedema coefficient "e" in the Rl-Central region. If the coefficient "e" is less than 0.78±0.04 in mild myopia, less than 1.08±0.04 in moderate myopia, less than 2.18±0.1 in myopia alta, it is supposed to be measured once again 6 months later. If the coefficient "e" accompanying any degree of myopia increased by 9% or more, the acquired myopia progression is predicted.

EFFECT: method provides the early prediction of the myopia progression, prevents organic retinal changes by determining the oedema coefficient "e" in dynamics.

3 tbl, 3 ex

FIELD: medicine.

SUBSTANCE: if minimum changes of the eye grounds are observed and visometry and optical coherence tomography (OCT) fail to provide any informative findings, a microperimetry is conducted in the patient with symptoms of first appeared retrobulbar neuritis with using macula-8 program testing 45 points of eight degrees of central visual field with Goldmann III stimulus of 0.43 degrees of 200 ms long. Retrobulbar neuritis accompanying the onset of multiple sclerosis is diagnosed if the examinations show a moderate light-sensitivity in the nasal, upper or lower nasal segments of less than 16 dB within 8 degrees of the central visual field in a projection of a papillomacular bundle.

EFFECT: technique enables providing more reliable diagnosis in uncertain cases of the clinical course of the disease that is ensured by using microperimetry with macula-8 program additionally.

2 ex

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to ophthalmology, and can be applied in the diagnostics of the crystalline lens subluxation. Biomicroscopy is carried out by means of a portable slit lamp. Biomicroscopy is realised under conditions of the maximal drug mydriasis in a position of the patient lying on the back.

EFFECT: method provides clear visualisation of all signs of the crystalline lens subluxation of I degree due to the displacement of the vitreous body backwards under the impact of gravitation with the patient in the lying on the back position, as well as makes it possible to perform biomicroscopy in all quadrants of the eyeball and under any angle due to the mobility of the portable slit lamp.

2 ex

FIELD: medicine.

SUBSTANCE: ultrasonic biomicroscopy is used to measure the distance of the lens and corneal endothelium and the distance of the trabecule and iris in the lying and sitting patient. A difference of 0.5 mm and more of the lying and sitting distances of the lens and corneal endothelium is detected. A difference of 0.1 mm and more of the lying and sitting distances of the trabecule and iris is detected. The detected distance differences testify to the presence of degree I latent dislocation of the lens.

EFFECT: reliable and precise pre-operative detection of degree I latent dislocation of the lens ensured by a possibility to measure the depth variations of the anterior eye chamber, iris-lens diaphragm shift, ligament instabilities accompanying postural changes.

2 ex

FIELD: medicine.

SUBSTANCE: lachrymal prostaglandin E2 is measured before the implantation and on the 7-10th day following the implantation of a supplementary IOL. The pre- and post-operative prostaglandin concentrations are calculated. If the derived relation is 3.5-4 units, developing pigment dispersion syndrome is predicted.

EFFECT: method enables preventing developing pigment dispersion syndrome and pigment glaucoma in the given category of patients by the reliable prediction of the above syndrome in the early postoperative period.

3 ex

FIELD: medicine.

SUBSTANCE: one month after a phacoemulsification of complicated cataract and an intracapsular implantation of an intraocular lens, 3-4 2mm notches are applied on the periphery of an anterior capsulorrhexis. That is followed by an YAG laser exposure at wave length 1,064 and power 1-2 mJ. If observing the preclinical signs of a contracture of a crystalline lens capsule, an ultrasonic biological microscopy is carried out to state if it is necessary to apply the notches.

EFFECT: method provides the more effective prevention of the above pathology by providing the reliable timely detection of the contracture of the capsular sac of the crystalline lens; the declared effect is selective and only covers the patients with the preclinical signs of the contracture as shown by the ultrasonic biological microscopy; it eliminated the capsular injuries caused by the effect of the surgical instruments and prevents the visual deterioration in the patients with concurrent conditions.

3 ex

FIELD: medicine.

SUBSTANCE: optical coherence tomography of the retinal covers localisation areas of the peripheral dystrophy. An eye ground image is displayed on the screen. A scanning is performed first along the peripheral retinal dystrophy, and then across the same. Signs of the prognostic risk of the peripheral retinal dystrophy are identified on the formed scanning images by means of the image process report 'High Difinition Images'.

EFFECT: according to findings of the non-invasive examination, the method enables identifying the prognostically dangerous forms of the peripheral retinal dystrophy.

3 ex

FIELD: medicine.

SUBSTANCE: invention can be used for diagnosing secondary glaucoma is the patients suffering vascular corneal leukoma. A method involves an optical coherent tomography of an anterior eye segment (OCT AES), an ultrasonic biomicroscopy (UBM) followed by measuring a critical frequency of flashing phosphene extinguishing (CFPE) with a echo biometry. If the OCT AES and UBM findings show the presence of iris-corneal adhesions with a closed angle of the anterior chamber through one or more quadrants, the CFPE values are less than 40 Hz, and the echo biometry shows an increase of an anterio-posterior axis by more than 1.0 mm for one year, secondary glaucoma is diagnosed.

EFFECT: method provides the accurate and objective diagnosis in the patients of the given group with the poorly transparent cornea having irregular curvature, shape and turgor.

2 ex

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely ophthalmology. The method involves the low-intensity EHF exposure at water molecular resonance frequency within the range of 65±0.5 GHz followed by the radio-response recording. The examination covers an avascular zone of an eyeball in relation to a visual axis, and along four meridians if an applicator aerial displaced 15-20 degrees from the visual axis. Diagnostic signs of the myopia progression include water echo enhancement as compared to a normal value (1.6-1.7·10-13 Wt/cm2), as well as data difference if observing an echo bias from an optic axis.

EFFECT: method provides higher diagnostic accuracy ensured by considering the volumetric data of a vitreous body.

FIELD: medicine.

SUBSTANCE: invention relates to field of medicine, namely to ophthalmology. In order to determine indications for treatment of ophthalmological complications of systemic atherosclerosis by means of method of optic coherent tomography thickness of peripapillary nervous fibres is measured in three segments. If thickness of peripapillary nervous fibres in upper segment is lower than 118.58 mcm, in nasal - lower than 66.58 mcm, in lower segment - lower than 111.83 mcm, in temporal - lower than 66.42 mcm, treatment is considered to be indicated.

EFFECT: method makes it possible to determine indications for treatment of ophthalmological complications of systemic atherosclerosis.

4 dwg, 3 ex, 1 tbl

FIELD: medicine, ophthalmology.

SUBSTANCE: on should carry out iridic optic coherent tomography to determine stromal thickness and density of iris and pigment leaf. At detected inborn stromal underdevelopment and abnormal hypertrophy of pigment leaf one should diagnose Frank-Kamenetsky's glaucoma. In case of normal thickness of iridic pigment leaf and iridic stromal thickening at forming nontransparent connective tissue and decreasing its thickness against the norm it is possible to predict iridic essential mesodermal dystrophy.

EFFECT: higher accuracy of diagnostics.

1 dwg, 2 ex

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