Ophthalmic lens with a passive event-based coloration system
SUBSTANCE: invention relates to medicine. Ophthalmic Lens with passive event coloration mechanisms comprises: a soft lens portion, wherein the soft lens portion comprises a polymerized Reactive Monomer Mixture; and an event coloration mechanism. Event coloration mechanism is capable of triggering a visual indication in the Ophthalmic Lens based on an occurrence of a predefined event. Event coloration mechanism is in contact with a portion of the soft lens portion. Moreover, the event coloration mechanism is arranged to be located within the optical zone of the lens in such a way that the activation of the coloring mechanism based on the event is visible to the lens user.
EFFECT: application of this invention will allow a patient to maintain safe and effective levels of certain biomarkers.
19 cl, 4 dwg
FIELD: physics, optics.
SUBSTANCE: correcting optical lens, adapted to move together with the eye of the user and change the refracting power thereof, comprises a first radial optical area having a first refracting power which, coupled with the refracting power of the eye of the user, results in a first effective refracting power which rises as the radius of the first radial optical area increases, and a second radial optical area having a second refracting power which, coupled with the refracting power of the eye of the user, results in a second effective refracting power which falls as radius of the second radial optical area increases. The first effective refracting power is greater than the second effective refracting power. The dimensions and refracting power of the first and second radial optical areas are intended to weaken visibility of defocused radiation for the user.
EFFECT: eliminating or minimising visibility of ghost images through control of the sign of spherical aberration or other asphericity which depends on a specific area.
20 cl, 9 dwg
FIELD: physics, optics.
SUBSTANCE: contact lens is stabilised by development of design parameters of at least one of stabilising zones. Said zone is perfected by description of lens structure parameters by mathematical definitions, simulation of lens structure with the help of model that features the balance of moments of motions and selection of structure proceeding from the results of said simulation. At least one of stabilising zones is defined by one or more parts of variable depth in every stabilising zone. Maximum depth of at least one said stabilising zone makes 0.010-0.060 mm.
EFFECT: better stabilisation.
7 cl, 12 dwg, 4 tbl
SUBSTANCE: invention relates to organosilicon prepolymers, containing fragments, which absorb ultraviolet (UV) radiation. Claimed is an actinically cross-linkable polymer, which contains cross-linkable polysiloxane polymer units, formed from one or several hydrophilic vinyl monomers, and double photofunctional polymer units, formed from a polymerisable compound, containing an ethylene-unsaturated group, a photoinitiating fragment and a fragment, absorbing UV-radiation, or a latent fragment, absorbing UV-radiation. Soft silicone hydrogel contact lenses, manufactured from the claimed prepolymer, are also claimed.
EFFECT: it is possible to manufacture the high-quality contact lenses with low expenditures, providing high homogeneity and reproducibility of an initial lens shape.
14 cl, 16 ex
SUBSTANCE: invention refers to transparent silicone hydrogels. What is presented is silicone hydrogel prepared by polymerisation of mixture of monomers containing (a) 30-98 wt % of at least one silicone (meth)acrylamide monomer and (b) 1-50 wt % of at least one non-silicone (meth)acrylamide monomer containing two or more hydroxyl groups in its molecule; wherein weight percentage is calculated from a total amount of monomer and polymer components in the monomer mixture, and a total amount of monomers (a) and (b) makes 90 wt % or more in relation to the total amount of the monomer and polymer components in the monomer mixture. There are also presented a medical device, an ophthalmic lens and a contact lens made of the above silicone hydrogel.
EFFECT: presented silicone hydrogel has the high content of acrylamide monomer and the excellent balance of humidity, elasticity, wetting ability and transparency, and is applicable to produce lenses having the excellent characteristics.
19 cl, 4 tbl, 27 ex
FIELD: physics, optics.
SUBSTANCE: displaceable presbyopic contact lens comprises an optical zone, a lens portion surrounding the optical zone, a conical portion surrounding the lens portion from the outside to the edge of the contact lens and pseudotruncation which is asymmetrical about the vertical meridian. The point where the optical zone borders with the lens portion is an optical-lens boundary. The point where the lens portion borders with the conical part is a lens boundary of the edges of the cone. The structure of the lens surface is defined by the equation: T3=T1+(T2-T1)*(Sin ((P3-P1)/(P2-P1) *90))n , where P1 is the distance from the centre of the lens to the optical-lens boundary, T1 is the thickness of the optical lens boundary, P2 is the distance from the centre of the lens to the lens boundary of the edges of the cone, T2 is the thickness of the lens boundary, P3is an arbitrary point on the contact lens located between and including P1 and P2, and T3 is the thickness defined at point P3.
EFFECT: facilitating displacement of the lens owing to its support on the lower lid and more comfort when wearing the lens.
6 cl, 7 dwg
FIELD: physics, optics.
SUBSTANCE: contact lens comprises an optical zone, a peripheral zone surrounding the optical zone, a front surface and a back surface having movement elements thereon. The movement elements are dimples. The dimples are spaced apart such that their centres are 300-400 mcm apart. The dimples have a depth between 20 mcm and 30 mcm and a diameter between 100 mcm and 300 mcm.
EFFECT: improved lens movement.
7 cl, 4 dwg
FIELD: physics, optics.
SUBSTANCE: lens comprises an optical portion having a central vision region and a peripheral region and extending from the centre of the lens to the outer periphery, and a carrier portion connected to the outer periphery of the optical portion by a blending zone and extending from the outer periphery of the optical portion to the outer periphery of the carrier portion. The has an optical power distribution that creates on-axis and off-axis myopic defocus to reduce or remove on-axis and off-axis defocus created by the optical system of the eye of a patient wearing the lens. On-axis and off-axis defocus is created by increasing positive optical power for light rays passing through the central vision and peripheral regions of the optical portion. The optical power distribution is described by a compound mathematical function that includes at least first and second error functions.
EFFECT: preventing or slowing progression of myopia without noticeable deterioration of central vision of a patient.
20 cl, 4 dwg
SUBSTANCE: invention relates to compounds described by formula I. In general formula I: Y-L2-Z-L1-X, Z stands for bivalent radical of formula (1a):
in which R3a, R3b, R3c and R1z stand for hydrogen; X stands for monovalent radical of formula
in which R1 and R2 independently represent C1-C4-alkyl group, optionally substituted with phenyl; A stands for hydroxygroup or di-C1-C4-alkylaminogroup; B stands for 6-membered heterocycle with two nitrogen atoms as heteroatoms; L1 stands for fragment -C(O)L3C(O)-, where L3 stands for linear or branched C1-C4-alkylene radical, or B stands for covalent bond and L1 stands for fragment -C(O)L3C(O)-O-(CH2)p-O-, where p stands for integer number, equal from 1 to 5; or X stands for diphenylphosphine oxide group, L1 stands for fragment -C(O)L3C(O)-O-(CH2)p-Ph-, where Ph is substituted with two C1-C4-alkyl groups, where p stands for integer number, equal from 1 to 5; Y stands for monovalent radical -O-C(O)-C(R14)=CH2, where R14 stands for C1-C4-alkyl group; and L2 stands for bridge -(CH2)2-. Invention also relates to ophthalmological lens, containing polymer, based on invention compounds.
EFFECT: obtained are novel compounds, which can be applied for manufacturing ophthalmological lenses absorbing UV-radiation.
5 cl, 1 tbl, 8 dwg, 5 ex
FIELD: physics, optics.
SUBSTANCE: method of making a contact lens includes dosing material of optical quality into the front curvature matrix of a contact lens; placing a rear curvature matrix on the surface of the material and connecting the front and rear curvature matrices to form a contact lens matrix and curing the material by varying the intensity of curing light along the profile of the contact lens matrix such that the central part of the contact lens becomes stiffer than the peripheral part. A second version of the method includes depositing a first reaction inhibitor on the surface of the front curvature matrix of the contact lens; dosing material of optical quality into the front curvature matrix; depositing a second reaction inhibitor on the surface of the rear curvature matrix; placing the rear curvature matrix on the surface of the material of optical and superposition thereof with the front curvature matrix to form a contact lens matrix. The first and second reaction inhibitors must have a different composition and concentration. Material in the contact lens matrix is cured to form a predetermined stress profile.
EFFECT: reduced lens stabilisation requirements.
SUBSTANCE: series of lenses for correcting the peripheral defocusing of an eye comprises several soft contact lenses. Each of the soft contact lenses of the series has a central optical force general for all lenses within the series. Each of the soft contact lenses of the series has the same optical power differential specified in a number of various optical power differentials for the lenses within the series. A method for correcting the peripheral defocusing of an eye involves selecting a first soft contact lens in the above series and putting it in the eye; assessing a vision quality to show the presence of hypercorrection or undercorrection in the peripheral retina; replacing the first lens for an alternative lens from the series of soft contact lenses having a higher optical power differential, if the undercorrection has been stated after putting the first lens in, or a lower optical power differential, if the hypercorrection has been stated after putting the first lens in.
EFFECT: lower risk of the hyper- or undercorrection of the defocusing in the peripheral retina of a specific eye, provided delay of myopia progression.
8 cl, 7 dwg
SUBSTANCE: implant layers are presented in the form of congruent ellipsoids of rotation consisting of polymers and/or copolymers of glycosaminoglycans, lactic acid and polyvinylpyrrolidone; all drug-saturated layers are alternated with drug-unsaturated layers, while solubility of each implant layer is provided by hydrolysis of cross linkage and directly proportional to their number.
EFFECT: achieving and maintaining the required drug concentration in the vitreal cavity for the required period of time, no risk of damaging the intraocular structures with high-concentrated drug substances, reducing the intraoperative injury.
SUBSTANCE: implant for the revascularisation of a posterior pole of eyeball is a porous composite of polyethylene tetraphthalate or polycarbonate track-etched membranes with the improved medical-biological properties. Improving the medical-biological properties of the track-etched membranes requires additional plasma processing of cyclohexane.
EFFECT: using the given implant enables improving the trophism and mechanical properties of the sclera in the posterior pole of the eyeball that prevents an optic nerve disorder.
2 dwg, 3 ex
SUBSTANCE: invention can be used for performing a goniopuncture of trabeculo-Descemet's membrane following a non-penetrating deep sclerectomy (NPDS) if observing disturbed transparency of a cornea or fluid flow of an anterior chamber. The trabeculo-Descemet's membrane is micro-perforated from an angle of the anterior chamber within a projection of a postoperative intrascleral cavity by means of a non-traumatic boomerang needle 10-0, needle bend 3/8. The needle is pricked into the cornea at 3-3.5 mm from a limb with its distal end delivered towards an opened portion of the Descemet's membrane. A needle tip is brought through the cornea and further and advanced along a trajectory aligned with its flexion; the needle tip perforates the trabeculo-Descemet's membrane.
EFFECT: method enables achieving the stable normalisation of intraocular pressure following a minimum surgical intervention.
SUBSTANCE: nasolachrymal canal is intubated with a perforated silicone tube with a hole diameter 23G; the holes are staggered at 3 or 4 mm from each other. A distal end of the tube is blocked, whereas a proximal one is fixed in a projection of semilunar fold. A medicinal gel is introduced into a tube lumen every 7 days during the whole period of intubation - up to 3 months.
EFFECT: method provides the prolonged dilation of the lumen of the lachrymal passages and a possibility of the dosed administration of a medicinal preparation around a silicone frame for a long period of time and the recovery of the lachrymal passages patency, and the prevention of recurrent stricture formation, and the lower injury rate.
SUBSTANCE: anaesthetising patients with chronic pain syndrome undergoing a cyclophotocoagulation surgery involves the intravenous administration of the hormonal preparation dexamethasone in a dose of no more than 8 mg followed by the anxiolytic droperidol in a dose of no more than 2.5 mg 5 minutes prior to the operation before the peribulbar anaesthesia. A peripheral block in the form of the peribulbar anaesthesia involving administration of no more than 6 ml of a local anaesthetic follows. At the moment the surgical procedure starts, benzodiazepin, e.g. diazepam, is administered in a dose of no more than 5 mg.
EFFECT: achieving adequate anaesthesia in the given category of patients by blocking all the links of a pathological pain chain.
SUBSTANCE: method involves removing an epithelial layer, exposing a cornea by saturating it through multiple instillations of 0.1% riboflavin followed by the ultraviolet exposure. After the epithelial layer has been removed, a ring made of an ultraviolet-protected contact lens is applied on a surface of the eyeball perilimbally. An outer diameter of the ring covers the limb by no more than 2 mm, whereas an inner diameter of the ring is equal to a basic diameter of the keratoconus. The whole duration of the ultraviolet exposure involves additional instillations of riboflavin on the cornea every 3-4 minutes. The exposure is characterised by wavelength 365 nm, power 3.0 mWt/cm2 at 50 mm for 30 minutes with the ring to be removed after the exposure is completed.
EFFECT: method is easy to implement, involves no difficulties for specialists, providing higher clinical effectiveness by limiting the ultraviolet exposure area, preventing the ultraviolet involvement of the limb and reducing a risk of postoperative complications.
SUBSTANCE: group of inventions refers to surgery. A surgical console comprises a pneumatically operated valve; the first port and the second port connected to the valve configured to feed compressed gas into each of the first port and the second port alternatively; a pressure sensor connected to the ports; and a controller connected to the valve and pressure sensor. The controller is configured to control the time of open and closed state of a valve passage in accordance with the working cycle of the valve. The time of the open state of the valve corresponds to the first port open time, whereas the time of the close state of the valve corresponds to the first port close time. The controller is also configured to receive a measured port pressure differential and to calculate the port pressure differential in accordance with the pressure sensor data, and to modify the working cycle of the valve depending on the difference of the measured or calculated pressure differential and the desired mean pressure differential for reducing a difference of these values. What is disclosed is a method for the valve adjustment.
EFFECT: maintaining the pressure required for the correct operation of the attached instruments.
19 cl, 6 dwg
SUBSTANCE: conjunctival flap is formed. Surface sclera and deep triangular flaps are formed with base to limbus with exposure of ciliary body. 2 scleral channels are formed on each side of triangular flap, perpendicular to them. External end of sclera channels must project beyond bed of surface sclera flap. Two collagen drainages "xenoplast" 0.8-1.2 mm thick, 1.0-1.5 mm wide, 4.0-5.0 mm long, are sutured to formed sclera bed. Length of collagen drainages must not exceed length of sclera flap. Anterior eye chamber is opened by cut along limbus. Iridectomy is performed. Anterior chamber is fully filled with viscoelastic. Ends of two drainages are introduced into anterior chamber, with formation of window in trabeculo-Descemet's membrane. Root of iris must not overlap ends of drainages. Surface sclera flap is laid into place and fixed with sutures.
EFFECT: method provides activation of intraocular fluid outflow for long term, formation of flat spilled filtration pillow with strong wall, prevention of scarring of created pathways for outflow without application of antimethabolites due to formation of sclera channels, external end of which lies beyond bed of surface sclera flap, application of collagen drainages without their overlapping by iris root and length which does not exceed length of scleral flap.
4 cl, 2 ex
SUBSTANCE: invention refers to medicine, particularly to ophthalmology, and can be used in treating amblyopia in children. One 10-minute procedure involves alternating 1-2-minute exposure to green-range laser speckle structures at wavelength 0.5-0.65 mcm and red-range laser speckle structures at wavelength 0.63-0.7 mcm. Laser fluence is (4-8)×10-5 W/cm2. That is combined with autoscan exposure to a travelling magnetic field from temporal lobes to an occipital region by bitemporal method at a scan frequency of 90-180 Hz. A field density is 30-45 mT. The procedures are daily for 10 days.
EFFECT: method provides stimulating the maximum count of retinal cells responsible for colour vision, prevents the eye tissue adaptation to laser light, optimises delivering visual pulses along the visual pathway to the visual cortex.
1 tbl, 2 ex
SUBSTANCE: invention relates to medicine, namely to ophthalmology, and can be used for the removal of silicone oil from the anterior eye chamber. 2 paracenteses are performed. An irrigation cannula of the phacoemulsifier is introduced into one of the paracenteses. Supply of physiological solution is realised. Removal of silicone takes place passively (by gravity) through the second paracentesis.
EFFECT: method makes it possible to remove silicone oil form the anterior eye chamber in a reliable way with low trauma due to the uniform, without differences in pressure, supply of physiological solution by means of an irrigation system and passive removal of silicone oil through the paracentesis.
SUBSTANCE: light sensitivity of retina is determined in 29 points of macular area by method of microperimetry under control of auto-tracking. If value of light sensitivity in 29 points constitutes more than 17 dB, then prediction of pleoptic treatment of amblyopia is favorable. If average value of light sensitivity constitutes from 15.6 dB to 17 dB including, then prediction of treatment is relatively favourable. If average value of light sensitivity constitutes less than 15.6 dB, then prediction of treatment is unfavourable.
EFFECT: method makes it possible to make acute prediction of efficiency of pleoptic treatment of children and teenagers, determine preservation of visual functions due to optimal prediction method, ensures obtaining reliable data of retina light sensitivity, independent on patient's fixation stability due to application of microperimetry under control of auto-tracking.